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1. 发明授权

US6048353A Trephine device for locating and cutting a cylindrical or reverse tapered aperture in flexible material 失效
标题翻译： Trephine装置用于定位和切割柔性材料中的圆柱形或反向锥形孔
公开(公告)号：US6048353A
公开(公告)日：2000-04-11
申请号：US262192
申请日：1999-03-04
申请人： Paul S. Freed , Adrian Kantrowitz , Seymour Mermelstein
发明人： Paul S. Freed , Adrian Kantrowitz , Seymour Mermelstein
IPC分类号： A61B17/16 , A61B17/32 , A61F5/445 , A61B17/14
CPC分类号： A61B17/32053 , A61B17/1695 , A61F5/445
摘要： A trephine device for preparing apertures through a flexible material, such as skin of a patient, including a base plate having an upper surface and an opposed lower surface, where the upper surface has at least one upwardly protruding skin deforming contoured surface. The base plate is adapted to be removably inserted into a pocket surgically prepared in tissue of the patient. The device can include a handle member mounted on and projecting upwardly from the upper surface of the base plate. A clamping member is connected to the trephine device in overlying relationship to the upper surface of the base plate. The clamping member facilitates deformable, clamping, sandwiched engagement of the flexible material between the upper surface of the base plate and the clamping member. When the base plate is inserted into the pocket surgically prepared in the tissue of the patient, the skin of the patient is engageable between the base plate and the clamping member. The trephine device includes a cutter positionable relative to the handle member. The cutter is movable relative to the clamping member into cutting engagement with the flexible material deformably engaged by the clamping member to form an aperture having a cylindrical wall or a reverse tapered wall in the flexible material.
摘要翻译：用于通过诸如患者皮肤的柔性材料制备孔的环钻设备，包括具有上表面和相对的下表面的基板，其中上表面具有至少一个向上突出的皮肤变形的轮廓表面。基板适于可拆卸地插入到手术组织制备在患者组织中的口袋中。该装置可以包括安装在基板的上表面上并从基板的上表面向上突出的把手件。夹紧构件以与基板的上表面重叠的关系连接到环钻装置。夹紧构件促进柔性材料在基板的上表面和夹紧构件之间的可变形，夹紧，夹紧接合。当基板插入到手术组织在患者组织中的口袋中时，患者的皮肤可接合在基板和夹紧构件之间。环钻设备包括可相对于手柄构件定位的刀具。切割器相对于夹紧构件可移动，与由可夹紧构件可变形地接合的柔性材料切割接合以形成在柔性材料中具有圆柱形壁或倒锥形壁的孔。

2. 发明申请

US20080281412A1 RIGID BODY AORTIC BLOOD PUMP IMPLANT 有权
标题翻译：刚体动物血液泵植入物
公开(公告)号：US20080281412A1
公开(公告)日：2008-11-13
申请号：US12120457
申请日：2008-05-14
申请人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
发明人： Robert M. Smith , Adrian Kantrowitz , Valluvan Jeevanandam , Allen B. Kantrowitz , Paul S. Freed
IPC分类号： A61M1/12
CPC分类号： A61M1/107 , A61M1/1037 , A61M1/106 , A61M1/1072 , A61M1/122 , A61M1/125 , B33Y80/00
摘要： An implantable aortic blood pump includes a rigid body having wall extending along a long axis and defining an inflation port portion with an inflation aperture therethrough. The aperture is fluid communication with an inner surface of the body and on a fluid supply, the body is preferably independent of an external brace or an external stiffener, yet still has a cantilevered deformation of less than 8 millimeters in response to a 200 gram weight suspended from a front body edge. A deflecting structure of a membrane deflects in response to fluid pressure so as to pump blood when the pump is secured to a subject aorta.
摘要翻译：可植入主动脉血泵包括刚体，其具有沿着长轴延伸的壁，并且限定具有穿过其的充气孔的充气口部分。孔与主体的内表面和流体供应源流体连通，主体优选地独立于外部支架或外部加强件，但是响应于200克重量仍然具有小于8毫米的悬臂变形从前身边缘悬挂。膜的偏转结构响应于流体压力而偏转，以便当泵固定到主体主动脉时泵送血液。

