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1. 发明授权

US06623952B1 Spumavirus isolated from humans 失效
标题翻译：从人类分离的真菌感染病毒
公开(公告)号：US06623952B1
公开(公告)日：2003-09-23
申请号：US09830616
申请日：2001-09-05
申请人： Paul A. Sandstrom , Thomas M. Folks , Walid M. Heneine , William M. Switzer , Jennifer Brown
发明人： Paul A. Sandstrom , Thomas M. Folks , Walid M. Heneine , William M. Switzer , Jennifer Brown
IPC分类号： C12N700
CPC分类号： C12N15/86 , A61K39/12 , A61K39/21 , A61K48/00 , A61K2039/525 , A61K2039/5256 , C07K14/005 , C12N7/00 , C12N2740/17021 , C12N2740/17022 , C12N2740/17032 , C12N2740/17043
摘要： The present invention comprises a spumavirus isolated from a human. More specifically, the spumavirus of the present invention was isolated from a human who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.
摘要翻译：本发明包括从人分离的真菌病毒。更具体地，将本发明的真菌病毒与暴露于非人灵长类动物的人分离。重要的是，本发明的真菌病毒或针对该病毒的抗体可用于检测体液中的真菌病毒或抗体的存在，相关病毒的致病性研究以及用于基因治疗的载体。由于存在快速分裂的细胞和重组活病毒疫苗接种，本发明的真菌病毒也可用于治疗人体中的病症。

2. 发明授权

US06596478B1 Method and composition to detect C-type retroviral infection 失效
标题翻译：检测C型逆转录病毒感染的方法和组成
公开(公告)号：US06596478B1
公开(公告)日：2003-07-22
申请号：US09720218
申请日：2001-03-12
申请人： Walid M. Heneine , William M. Switzer , Paul A. Sandstrom , Aprille L. Matthews , Thomas M. Folks
发明人： Walid M. Heneine , William M. Switzer , Paul A. Sandstrom , Aprille L. Matthews , Thomas M. Folks
IPC分类号： C12Q170
CPC分类号： G01N33/56983
摘要： The present invention comprises methods, devices and compositions for detection of endogenous retroviruses found in xenotransplant materials. The methods and compositions are suited for detection of endogenous type-C retroviruses and in particular, for porcine endogenous retrovirus, PERV.
摘要翻译：本发明包括用于检测异种移植物质中发现的内源性逆转录病毒的方法，装置和组合物。该方法和组合物适用于检测内源性C型逆转录病毒，特别适用于猪内源性逆转录病毒（PERV）。

3. 发明授权

US5882912A Retrovirus isolated from humans 失效
标题翻译：从人类分离的逆转录病毒
公开(公告)号：US5882912A
公开(公告)日：1999-03-16
申请号：US798071
申请日：1997-02-12
申请人： Paul A. Sandstrom , Jennifer Brown , Thomas M. Folks , Walid Heneine , William M. Switzer
发明人： Paul A. Sandstrom , Jennifer Brown , Thomas M. Folks , Walid Heneine , William M. Switzer
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P31/12 , C12N7/00 , C12N15/867 , C12N15/00
CPC分类号： C12N15/86 , C12N7/00 , A61K48/00 , C12N2740/17021 , C12N2740/17043
摘要： The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies.
摘要翻译：本发明包括从人分离的真菌病毒。更具体地，将本发明的真菌病毒与暴露于非人类灵长类动物的人分离。重要的是，本发明的真菌病毒或针对该病毒的抗体可用于检测体液中的真菌病毒或抗体的存在，相关病毒的致病性研究以及用于基因治疗的载体。

