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1. 发明授权

US07780631B2 Apparatus and method for penetration with shaft having a sensor for sensing penetration depth 有权
标题翻译：用于穿透轴的装置和方法具有用于感测穿透深度的传感器
公开(公告)号：US07780631B2
公开(公告)日：2010-08-24
申请号：US10008159
申请日：2001-11-06
申请人： Paul Lum , Hewlett E. Melton, Jr. , Tad Decataur Simons , Michael Greenstein , Dominique M. Freeman
发明人： Paul Lum , Hewlett E. Melton, Jr. , Tad Decataur Simons , Michael Greenstein , Dominique M. Freeman
IPC分类号： A61M5/00
CPC分类号： A61B5/053 , A61B5/150022 , A61B5/15003 , A61B5/150137 , A61B5/150167 , A61B5/150175 , A61B5/150389 , A61B5/150412 , A61B5/15117 , A61B5/15121 , A61B5/15125 , A61B5/15128 , A61B5/15194 , A61B18/14 , A61B2018/00738 , A61B2018/00755 , A61B2018/00875 , A61B2018/126 , A61B2018/1425 , A61B2090/062 , A61M5/46
摘要： An apparatus having a shaft that can sense the depth of penetration, for penetrating into an object (the substrate). The substrate being penetrated has impedance that varies according to the depth under a surface of the substrate. The shaft has a tip for penetration and has conductive ends near to the tip of the shaft. A change of impedance of material of the object between the conductive ends can be sensed to provide information on the depth of penetration. A processor can be provided external to the object being penetrated by the shaft to gather and process the impedance information to determine whether the desired depth has been achieved.
摘要翻译：一种具有可以感测穿透深度的轴的装置，用于穿透物体（基底）。穿透的衬底具有根据衬底表面下方的深度而变化的阻抗。轴具有用于穿透的尖端并且具有靠近轴的尖端的导电端。可以感测导电端之间的物体的材料阻抗的变化，以提供关于穿透深度的信息。处理器可以设置在被轴穿透的对象的外部，以收集和处理阻抗信息以确定是否已经实现期望的深度。

2. 发明授权

US06391005B1 Apparatus and method for penetration with shaft having a sensor for sensing penetration depth 失效
标题翻译：用于穿透轴的装置和方法具有用于感测穿透深度的传感器
公开(公告)号：US06391005B1
公开(公告)日：2002-05-21
申请号：US09050853
申请日：1998-03-30
申请人： Paul Lum , Hewlett E. Melton, Jr. , Tad Decataur Simons , Michael Greenstein
发明人： Paul Lum , Hewlett E. Melton, Jr. , Tad Decataur Simons , Michael Greenstein
IPC分类号： A61M500
CPC分类号： A61B5/053 , A61B5/150022 , A61B5/15003 , A61B5/150137 , A61B5/150167 , A61B5/150175 , A61B5/150389 , A61B5/150412 , A61B5/15117 , A61B5/15121 , A61B5/15125 , A61B5/15128 , A61B5/15194 , A61B18/14 , A61B2018/00738 , A61B2018/00755 , A61B2018/00875 , A61B2018/126 , A61B2018/1425 , A61B2090/062 , A61M5/46
摘要： An apparatus having a shaft that can sense the depth of penetration, for penetrating into an object (the substrate). The substrate being penetrated has impedance that varies according to the depth under a surface of the substrate. The shaft has a tip for penetration and has conductive ends near to the tip of the shaft. A change of impedance of material of the object between the conductive ends can be sensed to provide information on the depth of penetration. A processor can be provided external to the object being penetrated by the shaft to gather and process the impedance information to determine whether the desired depth has been achieved.
摘要翻译：一种具有可以感测穿透深度的轴的装置，用于穿透物体（基底）。穿透的衬底具有根据衬底表面下方的深度而变化的阻抗。轴具有用于穿透的尖端并且具有靠近轴的尖端的导电端。可以感测导电端之间的物体的材料阻抗的变化，以提供关于穿透深度的信息。处理器可以设置在被轴穿透的对象的外部，以收集和处理阻抗信息以确定是否已经实现期望的深度。

3. 发明授权

US06276196B1 Thermometric vapor sensor with evaporation surface having micropores 有权
公开(公告)号：US06276196B1
公开(公告)日：2001-08-21
申请号：US09733511
申请日：2000-12-07
申请人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
发明人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
IPC分类号： G01N700
摘要： A sensor for sensing in a gas stream a vapor of a liquid. The sensor includes a micropore and a wet temperature sensor. The micropore has an evaporation end and has a lumen to conduct liquid from a supply of the liquid for evaporation at the evaporation end. The wet temperature sensor has a heat sensitive part in contact with the liquid in the micropore. The heat sensitive part circumscribes the micropore and forms part of the lumen. Heat loss due to evaporation of the liquid when the wet temperature sensor wet with the liquid is placed in the gas stream will result in the temperature sensed by the wet temperature sensor being lower than the non-evaporative temperature of the gas stream. This lowering in temperature can be measured to determine the concentration of the vapor in the gas stream. An example of such a sensor has a thermocouple junction having micropores passing through the thermocouple junction.

