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1. 发明授权

US08202725B2 Cell sodding method and apparatus 有权
标题翻译：细胞浸渍法和装置
公开(公告)号：US08202725B2
公开(公告)日：2012-06-19
申请号：US11314281
申请日：2005-12-22
申请人： Paul E. Kosnik , Christopher T. England , Robert G. Dennis , Stuart K. Williams
发明人： Paul E. Kosnik , Christopher T. England , Robert G. Dennis , Stuart K. Williams
IPC分类号： C12N5/00
CPC分类号： C12N5/0697 , C12M21/08 , C12M25/10 , C12M25/14 , C12M27/10 , C12M29/10 , C12N2533/30
摘要： Tissue engineering methods and biochamber apparatus are provided for making tissue grafts for implantation into a patient. The methods include applying a sustained low magnitude pressure gradient transmurally across a permeable scaffold material using a media containing cells, preferably microvascular epithelial cells, to be deposited on the scaffold for the production of tissue grafts, preferably vascular grafts, to promote accelerated adhesion and maturation of cells on the scaffold material. Biochambers for preparing tubular tissue grafts are provided which contain connectors for holding a graft substrate, proximal and distal tubing for connection to an optional perfusion system, and structure for switching between transmural flow of a cell suspension across the graft substrate and translumenal flow through the lumen of the graft.
摘要翻译：提供组织工程方法和生物处理设备用于制造植入患者体内的组织移植物。所述方法包括使用包含细胞（优选微血管上皮细胞）的培养基透过可渗透的支架材料跨度施加持续的低幅度压力梯度，以沉积在支架上用于生产组织移植物，优选血管移植物，以促进加速粘附和成熟的细胞在脚手架材料上。提供了用于制备管状组织移植物的生物体，其包含用于保持移植物基质的连接器，用于连接到任选的灌注系统的近端和远端管，以及用于在穿过移植物基质的细胞悬浮液的跨壁流和通过内腔的经血流之间切换的结构的移植物。

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