4. 发明授权

US06787126B1 Method and kit for detecting resistance to antiviral drugs 有权
标题翻译：检测抗病毒药物耐药性的方法和试剂盒
公开(公告)号：US06787126B1
公开(公告)日：2004-09-07
申请号：US09719906
申请日：2001-07-30
申请人： Walid M. Heneine , Gerardo Garcia Lerma , Shinji Yamamoto , William M. Switzer , Thomas M. Folks
发明人： Walid M. Heneine , Gerardo Garcia Lerma , Shinji Yamamoto , William M. Switzer , Thomas M. Folks
IPC分类号： C12Q100
CPC分类号： C12Q1/702
摘要： An assay and kit for the detection of phenotypic resistance of a retrovirus to a reverse transcriptase inhibitor drug in a biological sample. The assay is based on the direct analysis of the susceptibility of retroviral reverse transcriptase to inhibition by a reverse transcriptase inhibitor drug. The enzymatic activity of the reverse transcriptase is determined by measuring the DNA product produced when an RNA template and a first complementary DNA primer from a suitable region of the encephalomyocarditis virus genome are incubated with a biological sample containing reverse transcriptase in the presence of the drug to which resistance is being determined.
摘要翻译：用于检测逆转录病毒对生物样品中逆转录酶抑制剂药物的表型抗性的测定和试剂盒。该测定法基于逆转录病毒逆转录酶对逆转录酶抑制剂药物的抑制的易感性的直接分析。通过测量在来自脑心肌炎病毒基因组的合适区域的RNA模板和第一个互补DNA引物与含有逆转录酶的生物样品在药物存在下孵育时产生的DNA产物来测定逆转录酶的酶活性，正在确定哪个阻力。

5. 发明授权

US07691572B2 Method and kit for detecting resistance to antiviral drugs 有权
标题翻译：检测抗病毒药物耐药性的方法和试剂盒
公开(公告)号：US07691572B2
公开(公告)日：2010-04-06
申请号：US11054023
申请日：2005-02-09
申请人： Walid M. Heneine , Gerardo Garcia-Lerma , Shinji Yamamoto , William M. Switzer , Thomas M. Folks
发明人： Walid M. Heneine , Gerardo Garcia-Lerma , Shinji Yamamoto , William M. Switzer , Thomas M. Folks
IPC分类号： C12Q1/70 , A61K39/21
CPC分类号： C12Q1/702
摘要： Assays and kits for the detection of phenotypic resistance of a retrovirus to reverse transcriptase inhibitor-drugs in a biological sample. The assays are based on the direct analysis of the susceptibility of retroviral reverse transcriptase to inhibition by a reverse transcriptase inhibitor drug. The enzymatic activity of the reverse transcriptase is determined by measuring the DNA product produced when an RNA template and a first complementary DNA primer from a suitable region of the encephalomyocarditis virus genome are incubated with a biological sample containing reverse transcriptase in the presence of the drug to which resistance is being determined. The DNA product is amplified and detection of the amplified DNA indicates resistance to the drug employed in the assay. Detection of relatively greater amounts of amplified DNA when certain drugs are used indicates the presence of multiple nucleoside analog resistant strains or mutations.
摘要翻译：用于检测逆转录病毒逆转录酶抑制剂药物在生物样品中的表型抗性的测定和试剂盒。该测定法基于逆转录病毒逆转录酶对逆转录酶抑制剂药物的抑制的易感性的直接分析。通过测量在来自脑心肌炎病毒基因组的合适区域的RNA模板和第一个互补DNA引物与含有逆转录酶的生物样品在药物存在下孵育时产生的DNA产物来测定逆转录酶的酶活性，正在确定哪个阻力。 DNA产物被扩增，扩增的DNA的检测表明对测定中使用的药物具有抗性。当使用某些药物时检测相对较大量的扩增DNA表明存在多种核苷类似物抗性菌株或突变。

6. 发明授权

US06800475B1 Isolation of a human retrovirus 有权
标题翻译：人类逆转录病毒的分离
公开(公告)号：US06800475B1
公开(公告)日：2004-10-05
申请号：US10018627
申请日：2001-12-14
申请人： William M. Switzer , Walid Heneine , Paul A. Sandstrom , Thomas M. Folks
发明人： William M. Switzer , Walid Heneine , Paul A. Sandstrom , Thomas M. Folks
IPC分类号： C12N700
CPC分类号： C07K14/005 , A61K35/00 , A61K48/00 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2740/17021 , C12N2740/17022 , C12N2740/17043
摘要： The present invention comprises compositions and methods comprising a spumavirus isolated from a human. More specifically, the spumavirus of the present invention was isolated from a human who had exposure to nonhuman primates. Importantly, the methods and compositions of the present invention comprising the spumavirus and including antibodies to the spumavirus, can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The present invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.
摘要翻译：本发明包括组合物和方法，其包含从人分离的真菌病毒。更具体地，将本发明的真菌病毒与暴露于非人灵长类动物的人分离。重要的是，包含该真菌病毒并包括针对该病毒的抗体的本发明的方法和组合物可用于检测体液中的真菌病毒或抗体的存在，相关病毒的致病性研究以及用于基因治疗的载体。本发明还可用于治疗由于快速分裂的细胞的存在和用于重组活病毒疫苗接种的人的病症。

