专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09066951B2 Drugs to treat HPV infection 有权
标题翻译：药物治疗HPV感染
公开(公告)号：US09066951B2
公开(公告)日：2015-06-30
申请号：US12994592
申请日：2009-05-29
申请人： Paul F. Lambert , Paul G. Ahlquist , Dohun Pyeon , Hao Shun Huang
发明人： Paul F. Lambert , Paul G. Ahlquist , Dohun Pyeon , Hao Shun Huang
IPC分类号： A01N43/64 , A61K31/53 , A61K31/166 , A61K31/167 , A61K9/00
CPC分类号： A61K31/53 , A61K9/0031 , A61K9/0034 , A61K31/166 , A61K31/167
摘要： A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.
摘要翻译：公开了抑制HPV病毒感染的方法。在一个实施方案中，该方法包括将乳头瘤病毒暴露于有效量的选自化合物13，化合物14和化合物13和14的类似物的化合物。在另一个实施方案中，该方法包括施用选自由化合物13，化合物14和化合物13和14的类似物组成的组组成敏感组织或细胞。

2. 发明申请

US20110165220A1 DRUGS TO PREVENT HPV INFECTION 有权
标题翻译：药物预防HPV感染
公开(公告)号：US20110165220A1
公开(公告)日：2011-07-07
申请号：US12994592
申请日：2009-05-29
申请人： Paul F. Lambert , Paul G. Ahlquist , Dohun Pyeon , Hao Shun Huang
发明人： Paul F. Lambert , Paul G. Ahlquist , Dohun Pyeon , Hao Shun Huang
IPC分类号： A61K31/53 , A61K31/16 , A61K9/00 , A61P31/20
CPC分类号： A61K31/53 , A61K9/0031 , A61K9/0034 , A61K31/166 , A61K31/167
摘要： A method of inhibiting HPV virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of a compound selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14. In another embodiment, the method involves administering an inhibitor selected from the group consisting of Compound 13, Compound 14, and analogs of Compounds 13 and 14 to a susceptible tissue or cell.
摘要翻译：公开了抑制HPV病毒感染的方法。在一个实施方案中，该方法包括将乳头瘤病毒暴露于有效量的选自化合物13，化合物14和化合物13和14的类似物的化合物。在另一个实施方案中，该方法包括施用选自由化合物13，化合物14和化合物13和14的类似物组成的组组成敏感组织或细胞。

3. 发明申请

US20090136486A1 Biomarkers for human papilloma virus-associated cancer 有权
标题翻译：人类乳头状瘤病毒相关癌症的生物标志物
公开(公告)号：US20090136486A1
公开(公告)日：2009-05-28
申请号：US12220465
申请日：2008-07-24
申请人： Dohun Pyeon , Paul F. Lambert , Michael A. Newton , Paul G. Ahlquist
发明人： Dohun Pyeon , Paul F. Lambert , Michael A. Newton , Paul G. Ahlquist
IPC分类号： A61K39/395 , C12Q1/68 , A61P35/00 , G01N33/53
CPC分类号： C12Q1/6886 , C12Q1/708 , C12Q2600/112 , C12Q2600/136
摘要： Cervical cancer cells and HPV+ head and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers, TCAM1 and SYCP2 are early detection markers. Various methods for identifying a human or non-human animal as a candidate for further examination for cervical cancer, preneoplastic lesion for cervical cancer, head and neck cancer, or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.
摘要翻译：子宫颈癌细胞和HPV +头颈癌细胞表达体细胞无正常表达的三种睾丸特异性基因：睾丸细胞粘附分子1（TCAM1），突触核蛋白复合蛋白2（SYCP2）和基质抗原3（STAG3）。在三个标记中，TCAM1和SYCP2是早期检测标记。公开了用于鉴定人类或非人类动物作为子宫颈癌进一步检查，宫颈癌前肿瘤病变，头颈部癌症或头颈癌的癌前病变的候选者的各种方法。检测所述癌症和癌前病变的方法，筛选用于治疗所述癌症和癌前病变的药物的方法，用于监测所述癌症治疗有效性的方法，以及治疗所述癌症的方法。进一步公开的是可用于实施上述方法的试剂盒。

4. 发明授权

US11058699B2 Method and compositions for inhibition of double stranded DNA viruses 有权
公开(公告)号：US11058699B2
公开(公告)日：2021-07-13
申请号：US13000279
申请日：2009-06-29
申请人： Paul F. Lambert , Shane Pearce , Paul G. Ahlquist , Dohun Pyeon
发明人： Paul F. Lambert , Shane Pearce , Paul G. Ahlquist , Dohun Pyeon
IPC分类号： A61P31/20 , A61K31/7048 , A61K31/52 , A61K31/047 , A61K31/505
摘要： A method of inhibiting double-stranded DNA virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors. In another embodiment, the method involves administering an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors to a susceptible tissue or cell.

