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1. 发明授权

US06553263B1 Implantable pulse generators using rechargeable zero-volt technology lithium-ion batteries 有权
标题翻译：使用可充电零伏技术的锂离子电池的可植入脉冲发生器
公开(公告)号：US06553263B1
公开(公告)日：2003-04-22
申请号：US09627803
申请日：2000-07-28
申请人： Paul M. Meadows , Carla M. Mann , Hisashi Tsukamoto , Joey Chen
发明人： Paul M. Meadows , Carla M. Mann , Hisashi Tsukamoto , Joey Chen
IPC分类号： A61N140
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/36071
摘要： An implantable medical device, such as an implantable pulse generator (IPG) used with a spinal cord stimulation (SCS) system, includes a rechargeable lithium-ion battery having an anode electrode with a substrate made substantially from titanium. Such battery construction allows the rechargeable battery to be discharged down to zero volts without damage to the battery. The implantable medical device includes battery charging and protection circuitry that controls the charging of the battery so as to assure its reliable and safe operation. A multi-rate charge algorithm is employed that minimizes charging time while ensuring the battery cell is safely charged. Fast charging occurs at safer lower battery voltages (e.g., battery voltage above about 2.5 V), and slower charging occurs when the battery nears full charge higher battery voltages (e.g., above about 4.0 V). When potentially less-than-safe very low voltages are encountered (e.g., less than 2.5 V), then very slow (trickle) charging occurs to bring the battery voltage back up to the safer voltage levels where more rapid charging can safely occur. The battery charging and protection circuitry also continuously monitors the battery voltage and current. If the battery operates outside of a predetermined range of voltage or current, the battery protection circuitry disconnects the battery from the particular fault, i.e. charging circuitry or load circuits.
摘要翻译：诸如与脊髓刺激（SCS）系统一起使用的可植入脉冲发生器（IPG）的可植入医疗装置包括具有阳极电极的可再充电锂离子电池，其具有基本上由钛制成的衬底。这种电池结构允许可再充电电池被放电到零伏特而不损坏电池。可植入医疗装置包括电池充电和保护电路，其控制电池的充电，以确保其可靠和安全的操作。使用多速率充电算法，其最小化充电时间，同时确保电池单元被安全地充电。快速充电发生在更安全的较低的电池电压（例如，电池电压高于约2.5V）时，并且当电池接近充满更高的电池电压（例如高于约4.0V）时，发生较慢的充电。当遇到潜在的不太安全的非常低的电压（例如，小于2.5V）时，发生非常慢的（涓流）充电，以使电池电压恢复到更安全的电压水平，其中可以安全地发生更快速的充电。电池充电和保护电路还连续监测电池电压和电流。如果电池在预定的电压或电流范围之外运行，则电池保护电路将电池与特定故障（即充电电路或负载电路）断开连接。

2. 发明授权

US07818068B2 Implantable pulse generators using rechargeable zero-volt technology lithium-ion batteries 有权
标题翻译：使用可充电零伏技术的锂离子电池的可植入脉冲发生器
公开(公告)号：US07818068B2
公开(公告)日：2010-10-19
申请号：US11623650
申请日：2007-01-16
申请人： Paul M. Meadows , Carla M. Mann , Hisashi Tsukamoto , Joey Chen
发明人： Paul M. Meadows , Carla M. Mann , Hisashi Tsukamoto , Joey Chen
IPC分类号： A61N1/40 , H01M4/52
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/36071
摘要： An implantable medical device, such as an implantable pulse generator (IPG) used with a spinal cord stimulation (SCS) system, includes a rechargeable lithium-ion battery having an anode electrode with a substrate made substantially from titanium. Such battery construction allows the rechargeable battery to be discharged down to zero volts without damage to the battery. The implantable medical device includes battery charging and protection circuitry that controls the charging of the battery so as to assure its reliable and safe operation.
摘要翻译：诸如与脊髓刺激（SCS）系统一起使用的可植入脉冲发生器（IPG）的可植入医疗装置包括可充电锂离子电池，其具有阳极电极和基本上由钛制成的基底。这种电池结构允许可再充电电池被放电到零伏特而不损坏电池。可植入医疗装置包括电池充电和保护电路，其控制电池的充电，以确保其可靠和安全的操作。

