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1. 发明授权

US08568356B2 Ambulatory medical apparatus with hand held communication device 有权
公开(公告)号：US08568356B2
公开(公告)日：2013-10-29
申请号：US13039259
申请日：2011-03-02
申请人： Ronald J. Lebel , Varaz Shahmirian , Daniel Villegas , David Choy , Philip T. Weiss , Paul Meadows
发明人： Ronald J. Lebel , Varaz Shahmirian , Daniel Villegas , David Choy , Philip T. Weiss , Paul Meadows
IPC分类号： A61M37/00 , A61K9/22
CPC分类号： A61M5/172 , A61B5/0002 , A61B5/14532 , A61B5/6847 , A61B2560/0209 , A61M5/14244 , A61M5/14276 , A61M5/168 , A61M5/16831 , A61M2005/14208 , A61M2205/18 , A61M2205/3507 , A61M2205/3523 , A61M2205/50 , A61M2205/581 , A61M2205/582 , A61M2205/6018 , A61M2205/8206 , A61M2207/00 , A61N1/37211 , A61N1/37247 , A61N1/37252 , A61N1/37258 , A61N1/37264 , A61N1/3727 , A61N1/37276 , A61N1/375 , G06F3/0619 , G06F3/065 , G06F3/0673 , G06F8/60 , G06F8/65 , G06F19/00 , G06F19/3468 , G06Q50/22 , G16H40/40 , Y02D10/42 , Y10S128/13 , Y10S128/903 , Y10T29/49117 , Y10T29/49826
摘要： A communication device (CD) exchanges messages with an implantable infusion pump via telemetry such that commands are supplied thereto and operational information is obtained therefrom. The CD is controlled, at least in part, by a processor IC according to a software program operating therein and provides feedback to a user via a visual display, an audio alarm, and a vibrational alarm, and allows input from the user via a touch sensitive keypad. Certain input functions are restricted by password. The visual display includes an icon and fixed element display region and a bitmap display region. The fixed element display region includes time and date displays, battery and drug level displays that decrement, and a moving delivery state display. Various screens allow operational or log information to be displayed and/or user entry of commands. Program features when disabled are removed from a series of screen options that can be scrolled through.

2. 发明授权

US08121701B2 System and method for displaying stimulation field generated by electrode array 有权
标题翻译：用于显示由电极阵列产生的刺激场的系统和方法
公开(公告)号：US08121701B2
公开(公告)日：2012-02-21
申请号：US12120162
申请日：2008-05-13
申请人： Carla Mann Woods , David K. L. Peterson , Paul Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K. L. Peterson , Paul Meadows , Gerald E. Loeb
IPC分类号： A61N1/08
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

3. 发明授权

US06516227B1 Rechargeable spinal cord stimulator system 有权
公开(公告)号：US06516227B1
公开(公告)日：2003-02-04
申请号：US09626010
申请日：2000-07-26
申请人： Paul Meadows , Carla M. Mann , David Karl-Lee Peterson , Joey Chen
发明人： Paul Meadows , Carla M. Mann , David Karl-Lee Peterson , Joey Chen
IPC分类号： A61N118
CPC分类号： A61N1/37252 , A61N1/0553 , A61N1/36071 , A61N1/36185 , A61N1/37241 , A61N1/37247 , A61N1/3787 , H01H85/201 , H01H85/32
摘要： A spinal cord stimulation (SCS) system provides multiple stimulation channels, each capable of producing up to 10 mA of current into a 1 K&OHgr; load. The SCS system further includes a replenishable power source, e.g., a rechargeable battery, that requires only an occasional recharge, and offers a life of at least 10 years at typical settings. Each of the multiple stimulus channels of the system may be combined with other channels to deliver more than 10 mA of current. Additionally, the SCS system has the capability to stimulate simultaneously on all available channels. Each channel has at least two outputs (one positive and one negative) that can be mapped via a low impedance switching matrix to any electrode contact or the system case, thereby allowing a clinician to provide unique electrical stimulation fields for each current channel. Moreover, this feature, combined with multi-contact electrodes arranged in two or three dimensional arrays, allows “virtual electrodes” to be realized. When the system's replenishable power source is fully charged, the user may operate the SCS system independent of external controllers or power sources. The replenishable power source may be replenished using non-invasive means. The SCS system monitors the state of charge of the internal power source and controls the charging process by monitoring the amount of energy used by the SCS system, and hence the state of charge of the power source. A suitable bidirectional telemetry link allows the SCS system to inform the patient or clinician regarding the status of the system, including the state of charge, and makes requests to initiate an external charge process. Processing circuitry within the implanted portions of the system automatically controls the applied stimulation pulses as a new burst of pulses begins in order to gradually ramp up the amplitude of the pulses to a desired level. Other processing circuitry allows electrode impedance measurements to be regularly made.