4. 发明授权

US06202480B1 Thermometric vapor sensor with evaporation surface having micropores 失效
标题翻译：具有蒸发表面的微孔蒸气传感器具有微孔
公开(公告)号：US06202480B1
公开(公告)日：2001-03-20
申请号：US09054852
申请日：1998-04-02
申请人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
发明人： Ganapati R. Mauze , Michael Greenstein , Paul Lum , Hewlett E. Melton, Jr.
IPC分类号： G01N2562
CPC分类号： G01N25/64
摘要： A sensor for sensing in a gas stream a vapor of a liquid. The sensor includes a micropore and a wet temperature sensor. The micropore has an evaporation end and has a lumen to conduct liquid from a supply of the liquid for evaporation at the evaporation end. The wet temperature sensor has a heat sensitive part in contact with the liquid in the micropore. The heat sensitive part circumscribes the micropore and forms part of the lumen. Heat loss due to evaporation of the liquid when the wet temperature sensor wet with the liquid is placed in the gas stream will result in the temperature sensed by the wet temperature sensor being lower than the non-evaporative temperature of the gas stream. This lowering in temperature can be measured to determine the concentration of the vapor in the gas stream. An example of such a sensor has a thermocouple junction having micropores passing through the thermocouple junction.
摘要翻译：一种传感器，用于在气流中检测液体的蒸汽。该传感器包括微孔和湿温度传感器。微孔具有蒸发端，并且具有内腔以在蒸发端从用于蒸发的液体供应源输送液体。湿式温度传感器具有与微孔中的液体接触的热敏部分。热敏部分围绕微孔并形成管腔的一部分。将潮湿的温度传感器用液体湿润时液体的蒸发导致的热损失被放置在气流中将导致由湿式温度传感器感测到的温度低于气流的非蒸发温度。可以测量这种温度降低以确定气流中的蒸气的浓度。这种传感器的示例具有热电偶结，其具有穿过热电偶结的微孔。

5. 发明授权

US06364890B1 Extraction and transportation of blood for analysis 有权
标题翻译：提取和运输血液进行分析
公开(公告)号：US06364890B1
公开(公告)日：2002-04-02
申请号：US09614318
申请日：2000-07-12
申请人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
发明人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
IPC分类号： A61B1732
CPC分类号： A61B5/15144 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15113
摘要： A device for sampling blood from the skin of a patient by puncture. The device includes one or more lancets for lancing the skin and a fluid-conducting plate unit for transporting blood from the lancing wound. The plate unit has one or more channels for conducting fluid to one or more target locations. Preferably there is a first channel for conducting away a first portion of fluid that contains more of a fluid that is emitted initially (initial fluid) from the puncture wound and a second channel for conducting a second portion of fluid that contains less of the initial fluid from the puncture wound. Blood is drawn into the channels by capillary force. The device can be used to lance the skin and obtain a representative sample of blood with relatively simple procedures.
摘要翻译：一种用于通过穿刺从患者皮肤取样血液的装置。该装置包括用于切割皮肤的一个或多个刺血针和用于从穿刺伤口输送血液的导流板单元。板单元具有用于将流体传导到一个或多个目标位置的一个或多个通道。优选地，存在用于传导第一部分流体的第一通道，所述第一部分流体包含更多的来自穿刺伤口的最初发射的流体（初始流体）和用于传导含有较少初始流体的第二部分流体的第二通道从穿刺伤口。通过毛细血管力将血液吸入通道。该装置可用于以相对简单的程序来刺激皮肤并获得代表性的血液样品。