3. 发明授权

US4634422A Percutaneous access device and method for implanting same 失效
标题翻译：经皮进入装置及其植入方法
公开(公告)号：US4634422A
公开(公告)日：1987-01-06
申请号：US615883
申请日：1984-05-31
申请人： Adrian Kantrowitz , Paul S. Freed , Frizell L. Vaughan , Isadore A. Bernstein , Robert H. Gray
发明人： Adrian Kantrowitz , Paul S. Freed , Frizell L. Vaughan , Isadore A. Bernstein , Robert H. Gray
IPC分类号： A61F2/02 , A61M1/00 , A61M31/00 , A61M5/32 , C12N5/02
CPC分类号： A61M39/0247 , A61M2039/0291 , Y10S623/901
摘要： A percutaneous access device (PAD) is provided with a sleeve or separable member which may be detached from the device to enable the culturing of a multilayer fibroblast coating on the member in a stable and undisturbed environment. The member is constructed so that when it is assembled into the device and the device is implanted in a patient, the cultured coating of the member is exposed to the patient's dermis whose fibroblasts will, after a relatively short healing period, merge with the fibroblasts of the coating to form a barrier layer interlocked with the member to prevent epidermal ingrowth or marsupialization of the implanted device.Implantation techniques for further facilitating the formation of the dermal barrier are also disclosed.
摘要翻译：经皮进入装置（PAD）设置有套筒或可分离构件，其可以与装置分离，以便能够在稳定且不受干扰的环境中在构件上培养多层成纤维细胞涂层。构件被构造成使得当其组装到装置中并且将装置植入患者体内时，将该构件的培养包被暴露于患者的真皮，其成纤维细胞在相当短的愈合期后将与成纤维细胞所述涂层形成与所述构件互锁的阻挡层，以防止所述植入装置的表皮向内生长或有囊动作。还公开了用于进一步促进真皮屏障形成的植入技术。

4. 发明授权

US5169379A In-series ventricular assist system and method of controlling same 失效
标题翻译：一系列静态辅助系统及其控制方法
公开(公告)号：US5169379A
公开(公告)日：1992-12-08
申请号：US365817
申请日：1989-06-14
申请人： Paul S. Freed , Kevin P. Gage , Adrian Kantrowitz
发明人： Paul S. Freed , Kevin P. Gage , Adrian Kantrowitz
IPC分类号： A61M1/12 , A61F2/958 , A61M1/10
CPC分类号： A61M1/106 , A61M1/1072 , A61M2025/102 , A61M2025/1022
摘要： An in-series ventricular assist system for assisting the circulation of blood in a patient is disclosed. A pumping bladder is disposed in the thoractic aorta of the patient and selected physiologic events relating to each heart beat are monitored by appropriate sensors. A gas handling subsystem inflates and deflates the pumping bladder in accordance with the detected physiologic events and a predetermined set of assist system parameters. A microprocessor evaluates the effects of inflation and deflation of the pumping bladder and the corresponding assistance on the patient for each heart beat. The microprocessor is operable to alter or adjust the assist system parameters for each subsequent heart beat in accordance with the effects of assistance of the pumping bladder on the patient. In the preferred embodiment, the assist system parameters which are set by the microprocessor for inflating and deflating the pumping bladder during the immediately preceding heart beat are used as the base line for making small adjustments in those parameters for the present heart beat. Alternatively, the microprocessor may be made operable to store the assist system parameters associated within an immediately preceding predetermined number of prior heart beats to compare the detected physiologic events from each of the stored preceding heart beats with those of the current heart beat.

