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1. 发明申请

US20070224241A1 TEMPERATURE- AND pH-RESPONSIVE POLYMER COMPOSITIONS 有权
标题翻译：温度和pH响应聚合物组合物
公开(公告)号：US20070224241A1
公开(公告)日：2007-09-27
申请号：US11687522
申请日：2007-03-16
申请人： Patrick Stayton , Allan Hoffman , Xiangchun Yin , Lakeshia Taite , Jessica Garbern
发明人： Patrick Stayton , Allan Hoffman , Xiangchun Yin , Lakeshia Taite , Jessica Garbern
IPC分类号： A61F2/02 , C08L61/20
CPC分类号： C08L53/00 , A61K47/58 , A61K47/6903 , A61K47/6907 , A61K47/6933 , B82Y5/00 , C08F8/00 , C08F220/04 , C08F220/06 , C08F220/54 , C08F220/58 , C08F293/00 , C08F293/005 , C08F2438/03 , C08F2800/20 , C08F2810/20 , C08L2312/00 , C08L2666/02 , C08L2666/04
摘要： Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions.
摘要翻译：温度和pH响应共聚物组合物，以及包括组合物的药物递送装置，缀合物，纳米颗粒和胶束。

2. 发明申请

US20060127925A1 Stimuli-responsive polymer conjugates and related methods 有权
标题翻译：刺激响应聚合物共轭物和相关方法
公开(公告)号：US20060127925A1
公开(公告)日：2006-06-15
申请号：US11197771
申请日：2005-08-03
申请人： Patrick Stayton , Allan Hoffman , Noah Malmstadt , Tsuyoshi Shimoboji , Samarth Kulkarni
发明人： Patrick Stayton , Allan Hoffman , Noah Malmstadt , Tsuyoshi Shimoboji , Samarth Kulkarni
IPC分类号： C12Q1/68 , G01N33/53 , C12M1/34 , B05D3/02
CPC分类号： G01N33/54353 , C12N15/1006 , C12N15/1034 , G01N33/54346 , G01N33/545
摘要： Conjugates that include polymers that are reversibly self-associative in response to a stimulus and methods for using the conjugates.
摘要翻译：包括响应于刺激的可逆地自缔合的聚合物和使用共轭物的共轭物。

3. 发明申请

US20050136102A1 Enhanced transport using membrane disruptive agents 有权
标题翻译：增强运输使用膜破坏剂
公开(公告)号：US20050136102A1
公开(公告)日：2005-06-23
申请号：US10857626
申请日：2004-05-28
申请人： Allan Hoffman , Patrick Stayton , Oliver Press , Niren Murthy , Chantal Reed , Lawrence Crum , Pierre Mourad , Tyrone Porter
发明人： Allan Hoffman , Patrick Stayton , Oliver Press , Niren Murthy , Chantal Reed , Lawrence Crum , Pierre Mourad , Tyrone Porter
IPC分类号： A61K47/32 , A61K9/00 , A61K31/7105 , A61K31/711 , A61K41/00 , A61K47/42 , A61K47/48 , A61N1/30 , A61K9/70
CPC分类号： A61K47/481 , A61K41/0028 , A61K41/0047 , A61K47/48376 , A61K47/6801
摘要： Compositions and methods for transport or release of therapeutic and diagnostic agents or metabolites or other analytes from cells, compartments within cells, or through cell layers or barriers are described. The compositions include a membrane barrier transport enhancing agent and are usually administered in combination with an enhancer and/or exposure to stimuli to effect disruption or altered permeability, transport or release. In a preferred embodiment, the compositions include compounds which disrupt endosomal membranes in response to the low pH in the endosomes but which are relatively inactive toward cell membranes, coupled directly or indirectly to a therapeutic or diagnostic agent. Other disruptive agents can also be used, responsive to stimuli and/or enhancers other than pH, such as light, electrical stimuli, electromagnetic stimuli, ultrasound, temperature, or combinations thereof. The compounds can be coupled by ionic, covalent or H bonds to an agent to be delivered or to a ligand which forms a complex with the agent to be delivered. Agents to be delivered can be therapeutic and/or diagnostic agents. Treatments which enhance delivery such as ultrasound, iontopheresis, and/or electrophereis can also be used with the disrupting agents.
摘要翻译：描述了用于从细胞，细胞内的细胞室或通过细胞层或屏障转运或释放治疗和诊断试剂或代谢物或其它分析物的组合物和方法。组合物包括膜屏障转运增强剂，并且通常与增强剂和/或暴露于刺激物一起施用以实现破坏或改变渗透性，运输或释放。在优选的实施方案中，组合物包括响应于内体中的低pH而破坏内体膜的化合物，但是与细胞膜相对无活性的化合物，直接或间接地与治疗剂或诊断剂偶联。还可以使用其它破坏剂，对除了pH之外的刺激和/或增强剂如光，电刺激，电磁刺激，超声，温度或其组合都有反应。这些化合物可以通过离子，共价键或H键连接到待递送的试剂上，或者与配制剂形成配合物。待递送的药剂可以是治疗和/或诊断剂。还可以与破坏剂一起使用增强交付如超声，离子层析和/或电穿孔的处理。

