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1. 发明授权

US07252800B2 Sterilization system and method and inlet control apparatus therefor 有权
标题翻译：灭菌系统及方法及入口控制装置
公开(公告)号：US07252800B2
公开(公告)日：2007-08-07
申请号：US10403140
申请日：2003-03-31
申请人： Paul T. Jacobs , Szu-Min Lin , Jenn-Hann Wang , James P. Kohler , Richard Jed Kendall , Anahid Gamsarian
发明人： Paul T. Jacobs , Szu-Min Lin , Jenn-Hann Wang , James P. Kohler , Richard Jed Kendall , Anahid Gamsarian
IPC分类号： A61L2/20
CPC分类号： A61L2/208 , A61L2/28 , A61L2202/122
摘要： A chemical vapor sterilization process is enhanced by concentrating a germicide via exploitation of the difference between the vapor pressures of the germicide and its solvent. A diffusion restriction can be placed into the diffusion path to assist this process and the path then opened to provide rapid diffusion of the thus concentrated germicide.
摘要翻译：通过利用杀菌剂及其溶剂的蒸气压之间的差异来浓缩杀菌剂来增强化学蒸气灭菌过程。扩散限制可以放置在扩散路径中以辅助该过程，然后打开路径以提供如此浓缩的杀菌剂的快速扩散。

2. 发明授权

US07670550B2 Rapid sterilization system 有权
标题翻译：快速灭菌系统
公开(公告)号：US07670550B2
公开(公告)日：2010-03-02
申请号：US11093526
申请日：2005-03-30
申请人： Szu-Min Lin , Paul T. Jacobs , Jenn-Hann Wang , James P. Kohler , Richard Jed Kendall , Harold R. Williams , Robert Lukasik
发明人： Szu-Min Lin , Paul T. Jacobs , Jenn-Hann Wang , James P. Kohler , Richard Jed Kendall , Harold R. Williams , Robert Lukasik
IPC分类号： A61L2/20
CPC分类号： A61L2/24 , A61L2/208 , A61L2202/122 , A61L2202/14
摘要： A method of sterilizing an article includes placing the article into a chamber containing an inner atmosphere and exhausting the inner atmosphere to lower pressure in the chamber. Hydrogen peroxide vapor is present in the chamber during at least a portion of the step of exhausting the inner atmosphere. Exhaustion of the inner atmosphere is terminated and additional hydrogen peroxide is admitted into the chamber. Hydrogen peroxide vapor contacts the article for a sufficient period to effect sterilization of the article.
摘要翻译：对物品进行灭菌的方法包括将物品放置在含有内部气氛的室中并排出内部气氛以使室内的压力降低。在排气内部气氛的步骤的至少一部分期间，过氧化氢蒸汽存在于室中。内部气氛的耗尽终止，另外的过氧化氢进入腔室。过氧化氢蒸气与制品接触足够的时间以实现制品的灭菌。

3. 发明授权

US07246627B2 Monitoring of cleaning process 有权
标题翻译：清洁过程监控
公开(公告)号：US07246627B2
公开(公告)日：2007-07-24
申请号：US10326041
申请日：2002-12-20
申请人： Paul T. Jacobs , Jenn-Hann Wang , Szu-Min Lin
发明人： Paul T. Jacobs , Jenn-Hann Wang , Szu-Min Lin
IPC分类号： B08B3/02
CPC分类号： A61L2/186 , A61B90/70 , A61L2/183 , A61L2202/17 , A61L2202/24 , B08B3/00
摘要： An apparatus for monitoring a cleaning process for a medical device includes a cleaning chamber for receiving and cleaning the instrument with a cleaning liquid, a receiving well within the cleaning chamber, a removable soil standard receivable within the receiving well whereby to be exposed to the cleaning process within the cleaning chamber; and a soil detector coupled to the cleaning chamber and adapted to provide an indication of the amount of the soil on the soil standard while the soil standard is received within the receiving well.
摘要翻译：一种用于监测医疗装置的清洁过程的装置包括清洁室，用于接收和清洁具有清洁液体的仪器，清洁室内的接收井，可接收在接收井内的可移除的土壤标准，从而暴露于清洁清洁室内的过程; 以及土壤检测器，其耦合到所述清洁室并且适于在所述接收井内接收到土壤标准的同时提供土壤标准上土壤的量的指示。

