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    • 5. 发明申请
    • Efficient liposomal encapsulation
    • 高效的脂质体包封
    • US20090191259A1
    • 2009-07-30
    • US10500932
    • 2003-01-08
    • Xingong LiTong ShangguanAlla PolozovaPaul R. MeersWalter R. Perkins
    • Xingong LiTong ShangguanAlla PolozovaPaul R. MeersWalter R. Perkins
    • A61K9/127A61K31/7088A61K38/02A61K31/711A61K39/00A61K39/395
    • B01J13/02A61K9/1277A61K47/6911
    • The present invention concerns a method for preparing liposomes, said method comprising the following steps: (I) mixing at least one liposome-forming lipid, a water-miscible organic solvent and aqueous medium Y to form a gel or liquid containing gel particles without sonication; and thereafter (II) (a) mixing the gel or liquid containing gel particles with aqueous medium Z1 to directly form the liposomes; (b) (i) mixing the gel or liquid containing gel particles with aqueous medium Z1 to form a curd or curdy substance; and (ii) mixing the curd or curdy substance with aqueous medium Z2 to directly form the liposomes; or (c) (i) cooling the gel or liquid containing gel particles to form a waxy substance; and (ii) mixing the waxy substance with aqueous medium Z1 to directly form the liposomes; wherein aqueous media Y, Z1 and Z2 are the same or different.
    • 本发明涉及一种制备脂质体的方法,所述方法包括以下步骤:(I)将至少一种形成脂质体的脂质,水混溶性有机溶剂和水性介质Y混合以形成不含超声波处理的含有凝胶颗粒的凝胶或液体 ; 然后(II)(a)将含有凝胶颗粒的凝胶或液体与水性介质Z1混合以直接形成脂质体; (b)(i)将含有凝胶颗粒的凝胶或液体与水性介质Z1混合以形成凝乳或卷曲物质; 和(ii)将凝乳或卷曲物质与水性介质Z2混合以直接形成脂质体; 或(c)(i)冷却含有凝胶颗粒的凝胶或液体以形成蜡状物质; 和(ii)将蜡状物质与水性介质Z1混合以直接形成脂质体; 其中水性介质Y,Z1和Z2相同或不同。
    • 7. 发明申请
    • Formulations of DNase and Methods of Use Thereof
    • DNase的制剂及其使用方法
    • US20080131497A1
    • 2008-06-05
    • US11864127
    • 2007-09-28
    • Walter R. PerkinsVladimir MalininPaul R. Meers
    • Walter R. PerkinsVladimir MalininPaul R. Meers
    • A61K9/127A61K38/54A61K9/12A61P11/00C12N9/96
    • A61K9/127
    • Compositions comprising DNase encapsulated in a liposome are provided. Additionally, provided are compositions comprising a free enzyme and empty liposomes, compositions comprising a free enzyme and an antiinfective encapsulated in a liposome, compositions comprising a free enzyme, a free-antiinfective, and empty liposomes, compositions comprising a free enzyme, a free antiinfective, and an antiinfective encapsulated in a liposome, and a composition comprising a free enzyme, empty liposomes, and an antiinfective encapsulated in a liposome, and compositions comprising a free enzyme, a free antiinfective, empty liposomes, an antiinfective encapsulated in a liposome, and pharmaceutical compositions comprising the aforementioned compositions. The Also provided are methods of treating pneumonia, bronchitis, cystic fibrosis, or emphysema comprising administering to a subject in need thereof a therapeutically effective amount of the aforementioned pharmaceutical composition.
    • 提供了包含在脂质体中的DNase的组合物。 另外,提供了包含游离酶和空脂质体的组合物,包含游离酶和包封在脂质体中的抗感染剂的组合物,包含游离酶,游离抗感染剂和空脂质体的组合物,包含游离酶,游离抗感染剂 和包封在脂质体中的抗感染剂,以及包含游离酶,空脂质体和包封在脂质体中的抗感染药物的组合物,以及包含游离酶,游离抗感染剂,空脂质体,包封在脂质体中的抗感染剂和 包含上述组合物的药物组合物。 还提供了治疗肺炎,支气管炎,囊性纤维化或肺气肿的方法,包括向有需要的受试者施用治疗有效量的上述药物组合物。