3. 发明授权

US07248929B2 Implantable devices using rechargeable zero-volt technology lithium-ion batteries 有权
公开(公告)号：US07248929B2
公开(公告)日：2007-07-24
申请号：US10419000
申请日：2003-04-18
申请人： Paul M Meadows , Carla Mann Woods , Hisashi Tsukamoto , Joey Chen
发明人： Paul M Meadows , Carla Mann Woods , Hisashi Tsukamoto , Joey Chen
IPC分类号： A61N1/40
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/36071
摘要： An implantable medical device, such as an implantable pulse generator (IPG) used with a spinal cord stimulation (SCS) system, includes a rechargeable lithium-ion battery having an anode electrode with a substrate made substantially from titanium. Such battery construction allows the rechargeable battery to be discharged down to zero volts without damage to the battery. The implantable medical device includes battery charging and protection circuitry that controls the charging of the battery so as to assure its reliable and safe operation. A multi-rate charge algorithm is employed that minimizes charging time while ensuring the battery cell is safely charged. Fast charging occurs at safer lower battery voltages (e.g., battery voltage above about 2.5 V), and slower charging occurs when the battery nears full charge higher battery voltages (e.g., above about 4.0 V). When potentially less-than-safe very low voltages are encountered (e.g., less than 2.5 V), then very slow (trickle) charging occurs to bring the battery voltage back up to the safer voltage levels where more rapid charging can safely occur. The battery charging and protection circuitry also continuously monitors the battery voltage and current. If the battery operates outside of a predetermined range of voltage or current, the battery protection circuitry disconnects the battery from the particular fault, i.e. charging circuitry or load circuits.

4. 发明授权

US07184836B1 Implantable devices using rechargeable zero-volt technology lithium-ion batteries 有权
标题翻译：可植入器件采用可充电零伏技术的锂离子电池
公开(公告)号：US07184836B1
公开(公告)日：2007-02-27
申请号：US10419018
申请日：2003-04-18
申请人： Paul M Meadows , Carla Mann Woods , Joey Chen , Hisashi Tsukamoto
发明人： Paul M Meadows , Carla Mann Woods , Joey Chen , Hisashi Tsukamoto
IPC分类号： A61N1/18
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/36071
摘要： An implantable medical device, such as an implantable pulse generator (IPG) used with a spinal cord stimulation (SCS) system, includes a rechargeable lithium-ion battery having an anode electrode with a substrate made substantially from titanium. Such battery construction allows the rechargeable battery to be discharged down to zero volts without damage to the battery. The implantable medical device includes battery charging and protection circuitry that controls the charging of the battery so as to assure its reliable and safe operation. A multi-rate charge algorithm is employed that minimizes charging time while ensuring the battery cell is safely charged. Fast charging occurs at safer lower battery voltages (e.g., battery voltage above about 2.5 V), and slower charging occurs when the battery nears full charge higher battery voltages (e.g., above about 4.0 V). When potentially less-than-safe very low voltages are encountered (e.g., less than 2.5 V), then very slow (trickle) charging occurs to bring the battery voltage back up to the safer voltage levels where more rapid charging can safely occur. The battery charging and protection circuitry also continuously monitors the battery voltage and current. If the battery operates outside of a predetermined range of voltage or current, the battery protection circuitry disconnects the battery from the particular fault, i.e. charging circuitry or load circuits.
摘要翻译：诸如与脊髓刺激（SCS）系统一起使用的可植入脉冲发生器（IPG）的可植入医疗装置包括可充电锂离子电池，其具有阳极电极和基本上由钛制成的基底。这种电池结构允许可再充电电池被放电到零伏特而不损坏电池。可植入医疗装置包括电池充电和保护电路，其控制电池的充电，以确保其可靠和安全的操作。使用多速率充电算法，其最小化充电时间，同时确保电池单元被安全地充电。快速充电发生在更安全的较低的电池电压（例如，电池电压高于约2.5V）时，并且当电池接近充满更高的电池电压（例如高于约4.0V）时，发生较慢的充电。当遇到潜在的不太安全的非常低的电压（例如，小于2.5V）时，发生非常慢的（涓流）充电，以使电池电压恢复到更安全的电压水平，其中可以安全地发生更快速的充电。电池充电和保护电路还连续监测电池电压和电流。如果电池在预定的电压或电流范围之外运行，则电池保护电路将电池与特定故障（即充电电路或负载电路）断开连接。

