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1. 发明授权

US08318109B2 Microfluidic devices for fluid manipulation and analysis 有权
标题翻译：用于流体操纵和分析的微流体装置
公开(公告)号：US08318109B2
公开(公告)日：2012-11-27
申请号：US12685582
申请日：2010-01-11
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译：本发明涉及用于操纵和分析流体样品的微流体装置和方法。所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。

2. 发明申请

US20120064612A1 MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS 有权
标题翻译：用于流体操纵和分析的微流体装置
公开(公告)号：US20120064612A1
公开(公告)日：2012-03-15
申请号：US13225280
申请日：2011-09-02
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
IPC分类号： C12M1/34
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译：本发明涉及用于操纵和分析流体样品的微流体装置和方法。所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。

3. 发明授权

US08557198B2 Microfluidic devices for fluid manipulation and analysis 有权
标题翻译：用于流体操纵和分析的微流体装置
公开(公告)号：US08557198B2
公开(公告)日：2013-10-15
申请号：US13225280
申请日：2011-09-02
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
IPC分类号： B01L3/00
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译：本发明涉及用于操纵和分析流体样品的微流体装置和方法。所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。

4. 发明申请

US20100173395A1 MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS 有权
标题翻译：用于流体操纵和分析的微流体装置
公开(公告)号：US20100173395A1
公开(公告)日：2010-07-08
申请号：US12685582
申请日：2010-01-11
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
IPC分类号： C12M1/00 , G01N33/00 , G01N21/00
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译：本发明涉及用于操纵和分析流体样品的微流体装置和方法。所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。

5. 发明申请

US20090022624A1 MICROFLUIDIC DEVICES FOR FLUID MANIPULATION AND ANALYSIS 审中-公开
标题翻译：用于流体操纵和分析的微流体装置
公开(公告)号：US20090022624A1
公开(公告)日：2009-01-22
申请号：US12182434
申请日：2008-07-30
申请人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
发明人： Patrick Saltsman , Mingchao Shen , Jeffrey M. Houkal , Christy A. Lancaster , C. Frederick Battrell , Bernhard H. Weigl
IPC分类号： G01N33/53 , G01N31/20
CPC分类号： B01L3/50273 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502715 , B01L3/502723 , B01L3/502738 , B01L3/502753 , B01L2200/0621 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/049 , B01L2400/0605 , B01L2400/0633 , F04B43/043 , G01N33/5304 , G01N33/80
摘要： The present invention relates to microfluidic devices and methods for manipulating and analyzing fluid samples. The disclosed microfluidic devices utilize a plurality of microfluidic channels, inlets, valves, filter, pumps, liquid barriers and other elements arranged in various configurations to manipulate the flow of a fluid sample in order to prepare such sample for analysis.
摘要翻译：本发明涉及用于操纵和分析流体样品的微流体装置和方法。所公开的微流体装置利用多个微流体通道，入口，阀，过滤器，泵，液体屏障和以各种配置布置的其它元件来操纵流体样品的流动，以制备用于分析的样品。

6. 发明授权

US07416892B2 Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing 有权
标题翻译：用于流体微流控操作，扩增和分析的方法和系统，例如细菌测定和抗球蛋白测试
公开(公告)号：US07416892B2
公开(公告)日：2008-08-26
申请号：US10762586
申请日：2004-01-21
申请人： C. Frederick Battrell , Mingchao Shen , Bernhard H. Weigl , Jeffrey M. Houkal , Christy A. Lancaster , Wayne Breidford
发明人： C. Frederick Battrell , Mingchao Shen , Bernhard H. Weigl , Jeffrey M. Houkal , Christy A. Lancaster , Wayne Breidford
IPC分类号： G01N31/00 , G01N1/00
CPC分类号： F04B43/043 , B01F5/0473 , B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/502753 , B01L7/52 , B01L2200/10 , B01L2300/0636 , B01L2300/0681 , B01L2300/0816 , B01L2300/0861 , B01L2300/0867 , B01L2300/1805 , B01L2400/0487 , B01L2400/0633 , C12Q1/686 , Y10T436/107497 , Y10T436/25 , Y10T436/2525 , Y10T436/25375 , C12Q2565/625 , C12Q2565/629
摘要： A microfluidic system for isolation and amplification of DNA or RNA from aqueous solutions and detection of the DNA or RNA on a lateral flow detection strip, including a disposable microfluidic card for use in analysis of bacteria in platelets and an analysis of sexually transmitted diseases (STD) in urine. The card will include an embedded membrane that filters out cells and cellular debris. Any biological debris on the membrane will be lysed and the DNA or RNA amplified via PCR amplification protocol, including appropriate reagents and thermal cycling conditions. The amplified DNA or RNA are transferred to a lateral flow detection strip for a visual diagnostic read out. An alternate embodiment includes a microfluidic card for use in typing antiglobulin assays.
摘要翻译：一种用于从水溶液中分离和扩增DNA或RNA的微流体系统，并检测侧流检测条上的DNA或RNA，包括用于血小板中细菌分析的一次性微流控卡和性传播疾病分析（STD ）在尿液。该卡将包括一个过滤掉细胞和细胞碎片的嵌入膜。膜上的任何生物碎片将被裂解，并通过PCR扩增方案扩增DNA或RNA，包括适当的试剂和热循环条件。将扩增的DNA或RNA转移到侧向流动检测条中以进行视觉诊断读出。替代实施方案包括用于分选抗球蛋白测定的微流控卡。