4. 发明授权

US5358514A Implantable microdevice with self-attaching electrodes 失效
标题翻译：具有自连接电极的可植入微型设备
公开(公告)号：US5358514A
公开(公告)日：1994-10-25
申请号：US62283
申请日：1993-05-17
申请人： Joseph H. Schulman , Primoz Strojnik , Paul Meadows
发明人： Joseph H. Schulman , Primoz Strojnik , Paul Meadows
IPC分类号： A61N1/372 , A61N1/378 , A61N1/36
CPC分类号： A61N1/372 , A61N1/3787 , A61N1/37205
摘要： An implantable microminiature stimulator and/or sensor (microdevice) is housed within a sealed housing that includes all the requisite electronic circuitry for inductively receiving power and control signals to sense of biopotential or other biomedical signals and/or to generate electrical stimulation pulse(s) between opposing electrodes. In a preferred embodiment, the housing of the microdevice is tubular, with opposing electrodes extending from each end. The electrodes are self-attaching electrodes that attach to a nerve or muscle without suturing. The electrodes are configured to helically curl around the desired nerve, thereby permitting the microdevice to stimulate the nerve or muscle, or sense signals associated with the nerve or muscle, using a minimal amount of energy. The electrodes and microdevice are sufficiently small to allow attachment to a single nerve, thereby preventing tethering of the nerve or muscle, and to allow their implantation within living tissue through small incisions or puncture holes. The muscle or nerve to which the microdevice is attached may be of any type, e.g., skeletal, smooth or cardiac.
摘要翻译：可植入的微型激发器和/或传感器（微型装置）容纳在密封的壳体内，其包括用于感应地接收功率和控制信号以感测生物电位或其他生物医学信号的所有必需的电子电路和/或产生电刺激脉冲，在相对的电极之间。在优选实施例中，微型装置的壳体是管状的，相对电极从每端延伸。电极是附着于神经或肌肉而不缝合的自附接电极。电极被配置为螺旋地卷绕期望的神经，从而允许微器件使用最小量的能量来刺激神经或肌肉，或感测与神经或肌肉相关的信号。电极和微器件足够小以允许附接到单个神经，从而防止神经或肌肉束缚，并允许它们通过小切口或穿刺孔植入生物组织内。微型装置附着的肌肉或神经可以是任何类型，例如骨骼，光滑或心脏。

5. 发明申请

US20060149335A1 Devices and methods for brain stimulation 有权
公开(公告)号：US20060149335A1
公开(公告)日：2006-07-06
申请号：US11030546
申请日：2005-01-05
申请人： Paul Meadows
发明人： Paul Meadows
IPC分类号： A61N1/34
CPC分类号： A61N1/3606 , A61N1/0529 , A61N1/0534 , A61N1/36003 , A61N1/36017 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082
摘要： A device for brain stimulation that includes a lead having a longitudinal surface; at least one stimulation electrode disposed along the longitudinal surface of the lead; and at least one recording electrode, separate from the at least one stimulation electrode, disposed along the longitudinal surface of the lead.

6. 发明申请

US20060051896A1 Stacking circuit elements 有权
标题翻译：堆叠电路元件
公开(公告)号：US20060051896A1
公开(公告)日：2006-03-09
申请号：US10937149
申请日：2004-09-09
申请人： Paul Meadows
发明人： Paul Meadows
IPC分类号： H01L21/44
CPC分类号： A61N1/375 , A61N1/05 , H01L21/76898 , H01L23/481 , H01L25/0657 , H01L25/50 , H01L2225/06513 , H01L2225/06517 , H01L2225/06541 , H01L2225/06555 , H01L2924/0002 , H01L2924/00
摘要： A method of stacking dice in an electronic circuit includes controlling a size of a hole made in a connection pad on each die of said dice to selectively provide an electrical connection to a particular die in the stack. Additionally, a method of stacking dice in an electronic circuit includes forming holes in each of the dice, and providing electrical connection material selectively at some of the holes to provide for selective electrical connections among the dice. A stack of dice in an electronic circuit includes a number of dice stacked on top of each other, each die in the stack having one or more holes therein, conductive material extending through the holes and making electrical connection between one or more of the dice in the stack and the electronic circuit. An implantable stimulator with a stack of pulse generator integrated circuits (ICs) includes a number of pulse generator ICs stacked on top of each other, each IC having a number of holes formed therein, wherein the holes are aligned, and conductive material extending through the holes and making electrical connection between one or more of said ICs in the stack and an electronic circuit of the stimulator.
摘要翻译：在电子电路中堆叠骰子的方法包括控制在所述骰子的每个管芯上的连接焊盘中形成的孔的尺寸，以选择性地提供与堆叠中的特定管芯的电连接。此外，在电子电路中堆叠骰子的方法包括在每个骰子中形成孔，并且在一些孔处选择性地提供电连接材料，以提供骰子之间的选择性电连接。电子电路中的一堆骰子包括堆叠在彼此之上的多个骰子，堆叠中的每个骰子中具有一个或多个孔，导电材料延伸穿过该孔并使一个或多个骰子之间的电连接堆叠和电子电路。具有脉冲发生器集成电路（IC）的堆叠的可植入刺激器包括堆叠在一起的多个脉冲发生器IC，每个IC具有形成在其中的多个孔，其中孔对准，并且导电材料延伸穿过并且在堆叠中的一个或多个所述IC和刺激器的电子电路之间进行电连接。

