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1. 发明申请

US20050265958A1 Nitric oxide releasing compositions and associated methods 审中-公开
标题翻译：一氧化氮释放组合物及相关方法
公开(公告)号：US20050265958A1
公开(公告)日：2005-12-01
申请号：US11129883
申请日：2005-05-16
申请人： Jennifer West , Lakeshia Taite
发明人： Jennifer West , Lakeshia Taite
IPC分类号： A61K31/74 , A61K31/785 , A61K47/48
CPC分类号： A61K31/74 , A61K47/549 , A61K47/60 , A61K47/645
摘要： Dendritic nitric oxide donors having the formula: [P]-[(A)y]x-[(NO)z]q wherein P is a core that comprises a biocompatible polymer; A is a branching unit monomer that comprises at least one end group capable of reversibly attaching NO; (NO) is nitric oxide; x, y, and z are positive integers greater than or equal to 1; and q is a positive integer greater than or equal to y, as well as medical devices and kits that comprise dendritic nitirc oxide donors, are provided. Also provided are methods of delivering nitric oxide into a recipient subject comprising: providing a dendritic nitric oxide donor; and administering the dendritic nitric oxide donor into the recipient subject, such that the dendritic nitric oxide donor releases NO in the recipient subject.
摘要翻译：具有下式的树枝状一氧化氮供体：<？in-line-formula description =“In-line Formulas”end =“lead”？> [P] - [（A） x-in-line-formula description =“In-line Formulas”end =“tail”？>其中 P是包含生物相容性聚合物的核心; A是包含能够可逆地附着NO的至少一个端基的支化单体单体; （NO）是一氧化氮; x，y和z是大于或等于1的正整数; 并且q是大于或等于y的正整数，以及包含树突状氧化锆供体的医疗装置和试剂盒。还提供了将一氧化氮输送到受体对象中的方法，包括：提供树突状一氧化氮供体; 并将所述树突状一氧化氮供体施用于受体受试者，使得所述树突状一氧化氮供体在受体受试者中释放NO。

2. 发明申请

US20070224241A1 TEMPERATURE- AND pH-RESPONSIVE POLYMER COMPOSITIONS 有权
标题翻译：温度和pH响应聚合物组合物
公开(公告)号：US20070224241A1
公开(公告)日：2007-09-27
申请号：US11687522
申请日：2007-03-16
申请人： Patrick Stayton , Allan Hoffman , Xiangchun Yin , Lakeshia Taite , Jessica Garbern
发明人： Patrick Stayton , Allan Hoffman , Xiangchun Yin , Lakeshia Taite , Jessica Garbern
IPC分类号： A61F2/02 , C08L61/20
CPC分类号： C08L53/00 , A61K47/58 , A61K47/6903 , A61K47/6907 , A61K47/6933 , B82Y5/00 , C08F8/00 , C08F220/04 , C08F220/06 , C08F220/54 , C08F220/58 , C08F293/00 , C08F293/005 , C08F2438/03 , C08F2800/20 , C08F2810/20 , C08L2312/00 , C08L2666/02 , C08L2666/04
摘要： Temperature- and pH-responsive copolymer compositions, and drug delivery devices, conjugates, nanoparticles, and micelles that include the compositions.
摘要翻译：温度和pH响应共聚物组合物，以及包括组合物的药物递送装置，缀合物，纳米颗粒和胶束。

3. 发明申请

US20060067909A1 Peptide-modified polyurethane compositions and associated methods 有权
标题翻译：肽改性聚氨酯组合物及相关方法
公开(公告)号：US20060067909A1
公开(公告)日：2006-03-30
申请号：US11129941
申请日：2005-05-16
申请人： Jennifer West , Ho-Wook Jun , Lakeshia Taite
发明人： Jennifer West , Ho-Wook Jun , Lakeshia Taite
IPC分类号： A61K38/10 , C08G63/91 , A61K31/785
CPC分类号： A61K38/00 , A61K38/17 , A61K47/59 , A61K47/60 , A61K47/6889 , C07K7/06 , C08G18/08 , C08G18/10 , C08G18/4854 , C08G18/6446 , C08G18/833 , C08L75/04 , C08G18/324 , C08G18/3821 , C08G18/64
摘要： Peptide-modified polyurethanes comprising the reaction product of an isocyanate, a chain extender, and a peptide are provided. Also provided processes for making a peptide-modified polyurethane comprising: providing an isocyanate; providing a chain extender; providing a peptide; and allowing the isocyanate, chain extender, and peptide to react thereby forming the peptide-modified polyurethane, as well as methods for treating a subject comprising: providing a peptide-modified polyurethane that comprises the reaction product of an isocyanate, a chain extender, and a peptide; and administering the peptide-modified polyurethane to the subject.
摘要翻译：提供了包含异氰酸酯，扩链剂和肽的反应产物的肽改性的聚氨酯。还提供了制备肽改性聚氨酯的方法，包括：提供异氰酸酯; 提供扩链剂; 提供肽; 并且允许异氰酸酯，扩链剂和肽反应，从而形成肽修饰的聚氨酯，以及用于治疗受试者的方法，包括：提供肽改性的聚氨酯，其包含异氰酸酯，扩链剂和一种肽以及向受试者施用肽改性的聚氨酯。

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