7. 发明授权

US07648835B2 System and method for heating, cooling and heat cycling on microfluidic device 有权
标题翻译：微流体装置上加热，冷却和热循环的系统和方法
公开(公告)号：US07648835B2
公开(公告)日：2010-01-19
申请号：US12199613
申请日：2008-08-27
申请人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
发明人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5027 , B01L7/52 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/1822 , B01L2300/185 , B01L2300/1877
摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.
摘要翻译：微流控卡上集成的热交换系统。根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。微流控卡包括一个或多个含有放热或吸热材料的储存器。一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。可以在单个卡上包括多个储存器以提供变化的温度。测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予独立电路中的分析流体。根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。

8. 发明申请

US20090081771A1 SYSTEM AND METHOD FOR HEATING, COOLING AND HEAT CYCLING ON MICROFLUIDIC DEVICE 有权
标题翻译：用于加热，冷却和热循环的微流控装置的系统和方法
公开(公告)号：US20090081771A1
公开(公告)日：2009-03-26
申请号：US12199613
申请日：2008-08-27
申请人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
发明人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
IPC分类号： C12M1/40
CPC分类号： B01L3/5027 , B01L7/52 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/1822 , B01L2300/185 , B01L2300/1877
摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.
摘要翻译：微流控卡上集成的热交换系统。根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。微流控卡包括一个或多个含有放热或吸热材料的储存器。一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。可以在单个卡上包括多个储存器以提供变化的温度。测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予独立电路中的分析流体。根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。

9. 发明申请

US20090325276A1 INTEGRATED MICROFLUIDIC ASSAY DEVICES AND METHODS 审中-公开
标题翻译：综合微流感测定装置及方法
公开(公告)号：US20090325276A1
公开(公告)日：2009-12-31
申请号：US12411020
申请日：2009-03-25
申请人： C. Frederick Battrell , John Gerdes , Wayne L. Breidford , Jason Capodanno , Stephen Mordue , John Clemmens , Denise Maxine Hoekstra , Christy A. Lancaster , John R. Williford , Patrick Maloney , Joan Haab
发明人： C. Frederick Battrell , John Gerdes , Wayne L. Breidford , Jason Capodanno , Stephen Mordue , John Clemmens , Denise Maxine Hoekstra , Christy A. Lancaster , John R. Williford , Patrick Maloney , Joan Haab
IPC分类号： C12M1/00
CPC分类号： G01N33/5302 , B01F11/0071 , B01F13/0059 , B01L3/502715 , B01L7/52 , B01L2300/0636 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B01L2400/0481 , B01L2400/0487 , B01L2400/0638 , Y02A50/58
摘要： Combinations of microfluidic diagnostic testing modules for simultaneous evaluations of serological and molecular biological targets are provided, and include panel testing for both antibodies (or antigens) and nucleic acid targets in one single-use device. These improvements are directed to evaluating the overall progress and activity of a pathogenic process in real time, at the point of care, not merely the presence or absence of a particular diagnostic marker, which can often be incomplete or misleading.
摘要翻译：提供了用于同时评估血清学和分子生物学靶标的微流体诊断测试模块的组合，并且包括在一次性使用的装置中对抗体（或抗原）和核酸靶标进行面板测试。这些改进旨在评估致病过程的总体进展和活动，而不仅仅是特定诊断标记的存在或不存在，这通常是不完整的或具有误导性的。

10. 发明申请

US20120105600A1 FUNCTIONAL IMAGING OF CELLS WITH OPTICAL PROJECTION TOMOGRAPHY 有权
标题翻译：用光学投影图像进行功能成像
公开(公告)号：US20120105600A1
公开(公告)日：2012-05-03
申请号：US12999515
申请日：2009-06-08
申请人： Michael G. Meyer , J. Richard Rahn , Anna V. Tourovskaia , Julia Oi Yan Yu , Christy A. Lancaster , Thomas Neumann , Mark E. Fauver
发明人： Michael G. Meyer , J. Richard Rahn , Anna V. Tourovskaia , Julia Oi Yan Yu , Christy A. Lancaster , Thomas Neumann , Mark E. Fauver
IPC分类号： H04N13/02
CPC分类号： G06T11/006 , G01N15/1434 , G01N15/1475 , G01N21/49 , G01N21/6458 , G01N2015/1445
摘要： A method for 3D imaging of a biologic object (1) in an optical tomography system where a subcellular structure of a biological object (1) is labeled by introducing at least one nanoparticle-biomarker. The labeled biological object (1) is moved relatively to a microscope objective (62) to present varying angles of view and the labeled biological object (1) is illuminated with radiation having wavelengths between 150 nm and 900 nm. Radiation transmitted through the labeled biological object (1) and the microscope objective (62) within at least one wavelength bands is sensed with a color camera, or with a set of at least four monochrome cameras. A plurality of cross-sectional images of the biological object (1) from the sensed radiation is formed and reconstructed to make a 3D image of the labeled biological object (1).
摘要翻译：一种用于在其中通过引入至少一种纳米颗粒 - 生物标志物标记生物体（1）的亚细胞结构的光学层析成像系统中的生物物体（1）的3D成像的方法。标记的生物体（1）相对于显微镜物镜（62）移动以呈现不同的视角，并且用波长在150nm和900nm之间的辐射照射标记的生物物体（1）。用彩色照相机或一组至少四个单色照相机检测在至少一个波长带内通过标记的生物物体（1）和显微镜物镜（62）发射的辐射。形成并重构来自感测辐射的生物体（1）的多个横截面图像，以便制成标记的生物体（1）的3D图像。

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