5. 发明授权

US5833655A Percutaneous access device having removable turret assembly 失效
标题翻译：具有可拆卸转塔组件的经皮进入装置
公开(公告)号：US5833655A
公开(公告)日：1998-11-10
申请号：US856905
申请日：1997-05-15
申请人： Paul S. Freed , George Taro , Adrian Kantrowitz
发明人： Paul S. Freed , George Taro , Adrian Kantrowitz
IPC分类号： A61M37/00 , A61M1/00 , A61N1/378 , A61M11/00
CPC分类号： A61M39/0247 , A61M2039/0267 , A61M2039/0282 , A61M2039/0294
摘要： A percutaneous access device implantable beneath the skin of a patient which includes a housing having a flange positionable beneath the skin and neck projecting outward through the skin. The percutaneous access device includes electrical communication through the flange and fluid access through the flange. The components providing fluid access and electrical communication are removable through the neck portion of the implant for testing and service as required without the need for further surgery on the patient. A turret body is received within the hollow interior of the neck having a fluid channel extending therethrough and containing current limiting devices securely disposed within the turret body.
摘要翻译：可植入患者皮肤下面的经皮进入装置，其包括壳体，所述壳体具有可定位在皮肤和颈部下方的凸缘，其向外突出穿过皮肤。经皮进入装置包括通过凸缘的电连通和通过凸缘的流体通路。提供流体通路和电气连通的部件可通过植入物的颈部部分移除，以便根据需要进行测试和服务，而无需对患者进一步手术。转塔体容纳在颈部的中空内部，具有延伸穿过其中的流体通道并且包含牢固地设置在转台体内的限流装置。

6. 发明授权

US5242415A Percutaneous access device 失效
标题翻译：经皮进入装置
公开(公告)号：US5242415A
公开(公告)日：1993-09-07
申请号：US929948
申请日：1992-08-14
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61M1/00
CPC分类号： A61M39/0247 , A61M2039/0261
摘要： A percutaneous access device includes a body having a horizontal disc-like base flange and a frusto conical projection extending centrally upwardly from one side of the base flange. An elongate flexible tube extends loosely through a bore through the projection and base flange and is sealingly bonded to the body adjacent the bottom of the bore. A coating of a silicone-polycarbonate is applied to the outer surface of the projection and is formed with a multiplicity of microscopic pores to facilitate the bonding of dermal cells to the device upon implantation. The body is of a relatively soft, flexible, biocompatible material so that the device absorbs forces tending to displace the implanted device.
摘要翻译：经皮进入装置包括具有水平盘状基部凸缘和从基部凸缘的一侧向中心向上延伸的截头圆锥形凸起的本体。细长的柔性管通过突出部和基部凸缘松动地延伸通过孔，并且密封地结合到与孔的底部相邻的主体。将聚硅氧烷聚碳酸酯的涂层施加到突起的外表面，并且形成有多个微孔，以便于在植入时将真皮细胞与装置结合。身体是相对柔软的，柔性的，生物相容的材料，使得该装置吸收倾向于移植植入装置的力。

7. 发明授权

US5139508A Surgical tool 失效
标题翻译：手术工具
公开(公告)号：US5139508A
公开(公告)日：1992-08-18
申请号：US796040
申请日：1991-11-20
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61B17/32
CPC分类号： A61B17/32053
摘要： A surgical tool for forming a circular opening through the skin which is of smaller diameter at the outer skin surface than at the inner surface of the skin employs a trephine having a circular cutting edge. The trephine is inserted into a pocket surgically formed beneath the skin with its cutting surface facing the skin. A rod member is then inserted through the skin and threaded into the trephine. The rod member is attached to a spring biassed plunger within a tool housing which is released from a ready position by withdrawal of a locking pin. Upon release of the plunger, the spring drives the plunger to drive the cutting edge of the trephine outwardly through the skin.
摘要翻译：用于形成通过皮肤的圆形开口的手术工具，其外皮表面的直径小于皮肤的内表面，采用具有圆形切割边缘的环钻。环钻被插入手术形成在皮肤下方的口袋中，其切割表面面向皮肤。然后将杆构件穿过皮肤并穿入环钻。杆构件附接到工具壳体内的弹簧偏压柱塞，该工具壳体通过撤销锁定销而从就绪位置释放。在释放柱塞时，弹簧驱动柱塞以通过皮肤向外驱动环钻的切割边缘。