6. 发明授权

US06660018B2 Multiple lancet device 失效
标题翻译：多重刺血针装置
公开(公告)号：US06660018B2
公开(公告)日：2003-12-09
申请号：US09846139
申请日：2001-04-30
申请人： Paul Lum , Michael Greenstein , Leslie A. Leonard , Dominique M Freeman
发明人： Paul Lum , Michael Greenstein , Leslie A. Leonard , Dominique M Freeman
IPC分类号： A61B1714
CPC分类号： A61B5/150977 , A61B5/150022 , A61B5/150068 , A61B5/150099 , A61B5/150396 , A61B5/150427 , A61B5/15142 , A61B5/157 , A61B17/205
摘要： A device for puncturing the skin of a patient. The device includes first and second protrusions, each protrusion puncturing the skin when pressed against the skin. The first and second protrusions are arranged such that the first protrusion punctures the skin at a location less than a predetermined distance from the second protrusion. The distance is chosen to be less than the discriminatable distance between distinct pain perception points in the patient, such that the patient perceives a single puncture when the first and second protrusions puncture the skin. In one embodiment of the invention, the device includes a base lip that applies a lateral force to the skin when the base lip is pressed against the skin. In this embodiment, the protrusions are pressed into the skin as the base lip is pressed against the skin.
摘要翻译：一种用于刺穿患者皮肤的装置。该装置包括第一和第二突起，每个突出部在压靠皮肤时刺入皮肤。第一突起和第二突起被布置成使得第一突起在距离第二突起小于预定距离的位置刺穿皮肤。该距离选择为小于患者中不同疼痛感知点之间的可区分距离，使得当第一和第二突起刺穿皮肤时，患者感知到单次穿刺。在本发明的一个实施例中，所述装置包括基底唇部，当基底唇被压靠在皮肤上时，所述基部唇缘向皮肤施加横向力。在该实施例中，当基底唇被压在皮肤上时，突起被压入皮肤。

7. 发明授权

US07666149B2 Cassette of lancet cartridges for sampling blood 有权
标题翻译：用于取样血液的柳叶刀墨盒盒
公开(公告)号：US07666149B2
公开(公告)日：2010-02-23
申请号：US10282927
申请日：2002-10-28
申请人： Tad Decatur Simons , Michael Greenstein , Dominique M. Freeman , Leslie Anne Leonard , David A. King , Paul Lum
发明人： Tad Decatur Simons , Michael Greenstein , Dominique M. Freeman , Leslie Anne Leonard , David A. King , Paul Lum
IPC分类号： A61B5/00 , B65D81/00
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150305 , A61B5/150358 , A61B5/150412 , A61B5/15113 , A61B5/15153 , A61B5/15159 , A61B5/15165 , A61B5/15174 , A61B2562/0295 , Y10S436/808
摘要： A cassette containing cartridges for sampling blood from a patient. The cassette includes a container for storing a plurality of cartridges and at least one cartridge in the container. The cartridge includes a cartridge case and a lancet. The lancet has a tip and is housed in the cartridge case. The lancet can be driven to extend the tip outside the cartridge case for lancing the skin of the patient to yield blood. The container has a compartment that contains at least one cartridge. A cartridge from the compartment can be loaded onto a glucometer that drives the lancet in the cartridge to lance the skin of a patient.
摘要翻译：包含用于从患者取血的药筒的药盒。盒式磁带包括用于存储多个盒的容器和容器中的至少一个盒。药筒包括药筒盒和刺血针。刺血针具有尖端并且容纳在盒壳体中。可以驱动柳叶刀将尖端延伸到药筒壳体外部，以便撕裂患者的皮肤以产生血液。容器具有包含至少一个盒的隔间。来自隔室的药筒可以被装载到驱动药筒中的刺血针的血糖仪上以刺穿患者的皮肤。

8. 发明授权

US6132449A Extraction and transportation of blood for analysis 失效
公开(公告)号：US6132449A
公开(公告)日：2000-10-17
申请号：US264597
申请日：1999-03-08
申请人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
发明人： Paul Lum , Leslie A. Leonard , Edward D. Verdonk , Dominique M. Freeman , Michael Greenstein , Catherine Keely-Templin
IPC分类号： A61B5/00 , A61B5/15 , A61B17/32
CPC分类号： A61B5/15144 , A61B5/150022 , A61B5/150099 , A61B5/150106 , A61B5/150427 , A61B5/150969 , A61B5/150984 , A61B5/15113 , A61B5/14532
摘要： A device for sampling blood from the skin of a patient by puncture. The device includes one or more lancets for lancing the skin and a fluid-conducting plate unit for transporting blood from the lancing wound. The plate unit has one or more channels for conducting fluid to one or more target locations. Preferably there is a first channel for conducting away a first portion of fluid that contains more of a fluid that is emitted initially (initial fluid) from the puncture wound and a second channel for conducting a second portion of fluid that contains less of the initial fluid from the puncture wound. Blood is drawn into the channels by capillary force. The device can be used to lance the skin and obtain a representative sample of blood with relatively simple procedures.

