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1. 发明授权

US10518090B2 System and method to modulate phrenic nerve to prevent sleep apnea 有权
公开(公告)号：US10518090B2
公开(公告)日：2019-12-31
申请号：US13538713
申请日：2012-06-29
申请人： Mark Gelfand , Howard R. Levin , Andrew Halpert
发明人： Mark Gelfand , Howard R. Levin , Andrew Halpert
IPC分类号： A61N1/36 , A61N1/05 , A61B5/08
摘要： An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.

2. 发明申请

US20130165989A1 System and Method to Modulate Phrenic Nerve to Prevent Sleep Apnea 审中-公开
标题翻译：调节膈神经以防止睡眠呼吸暂停的系统和方法
公开(公告)号：US20130165989A1
公开(公告)日：2013-06-27
申请号：US13538713
申请日：2012-06-29
申请人： Mark Gelfand , Howard R. Levin , Andrew Halpert
发明人： Mark Gelfand , Howard R. Levin , Andrew Halpert
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36135
摘要： An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
摘要翻译：一种用于治疗诸如中枢性睡眠呼吸暂停的呼吸障碍的可植入医疗装置，其中刺激从未通过经静脉引导系统提供给膈肌，刺激开始于吸气之后，以延长呼吸持续时间并将隔膜保持在收缩状态。

3. 发明授权

US08244359B2 System and method to modulate phrenic nerve to prevent sleep apnea 有权
标题翻译：调节膈神经的系统和方法，以防止睡眠呼吸暂停
公开(公告)号：US08244359B2
公开(公告)日：2012-08-14
申请号：US11601150
申请日：2006-11-17
申请人： Mark Gelfand , Howard R. Levin , Andrew Halpert
发明人： Mark Gelfand , Howard R. Levin , Andrew Halpert
IPC分类号： A61N1/36
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36135
摘要： An implantable medical device for treating breathing disorders such as central sleep apnea wherein stimulation is provided to the phrenic never through a transvenous lead system with the stimulation beginning after inspiration to extend the duration of a breath and to hold the diaphragm in a contracted condition.
摘要翻译：一种用于治疗诸如中枢性睡眠呼吸暂停的呼吸障碍的可植入医疗装置，其中刺激从未通过经静脉引导系统提供给膈神经，其中在吸气之后开始刺激以延长呼吸持续时间并且将膈肌保持在收缩状态。

4. 发明授权

US10441356B2 Methods for renal neuromodulation via neuromodulatory agents 有权
公开(公告)号：US10441356B2
公开(公告)日：2019-10-15
申请号：US15478113
申请日：2017-04-03
申请人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
发明人： Denise Zarins , Andrew Wu , Hanson Gifford, III , Mark Deem , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14 , A61F7/12 , A61M5/142 , A61M5/172 , A61N1/28 , A61N1/32 , A61N1/36 , A61N1/40 , A61N5/04 , A61N7/02 , A61N1/362 , A61N7/00 , A61B18/00
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues. In some embodiments, thermally-induced renal neuromodulation is achieved via delivery of a pulsed thermal therapy.

5. 发明授权

US08986294B2 Apparatuses for thermally-induced renal neuromodulation 有权
标题翻译：热诱导肾神经调节装置
公开(公告)号：US08986294B2
公开(公告)日：2015-03-24
申请号：US12700524
申请日：2010-02-04
申请人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Nicolas Zadno , Benjamin J. Clark , Erik Thai , Howard R. Levin , Mark Gelfand
IPC分类号： A61F7/12 , A61B18/12 , A61F7/00 , A61N7/00 , A61N1/28 , A61N1/40 , A61N5/04 , A61N7/02 , A61B18/02 , A61B18/04 , A61N1/36
CPC分类号： A61N7/022 , A61B18/02 , A61B18/04 , A61B18/12 , A61B18/1492 , A61B2018/0022 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61F7/007 , A61F7/12 , A61F7/123 , A61F2007/126 , A61M5/44 , A61M2210/1082 , A61N1/28 , A61N1/36007 , A61N1/403 , A61N5/00 , A61N5/025 , A61N5/045 , A61N5/0603 , A61N7/00 , A61N7/02 , A61N2007/003 , A61N2007/0078
摘要： Methods and apparatus are provided for thermally-induced renal neuromodulation. Thermally-induced renal neuromodulation may be achieved via direct and/or via indirect application of thermal energy to heat or cool neural fibers that contribute to renal function, or of vascular structures that feed or perfuse the neural fibers. In some embodiments, parameters of the neural fibers, of non-target tissue, or of the thermal energy delivery element, may be monitored via one or more sensors for controlling the thermally-induced neuromodulation. In some embodiments, protective elements may be provided to reduce a degree of thermal damage induced in the non-target tissues.
摘要翻译：提供了用于热诱导的肾神经调节的方法和装置。热诱导的肾神经调节可以通过直接和/或通过间接施加热能来加热或冷却有助于肾功能的神经纤维或者供给或灌注神经纤维的血管结构来实现。在一些实施例中，神经纤维，非目标组织或热能递送元件的参数可以经由一个或多个传感器来监测，以控制热诱导的神经调节。在一些实施方案中，可以提供保护元件以减少在非靶组织中诱导的热损伤程度。