4. 发明授权

US06589481B1 Apparatus and method to pretreat and sterilize a lumen device 失效
标题翻译：预处理和消毒管腔装置的装置和方法
公开(公告)号：US06589481B1
公开(公告)日：2003-07-08
申请号：US09222966
申请日：1998-12-30
申请人： Szu-Min Lin , Paul T. Jacobs , Jenn-Hann Wang , Alfredo M Choperena
发明人： Szu-Min Lin , Paul T. Jacobs , Jenn-Hann Wang , Alfredo M Choperena
IPC分类号： A61L200
CPC分类号： A61L2/186 , A61L2/14 , A61L2/16 , A61L2/208 , A61L2202/122 , A61L2202/24 , Y10S220/913 , Y10S422/906
摘要： Various forms of apparatus and methods for pretreating and sterilizing a lumen with a peroxide solution prior to sterilization of the interior of the lumen by exposing the lumen to reduced pressure and, optionally, plasma in a sterilization chamber. The pretreatment is preferably done before placing the lumen in the sterilization chamber. The method also includes exposure of the exterior of the lumen to peroxide vapor to sterilize the exterior of the lumen. Pretreatment of the interior of the lumen with liquid peroxide greatly improves the efficiency of sterilization of the interior. Exposure of the lumen to plasma reduces the time required for sterilization.
摘要翻译：在通过使内腔暴露于减压之前，以及任选地在灭菌室中的等离子体之前，用过氧化物溶液预处理和消毒内腔内部的内部的各种形式的装置和方法。预处理优选在将内腔置于灭菌室内之前进行。该方法还包括将内腔的外部暴露于过氧化物蒸气以对管腔的外部进行灭菌。用液体过氧化物预处理内腔内部，大大提高了内部灭菌的效率。将内腔暴露于血浆减少了灭菌所需的时间。

5. 发明授权

US06333002B1 Sterilization process using small amount of sterilant to determine the load 有权
标题翻译：消毒过程中使用少量灭菌剂来确定负荷
公开(公告)号：US06333002B1
公开(公告)日：2001-12-25
申请号：US09223125
申请日：1998-12-30
申请人： Paul T. Jacobs , Szu-Min Lin , Jenn-Hann Wang
发明人： Paul T. Jacobs , Szu-Min Lin , Jenn-Hann Wang
IPC分类号： G05B200
CPC分类号： A61L2/208 , A61L2/28 , A61L2202/122 , A61L2202/24 , Y10T436/206664
摘要： A method for determining and sterilizing a load in a sterilization chamber. A small amount of sterilant is introduced into the sterilization chamber and the concentration of sterilant is measured. The load of equipment to be sterilized is determined from the concentration of sterilant, and more sterilant is added, if necessary, based on the load. The process is repeated, if necessary, until the load is sterilized. The sterilant is preferably hydrogen peroxide, and the concentration of hydrogen peroxide is preferably determined by a spectrophotometric method in the infrared or ultraviolet regions. By monitoring the sterilant concentration and adding more as needed, the equipment in the chamber can be sterilized efficiently without exposing it to high concentrations of sterilant which could damage the equipment or leave too much residual on the equipment.
摘要翻译：一种用于确定和消毒灭菌室中的负载的方法。将少量灭菌剂引入消毒室中，并测量灭菌剂的浓度。要灭菌的设备的负荷由灭菌剂的浓度确定，如果需要，根据负载添加更多的灭菌剂。如果需要，重复该过程，直到负载消毒。杀菌剂优选为过氧化氢，优选通过分光光度法在红外线或紫外线区域中确定过氧化氢的浓度。通过监测灭菌剂浓度并根据需要添加更多，室内的设备可以高效灭菌，而不会将其暴露于高浓度的灭菌剂，这可能会损坏设备或在设备上留下太多的残留物。

