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1. 发明申请

US20050182103A1 Substituted 2,3-diphenyl pyridines 失效
标题翻译：取代的2,3-二苯基吡啶
公开(公告)号：US20050182103A1
公开(公告)日：2005-08-18
申请号：US10508043
申请日：2003-03-24
申请人： Paul Finke , Laura Meurer , John Debenham , Richard Toupence , Thomas Walsh
发明人： Paul Finke , Laura Meurer , John Debenham , Richard Toupence , Thomas Walsh
IPC分类号： C07D213/64 , A61K31/44 , A61K31/4418 , A61K31/4439 , A61K31/4545 , A61K31/455 , A61K31/496 , A61K31/5377 , A61K45/00 , A61K47/02 , A61K47/10 , A61K47/26 , A61K47/34 , A61P1/04 , A61P1/10 , A61P1/16 , A61P3/04 , A61P9/00 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/28 , A61P25/30 , A61P29/00 , A61P43/00 , C07D213/56 , C07D213/65 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/85 , C07D213/86 , C07D213/87 , C07D401/12 , C07D41/02
CPC分类号： C07D213/79 , C04B35/632 , C07D213/65 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/85 , C07D213/86 , C07D213/87 , C07D401/12
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson s disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症，脑血管事故和头部创伤，焦虑障碍，压力，癫痫，帕金森病，运动障碍和精神分裂症。这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻和肝硬化。

2. 发明申请

US20050272763A1 Substituted furo[2,3-b]pyridine derivatives 失效
标题翻译：取代的呋喃并[2,3-b]吡啶衍生物
公开(公告)号：US20050272763A1
公开(公告)日：2005-12-08
申请号：US10521821
申请日：2003-08-01
申请人： Richard Toupence , John Debenham , Mark Goulet , Christina Madsen-Duggan , Thomas Walsh , Shrenik Shah
发明人： Richard Toupence , John Debenham , Mark Goulet , Christina Madsen-Duggan , Thomas Walsh , Shrenik Shah
IPC分类号： C07D491/048 , A61K31/00 , A61K31/4355 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/4741 , A61K31/496 , A61K31/5377 , A61P1/00 , A61P1/10 , A61P1/16 , A61P3/04 , A61P9/10 , A61P11/06 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/28 , A61P25/30 , A61P43/00 , C07D453/06 , C07D491/02 , C07D491/04 , C07D519/00
CPC分类号： C07D491/04 , C07D453/06
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症，脑血管事故和头部创伤，焦虑症，压力，癫痫，帕金森病，运动障碍和精神分裂症。这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻和肝硬化。

3. 发明申请

US20070032517A1 Substituted naphthyridinone derivatives 失效
标题翻译：取代的萘啶酮衍生物
公开(公告)号：US20070032517A1
公开(公告)日：2007-02-08
申请号：US10576796
申请日：2004-10-29
申请人： John Debenham , George Doss , Christina Madsen-Duggan , Thomas Walsh
发明人： John Debenham , George Doss , Christina Madsen-Duggan , Thomas Walsh
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04 , A61K31/4375 , C07D471/14
摘要： Novel compounds of the structural formula (I) are antagonists and/or inverse agonists of the Cannabinoid-1 (CB1) receptor and are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. The compounds of the present invention are useful as centrally acting drugs in the treatment of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders including multiple sclerosis and Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis, cerebral vascular accidents, and head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, movement disorders, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, the treatment of obesity or eating disorders, as well as the treatment of asthma, constipation, chronic intestinal pseudo-obstruction, and cirrhosis of the liver.
摘要翻译：结构式（I）的新型化合物是大麻素-1（CB1）受体的拮抗剂和/或反向激动剂，可用于治疗，预防和抑制由CB1受体介导的疾病。本发明的化合物可用作治疗精神病，记忆缺陷，认知障碍，偏头痛，神经病，包括多发性硬化和神经 - 巴利综合征的神经炎症性疾病以及病毒性脑炎的炎症性后遗症，脑血管事故和头部创伤，焦虑症，压力，癫痫，帕金森病，运动障碍和精神分裂症。这些化合物还可用于治疗药物滥用障碍，治疗肥胖或进食障碍，以及治疗哮喘，便秘，慢性肠假性梗阻和肝硬化。