7. 发明授权

US06492165B1 Retrovirus isolated from humans 失效
标题翻译：从人类分离的逆转录病毒
公开(公告)号：US06492165B1
公开(公告)日：2002-12-10
申请号：US09692652
申请日：2000-10-19
申请人： Margaret E. Callahan , Thomas M. Folks , Paul Sandstrom , Shambavi Subbarao , Jennifer Brown , Walid Heneine , William M. Switzer
发明人： Margaret E. Callahan , Thomas M. Folks , Paul Sandstrom , Shambavi Subbarao , Jennifer Brown , Walid Heneine , William M. Switzer
IPC分类号： C12N1500
CPC分类号： C07K14/005 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2740/17021 , C12N2740/17022 , C12N2740/17043
摘要： The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.
摘要翻译：本发明包括从人分离的真菌病毒。更具体地，将本发明的真菌病毒与暴露于非人类灵长类动物的人分离。重要的是，本发明的真菌病毒或针对该病毒的抗体可用于检测体液中的真菌病毒或抗体的存在，相关病毒的致病性研究以及用于基因治疗的载体。由于存在快速分裂的细胞和重组活病毒疫苗接种，本发明的真菌病毒也可用于治疗人体中的病症。

8. 发明授权

US06787333B2 Retrovirus isolated from humans 有权
标题翻译：从人类分离的逆转录病毒
公开(公告)号：US06787333B2
公开(公告)日：2004-09-07
申请号：US10272394
申请日：2002-10-15
申请人： Margaret E. Callahan , Thomas M. Folks , Paul Sandstrom , Shambavi Subbarao , Jennifer Brown , Walid Heneine , William M. Switzer
发明人： Margaret E. Callahan , Thomas M. Folks , Paul Sandstrom , Shambavi Subbarao , Jennifer Brown , Walid Heneine , William M. Switzer
IPC分类号： C12Q106
CPC分类号： C07K14/005 , A61K48/00 , C12N7/00 , C12N15/86 , C12N2740/17021 , C12N2740/17022 , C12N2740/17043
摘要： The present invention comprises spumavirus isolated from humans. More specifically, the spumavirus of the present invention was isolated from humans who had exposure to nonhuman primates. Importantly, the spumavirus of the present invention or antibodies to the spumavirus can be used to detect the presence of spumavirus or antibodies in body fluids, for pathogenicity studies of related viruses, and as a vector for gene therapies. The spumavirus of the invention can also be used for treatment of conditions in humans due to the presence of rapidly dividing cells and for recombinant live virus vaccination.
摘要翻译：本发明包括从人分离的真菌病毒。更具体地，将本发明的真菌病毒与暴露于非人类灵长类动物的人分离。重要的是，本发明的真菌病毒或针对该病毒的抗体可用于检测体液中的真菌病毒或抗体的存在，相关病毒的致病性研究以及用于基因治疗的载体。由于存在快速分裂的细胞和重组活病毒疫苗接种，本发明的真菌病毒也可用于治疗人体中的病症。

