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1. 发明授权

US5509924A Epicardial stimulation electrode with energy directing capability 失效
标题翻译：具有能量指导能力的心外膜刺激电极
公开(公告)号：US5509924A
公开(公告)日：1996-04-23
申请号：US226741
申请日：1994-04-12
申请人： Paul M. Paspa , Peter A. Altman
发明人： Paul M. Paspa , Peter A. Altman
IPC分类号： A61N1/05
CPC分类号： A61N1/05
摘要： An epicardial defibrillation electrode having a wide insulating border which insulates the heart from the body is disclosed. The wide insulating border forces defibrillation current to flow through the heart without passing through surrounding tissues, thus increasing the current density throughout the heart, to depolarize the majority of the cardiac tissue with a minimum of energy. By increasing defibrillation efficacy in this way, the conductive surface area of each electrode can be decreased, thus allowing room for implantation of a plurality of conductive electrode portions for controlling energy delivery to the heart both spatially and temporally.
摘要翻译：公开了一种具有将身体心脏隔绝的宽绝缘边界的心外膜除颤电极。宽绝缘边界迫使除颤电流流过心脏而不通过周围组织，从而增加整个心脏的电流密度，以最小的能量去除大部分心脏组织。通过以这种方式提高除颤功效，可以减少每个电极的导电表面积，从而允许植入多个导电电极部分的空间，用于在空间和时间上控制向心脏的能量传递。

2. 发明授权

US5674272A Crush resistant implantable lead 失效
标题翻译：耐冲击植入式铅
公开(公告)号：US5674272A
公开(公告)日：1997-10-07
申请号：US465155
申请日：1995-06-05
申请人： M. Elizabeth Bush , Craig E. Mar , Peter A. Altman , Paul M. Paspa
发明人： M. Elizabeth Bush , Craig E. Mar , Peter A. Altman , Paul M. Paspa
IPC分类号： A61N1/05 , A61N1/375
CPC分类号： A61N1/056
摘要： The present invention is directed toward providing a composite lead body design for pacing and defibrillation leads. This lead body design improves the lead crush resistance in the lead segment that is implanted in the patient's clavicular region, while maintaining good fatigue resistance in the lead segment implanted in the heart. The clavicular segment has a generally flat profile. By flattening the clavicular segment proximal to the venous entry site, the lead will have a lower profile. Also, by substantially co-aligning the conductors within the clavicular segment, the crush resistance of the lead is significantly improved.
摘要翻译：本发明旨在提供用于起搏和除颤引线的复合引线体设计。该引线体设计提高了植入患者锁骨区域的引导段中的抗前列压抗性，同时在植入心脏的引线段中保持良好的抗疲劳性。锁骨节段具有大致平坦的轮廓。通过使靠近静脉进入部位的锁骨段变平，引线将具有较低的轮廓。此外，通过使锁骨段内的导体基本上共同对准，铅的抗压强度显着提高。

3. 发明授权

US08496926B2 Treatment for chronic myocardial infarction 有权
标题翻译：治疗慢性心肌梗死
公开(公告)号：US08496926B2
公开(公告)日：2013-07-30
申请号：US11735869
申请日：2007-04-16
申请人： Luis M. de la Fuente , Simon H. Stertzer , Julio Argentieri , Eduardo Penaloza , Peter A. Altman
发明人： Luis M. de la Fuente , Simon H. Stertzer , Julio Argentieri , Eduardo Penaloza , Peter A. Altman
IPC分类号： C12N5/00
CPC分类号： A61K9/0019 , A61K35/14 , A61K35/28 , A61K35/32 , A61K35/35
摘要： A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (ABM) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (MI) patients. The treatment is safe and improves ejection fraction (EF).
摘要翻译：一种治疗慢性心肌梗塞的方法，包括在慢性心肌梗死（MI）患者中，在低或运动不全的区域周围的自体骨髓（ABM）单核细胞的螺旋针经心内传递。治疗是安全的并且改善射血分数（EF）。