4. 发明授权

US08694594B2 Method and system for automated team support message delivery 有权
标题翻译：用于自动化团队支持消息传递的方法和系统
公开(公告)号：US08694594B2
公开(公告)日：2014-04-08
申请号：US13336080
申请日：2011-12-23
申请人： Thomas Walsh , Steven J. Catani , Maurice Collins , Lauren M. Didyk , Helene Gidley , David A. Gregorka , John Hetrick , Jeffrey Matthes , Thomas E. Sox , Victor J. Strecher , Raphaela Finkenauer O'Day
发明人： Thomas Walsh , Steven J. Catani , Maurice Collins , Lauren M. Didyk , Helene Gidley , David A. Gregorka , John Hetrick , Jeffrey Matthes , Thomas E. Sox , Victor J. Strecher , Raphaela Finkenauer O'Day
IPC分类号： G06F15/16
CPC分类号： G06Q10/10 , G06Q10/109
摘要： A method and system for providing personalized message delivery to one or more individual users of at least one team of users is disclosed. In accordance with the method and system, data specific to one or more individual users of at least one team of users is gathered, analyzed and used to determine preferences and order of precedence of the one or more individual users of the at least one team of users; and personalized message delivery is provided to the one or more individual users of the at least one team of users based upon the one or more individual users of the at least one team of users' preferences and order of precedence.
摘要翻译：公开了一种用于向至少一个用户团队的一个或多个个体用户提供个性化消息递送的方法和系统。根据该方法和系统，收集，分析和使用特定于至少一个用户团队的一个或多个个体用户的数据，以确定至少一个团队的一个或多个个体用户的优先级和顺序用户; 并且基于所述至少一个用户组的优先级和优先顺序的所述一个或多个个体用户，向所述至少一个用户团队的所述一个或多个个体用户提供个性化消息传送。

5. 发明申请

US20070004630A1 Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology 失效
标题翻译：肾上腺髓质素（AM）和基因相关产物（PAMP）在人类病理和生理学中的功能作用
公开(公告)号：US20070004630A1
公开(公告)日：2007-01-04
申请号：US11517599
申请日：2006-09-05
申请人： Frank Cuttitta , Alfredo Martinez , Mae Miller , Edward Unsworth , William Hook , Thomas Walsh , Karen Gray , Charles Macri
发明人： Frank Cuttitta , Alfredo Martinez , Mae Miller , Edward Unsworth , William Hook , Thomas Walsh , Karen Gray , Charles Macri
IPC分类号： A61K39/395 , A61K38/22
CPC分类号： C07K16/26 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/51 , C07K14/575 , C07K2317/34 , C07K2317/73
摘要： The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.
摘要翻译：本发明的方法证明，肾上腺髓质素（AM）在不同来源的人类癌细胞系中表达，并且作为驱动肿瘤增殖的通用自分泌生长因子起作用。本发明提供可用于治疗，药理和生理组合物的AM肽和AM抗体。本发明另外提供了使用包含本发明的AM肽和抗体的组合物来诊断，治疗和预防疾病的方法。本发明的方法还提供了用于鉴定AM在胰腺生理学中的作用的实验模型。与大鼠分离的胰岛有关的方法表明，AM以剂量依赖的方式抑制胰岛素分泌。中和AM生物活性的单克隆抗体MoAb-G6通过本发明的方法显示出增加胰岛素释放的五倍，这是通过加入合成AM而逆转的作用。

6. 发明授权

US07101548B2 Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology 有权
标题翻译：肾上腺髓质素（AM）和基因相关产物（PAMP）在人类病理和生理学中的功能作用
公开(公告)号：US07101548B2
公开(公告)日：2006-09-05
申请号：US09931700
申请日：2001-08-16
申请人： Frank Cuttitta , Alfredo Martinez , Mae Jean Miller , Edward J. Unsworth , William Hook , Thomas Walsh , Karen Gray , Charles Macri
发明人： Frank Cuttitta , Alfredo Martinez , Mae Jean Miller , Edward J. Unsworth , William Hook , Thomas Walsh , Karen Gray , Charles Macri
IPC分类号： A61K39/395
CPC分类号： C07K16/26 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/51 , C07K14/575 , C07K2317/34 , C07K2317/73
摘要： The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have shown that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was shown by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.
摘要翻译：本发明的方法证明，肾上腺髓质素（AM）在不同来源的人类癌细胞系中表达，并且作为驱动肿瘤增殖的通用自分泌生长因子起作用。本发明提供可用于治疗，药理和生理组合物的AM肽和AM抗体。本发明另外提供了使用包含本发明的AM肽和抗体的组合物来诊断，治疗和预防疾病的方法。本发明的方法还提供了用于鉴定AM在胰腺生理学中的作用的实验模型。与大鼠分离的胰岛相关的方法已经表明AM以剂量依赖的方式抑制胰岛素分泌。通过本发明的方法显示了中和AM生物活性的单克隆抗体MoAb-G6，以增加胰岛素释放的五倍，这是通过加入合成AM而逆转的作用。

7. 发明申请

US20060163548A1 Theater Rigging System 有权
公开(公告)号：US20060163548A1
公开(公告)日：2006-07-27
申请号：US10906348
申请日：2005-02-15
申请人： Stephen Kochan , Peter Svitavsky , Thomas Walsh , Thomas Young
发明人： Stephen Kochan , Peter Svitavsky , Thomas Walsh , Thomas Young
IPC分类号： B66D1/26
CPC分类号： A63J1/028 , B66D1/26 , B66D1/34 , B66D5/14 , B66D5/34
摘要： A theater rigging assembly having a beam, which is attached to structural support members of a theater or other performing arts venue. The assembly further includes a winch assembly and head block that can be positioned at any point along the beam and selectively fixed in position. The winch portion includes cables for raising and lowering battens or other loads. The head block includes head sheaves, which redirect the cables to loft sheaves that are selectively attached to the beam. The head sheaves are diagonally displaced to separate the cables. The winch portion includes a motor, a gear box, a drum and a brake. The brake includes a ratchet and two brake disks. It uses at least one friction surface that contacts at least one of the brake disks to cause a pawl to engage or disengage from the ratchet.