5. 发明授权

US07295878B1 Implantable devices using rechargeable zero-volt technology lithium-ion batteries 有权
标题翻译：可植入器件采用可充电零伏技术的锂离子电池
公开(公告)号：US07295878B1
公开(公告)日：2007-11-13
申请号：US10970879
申请日：2004-10-22
申请人： Paul M Meadows , Carla Mann Woods , Joey Chen , Hisashi Tsukamoto
发明人： Paul M Meadows , Carla Mann Woods , Joey Chen , Hisashi Tsukamoto
IPC分类号： A61N1/08
CPC分类号： A61N1/3787 , A61N1/3605
摘要： An implantable medical device, such as an implantable pulse generator (IPG) used with a spinal cord stimulation (SCS) system, includes a rechargeable lithium-ion battery having an anode electrode with a substrate made substantially from titanium. Such battery construction allows the rechargeable battery to be discharged down to zero volts without damage to the battery. The implantable medical device includes battery charging and protection circuitry that controls the charging of the battery so as to assure its reliable and safe operation. A multi-rate charge algorithm is employed that minimizes charging time while ensuring the battery cell is safely charged. Slow charging occurs at lower battery voltages (e.g., battery voltage below about 2.5 V), and fast charging occurs when the battery voltage has reached a safe level (e.g., above about 2.5 V). When potentially less-than-safe very low voltages are encountered (e.g., less than 2.5 V), then very slow (trickle) charging occurs to bring the battery voltage back up to the safer voltage levels where more rapid charging can safely occur. The battery charging and protection circuitry also continuously monitors the battery voltage and current. If the battery operates outside of a predetermined range of voltage or current, the battery protection circuitry disconnects the battery from the particular fault, i.e. charging circuitry or load circuits.
摘要翻译：诸如与脊髓刺激（SCS）系统一起使用的可植入脉冲发生器（IPG）的可植入医疗装置包括可充电锂离子电池，其具有阳极电极和基本上由钛制成的基底。这种电池结构允许可再充电电池被放电到零伏特而不损坏电池。可植入医疗装置包括电池充电和保护电路，其控制电池的充电，以确保其可靠和安全的操作。使用多速率充电算法，其最小化充电时间，同时确保电池单元被安全地充电。在较低的电池电压（例如，电池电压低于约2.5V）下发生慢速充电，并且当电池电压达到安全水平（例如高于约2.5V）时，发生快速充电。当遇到潜在的不太安全的非常低的电压（例如，小于2.5V）时，发生非常慢的（涓流）充电，以使电池电压恢复到更安全的电压水平，其中可以安全地发生更快速的充电。电池充电和保护电路还连续监测电池电压和电流。如果电池在预定的电压或电流范围之外运行，则电池保护电路将电池与特定故障（即充电电路或负载电路）断开连接。