4. 发明授权

US07998105B2 Method of treating coronary arteries with perivascular delivery of therapeutic agents 有权
标题翻译：治疗剂血管周围输送治疗冠状动脉的方法
公开(公告)号：US07998105B2
公开(公告)日：2011-08-16
申请号：US10671270
申请日：2003-09-24
申请人： Peter A. Altman
发明人： Peter A. Altman
IPC分类号： A61N1/30
CPC分类号： A61K9/127 , A61B18/1492 , A61B2017/00247 , A61B2018/00011 , A61B2018/00351 , A61B2018/00392 , A61B2018/00577 , A61B2018/00839 , A61B2018/1425 , A61B2018/1435 , A61B2218/002 , A61K9/1676 , A61K9/50 , A61K9/5084 , A61M2025/0089 , A61N1/0575
摘要： A method of treating the intraluminal disease in a coronary artery by injecting therapeutic agents perivascularly into the myocardium near the site of disease.
摘要翻译：一种通过将治疗剂血管周围注射到疾病部位附近的心肌中来治疗冠状动脉腔内疾病的方法。

5. 发明授权

US07104988B2 Cardiac drug delivery system 有权
标题翻译：心脏药物输送系统
公开(公告)号：US07104988B2
公开(公告)日：2006-09-12
申请号：US10101301
申请日：2002-03-19
申请人： Peter A. Altman , John D. Altman
发明人： Peter A. Altman , John D. Altman
IPC分类号： A61N1/05
CPC分类号： A61B18/1492 , A61B2017/00247 , A61B2018/00011 , A61B2018/00273 , A61B2018/00351 , A61B2018/00392 , A61B2018/00577 , A61B2018/00839 , A61B2018/1425 , A61B2018/1435 , A61B2218/002 , A61K9/127 , A61K9/1676 , A61K9/50 , A61M25/0084 , A61M2025/0089 , A61N1/0575 , B82Y5/00
摘要： A system is disclosed, for administering a therapeutic agent locally and to a depth within cardiac tissue. An elongate, flexible catheter contains a flexible electric conductor and supports at its distal end an implantable electrode incorporating a penetrating element, typically a fixation helix or a linear needle that penetrates cardiac tissue as the electrode is implanted. A therapeutic agent is delivered through the electrode, to the cardiac tissue surrounding the penetrating element. The electrode can act as a sensor, to monitor an electrical condition of the surrounding cardiac tissue, and to control delivery of the agent responsive to the sensed electrical condition. Several embodiments feature a distal reservoir adjacent the electrode for effecting transient deliveries of the therapeutic agent in minute quantities. Other embodiments are disclosed for providing sustained deliveries of the agents.
摘要翻译：公开了一种用于在局部施用治疗剂并且在心脏组织内施用深度的系统。细长的柔性导管包含柔性电导体并且在其远端处支撑可植入电极，该可植入电极结合穿透元件，通常为植入电极时穿透心脏组织的固定螺旋线或线性针。治疗剂通过电极传递到穿透元件周围的心脏组织。电极可以用作传感器，以监测周围心脏组织的电气状况，并且响应于感测到的电气状况来控制药剂的递送。几个实施例的特征在于与电极相邻的远端储存器，用于以微量的量实现治疗剂的瞬时输送。公开了用于提供药剂的持续递送的其它实施方案。

6. 发明授权

US07048711B2 Drug delivery catheter and steering guide catheter combination 有权
标题翻译：药物输送导管和导向导管组合
公开(公告)号：US07048711B2
公开(公告)日：2006-05-23
申请号：US10353233
申请日：2003-01-27
申请人： Daniel C. Rosenman , Peter A. Altman , Brian K. Hakim , Daniel J. Kayser , Robert E. Maston , Douglas McEtchin
发明人： Daniel C. Rosenman , Peter A. Altman , Brian K. Hakim , Daniel J. Kayser , Robert E. Maston , Douglas McEtchin
IPC分类号： A61M37/00
CPC分类号： A61M25/0084 , A61M25/0014 , A61M25/0045 , A61M25/0068 , A61M25/0069 , A61M25/0097 , A61M25/0136 , A61M25/0138 , A61M25/0147 , A61M25/04 , A61M2025/0081 , A61M2025/0089 , A61M2025/0175 , A61M2202/0468
摘要： A system and method for delivering a drug to a target site within a patient's body. The system and method include a steerable guide catheter and a drug delivery catheter. The steerable guide catheter has a first extension tube and a second extension tube that are joined together and form a shoulder. The delivery catheter has a distal docking segment and a proximal docking segment. The guide catheter is inserted into the patient's body, then the delivery catheter is inserted into the guide catheter. The distal docking segment engages the first extension tube, the proximal docking segment engages the second extension tube, and the shoulder limits the distance the delivery catheter can be inserted into the guide catheter. Also, once the delivery catheter is inserted it can be rotated to attach the helical tip to the target site. The guide catheter also includes a steering mechanism as well as a friction mechanism which controls the tension on the steering mechanism. The delivery catheter also includes two luer fittings, each having its own lumen.
摘要翻译：一种用于将药物递送到患者体内的目标部位的系统和方法。该系统和方法包括可导向的导管和药物输送导管。可引导导管具有连接在一起形成肩部的第一延伸管和第二延伸管。输送导管具有远端对接部分和近端对接部分。将引导导管插入患者体内，然后将输送导管插入引导导管。远端对接部分接合第一延伸管，近端对接部分接合第二延伸管，并且肩部限制输送导管插入导向导管的距离。另外，一旦输送导管被插入，就可旋转，将螺旋尖端附着到目标部位。引导导管还包括转向机构以及控制转向机构上的张力的摩擦机构。输送导管还包括两个鲁尔接头，每个具有自己的内腔。