8. 发明授权

US5920659A Method and apparatus for scaling image data having associated transparency data 失效
标题翻译：用于缩放具有相关透明度数据的图像数据的方法和装置
公开(公告)号：US5920659A
公开(公告)日：1999-07-06
申请号：US669079
申请日：1996-06-24
申请人： Vaughn Iverson , Thomas Walsh
发明人： Vaughn Iverson , Thomas Walsh
IPC分类号： G06T3/40 , G06K9/32
CPC分类号： G06T3/40
摘要： The resolution of one or more components of image data is changed to generate scaled image data and transparency processing is applied to the scaled image data, wherein the transparency processing is taken into account during the changing of the resolution of the image data. In a preferred embodiment in which a video codec applies transparency processing during the compression of subsampled video data, the capture processor applies the same transparency mask during data subsampling to decrease color-bleeding effects that may otherwise appear in the decoded video stream.
摘要翻译：改变图像数据的一个或多个分量的分辨率以生成缩放的图像数据，并且对缩放的图像数据应用透明度处理，其中在改变图像数据的分辨率期间考虑透明度处理。在其中视频编解码器在压缩二进制视频数据期间应用透明度处理的优选实施例中，捕获处理器在数据子采样期间应用相同的透明度掩码以减少否则可能出现在解码的视频流中的色彩渗透效应。

9. 发明申请

US20120046781A1 METHOD, APPARATUS AND SYSTEM FOR USE IN PROCESSING WAFERS 有权
标题翻译：用于处理波形的方法，装置和系统
公开(公告)号：US20120046781A1
公开(公告)日：2012-02-23
申请号：US13290900
申请日：2011-11-07
申请人： William J. Kalenian , Thomas Walsh , Dave Halley
发明人： William J. Kalenian , Thomas Walsh , Dave Halley
IPC分类号： G06F19/00
CPC分类号： B24B37/345 , B24B37/30 , H01L21/67161 , H01L21/67219 , H01L21/68785
摘要： The present embodiment provides for methods and systems for use in processing objects such as wafers, including polishing and/or grinding wafers. Some embodiments provide systems that include a front-end module and a processing module. The front end module couples with a storage device that stores objects for processing. The front-end module can comprise a single robot, a transfer station, and a plurality of end effectors. The processing module is coupled with the front-end module such that the single robot delivers objects from the storage device to the processing module. The processing module comprising a rotating table, and a spindle with a carrier configured to retrieve the delivered object and process the object on the rotating table.
摘要翻译：本实施例提供了用于处理诸如晶片的物体的方法和系统，包括抛光和/或研磨晶片。一些实施例提供了包括前端模块和处理模块的系统。前端模块与存储用于处理的对象的存储设备耦合。前端模块可以包括单个机器人，传送站和多个端部执行器。处理模块与前端模块耦合，使得单个机器人将物体从存储装置传送到处理模块。所述处理模块包括旋转台和具有承载件的主轴，所述托架被配置为检索所递送的物体并且处理所述旋转台上的物体。

10. 发明申请

US20070128983A1 Grinding apparatus and method 有权
标题翻译：研磨设备和方法
公开(公告)号：US20070128983A1
公开(公告)日：2007-06-07
申请号：US11548213
申请日：2006-10-10
申请人： Thomas Walsh , Salman Kassir
发明人： Thomas Walsh , Salman Kassir
IPC分类号： B24B51/00 , B24B1/00
CPC分类号： B24B49/16 , B24B7/22
摘要： The present embodiments provide methods, systems and apparatuses for use in grinding work pieces, such as wafers. Some embodiments provide methods that position a grind spindle to contact a first grinding spindle to a face of a work piece, remove a portion of the face, and control the removing of the portion of the face according to a control algorithm. This control algorithm can comprise determining a force applied to the work piece during the removing of the portion of the face, adjusting a feed rate of the first grind spindle when the force applied to the work piece has a predefined relationship with a first threshold level; and dressing a portion of the first grinding portion when the force applied to the work piece has a predefined relationship with a second threshold level that is greater than the first threshold.
摘要翻译：本实施例提供了用于研磨诸如晶片的工件的方法，系统和装置。一些实施例提供了一种方法，其定位研磨主轴以使第一研磨主轴接触工件的表面，去除面部的一部分，并且根据控制算法控制面部的部分的移除。该控制算法可以包括确定在去除面部的部分期间施加到工件的力，当施加到工件的力具有与第一阈值水平的预定关系时，调节第一研磨主轴的进给速度; 以及当施加到所述工件上的力具有与大于所述第一阈值的第二阈值水平的预定关系时，修整所述第一研磨部的一部分。

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