6. 发明授权

US07563329B2 Monitoring of cleaning process 有权
标题翻译：清洁过程监控
公开(公告)号：US07563329B2
公开(公告)日：2009-07-21
申请号：US11095251
申请日：2005-03-31
申请人： Szu-Min Lin , Paul T. Jacobs , Jenn-Hann Wang , Robert C. Platt , Peter C. Zhu
发明人： Szu-Min Lin , Paul T. Jacobs , Jenn-Hann Wang , Robert C. Platt , Peter C. Zhu
IPC分类号： B08B13/00 , G01N21/94 , G01N21/84
CPC分类号： A61L2/186 , A61B1/00057 , A61B1/123 , A61B90/70 , A61B2090/701 , A61B2090/702 , A61L2/183 , A61L2/28 , A61L2202/122 , A61L2202/17 , A61L2202/24 , G01N31/22
摘要： A method for monitoring a cleaning process for a medical instrument, includes the steps of placing the instrument in a cleaning chamber; placing a soil standard in the cleaning chamber; cleaning the instrument and the soil standard with a cleaning solution; and detecting whether soil remains on said soil standard. The soil standard includes two substantially parallel substrates separated with two substantially equal thickness spacers, wherein a gap is formed between the two substrates with soil in the gap.
摘要翻译：一种用于监测医疗器械的清洁过程的方法，包括将仪器放置在清洁室中的步骤; 将污物标准放在清洁室内; 用清洁液清洗仪器和土壤标准品; 并检测土壤是否保留在所述土壤标准上。土壤标准包括两个基本上平行的基底，两个基本上平行的基底用两个基本上相等的厚度的隔离物隔开，其中在间隙中的土壤之间在两个基底之间形成间隙。

7. 发明授权

US06599471B2 Sterilization process using small amount of sterilant to determine the load 有权
公开(公告)号：US06599471B2
公开(公告)日：2003-07-29
申请号：US09982213
申请日：2001-10-16
申请人： Paul T. Jacobs , Szu-Min Lin , Jenn-Hann Wang
发明人： Paul T. Jacobs , Szu-Min Lin , Jenn-Hann Wang
IPC分类号： A61L900
CPC分类号： A61L2/208 , A61L2/28 , A61L2202/122 , A61L2202/24 , Y10T436/206664
摘要： A method for determining and sterilizing a load in a sterilization chamber. A small amount of sterilant is introduced into the sterilization chamber and the concentration of sterilant is measured. The load of equipment to be sterilized is determined from the concentration of sterilant, and more sterilant is added, if necessary, based on the load. The process is repeated, if necessary, until the load is sterilized. The sterilant is preferably hydrogen peroxide, and the concentration of hydrogen peroxide is preferably determined by a spectrophotometric method in the infrared or ultraviolet regions. By monitoring the sterilant concentration and adding more as needed, the equipment in the chamber can be sterilized efficiently without exposing it to high concentrations of sterilant which could damage the equipment or leave too much residual on the equipment.

