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1. 发明授权

US06296605B1 High-pressure drive system 失效
标题翻译：高压驱动系统
公开(公告)号：US06296605B1
公开(公告)日：2001-10-02
申请号：US09344209
申请日：1999-06-24
申请人： Paul C. Michelman , R. Mitchell Baldwin, II , Howard R. Levin
发明人： Paul C. Michelman , R. Mitchell Baldwin, II , Howard R. Levin
IPC分类号： A61M110
CPC分类号： A61M1/1068 , A61M1/106 , A61M1/1065 , A61M1/12
摘要： A high pressure inflation system for driving an inflatable heart assistance device. The system includes a fluid source for supplying a fluid at a relatively high pressure and a compression tank plumbed in selective communication with the pneumatic source. The compression tank is operative to store a predetermined volume of the pressurized fluid at approximately the high pressure created by the fluid source. A transfer valve is disposed downstream of the compression tank and is coupled to the heart assistance device. The compression tank and transfer valve are maintained in close proximal relation to the heart assistance device with the transfer valve being responsive to predetermined signals to expose the heart assistance device to the compression tank pressure and expand the device to compress and assist the heart.
摘要翻译：用于驱动充气式心脏辅助装置的高压膨胀系统。该系统包括用于供应相对较高压力的流体的流体源和与气源选择性连通的压缩罐。压缩箱可操作以将预定体积的加压流体存储在大致由流体源产生的高压下。转移阀设置在压缩罐的下游并且耦合到心脏辅助装置。压缩罐和转换阀保持与心脏辅助装置的近近关系，转移阀响应于预定信号，以使心脏辅助装置暴露于压缩罐压力，并使装置膨胀以压缩和辅助心脏。

2. 发明授权

US5971910A Method and apparatus for assisting a heart to pump blood by applying substantially uniform pressure to the ventricles 失效
标题翻译：用于通过对心室施加基本均匀的压力来辅助心脏泵血的方法和装置
公开(公告)号：US5971910A
公开(公告)日：1999-10-26
申请号：US997052
申请日：1997-10-17
申请人： Joshua E. Tsitlik , Howard R. Levin , Naum Ziselson , Paul C. Michelman
发明人： Joshua E. Tsitlik , Howard R. Levin , Naum Ziselson , Paul C. Michelman
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/1068 , A61M1/1062
摘要： An apparatus and method for assisting a heart to pump blood includes a housing that defines an internal chamber for receiving a heart. The housing has a first opening to supply fluid to the internal chamber of the housing. Uniform pressure is applied to at least a majority portion of an exterior ventricular surface of a heart that is placed within the internal chamber so that the heart is substantially uniformly deformed to simulate a systolic phase.
摘要翻译：用于辅助心脏泵送血液的装置和方法包括限定用于接收心脏的内部腔室的壳体。壳体具有第一开口以将流体供应到壳体的内部腔室。将均匀的压力施加到放置在内室内的心脏的外心室表面的至少大部分部分，使得心脏基本均匀地变形以模拟收缩期。

3. 发明授权

US5902229A Drive system for controlling cardiac compression 失效
标题翻译：用于控制心脏压缩的驱动系统
公开(公告)号：US5902229A
公开(公告)日：1999-05-11
申请号：US52037
申请日：1998-03-30
申请人： Joshua E. Tsitlik , Howard R. Levin , Naum Ziselson , Paul C. Michelman
发明人： Joshua E. Tsitlik , Howard R. Levin , Naum Ziselson , Paul C. Michelman
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/106 , A61M1/1063 , A61M1/1068
摘要： An inflation system for independently controlling the rise time and plateau level of a pressure profile applied to an inflatable chamber includes a pneumatic source disposed in fluid communication with a pressure path including a regulation device for establishing respective high and low pressure levels. A supply mechanism is disposed at the output of the pressure path and is operative to alternately expose the inflatable liner to the high and low pressure levels to define an independently controllable rise time.
摘要翻译：用于独立控制施加到可充气室的压力分布的上升时间和平台高度的膨胀系统包括设置成与包括用于建立相应的高低压水平的调节装置的压力路径流体连通的气动源。供应机构设置在压力路径的输出处，并且可操作地将充气衬套交替地暴露于高低压水平以限定独立可控的上升时间。

