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1. 发明授权

US06339069B1 Peptide-lipid conjugates, liposomes and lipsomal drug delivery 有权
标题翻译：肽 - 脂质缀合物，脂质体和lipomal药物递送
公开(公告)号：US06339069B1
公开(公告)日：2002-01-15
申请号：US09343650
申请日：1999-06-29
申请人： Paul R. Meers , Charles Pak , Shaukat Ali , Andrew Janoff , J. Craig Franklin , Ravi K. Erukulla , Donna Cabral-Lilly , Patrick L. Ahl
发明人： Paul R. Meers , Charles Pak , Shaukat Ali , Andrew Janoff , J. Craig Franklin , Ravi K. Erukulla , Donna Cabral-Lilly , Patrick L. Ahl
IPC分类号： A61K4800
CPC分类号： A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1275 , A61K38/00 , A61K47/543 , A61K47/544 , A61K47/6911 , C07K1/1077 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0808 , C07K5/0819 , C07K5/0823 , C07K5/0827 , C07K5/1008 , C07K5/1013 , C07K5/1027 , C07K7/06 , C07K9/001
摘要： Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.
摘要翻译：将肽 - 脂质缀合物掺入脂质体中，以选择性地使目标肽酶分泌细胞附近的脂质体不稳定，从而将脂质体递送至靶细胞附近或直接进入细胞。因此，脂质体可用于治疗哺乳动物疾病，病症或病症，例如肿瘤，微生物感染和炎症，其特征在于发生肽酶分泌细胞。

2. 发明授权

US6087325A Peptide-lipid conjugates 失效
标题翻译：肽 - 脂质缀合物
公开(公告)号：US6087325A
公开(公告)日：2000-07-11
申请号：US950618
申请日：1997-10-15
申请人： Paul R. Meers , Charles Pak , Shaukat Ali , Andrew Janoff , J. Craig Franklin , Ravi K. Erukulla , Donna Cabral-Lilly
发明人： Paul R. Meers , Charles Pak , Shaukat Ali , Andrew Janoff , J. Craig Franklin , Ravi K. Erukulla , Donna Cabral-Lilly
IPC分类号： A61K9/127 , A61K38/00 , A61K47/48 , C07K1/107 , C07K5/06 , C07K5/08 , C07K5/083 , C07K5/093 , C07K5/097 , C07K5/10 , C07K5/103 , C07K7/06 , C07K9/00 , C07K5/00 , C07K7/00
CPC分类号： C07K7/06 , A61K47/48053 , A61K47/48238 , A61K47/48815 , A61K9/127 , A61K9/1271 , A61K9/1272 , C07K1/1077 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0808 , C07K5/0819 , C07K5/0823 , C07K5/0827 , C07K5/1008 , C07K5/1013 , C07K5/1027 , C07K9/001 , A61K38/00
摘要： Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.
摘要翻译：将肽 - 脂质缀合物掺入脂质体中，以选择性地使目标肽酶分泌细胞附近的脂质体不稳定，从而将脂质体递送至靶细胞附近或直接进入细胞。因此，脂质体可用于治疗哺乳动物疾病，病症或病症，例如肿瘤，微生物感染和炎症，其特征在于发生肽酶分泌细胞。