8. 发明授权

US4630597A Dynamic aortic patch for thoracic or abdominal implantation 失效
标题翻译：用于胸部或腹部植入的动态主动脉瓣
公开(公告)号：US4630597A
公开(公告)日：1986-12-23
申请号：US604944
申请日：1984-04-30
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61B17/12 , A61M1/10 , A61M1/12 , A61F1/24 , A61M1/03
CPC分类号： A61M1/1037 , A61B17/12109 , A61B17/12136 , A61M1/122 , A61M1/106
摘要： An improved dynamic aortic patch is constructed with an elongate semi-rigid shell member having a concave inner surface and a flexible membrane integrally bonded to the outer surface of the shell to define an inflatable and deflatable chamber between the concave inner surface and the membrane. The pumping capacity of the patch is determined by the concavity of the inner surface of the shell member, thus enabling the construction of a patch which may be implanted in the thoracic cavity (small concavity) or in the abdomen (large concavity). A fabric layer bonded to the membrane over the area overlying the outer surface of the shell has a peripheral suture flange projecting freely clear of the membrane, and a temporary shield adapted to overlie the fabric layer may be employed to assure that sutures placed to attach the patch within an opening in the aorta are not inadvertently passed through the membrane.
摘要翻译：改进的动态主动脉贴片由具有凹形内表面的细长半刚性壳构件和与外壳的外表面整体结合的柔性膜构成，以在凹内表面和膜之间限定可充气和可放气的腔室。贴片的抽吸能力由壳体内表面的凹度确定，从而能够构建可植入胸腔（小凹陷）或腹部（大凹陷）的贴片。在覆盖壳的外表面的区域上结合到膜上的织物层具有自由地远离膜突出的外围缝合线凸缘，并且可以采用适于覆盖在织物层上的临时护罩，以确保将缝合线主动脉开口内的斑块不会无意中通过膜。

9. 发明授权

US4092742A Dynamic prosthetic myocardium 失效
标题翻译：动态假体心肌
公开(公告)号：US4092742A
公开(公告)日：1978-06-06
申请号：US733677
申请日：1976-10-18
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61M1/10 , A61M1/12 , A61F1/24
CPC分类号： A61M1/1068 , A61M1/122 , A61M1/106
摘要： A prosthetic myocardium is disclosed for replacing necrotic or scarred myocardial tissue to positively simulate both myocardial contraction and expansion during systole and diastole. The prosthetic device includes several circumferentially arranged tilting arms which are sutured to the periphery of an opening in the heart formed by a medical excision. The tilting arms are pivotally supported and functionally interconnected with an axially reciprocal drive rod which effects synchronized inward and outward pivoting of the tilting arms to simulate the myocardial functions during heartbeat.
摘要翻译：公开了一种假体心肌来替代坏死或伤痕累积的心肌组织，以积极地模拟心脏收缩和收缩期和收缩期间的扩张。假体装置包括几个周向布置的倾斜臂，其被缝合到通过医疗切除形成的心脏中的开口的周边。倾斜臂枢转地支撑并且功能地与轴向往复驱动杆互连，其实现倾斜臂的同步向内和向外枢转以在心跳期间模拟心肌功能。

10. 发明授权

US4913700A Culture and transport assembly for percutaneous access device 失效
标题翻译：用于经皮进入装置的文化和运输组件
公开(公告)号：US4913700A
公开(公告)日：1990-04-03
申请号：US259991
申请日：1988-10-21
申请人： Adrian Kantrowitz , Paul S. Freed
发明人： Adrian Kantrowitz , Paul S. Freed
IPC分类号： A61M1/00 , A61M5/00
CPC分类号： A61M39/0247 , A61M2039/0288 , A61M2039/0291 , A61M2039/0294
摘要： A culture and transport assembly for enclosing a percutaneous access device within a sealed outer container to maintain the device under sterile conditions during transport while accommodating culturing of a coating of dermal cells on a portion of the device while the device is retained within the container. The container has a removable cap to which a culture well body is attached. The percutaneous access device is releasably clamped between the bottom of the body and an underlying platform with a portion of the device projecting into a bore in the body. When the device is so clamped, the bore constituted a sealed culture chamber in which the dermal cell culturing procedure may be performed by introducing cells and culturing solutions into the chamber via fluid passages extending from the chamber to connectors accessible at the exterior of the cap.
摘要翻译：一种培养和运输组件，其用于将经皮进入装置封闭在密封的外部容器内，以在运输过程中将装置维持在无菌条件下，同时在装置保持在容器内的同时容纳在装置的一部分上培养真皮细胞的涂层。容器具有可移除的盖子，文化井体与其相连。经皮进入装置可释放地夹紧在主体的底部和底部平台之间，其中该装置的一部分突出到主体中的孔中。当装置如此夹持时，孔构成密封的培养室，其中可以通过从腔室延伸到在帽外部可接近的连接器的流体通道将细胞和培养溶液引入室中来进行真皮细胞培养程序。

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