7. 发明申请

US20060150218A1 System for buying goods and services 审中-公开
标题翻译：购买商品和服务的系统
公开(公告)号：US20060150218A1
公开(公告)日：2006-07-06
申请号：US11325938
申请日：2005-12-30
申请人： Clifford Lazar , Paul Meadows
发明人： Clifford Lazar , Paul Meadows
IPC分类号： G06F17/30 , H04N5/445 , G06F3/00
CPC分类号： H04N5/765 , G06Q30/02 , G06Q30/06 , G06Q30/0601 , H04N5/775 , H04N5/85 , H04N7/17318 , H04N21/4147 , H04N21/42646 , H04N21/44008 , H04N21/44204 , H04N21/4722 , H04N21/47815 , H04N21/812 , H04N21/8352
摘要： A method and system to add functionality to digital video recorders (DVRs). In its various embodiments the present system has multiple functions: Increase response to TV commercials and product placements; selection of the power-on station thus benefiting a network or networks and/or a major marketer, Utilizing the infrastructure of the DVR and DVR hand-held remote to facilitate user response to commercials and product placements on DVD's other non-broadcast electronically transferred content, including but not limited to downloaded shows and movies, print ads, catalogs and other indicators of available products, enhancing interaction with vendor/advertisers. The present invention works with digital video recorders and other devices that process and pass real-time television broadcasts, delayed replays of broadcasts, recorded broadcasts, non-broadcast electronically transferred content and DVD's to television monitors.
摘要翻译：一种为数字录像机（DVR）添加功能的方法和系统。在其各种实施例中，本系统具有多种功能：增加对电视广告和产品展示的响应; 选择电源站从而使网络或网络和/或主要营销商受益，利用DVR和DVR手持式遥控器的基础设施，以方便用户对DVD的其他非广播电子传输内容上的广告和产品展示的响应包括但不限于下载的节目和电影，平面广告，目录和可用产品的其他指标，增强与供应商/广告商的互动。本发明适用于数字视频记录器和处理和传送实时电视广播，广播延迟播放，记录的广播，非广播电子传送的内容和DVD的电视监视器的其他设备。

8. 发明授权

US07930030B2 Implantable pulse generator having current steering means 有权
标题翻译：具有电流转向装置的可植入式脉冲发生器
公开(公告)号：US07930030B2
公开(公告)日：2011-04-19
申请号：US12120182
申请日：2008-05-13
申请人： Carla Mann Woods , David K. L. Peterson , Paul Meadows , Gerald E. Loeb
发明人： Carla Mann Woods , David K. L. Peterson , Paul Meadows , Gerald E. Loeb
IPC分类号： A61N1/08
CPC分类号： A61N1/36185 , A61N1/0551 , A61N1/0553 , A61N1/36071 , A61N1/37235 , A61N1/37247
摘要： An implantable pulse generator includes a current steering capability that allows a clinician or patient to quickly determine a desired electrode stimulation pattern, including which electrodes of a group of electrodes within an electrode array should receive a stimulation current, including the amplitude, width and pulse repetition rate of such current. Movement of the selected group of electrodes is facilitated through the use of remotely generated directional signals, generated by a pointing device, such as a joystick. As movement of the selected group of electrodes occurs, current redistribution amongst the various electrode contacts takes place. The redistribution of stimulus amplitudes utilizes re-normalization of amplitudes so that the perceptual level remains fairly constant. This prevents the resulting paresthesia from falling below the perceptual threshold or above the comfort threshold.
摘要翻译：可植入脉冲发生器包括电流转向能力，其允许临床医生或患者快速确定期望的电极刺激图案，包括电极阵列内的一组电极中的哪些电极应接收刺激电流，包括振幅，宽度和脉冲重复这样的比率。所选择的电极组的移动通过使用由诸如操纵杆的指示装置产生的远程产生的方向信号来促进。随着所选择的电极组的移动发生，各种电极接触件之间的电流再分配发生。刺激幅度的再分配利用振幅的再归一化，使得感知水平保持相当恒定。这可以防止由此产生的感觉异常降低到感知阈值以下或高于舒适阈值。