5. 发明授权

US08012678B2 Biomarkers for human papilloma virus-associated cancer 有权
标题翻译：人类乳头状瘤病毒相关癌症的生物标志物
公开(公告)号：US08012678B2
公开(公告)日：2011-09-06
申请号：US12220465
申请日：2008-07-24
申请人： Dohun Pyeon , Paul F. Lambert , Michael A. Newton , Paul G. Ahlquist
发明人： Dohun Pyeon , Paul F. Lambert , Michael A. Newton , Paul G. Ahlquist
IPC分类号： G01N33/574 , C12Q1/00
CPC分类号： C12Q1/6886 , C12Q1/708 , C12Q2600/112 , C12Q2600/136
摘要： Cervical cancer cells and HPV+ head and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers, TCAM1 and SYCP2 are early detection markers. Various methods for identifying a human or non-human animal as a candidate for further examination for cervical cancer, preneoplastic lesion for cervical cancer, head and neck cancer, or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.
摘要翻译：子宫颈癌细胞和HPV +头颈癌细胞表达体细胞无正常表达的三种睾丸特异性基因：睾丸细胞粘附分子1（TCAM1），突触蛋白复合蛋白2（SYCP2）和基质抗原3（STAG3）。在三个标记中，TCAM1和SYCP2是早期检测标记。公开了用于鉴定人类或非人类动物作为子宫颈癌进一步检查，宫颈癌前肿瘤病变，头颈部癌症或头颈癌的癌前病变的候选者的各种方法。检测所述癌症和癌前病变的方法，筛选用于治疗所述癌症和癌前病变的药物的方法，用于监测所述癌症治疗有效性的方法，以及治疗所述癌症的方法。进一步公开的是可用于实施上述方法的试剂盒。

6. 发明申请

US20090148950A1 PRODUCTION OF PACKAGED DNA SEQUENCES 有权
标题翻译：生产包装DNA序列
公开(公告)号：US20090148950A1
公开(公告)日：2009-06-11
申请号：US11275819
申请日：2006-01-30
申请人： Paul G. Ahlquist , Dohun Pyeon , Paul F. Lambert
发明人： Paul G. Ahlquist , Dohun Pyeon , Paul F. Lambert
IPC分类号： C12N15/87
CPC分类号： C12N7/00 , C12N2710/20022 , C12N2710/20052
摘要： A method of producing a packaged DNA sequence is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a DNA sequence to be packaged and a papillomaviral capsid sequence, wherein the DNA sequence to be packaged is between 7 Kb-8.5 Kb, (b) co-transfecting the products of step (a) into transfectable cells, wherein the DNA sequence is packaged, and (c) purifying packaged particles.
摘要翻译：公开了一种生产包装的DNA序列的方法。在一个实施方案中，该方法包括以下步骤：（a）选择要包装的DNA序列和乳头瘤病毒衣壳序列，其中待包装的DNA序列在7Kb-8.5Kb之间，（b）共转染产物步骤（a）转化成可转染细胞，其中包装DNA序列，和（c）纯化包装的颗粒。

7. 发明授权

US09790553B2 Biomarkers for human papilloma virus-associated cancers 有权
公开(公告)号：US09790553B2
公开(公告)日：2017-10-17
申请号：US13194624
申请日：2011-07-29
申请人： Dohun Pyeon , Paul F. Lambert , Michael A. Newton , Paul G. Ahlquist
发明人： Dohun Pyeon , Paul F. Lambert , Michael A. Newton , Paul G. Ahlquist
IPC分类号： C12Q1/68 , C12Q1/70
CPC分类号： C12Q1/6886 , C12Q1/708 , C12Q2600/112 , C12Q2600/136
摘要： Cervical cancer cells and HPV+ head and neck cancer cells express three testis-specific genes not normally expressed in somatic cells: testicular cell adhesion molecule 1 (TCAM1), synaptonemal complex protein 2 (SYCP2) and stromal antigen 3 (STAG3). Among the three markers, TCAM1 and SYCP2 are early detection markers. Various methods for identifying a human or non-human animal as a candidate for further examination for cervical cancer, preneoplastic lesion for cervical cancer, head and neck cancer, or preneoplastic lesion for head and neck cancer are disclosed. Methods of detecting said cancers and preneoplastic lesions, methods of screening for drugs for treating said cancers and preneoplastic lesions, methods for monitoring the effectiveness of a treatment for said cancers, and methods of treating said cancers are also disclosed. Further disclosed are kits that can be used to practice the above methods.