6. 发明授权

US07177691B2 Implantable pulse generators using rechargeable zero-volt technology lithium-ion batteries 有权
标题翻译：使用可充电零伏技术的锂离子电池的可植入脉冲发生器
公开(公告)号：US07177691B2
公开(公告)日：2007-02-13
申请号：US10419002
申请日：2003-04-18
申请人： Paul M Meadows , Carla Mann Woods , Hisashi Tsukamoto , Joey Chen
发明人： Paul M Meadows , Carla Mann Woods , Hisashi Tsukamoto , Joey Chen
IPC分类号： A61N1/375
CPC分类号： A61N1/3787 , A61N1/08 , A61N1/36071
摘要： An implantable medical device, such as an implantable pulse generator (IPG) used with a spinal cord stimulation (SCS) system, includes a rechargeable lithiumion battery having an anode electrode with a substrate made substantially from titanium. Such battery construction allows the rechargeable battery to be discharged down to zero volts without damage to the battery. The implantable medical device includes battery charging and protection circuitry that controls the charging of the battery so as to assure its reliable and safe operation. A multi-rate charge algorithm is employed that minimizes charging time while ensuring the battery cell is safely charged. Fast charging occurs at safer lower battery voltages (e.g., battery voltage above about 2.5 V), and slower charging occurs when the battery nears full charge higher battery voltages (e.g., above about 4.0 V). When potentially less-than-safe very low voltages are encountered (e.g., less than 2.5 V), then very slow (trickle) charging occurs to bring the battery voltage back up to the safer voltage levels where more rapid charging can safely occur. The battery charging and protection circuitry also continuously monitors the battery voltage and current. If the battery operates outside of a predetermined range of voltage or current, the battery protection circuitry disconnects the battery from the particular fault, i.e. charging circuitry or load circuits.
摘要翻译：可植入医疗装置，例如与脊髓刺激（SCS）系统一起使用的植入式脉冲发生器（IPG），包括具有阳极电极的可再充电锂离子电池，该阳极电极基本上由钛制成。这种电池结构允许可再充电电池被放电到零伏特而不损坏电池。可植入医疗装置包括电池充电和保护电路，其控制电池的充电，以确保其可靠和安全的操作。使用多速率充电算法，其最小化充电时间，同时确保电池单元被安全地充电。快速充电发生在更安全的较低的电池电压（例如，电池电压高于约2.5V）时，并且当电池接近充满更高的电池电压（例如高于约4.0V）时，发生较慢的充电。当遇到潜在的不太安全的非常低的电压（例如，小于2.5V）时，发生非常慢的（涓流）充电，以使电池电压恢复到更安全的电压水平，其中可以安全地发生更快速的充电。电池充电和保护电路还连续监测电池电压和电流。如果电池在预定的电压或电流范围之外运行，则电池保护电路将电池与特定故障（即充电电路或负载电路）断开连接。

7. 发明授权

US06516227B1 Rechargeable spinal cord stimulator system 有权
公开(公告)号：US06516227B1
公开(公告)日：2003-02-04
申请号：US09626010
申请日：2000-07-26
申请人： Paul Meadows , Carla M. Mann , David Karl-Lee Peterson , Joey Chen
发明人： Paul Meadows , Carla M. Mann , David Karl-Lee Peterson , Joey Chen
IPC分类号： A61N118
CPC分类号： A61N1/37252 , A61N1/0553 , A61N1/36071 , A61N1/36185 , A61N1/37241 , A61N1/37247 , A61N1/3787 , H01H85/201 , H01H85/32
摘要： A spinal cord stimulation (SCS) system provides multiple stimulation channels, each capable of producing up to 10 mA of current into a 1 K&OHgr; load. The SCS system further includes a replenishable power source, e.g., a rechargeable battery, that requires only an occasional recharge, and offers a life of at least 10 years at typical settings. Each of the multiple stimulus channels of the system may be combined with other channels to deliver more than 10 mA of current. Additionally, the SCS system has the capability to stimulate simultaneously on all available channels. Each channel has at least two outputs (one positive and one negative) that can be mapped via a low impedance switching matrix to any electrode contact or the system case, thereby allowing a clinician to provide unique electrical stimulation fields for each current channel. Moreover, this feature, combined with multi-contact electrodes arranged in two or three dimensional arrays, allows “virtual electrodes” to be realized. When the system's replenishable power source is fully charged, the user may operate the SCS system independent of external controllers or power sources. The replenishable power source may be replenished using non-invasive means. The SCS system monitors the state of charge of the internal power source and controls the charging process by monitoring the amount of energy used by the SCS system, and hence the state of charge of the power source. A suitable bidirectional telemetry link allows the SCS system to inform the patient or clinician regarding the status of the system, including the state of charge, and makes requests to initiate an external charge process. Processing circuitry within the implanted portions of the system automatically controls the applied stimulation pulses as a new burst of pulses begins in order to gradually ramp up the amplitude of the pulses to a desired level. Other processing circuitry allows electrode impedance measurements to be regularly made.