9. 发明授权

US07801615B2 Rechargeable spinal cord stimulator system 有权
标题翻译：充电脊髓刺激器系统
公开(公告)号：US07801615B2
公开(公告)日：2010-09-21
申请号：US11947753
申请日：2007-11-29
申请人： Paul Meadows , Carla Mann Woods , David Peterson , Joey Chen , David Payne
发明人： Paul Meadows , Carla Mann Woods , David Peterson , Joey Chen , David Payne
IPC分类号： A61N1/00
CPC分类号： A61N1/37252 , A61N1/0553 , A61N1/36071 , A61N1/36185 , A61N1/37241 , A61N1/37247 , A61N1/3787 , H01H85/201 , H01H85/32
摘要： Implantable pulse generators and spinal cord stimulation (SCS) systems are provided. The implantable pulse generator comprises telemetry circuitry configured for wirelessly receiving programming signals from an external programmer, and a plurality of bi-directional current sources configured for being respectively coupled to a plurality of electrodes. The implantable pulse generator further comprises control circuitry configured for directing the bi-directional current sources to output current pulses of a selected amplitude and polarity to the electrodes in accordance with the programming signals. The SCS system may comprise a plurality of electrodes, an external programmer configured for transmitting programming signals, and the afore-described implantable pulse generator as described above. In one embodiment, the SCS system further comprises one or more stimulation leads carrying the electrodes, in which case, the implantable pulse generator may further include a connector removably mated to the stimulation lead(s).
摘要翻译：提供了植入式脉冲发生器和脊髓刺激（SCS）系统。可植入式脉冲发生器包括配置用于无线地接收来自外部编程器的编程信号的遥测电路和被配置为分别耦合到多个电极的多个双向电流源。可植入脉冲发生器还包括控制电路，其被配置为根据编程信号将双向电流源引导至选定的幅度和极性的电流脉冲至电极。 SCS系统可以包括多个电极，被配置为用于发送编程信号的外部编程器和如上所述的上述可植入脉冲发生器。在一个实施例中，SCS系统还包括携带电极的一个或多个刺激引线，在这种情况下，可植入脉冲发生器还可包括可拆卸地配合到刺激引线的连接器。

10. 发明申请

US20070276450A1 RECHARGEABLE SPINAL CORD STIMULATION SYSTEM 有权
标题翻译：可充电脊髓刺激系统
公开(公告)号：US20070276450A1
公开(公告)日：2007-11-29
申请号：US11625283
申请日：2007-01-20
申请人： Paul Meadows , Carla Woods , David Peterson , Joey Chen , David Payne
发明人： Paul Meadows , Carla Woods , David Peterson , Joey Chen , David Payne
IPC分类号： A61N1/05
CPC分类号： A61N1/37252 , A61N1/0553 , A61N1/36071 , A61N1/36185 , A61N1/37241 , A61N1/37247 , A61N1/3787 , H01H85/201 , H01H85/32
摘要： A spinal cord stimulation (SCS) system includes multiple electrodes, multiple, independently programmable, stimulation channels within an implantable pulse generator (IPG) which channels can provide concurrent, but unique stimulation fields, permitting virtual electrodes to be realized. The SCS system includes a replenishable power source (e.g., rechargeable battery), that may be recharged using transcutaneous power transmissions between antenna coil pairs. An external charger unit, having its own rechargeable battery can be used to charge the IPG replenishable power source. A real-time clock can provide an auto-run schedule for daily stimulation. An included bi-directional telemetry link in the system informs the patient or clinician the status of the system, including the state of charge of the IPG battery. Other processing circuitry in the IPG allows electrode impedance measurements to be made. Further circuitry in the external battery charger can provide alignment detection for the coil pairs.
摘要翻译：脊髓刺激（SCS）系统包括在可植入脉冲发生器（IPG）内的多个电极，多个独立可编程的刺激通道，其通道可以提供同时但独特的刺激场，允许实现虚拟电极。 SCS系统包括可补充电源（例如，可充电电池），其可以使用天线线圈对之间的经皮功率传输进行再充电。可以使用具有自己的可充电电池的外部充电器单元为IPG可补充电源充电。实时时钟可以提供每日刺激的自动运行时间表。系统中包括的双向遥测连接通知患者或临床医生系统的状态，包括IPG电池的充电状态。 IPG中的其他处理电路允许进行电极阻抗测量。外部电池充电器中的进一步电路可以为线圈对提供对准检测。

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