9. 发明授权

US09044509B2 Inhibition of HIV infection through chemoprophylaxis 有权
标题翻译：通过化学预防来抑制艾滋病毒感染
公开(公告)号：US09044509B2
公开(公告)日：2015-06-02
申请号：US11669547
申请日：2007-01-31
申请人： Walid M. Heneine , Thomas M. Folks , Robert Janssen , Ronald Otten , Jose Gerardo Garcia Lerma
发明人： Walid M. Heneine , Thomas M. Folks , Robert Janssen , Ronald Otten , Jose Gerardo Garcia Lerma
IPC分类号： A61K31/675 , A61K31/505 , A61K45/06 , A61K31/7072 , A61K31/513
CPC分类号： A61K31/675 , A61K9/0034 , A61K9/0053 , A61K31/513 , A61K31/683 , A61K31/7072 , A61K45/06 , A61K2300/00
摘要： A process is provided for protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus. Protection is achieved by administering to the primate host a combination of a pharmaceutically effective amount of a nucleoside reverse transcriptase inhibitor and a pharmaceutically effective amount of a nucleotide reverse transcriptase inhibitor prior to exposure to the immunodeficiency retrovirus. The administration is effective if provided in a single dose within 24 hours of the exposure. A regime of regular daily doses is also effective in providing protection against an immunodeficiency retrovirus becoming self-replicating after infecting a primate host. A process for controlling retrovirus transmission within a population includes the administration to a subpopulation at high risk for contracting an immunodeficiency retroviral infection the detailed combination prior to sexual exposure to a source of immunodeficiency retrovirus so as to preclude the immunodeficiency retrovirus from becoming self-replicating in a member of the subpopulation.
摘要翻译：提供了一种保护灵长类动物宿主免受免疫缺陷逆转录病毒的自身复制感染的过程。在暴露于免疫缺陷型逆转录病毒之前，通过向灵长类动物宿主施用药学有效量的核苷逆转录酶抑制剂和药学有效量的核苷酸逆转录酶抑制剂的组合来实现保护。如果在暴露后24小时内以单一剂量提供，则该药物是有效的。定期日剂量的方案对于在感染灵长类动物宿主后免疫缺陷逆转录病毒变得自我复制也是有效的。用于控制群体内的逆转录病毒传播的方法包括在性暴露于免疫缺陷型逆转录病毒来源之前对具有高免疫缺陷型逆转录病毒感染的细菌组合的高风险亚群的施用，以排除免疫缺陷型逆转录病毒在自身复制中的自我复制一个亚群的成员。

10. 发明申请

US20080292657A1 PRIMATE T-LYMPHOTROPIC VIRUSES 有权
标题翻译：主要的T淋巴细菌病毒
公开(公告)号：US20080292657A1
公开(公告)日：2008-11-27
申请号：US11678596
申请日：2007-02-24
申请人： William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , Eitel Mpoudi-Ngole
发明人： William M. Switzer , Walid Heneine , Thomas M. Folks , Nathan D. Wolfe , Donald S. Burke , Eitel Mpoudi-Ngole
IPC分类号： A61K39/00 , C12N15/11 , C12N7/00 , A61P37/00 , C12Q1/70 , C12N15/00
CPC分类号： C12Q1/701 , A61K2039/5256 , C07K14/005 , C12N15/86 , C12N2740/14021 , C12N2740/14022 , C12N2740/14043 , C12Q1/70
摘要： Disclosed are compositions and methods related to the isolation and identification of the primate T-lymphotropic viruses, HTLV-3 and HTLV-4. The diversity of HTLVs was investigated among central Africans reporting contact with NHP blood and body fluids through hunting, butchering, and keeping primate pets. Herein it is shown that this population is infected with a variety of HTLVs, including two retroviruses; HTLV-4 is the first member of a novel phylogenetic lineage that is distinct from all known HTLVs and STLVs; HTLV-3 falls within the genetic diversity of STLV-3, a group that has not previously been seen in humans. The present disclosure also relates to vectors and vaccines for use in humans against infection and disease. The disclosure further relates to a variety of bioassays and kits for the detection and diagnosis of infection with and diseases caused by HTLV-3 and HTLV-4 and related viruses.
摘要翻译：公开了与灵长动物T淋巴细胞病毒HTLV-3和HTLV-4的分离和鉴定有关的组合物和方法。通过狩猎，屠宰和饲养灵长类宠物报告与NHP血液和体液接触的中非非洲人之间调查了HTLV的多样性。在本文中，显示该群体感染了多种HTLV，包括两种逆转录病毒; HTLV-4是与所有已知的HTLV和STLV不同的新型系统发育谱系的第一个成员; HTLV-3属于STLV-3的遗传多样性，STLV-3是人类以前未见过的一种。本公开还涉及用于人类抵抗感染和疾病的载体和疫苗。本公开还涉及用于检测和诊断由HTLV-3和HTLV-4及相关病毒引起的感染和疾病的各种生物测定和试剂盒。

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