8. 发明授权

US06451254B1 Sterilization of diffusion-restricted area by revaporizing the condensed vapor 失效
标题翻译：通过蒸发冷凝蒸气灭菌扩散限制区域
公开(公告)号：US06451254B1
公开(公告)日：2002-09-17
申请号：US09223594
申请日：1998-12-30
申请人： Jenn-Hann Wang , Szu-Min Lin , Paul T. Jacobs
发明人： Jenn-Hann Wang , Szu-Min Lin , Paul T. Jacobs
IPC分类号： A01N100
CPC分类号： A61L2/208 , A01N25/18 , A01N59/00 , A61L2/14 , A61L2202/122 , A61L2202/24 , A01N2300/00
摘要： A method for sterilizing the interior of a diffusion restricted area by introducing a sterilant in a chamber, condensing the vapor, reducing the pressure in the chamber to revaporize the condensed vapor, and maintaining the device in the chamber until the device is sterilized. The sterilant has a vapor pressure less than the vapor pressure of water and is preferably hydrogen peroxide. The pressure in the chamber while maintaining the device in the chamber may be held constant, varied, or increased. Plasma may additionally be introduced into the chamber to improve the rate of sterilization.
摘要翻译：一种通过在室中引入消毒剂来消毒扩散受限区域的内部的方法，使蒸汽冷凝，减小腔室中的压力以再蒸发冷凝的蒸汽，并将该装置保持在腔室中，直到该装置被灭菌。灭菌剂的蒸气压小于水的蒸气压，优选为过氧化氢。保持室内的装置的腔室中的压力可以保持恒定，变化或增加。另外可以将等离子体引入腔室以提高灭菌速率。

9. 发明授权

US06673313B2 Sterilizing a device by revaporizing a condensed vapor 失效
标题翻译：通过蒸发冷凝的蒸气灭菌装置
公开(公告)号：US06673313B2
公开(公告)日：2004-01-06
申请号：US10187128
申请日：2002-06-28
申请人： Jenn-Hann Wang , Szu-Min Lin , Paul T. Jacobs
发明人： Jenn-Hann Wang , Szu-Min Lin , Paul T. Jacobs
IPC分类号： A61L220
CPC分类号： A61L2/208 , A01N25/18 , A01N59/00 , A61L2/14 , A61L2202/122 , A61L2202/24 , A01N2300/00
摘要： A method for sterilizing the interior of a diffusion restricted area by introducing a sterilant in a chamber, condensing the vapor, reducing the pressure in the chamber to revaporize the condensed vapor, and maintaining the device in the chamber until the device is sterilized. The sterilant has a vapor pressure less than the vapor pressure of water and is preferably hydrogen peroxide. The pressure in the chamber while maintaining the device in the chamber may be held constant, varied, or increased. Plasma may additionally be introduced into the chamber to improve the rate of sterilization.
摘要翻译：一种通过在室中引入消毒剂来消毒扩散受限区域的内部的方法，使蒸汽冷凝，减小腔室中的压力以再蒸发冷凝的蒸汽，并将该装置保持在腔室中，直到该装置被灭菌。灭菌剂的蒸气压小于水的蒸气压，优选为过氧化氢。保持室内的装置中的压力可以保持恒定，变化或增加。另外可以将等离子体引入腔室以提高灭菌速率。

10. 发明授权

US07807100B2 Sterilization system and method with temperature-controlled condensing surface 有权
标题翻译：具有温度控制冷凝面的灭菌系统和方法
公开(公告)号：US07807100B2
公开(公告)日：2010-10-05
申请号：US10403217
申请日：2003-03-31
申请人： Alfredo Choperena , Harold R. Williams , Szu-Min Lin , Robert Lukasik , Richard Jed Kendall , James P. Kohler
发明人： Alfredo Choperena , Harold R. Williams , Szu-Min Lin , Robert Lukasik , Richard Jed Kendall , James P. Kohler
IPC分类号： A61L9/00 , A61L2/08 , A61L2/00
CPC分类号： A61L2/208 , A61L2/14 , A61L2/186 , A61L2/24 , A61L2202/122 , A61L2202/14 , A61L2202/24 , H01L35/00 , H04J14/0227 , H04J14/0241 , H04J14/0284 , H04Q11/0062 , H04Q2011/0084 , H04Q2011/0086
摘要： A chemical vapor sterilization process is enhanced by concentrating a germicide via condensation and re-vaporization thereof, exploiting the difference between the vapor pressures of the germicide and its solvent to extract some of the solvent during the condensation process.
摘要翻译：通过冷凝和再蒸发浓缩杀菌剂来增强化学蒸气灭菌过程，利用杀菌剂及其溶剂的蒸气压之间的差异，在冷凝过程中提取一些溶剂。

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