9. 发明授权

US5375600A Ultrasonic frequency-domain system and method for sensing fluid flow 失效
标题翻译：超声频域系统和感应流体流的方法
公开(公告)号：US5375600A
公开(公告)日：1994-12-27
申请号：US104309
申请日：1993-08-09
申请人： Hewlett E. Melton, Jr. , King-Wah W. Yeung , Michael Greenstein
发明人： Hewlett E. Melton, Jr. , King-Wah W. Yeung , Michael Greenstein
IPC分类号： A61B8/06 , G01P5/00 , G01P13/00 , G01S15/58
CPC分类号： G01S15/8984 , A61B8/06 , A61B8/488 , G01S15/582
摘要： Pulses of ultrasound are focused in the patient's body to create an interrogation volume where a characteristic of blood flow is to be measured. The bandwidth of the back-scattered Doppler return signal is measured. In order to measure flow velocity independent of direction, the interrogation volume is generated substantially as a sphere in which the range dimension is set equal to the lateral dimensions (azimuth and elevation) of the interrogation signal. The Doppler bandwidth is then scaled to provide a direction-independent measurement of flow velocity. In order to determine the direction of flow, the interrogation volume is generated substantially as an ellipsoid. The long axis of the ellipsoidal interrogation volume is then rotated until the measured Doppler bandwidth is at a minimum, which is reached when the long axis is aligned with the flow direction. The interrogation volume is preferably rotated and translated using differential phasing of the ultrasonic signals from different transducer elements in a two-dimensional array.
摘要翻译：超声波的脉冲聚焦在患者的身体中以产生要测量血流特征的询问体积。测量背散射多普勒返回信号的带宽。为了独立于方向测量流速，询问体积基本上产生为范围尺寸设置为等于询问信号的横向尺寸（方位角和仰角）的球体。然后缩放多普勒带宽以提供流速独立的方向测量。为了确定流动的方向，询问体积基本上产生为椭圆体。然后旋转椭圆询问体积的长轴直到测量的多普勒带宽处于最小值，当长轴与流动方向对准时达到最小。询问体积优选地以二维阵列使用来自不同换能器元件的超声波信号的微分相位来旋转和平移。

10. 发明授权

US5485845A Rotary encoder for intravascular ultrasound catheter 失效
标题翻译：旋转编码器用于血管内超声导管
公开(公告)号：US5485845A
公开(公告)日：1996-01-23
申请号：US434616
申请日：1995-05-04
申请人： Edward Verdonk , Michael Greenstein , Hewlett E. Melton, Jr. , Mir S. Seyed-Bolorforosh
发明人： Edward Verdonk , Michael Greenstein , Hewlett E. Melton, Jr. , Mir S. Seyed-Bolorforosh
IPC分类号： A61B8/12 , A61B19/00 , G01S5/24 , G01S15/74 , G01S15/87 , G01S15/89
CPC分类号： A61B8/12 , A61B8/445 , A61B8/4461 , G01S15/74 , G01S15/874 , G01S15/8943 , A61B2090/3929 , G01S5/24
摘要： An ultrasound system and method for intravascular ultrasonic imaging includes an array of beacons that are fixed to direct ultrasonic energy toward an imaging transducer, with individual beacons being identifiable in order to determine the angular position of the imaging transducer. Based upon the data related to beacon identification, operation of the imaging device is adaptively adjusted in order to compensate for variations in angular velocity of the transducer. Adaptive compensation may be performed by adjusting the pulse repetition rate of transmitted ultrasonic energy, by adjusting the scan conversion algorithm or mapping reflected ultrasonic energy, or by varying control of the drive structure for rotating the transducer. The beacons are preferably piezoelectrically active, but passive beacons may also be used. Position identification may be performed by techniques including amplitude sensing, phase sensing, pulse length sensing, and frequency sensing. As an alternative to rotation of the transducer, ultrasonic signals may be formed at a proximal end of a probe and then conducting the energy to the distal end via a waveguide.
摘要翻译：用于血管内超声成像的超声系统和方法包括固定以朝向成像换能器直接超声能量的信标阵列，其中各个信标是可识别的，以便确定成像换能器的角位置。基于与信标识别相关的数据，自适应地调整成像装置的操作，以补偿换能器的角速度的变化。可以通过调整扫描转换算法或映射反射的超声能量，或者通过改变用于旋转传感器的驱动结构的控制来调节发射的超声能量的脉冲重复率来执行自适应补偿。信标优选地是压电有源的，但也可以使用被动信标。可以通过包括幅度感测，相位感测，脉冲长度感测和频率感测的技术来执行位置识别。作为换能器旋转的替代方案，可以在探针的近端处形成超声波信号，然后经由波导将能量传导到远端。

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