4. 发明授权

US10441356B2 Methods for renal neuromodulation via neuromodulatory agents 有权
公开(公告)号：US10441356B2
公开(公告)日：2019-10-15
申请号：US15478113
申请日：2017-04-03
申请人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14 , A61F7/12 , A61M5/142 , A61M5/172 , A61N1/28 , A61N1/32 , A61N1/36 , A61N1/40 , A61N5/04 , A61N7/02 , A61N1/362 , A61N7/00 , A61B18/00
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

5. 发明授权

US08986294B2 Apparatuses for thermally-induced renal neuromodulation 有权
标题翻译：热诱导肾神经调节装置
公开(公告)号：US08986294B2
公开(公告)日：2015-03-24
申请号：US12700524
申请日：2010-02-04
申请人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
IPC分类号： A61F7/12 , A61B18/12 , A61F7/00 , A61N7/00 , A61N1/28 , A61N1/40 , A61N5/04 , A61N7/02 , A61B18/02 , A61B18/04 , A61N1/36
CPC分类号： A61N7/022 , A61B18/02 , A61B18/04 , A61B18/12 , A61B18/1492 , A61B2018/0022 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61F7/007 , A61F7/12 , A61F7/123 , A61F2007/126 , A61M5/44 , A61M2210/1082 , A61N1/28 , A61N1/36007 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/045 , A61N5/0603 , A61N7/00 , A61N7/02 , A61N2007/003 , A61N2007/0078
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.
摘要翻译：提供了用于热诱导的肾神经调节的方法和装置。热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。

6. 发明授权

US08771252B2 Methods and devices for renal nerve blocking 有权
标题翻译：肾神经阻滞的方法和装置
公开(公告)号：US08771252B2
公开(公告)日：2014-07-08
申请号：US11133925
申请日：2005-05-20
申请人： Mark Gelfand , Howard R. Levin
发明人： Mark Gelfand , Howard R. Levin
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61N1/326 , A61N1/36007 , A61N1/3605 , A61N1/36114 , A61N1/3627
摘要： A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluting implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.
摘要翻译：一种用于通过植入用于阻断肾脏和/或从肾脏的肾神经信号的装置来治疗与交感神经肾神经活动升高相关的心脏和肾脏疾病的方法和装置。该装置可以是药物泵或药物洗脱植入物，用于将神经阻断剂靶向递送至肾动脉的动脉周围空间。

7. 发明申请

US20140018723A1 Apparatuses for Renal Neuromodulation and Associated Systems and Methods 有权
标题翻译：肾脏神经调节和相关系统和方法的设备
公开(公告)号：US20140018723A1
公开(公告)日：2014-01-16
申请号：US13930863
申请日：2013-06-28
申请人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14 , A61B18/18 , A61N1/36
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

8. 发明申请

US20130012866A1 APPARATUSES FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 有权
公开(公告)号：US20130012866A1
公开(公告)日：2013-01-10
申请号：US13619851
申请日：2012-09-14
申请人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61M37/00 , A61N1/05
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

9. 发明授权

US08244359B2 System and method to modulate phrenic nerve to prevent sleep apnea 有权
标题翻译：调节膈神经的系统和方法，以防止睡眠呼吸暂停
公开(公告)号：US08244359B2
公开(公告)日：2012-08-14
申请号：US11601150
申请日：2006-11-17
申请人： Mark Gelfand , Howard R. Levin , Andrew Halpert
发明人： Mark Gelfand , Howard R. Levin , Andrew Halpert
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36135
摘要： An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
摘要翻译：一种用于治疗诸如中枢性睡眠呼吸暂停的呼吸障碍的可植入医疗装置，其中刺激从未通过经静脉引导系统提供给膈神经，其中在吸气之后开始刺激以延长呼吸持续时间并且将膈肌保持在收缩状态。

10. 发明授权

US08175711B2 Methods for treating a condition or disease associated with cardio-renal function 有权
标题翻译：治疗与心肾功能相关的病症或疾病的方法
公开(公告)号：US08175711B2
公开(公告)日：2012-05-08
申请号：US11368553
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
IPC分类号： A61N1/00 , A61F7/00 , A61K9/22
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating congestive heart failure, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于经由脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等治疗充血性心力衰竭的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，凋亡的坏死和/或诱导，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

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