8. 发明授权

US07769462B2 Rechargeable spinal cord stimulation system 有权
标题翻译：充电脊髓刺激系统
公开(公告)号：US07769462B2
公开(公告)日：2010-08-03
申请号：US11625283
申请日：2007-01-20
申请人： Paul M. Meadows , Carla Mann Woods , David K. Peterson , Joey Chen , David H. Payne
发明人： Paul M. Meadows , Carla Mann Woods , David K. Peterson , Joey Chen , David H. Payne
IPC分类号： A61N1/00
CPC分类号： A61N1/37252 , A61N1/0553 , A61N1/36071 , A61N1/36185 , A61N1/37241 , A61N1/37247 , A61N1/3787 , H01H85/201 , H01H85/32
摘要： A spinal cord stimulation (SCS) system includes multiple electrodes, multiple, independently programmable, stimulation channels within an implantable pulse generator (IPG) which channels can provide concurrent, but unique stimulation fields, permitting virtual electrodes to be realized. The SCS system includes a replenishable power source (e.g., rechargeable battery), that may be recharged using transcutaneous power transmissions between antenna coil pairs. An external charger unit, having its own rechargeable battery can be used to charge the IPG replenishable power source. A real-time clock can provide an auto-run schedule for daily stimulation. An included bi-directional telemetry link in the system informs the patient or clinician the status of the system, including the state of charge of the IPG battery. Other processing circuitry in the IPG allows electrode impedance measurements to be made. Further circuitry in the external battery charger can provide alignment detection for the coil pairs.
摘要翻译：脊髓刺激（SCS）系统包括在可植入脉冲发生器（IPG）内的多个电极，多个独立可编程的刺激通道，其通道可以提供同时但独特的刺激场，允许实现虚拟电极。 SCS系统包括可补充电源（例如，可充电电池），其可以使用天线线圈对之间的经皮功率传输进行再充电。可以使用具有自己的可充电电池的外部充电器单元为IPG可补充电源充电。实时时钟可以提供每日刺激的自动运行时间表。系统中包括的双向遥测连接通知患者或临床医生系统的状态，包括IPG电池的充电状态。 IPG中的其他处理电路允许进行电极阻抗测量。外部电池充电器中的进一步电路可以为线圈对提供对准检测。