3. 发明授权

US6143716A Liposomal peptide-lipid conjugates and delivery using same 失效
标题翻译：脂质体 - 脂质共轭物和使用它们的递送
公开(公告)号：US6143716A
公开(公告)日：2000-11-07
申请号：US168010
申请日：1998-10-07
申请人： Paul R. Meers , Charles Pak , Shaukat Ali , Andrew Janoff , J. Craig Franklin , Ravi K. Erukulla , Donna Cabral-Lilly
发明人： Paul R. Meers , Charles Pak , Shaukat Ali , Andrew Janoff , J. Craig Franklin , Ravi K. Erukulla , Donna Cabral-Lilly
IPC分类号： A61K9/127 , A61K38/00 , A61K47/48 , C07K1/107 , C07K5/06 , C07K5/08 , C07K5/083 , C07K5/093 , C07K5/097 , C07K5/10 , C07K5/103 , C07K7/06 , C07K9/00 , C07K5/00 , C07K7/00
CPC分类号： C07K7/06 , A61K47/48053 , A61K47/48238 , A61K47/48815 , A61K9/127 , A61K9/1271 , A61K9/1272 , C07K1/1077 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0808 , C07K5/0819 , C07K5/0823 , C07K5/0827 , C07K5/1008 , C07K5/1013 , C07K5/1027 , C07K9/001 , A61K38/00
摘要： Peptide-lipid conjugates are incorporated into liposomes so as to selectively destabilize the liposomes in the vicinity of target peptidase-secreting cells, and hence, to deliver the liposomes to the vicinity of the target cells, or directly into the cells. The liposomes can thus be used to treat mammals for diseases, disorders or conditions, e.g., tumors, microbial infection and inflammations, characterized by the occurrence of peptidase-secreting cells.
摘要翻译：将肽 - 脂质缀合物掺入脂质体中，以选择性地使目标肽酶分泌细胞附近的脂质体不稳定，从而将脂质体递送至靶细胞附近或直接进入细胞。因此，脂质体可用于治疗哺乳动物疾病，病症或病症，例如肿瘤，微生物感染和炎症，其特征在于发生肽酶分泌细胞。

4. 发明授权

US06573246B1 Modified ether glyceroglycolipids 失效
标题翻译：改性醚甘油糖脂
公开(公告)号：US06573246B1
公开(公告)日：2003-06-03
申请号：US09644470
申请日：2000-08-23
申请人： Robert Bittman , Ravi K. Erukulla , Andrew C. Peters , Eric G. Mayhew
发明人： Robert Bittman , Ravi K. Erukulla , Andrew C. Peters , Eric G. Mayhew
IPC分类号： A61K3170
CPC分类号： C07H15/04
摘要： This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage, 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.
摘要翻译：本发明提供脂质，其具有：1）甘油骨架; 2）优选饱和并含有16或18个碳原子的烃链，其通过醚键连接到主链的C-1上，3）连接于主链C-2上的甲基，优选通过醚键; 和4）以α或β端基构型连接在甘油骨架的C-3上的糖，通过其一个或多个羟基的修饰或取代来改变糖。本文还提供了含醚 - 脂质的组合物，以及将这些组合物施用于动物，例如患有癌症的那些以及各种其它疾病和病症的方法。

5. 发明授权

US6153736A Modified ether glyceroglycolipids 失效
标题翻译：改性醚甘油糖脂
公开(公告)号：US6153736A
公开(公告)日：2000-11-28
申请号：US722881
申请日：1996-09-26
申请人： Robert Bittman , Ravi K. Erukulla , Andrew C. Peters , Eric G. Mayhew
发明人： Robert Bittman , Ravi K. Erukulla , Andrew C. Peters , Eric G. Mayhew
IPC分类号： A61K31/00 , A61K31/70 , A61K31/7028 , A61P29/00 , A61P31/00 , A61P35/00 , C07H15/04 , C07H15/10 , C07H15/14 , C07H15/06 , C07H5/06
CPC分类号： C07H15/04
摘要： This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage; 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.
摘要翻译：本发明提供脂质，其具有：1）甘油骨架; 2）优选饱和并含有16或18个碳原子的烃链，其通过醚键与骨架的C-1连接; 3）优选通过醚键连接至主链C-2上的甲基; 和4）以α或β端基构型连接在甘油骨架的C-3上的糖，通过其一个或多个羟基的修饰或取代来改变糖。本文还提供了含醚 - 脂质的组合物，以及将这些组合物施用于动物，例如患有癌症的那些以及各种其它疾病和病症的方法。

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