8. 发明申请

US20110189258A1 METHOD AND COMPOSITIONS FOR INHIBITION OF DOUBLE STRANDED DNA VIRUSES 审中-公开
标题翻译：用于抑制双链DNA病毒的方法和组合物
公开(公告)号：US20110189258A1
公开(公告)日：2011-08-04
申请号：US13000279
申请日：2009-06-29
申请人： Dohun Pyeon , Paul F. Lambert , Shane Pearce , Paul G. Ahlquist
发明人： Dohun Pyeon , Paul F. Lambert , Shane Pearce , Paul G. Ahlquist
IPC分类号： A61F13/20 , A61K31/7048 , A61K31/047 , A61K31/513 , A61K31/52 , A61P31/20
CPC分类号： A61K31/7048 , A61K31/047 , A61K31/505 , A61K31/52 , C12N2710/20011 , G01N2333/025 , G01N2500/10
摘要： A method of inhibiting double-stranded DNA virus infection is disclosed. In one embodiment, the method involves exposing a papillomavirus to an effective amount of an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors. In another embodiment, the method involves administering an inhibitor selected from the group of G1, S, G2, and M cell cycle inhibitors to a susceptible tissue or cell.
摘要翻译：公开了抑制双链DNA病毒感染的方法。在一个实施方案中，该方法包括将乳头瘤病毒暴露于有效量的选自G1，S，G2和M细胞周期抑制剂的抑制剂。在另一个实施方案中，该方法包括向敏感组织或细胞施用选自G1，S，G2和M细胞周期抑制剂的抑制剂。

9. 发明授权

US07563597B2 Production of packaged DNA sequences 有权
标题翻译：生产包装的DNA序列
公开(公告)号：US07563597B2
公开(公告)日：2009-07-21
申请号：US11275819
申请日：2006-01-30
申请人： Paul G. Ahlquist , Dohun Pyeon , Paul F. Lambert
发明人： Paul G. Ahlquist , Dohun Pyeon , Paul F. Lambert
IPC分类号： C12P21/00
CPC分类号： C12N7/00 , C12N2710/20022 , C12N2710/20052
摘要： A method of producing a packaged DNA sequence is disclosed. In one embodiment, the method comprises the steps of: (a) selecting a DNA sequence to be packaged and a papillomaviral capsid sequence, wherein the DNA sequence to be packaged is between 7 Kb-8.5 Kb, (b) co-transfecting the products of step (a) into transfectable cells, wherein the DNA sequence is packaged, and (c) purifying packaged particles.
摘要翻译：公开了一种生产包装的DNA序列的方法。在一个实施方案中，该方法包括以下步骤：（a）选择要包装的DNA序列和乳头瘤病毒衣壳序列，其中待包装的DNA序列在7Kb-8.5Kb之间，（b）共转染产物步骤（a）转化成可转染细胞，其中包装DNA序列，和（c）纯化包装的颗粒。

10. 发明授权

US5602242A Hybrid RNA virus 失效
公开(公告)号：US5602242A
公开(公告)日：1997-02-11
申请号：US445990
申请日：1995-05-22
申请人： Paul G. Ahlquist , Roy C. French , Robert F. Sacher
发明人： Paul G. Ahlquist , Roy C. French , Robert F. Sacher
IPC分类号： C12N15/09 , A01H1/00 , A01H5/00 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/82 , C12N15/83 , C12N15/33 , C12N15/40
CPC分类号： C12N7/00 , C12N15/8203 , C12N2770/00011 , C12N2770/00022 , C12N2770/00023 , C12N2770/14011
摘要： A recombinant RNA virus is provided allowing encapsidation of genetically engineered viral sequences in heterologous, preferably rod-shaped coat, protein capsids. Since icosahedral viruses are limited in the amount of RNA they can carry, and rod-shaped viruses are expansible, this invention allows the size of recombinant virus RNA components to be increased (or decreased). Methods of making and using such recombinant viruses are also provided, specifically with respect to the transfection of plants to bring about genotypic and phenotypic changes.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式