4. 发明授权

US4552142A Ventilator system having a control valve in the ventilator circuit 失效
标题翻译：呼吸机系统在呼吸机电路中具有控制阀
公开(公告)号：US4552142A
公开(公告)日：1985-11-12
申请号：US608704
申请日：1984-05-10
申请人： Allan Hoffman , Harry Benford
发明人： Allan Hoffman , Harry Benford
IPC分类号： A61M16/20 , A61M25/00
CPC分类号： A61M16/208
摘要： The present invention relates to a ventilator system which utilizes a control valve to assist an attendant in disconnecting a ventilator conduit circuit from a patient's endotracheal tube. Prior to the present invention, when a ventilator system was operated in certain modes, disconnection of the endotracheal tube from the ventilator circuit caused water which may have accumulated in the ventilator circuit to spray over the patient and/or attendant. In the present invention, a control valve is connected between the outlet of the ventilator circuit and the patient's endotracheal tube. Normally, the valve is maintained in the open position to permit air to be supplied to the patient. However, when it is desired to disconnect the ventilator circuit from the patient's endotracheal tube, the control valve can be manually closed immediately prior to disconnecting the ventilator circuit, thereby preventing the spraying of any accumulated water.
摘要翻译：呼吸机系统技术领域本发明涉及一种呼吸机系统，其利用控制阀来辅助服务员将呼吸机导管电路与病人的气管插管断开连接。在本发明之前，当呼吸机系统以某些模式操作时，气管插管与呼吸机回路的断开导致可能积聚在呼吸机回路中的水喷洒在患者和/或服务员上。在本发明中，控制阀连接在呼吸机回路的出口与患者的气管插管之间。通常，阀被保持在打开位置，以允许向病人供应空气。然而，当希望将呼吸机回路与患者的气管插管断开时，可以在断开呼吸机回路之前立即手动关闭控制阀，从而防止喷射任何积水。

5. 发明申请

US20060132092A1 Method and apparatus for predicting temperature based state-of-charge 有权
标题翻译：用于预测基于温度的充电状态的方法和装置
公开(公告)号：US20060132092A1
公开(公告)日：2006-06-22
申请号：US11017348
申请日：2004-12-20
申请人： Allan Hoffman , Edward Abeska , Scott Rush
发明人： Allan Hoffman , Edward Abeska , Scott Rush
IPC分类号： H02J7/00
CPC分类号： G01R31/3651 , G01R31/3648
摘要： Methods and apparatus are provided for estimating the remaining state-of-charge of a non-rechargeable power source, such as a back-up battery for an electronic module normally connected to a primary power source. A processor within the electronic module implements a prediction algorithm, in order to monitor the temperature of the back-up attery, and to calculate various current draws of the back-up battery. The processor adjusts the nominal self-discharge rate of the back-up battery in accordance with the measured temperatures, and calculates an adjusted self-discharge quantity. The processor also accumulates current draw data and reduces the initial state-of-charge value of the back-up battery by the temperature-adjusted self-discharge quantity and the cumulative current draw quantities to determine a remaining state-of-charge of the back-up battery. At a predetermined state-of-charge threshold level, an indicator can be activated to advise a user to replace the back-up battery.
摘要翻译：提供了用于估计不可充电电源（例如通常连接到主电源的电子模块的备用电池）的剩余充电状态的方法和装置。电子模块内的处理器实现预测算法，以便监视备用电源的温度，并计算备用电池的各种电流消耗。处理器根据测量的温度调节备用电池的标称自放电率，并计算调整后的自放电量。处理器还累积电流抽取数据，并通过温度调节的自放电量和累积电流抽取量来减小备用电池的初始充电状态值，以确定后端电池的剩余充电状态 - 电池。在预定的充电阈值水平下，可以启动指示器以建议用户更换备用电池。

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