7. 发明授权

US06971998B2 Implant delivery catheter system and methods for its use 有权
标题翻译：植入物输送导管系统及其使用方法
公开(公告)号：US06971998B2
公开(公告)日：2005-12-06
申请号：US10292667
申请日：2002-11-12
申请人： Daniel C. Rosenman , Peter A. Altman , Mark A. Lovich , Micheal A. Schwartz , Aaron J. Miller
发明人： Daniel C. Rosenman , Peter A. Altman , Mark A. Lovich , Micheal A. Schwartz , Aaron J. Miller
IPC分类号： A61M25/00 , A61B17/00 , A61B17/34 , A61F2/02 , A61M5/178 , A61M31/00 , A61M37/00 , A61N1/05
CPC分类号： A61M37/0069 , A61B17/3468 , A61B17/3478 , A61B2017/00247 , A61B2018/00392 , A61F2/2493 , A61K9/0024 , A61M2025/0089 , A61N1/0568 , A61N2001/0578
摘要： Catheter systems and methods for implanting helical or dart-like implants into the myocardium or other body tissue. The catheter system includes a helix for fixing the distal end of the catheter to the myocardium, an implant held by the helix, mechanisms for driving the fixation helix into the myocardium, and mechanisms for driving the implant into the myocardium, removing the fixation helix and leaving the implant behind. The implant may be coated, filled, or made of a drug or drug eluting compound, or drug delivery matrix of any composition.
摘要翻译：用于将螺旋或箭头状植入物植入心肌或其他身体组织的导管系统和方法。导管系统包括用于将导管的远端固定到心肌的螺旋，由螺旋固定的植入物，用于驱动固定螺旋进入心肌的机构，以及用于驱动植入物进入心肌的机构，去除固定螺旋和留下植入物。植入物可以被涂覆，填充或由药物或药物洗脱化合物或任何组合物的药物递送基质制成。

8. 再颁专利

USRE37463E1 Implantable device for penetrating and delivering agents to cardiac tissue 有权
标题翻译：用于穿透和递送药物到心脏组织的可植入装置
公开(公告)号：USRE37463E1
公开(公告)日：2001-12-11
申请号：US09146120
申请日：1998-09-01
申请人： Peter A. Altman
发明人： Peter A. Altman
IPC分类号： A61N105
CPC分类号： A61N1/056 , A61F2/00 , A61N1/0573
摘要： An implantable devices for the effective elimination of an arrhythmogenic site from the myocardium is presented. By inserting small biocompatible conductors and/or insulators into the heart tissue at the arrhythmogenic site, it is possible to effectively eliminate a portion of the tissue from the electric field and current paths within the heart. The device would act as an alternative to the standard techniques for the removal of tissue from the effective contribution to the hearts electrical action which require the destruction of tissue via energy transfer (RF, microwave, cryogenic, etc.). This device is a significant improvement in the state of the art in that it does not require tissue necrosis. In one preferred embodiment the device is a non conductive helix that is permanently implanted into the heart wall around the arrhythmogenic site. In variations on the embodiment, the structure is wholly or partially conductive, the structure is used as an implantable substrate for anti arrhythmic, inflammatory, or angiogenic pharmacological agents, and the structure is deliverable by a catheter with a disengaging stylet. In other preferred embodiments that may incorporate the same variations, the device is a straight or curved stake, or a group of such stakes that are inserted simultaneously.
摘要翻译：提出了一种用于从心肌有效消除致心律失常部位的可植入装置。通过将小的生物相容性导体和/或绝缘体插入致心律失常部位的心脏组织中，可以从心脏内的电场和电流路径有效地消除组织的一部分。该装置将用作用于从对通过能量转移（RF，微波，低温等）破坏组织的对心脏电作用的有效贡献中去除组织的标准技术的替代。该装置是现有技术的显着改进，因为其不需要组织坏死。在一个优选实施例中，该装置是永久地植入心律失常部位周围心脏壁的非导电螺旋。在实施方案的变型中，结构全部或部分导电，该结构用作抗心律不齐，炎性或血管生成药理学的可植入底物，并且该结构可通过具有分离探针的导管递送。在可以包含相同变化的其它优选实施例中，该装置是同时插入的直的或弯曲的桩或一组这样的桩。