6. 发明授权

US08771252B2 Methods and devices for renal nerve blocking 有权
标题翻译：肾神经阻滞的方法和装置
公开(公告)号：US08771252B2
公开(公告)日：2014-07-08
申请号：US11133925
申请日：2005-05-20
申请人： Mark Gelfand , Howard R. Levin
发明人： Mark Gelfand , Howard R. Levin
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61N1/326 , A61N1/36007 , A61N1/3605 , A61N1/36114 , A61N1/3627
摘要： A method and apparatus for treatment of cardiac and renal diseases associated with the elevated sympathetic renal nerve activity by implanting a device to block the renal nerve signals to and from the kidney. The device can be a drug pump or a drug eluting implant for targeted delivery of a nerve-blocking agent to the periarterial space of the renal artery.
摘要翻译：一种用于通过植入用于阻断肾脏和/或从肾脏的肾神经信号的装置来治疗与交感神经肾神经活动升高相关的心脏和肾脏疾病的方法和装置。该装置可以是药物泵或药物洗脱植入物，用于将神经阻断剂靶向递送至肾动脉的动脉周围空间。

7. 发明申请

US20140018723A1 Apparatuses for Renal Neuromodulation and Associated Systems and Methods 有权
标题翻译：肾脏神经调节和相关系统和方法的设备
公开(公告)号：US20140018723A1
公开(公告)日：2014-01-16
申请号：US13930863
申请日：2013-06-28
申请人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark E. Deem , Hanson Gifford, III , Denise Zarins , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61B18/14 , A61B18/18 , A61N1/36
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.
摘要翻译：提供使用脉冲电场进行肾神经调节以实现电穿孔或电融合的方法和装置。预期肾脏神经调节（例如去神经支配）可以减少急性心肌梗塞的扩张，减少或预防与充血性心力衰竭有关的形态学变化的发生，和/或有效治疗晚期肾脏疾病。本发明的实施例被配置用于经皮血管内递送脉冲电场以实现这种神经调节。

8. 发明申请

US20130012866A1 APPARATUSES FOR RENAL NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS 有权
公开(公告)号：US20130012866A1
公开(公告)日：2013-01-10
申请号：US13619851
申请日：2012-09-14
申请人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
发明人： Mark Deem , Hanson Gifford, III , Denise Demarais , Douglas Sutton , Erik Thai , Mark Gelfand , Howard R. Levin
IPC分类号： A61M37/00 , A61N1/05
CPC分类号： A61N1/36007 , A61B8/0891 , A61B8/12 , A61B18/1206 , A61B18/1233 , A61B18/1492 , A61B18/18 , A61B2018/00071 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00505 , A61B2018/00511 , A61B2018/00577 , A61B2018/00613 , A61B2018/00642 , A61B2018/00904 , A61B2018/126 , A61B2018/1467 , A61M5/14 , A61M25/0023 , A61N1/0412 , A61N1/05 , A61N1/0551 , A61N1/18 , A61N1/205 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36057 , A61N1/3606 , A61N1/36103 , A61N1/36114 , A61N1/36117 , A61N1/36139 , A61N5/00 , A61N7/00 , A61N2007/0021 , A61N2007/003
摘要： Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

9. 发明授权

US08175711B2 Methods for treating a condition or disease associated with cardio-renal function 有权
标题翻译：治疗与心肾功能相关的病症或疾病的方法
公开(公告)号：US08175711B2
公开(公告)日：2012-05-08
申请号：US11368553
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
IPC分类号： A61N1/00 , A61F7/00 , A61K9/22
CPC分类号： A61N1/05 , A61N1/0551 , A61N1/327 , A61N1/40
摘要： Methods and apparatus are provided for treating congestive heart failure, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于经由脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等治疗充血性心力衰竭的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，凋亡的坏死和/或诱导，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

10. 发明授权

US08145317B2 Methods for renal neuromodulation 有权
标题翻译：肾脏神经调节方法
公开(公告)号：US08145317B2
公开(公告)日：2012-03-27
申请号：US11368577
申请日：2006-03-06
申请人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
发明人： Denise Demarais , Hanson Gifford, III , Mark Deem , Douglas Sutton , Howard R. Levin , Mark Gelfand
IPC分类号： A61N1/00 , A61F7/00 , A61K9/22
CPC分类号： A61N1/05 , A61M5/14276 , A61M5/1723 , A61M2210/1082 , A61N1/0551 , A61N1/326 , A61N1/327 , A61N1/36017 , A61N1/36117 , A61N1/3627 , A61N1/40
摘要： Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.
摘要翻译：提供了用于经由脉冲电场，经由刺激电场，经由局部药物递送，经由高频超声波，经由热技术等来治疗高血压的方法和装置。这种神经调节可以实现不可逆的电穿孔或电融合，坏死和 /或诱导凋亡，基因表达的改变，动作电位衰减或阻断，细胞因子上调的变化和靶神经纤维中的其他条件。在一些实施方案中，神经调节被应用于有助于肾功能的神经纤维。在一些实施方案中，这种神经调节以双向方式进行。与单侧执行的肾神经调节相比，双侧肾神经调节可以在一些患者中提供增强的治疗效果，即与在支配单个肾脏的神经组织上进行的肾神经调节相比。

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