9. 发明授权

US07496404B2 Rechargeable spinal cord stimulator system 有权
标题翻译：充电脊髓刺激器系统
公开(公告)号：US07496404B2
公开(公告)日：2009-02-24
申请号：US11009508
申请日：2004-12-10
申请人： Paul M Meadows , Carla M Woods , David K Peterson , Joey Chen , David H Payne
发明人： Paul M Meadows , Carla M Woods , David K Peterson , Joey Chen , David H Payne
IPC分类号： A61N1/00
CPC分类号： A61N1/37252 , A61N1/0553 , A61N1/36071 , A61N1/36185 , A61N1/37241 , A61N1/37247 , A61N1/3787 , H01H85/201 , H01H85/32
摘要： A spinal cord stimulation (SCS) system includes multiple electrodes, multiple, independently programmable, stimulation channels within an implantable pulse generator (IPG) which channels can provide concurrent, but unique stimulation fields, permitting virtual electrodes to be realized. The SCS system includes a replenishable power source (e.g., rechargeable battery), that may be recharged using transcutaneous power transmissions between antenna coil pairs. An external charger unit, having its own rechargeable battery can be used to charge the IPG replenishable power source. A real-time clock can provide an auto-run schedule for daily stimulation. An included bi-directional telemetry link in the system informs the patient or clinician the status of the system, including the state of charge of the IPG battery. Other processing circuitry in the IPG allows electrode impedance measurements to be made. Further circuitry in the external battery charger can provide alignment detection for the coil pairs.
摘要翻译：脊髓刺激（SCS）系统包括在可植入脉冲发生器（IPG）内的多个电极，多个独立可编程的刺激通道，其通道可以提供同时但独特的刺激场，允许实现虚拟电极。 SCS系统包括可补充电源（例如，可充电电池），其可以使用天线线圈对之间的经皮功率传输进行再充电。具有自己的可充电电池的外部充电器单元可用于为IPG可补充电源充电。实时时钟可以提供每日刺激的自动运行时间表。系统中包括的双向遥测连接通知患者或临床医生系统的状态，包括IPG电池的充电状态。 IPG中的其他处理电路允许进行电极阻抗测量。外部电池充电器中的进一步电路可以为线圈对提供对准检测。

10. 发明申请

US20090062883A1 RECHARGEABLE SPINAL CORD STIMULATOR SYSTEM 有权
标题翻译：可充电脊髓刺激系统
公开(公告)号：US20090062883A1
公开(公告)日：2009-03-05
申请号：US11947753
申请日：2007-11-29
申请人： Paul M. Meadows , Carla Mann Woods , David K. Peterson , Joey Chen , David H. Payne
发明人： Paul M. Meadows , Carla Mann Woods , David K. Peterson , Joey Chen , David H. Payne
IPC分类号： A61N1/34
CPC分类号： A61N1/37252 , A61N1/0553 , A61N1/36071 , A61N1/36185 , A61N1/37241 , A61N1/37247 , A61N1/3787 , H01H85/201 , H01H85/32
摘要： A spinal cord stimulation (SCS) system includes multiple electrodes, multiple, independently programmable, stimulation channels within an implantable pulse generator (IPG) which channels can provide concurrent, but unique stimulation fields, permitting virtual electrodes to be realized. The SCS system includes a replenishable power source (e.g., rechargeable battery), that may be recharged using transcutaneous power transmissions between antenna coil pairs. An external charger unit, having its own rechargeable battery can be used to charge the IPG replenishable power source. A real-time clock can provide an auto-run schedule for daily stimulation. An included bi-directional telemetry link in the system informs the patient or clinician the status of the system, including the state of charge of the IPG battery. Other processing circuitry in the IPG allows electrode impedance measurements to be made. Further circuitry in the external battery charger can provide alignment detection for the coil pairs.
摘要翻译：脊髓刺激（SCS）系统包括在可植入脉冲发生器（IPG）内的多个电极，多个独立可编程的刺激通道，其通道可以提供同时但独特的刺激场，允许实现虚拟电极。 SCS系统包括可补充电源（例如，可充电电池），其可以使用天线线圈对之间的经皮功率传输进行再充电。可以使用具有自己的可充电电池的外部充电器单元为IPG可补充电源充电。实时时钟可以提供每日刺激的自动运行时间表。系统中包括的双向遥测连接通知患者或临床医生系统的状态，包括IPG电池的充电状态。 IPG中的其他处理电路允许进行电极阻抗测量。外部电池充电器中的进一步电路可以为线圈对提供对准检测。

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