9. 发明授权

US5545183A Method and apparatus for delivering defibrillation therapy through a sensing electrode 失效
标题翻译：通过感测电极进行除颤治疗的方法和装置
公开(公告)号：US5545183A
公开(公告)日：1996-08-13
申请号：US351864
申请日：1994-12-07
申请人： Peter A. Altman
发明人： Peter A. Altman
IPC分类号： A61N1/04 , A61N1/05 , A61N1/39
CPC分类号： A61N1/3962 , A61N1/056 , A61N1/0563
摘要： A pulse generator circuit and method for using a defibrillation lead positioned close to the right ventricular apex to optimize energy delivery and sensing. This method includes operating a defibrillator-pacemaker system in a true bipolar sensing mode as long as high voltage therapy is not required. When required, the defibrillator-pacemaker system delivers a first high voltage therapy via an RV defibrillation electrode, and, using true bipolar sensing, determines whether the first high voltage therapy was successful. If the first high voltage therapy is deemed to be successful, then true bipolar sensing is resumed. Otherwise, the defibrillator-pacemaker system causes a ring electrode to be electrically connected to the RV defibrillation electrode, delivers a second high voltage therapy, and, using integrated bipolar sensing determines whether the second high voltage therapy was successful. In this way, because no new circuit elements are added within the lead, the lead size and complexity are not increased.
摘要翻译：脉冲发生器电路和方法，用于使用靠近右心室顶点定位的除颤引线来优化能量输送和感测。只要不需要高压治疗，该方法包括以真正的双极感测模式操作除颤器起搏器系统。当需要时，除颤器起搏器系统通过RV除颤电极进行第一次高压治疗，并且使用真正的双极性感测来确定第一次高压治疗是否成功。如果第一次高电压治疗被认为是成功的，则恢复真正的双极性感测。否则，除颤起搏器系统使得环形电极与RV除颤电极电连接，进行第二高电压治疗，并且使用集成的双极性检测来确定第二高电压治疗是否成功。这样，由于在引线内没有添加新的电路元件，因此引线尺寸和复杂度不会增加。

10. 发明申请

US20100278783A1 Method of Preparing Autologous Cells and Method of Use for Therapy 有权
标题翻译：自体细胞的制备方法和治疗方法
公开(公告)号：US20100278783A1
公开(公告)日：2010-11-04
申请号：US12434537
申请日：2009-05-01
申请人： Didier Rouy , Peter A. Altman , Benjamin Koziner
发明人： Didier Rouy , Peter A. Altman , Benjamin Koziner
IPC分类号： A61K45/00 , C12N5/0775 , A61P37/06
CPC分类号： C12N5/0663 , A61K9/0019 , A61K35/00 , A61K35/10 , A61K35/28 , A61K2035/124 , C12N2500/84 , C12N2502/11 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158
摘要： A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium which can be used in a clinical setting, and a business method for performing such expansions in the future as a service for patients. A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium including a diagnostic kit for the autologous cell therapy to determine whether a patient will respond to the autologous cell therapy for treatment of a disease, in which said kit comprising a system for detecting gene and protein expression comprising at least two isolated DNA molecules wherein each isolated DNA molecule detects expression of a gene that is differentially expressed in the tissue of the patient that is intended to be the source of the autologous cell therapy.
摘要翻译：用于扩展可用于临床环境的自体培养基中自体骨髓衍生的间充质细胞的方法，以及将来作为患者服务进行这种扩展的商业方法。一种在自体培养基中扩增源于自体骨髓的间充质细胞的方法，包括用于自体细胞治疗的诊断试剂盒，以确定患者是否将对自体细胞疗法响应治疗疾病，其中所述试剂盒包含用于检测包含至少两个分离的DNA分子的基因和蛋白质表达，其中每个分离的DNA分子检测在旨在成为自体细胞治疗来源的患者组织中差异表达的基因的表达。

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