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1. 发明授权

US08491483B2 Contrast agent imaging with agent specific ultrasound detection 有权
标题翻译：对比剂成像与特异性超声检测
公开(公告)号：US08491483B2
公开(公告)日：2013-07-23
申请号：US12233940
申请日：2008-09-19
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14 , A61B8/00
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.
摘要翻译：可以通过处理立方基本信息来获得容器中诸如冠状动脉之间的流动的高度特异性测量。通过显示具有高度对比组织特异性的血管中的流动，基于超声的基于3D造影剂的冠状动脉血管造影可能是可能的。与三次基本能量的显示同时提供来自三次基本信号的试剂速度的测量和显示，例如提供由能量和速度两者分度的显示图。结合长速度测量间隔的三次基波检测的高脉冲重复频率（PRF）可以提高低速度灵敏度和测量精度。脉冲波（PW）多普勒可以通过使用立方基本敏感脉冲序列来改善。使用三维基本敏感技术与其他运动估计技术（如二维速度估计或斑点跟踪）相比，使用其他造影剂检测技术的操作可能比实际上减少的杂波更好。

2. 发明申请

US20090082672A1 Contrast Agent Imaging With Agent Specific Ultrasound Detection 审中-公开
公开(公告)号：US20090082672A1
公开(公告)日：2009-03-26
申请号：US12234422
申请日：2008-09-19
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.

3. 发明授权

US07998076B2 Advanced characterization of contrast agents with ultrasound 有权
标题翻译：超声造影剂的高级特征
公开(公告)号：US07998076B2
公开(公告)日：2011-08-16
申请号：US11237221
申请日：2005-09-27
申请人： Patrick J. Phillips , James E. Chomas , Ismayil M. Guracar
发明人： Patrick J. Phillips , James E. Chomas , Ismayil M. Guracar
IPC分类号： A61B8/14 , A61B8/00 , G06K9/00
CPC分类号： G01S15/8981 , A61B8/481 , G01S7/52039
摘要： Contrast agents are characterized with ultrasound. Flowing or unbound contrast agents are distinguished automatically from bound or relatively stationary contrast agents. The bound or relatively stationary contrast agents are highlighted on a display. A processor distinguishes different types of contrast agents or contrast agents in different binding states with relative signal strength or velocity. Attached contrast agents are differentiated from phagocytosed contrast agents. Monitoring absolute signal strength as a function of time may indicate binding. Any one or more of these features may be used.
摘要翻译：造影剂用超声波表征。流动或未结合的造影剂自动与界定或相对静止的造影剂区分开。绑定或相对静止的造影剂在显示器上突出显示。处理器将不同类型的造影剂或造影剂以相对信号强度或速度区别在不同的结合状态。附着的造影剂与吞噬的造影剂不同。监测绝对信号强度作为时间的函数可能表示绑定。可以使用这些特征中的一个或多个。

4. 发明申请

US20090012400A1 Contrast Agent Imaging With Agent Specific Ultrasound Detection 审中-公开
标题翻译：对比剂成像与特定特定超声检测
公开(公告)号：US20090012400A1
公开(公告)日：2009-01-08
申请号：US12234448
申请日：2008-09-19
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.
摘要翻译：可以通过处理立方基本信息来获得容器中诸如冠状动脉之间的流动的高度特异性测量。通过显示具有高度对比组织特异性的血管中的流动，基于超声的基于3D造影剂的冠状动脉血管造影可能是可能的。与三次基本能量的显示同时提供来自三次基本信号的试剂速度的测量和显示，例如提供由能量和速度两者分度的显示图。结合长速度测量间隔的三次基波检测的高脉冲重复频率（PRF）可以提高低速度灵敏度和测量精度。脉冲波（PW）多普勒可以通过使用立方基本敏感脉冲序列来改善。使用三维基本敏感技术与其他运动估计技术（如二维速度估计或斑点跟踪）相比，使用其他造影剂检测技术的操作可能比实际上减少的杂波更好。

5. 发明授权

US07004906B1 Contrast agent imaging with agent specific ultrasound detection 有权
公开(公告)号：US07004906B1
公开(公告)日：2006-02-28
申请号：US10899803
申请日：2004-07-26
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.

6. 发明授权

US07837626B2 Contrast agent manipulation with medical ultrasound imaging 有权
标题翻译：对比剂操作与医学超声成像
公开(公告)号：US07837626B2
公开(公告)日：2010-11-23
申请号：US11197954
申请日：2005-08-05
申请人： James E. Chomas , Ismayil M. Guracar , Patrick J. Phillips , John D. Marshall
发明人： James E. Chomas , Ismayil M. Guracar , Patrick J. Phillips , John D. Marshall
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , G01S7/52022 , G01S15/8927
摘要： Contrast agents are manipulated with acoustic radiation force while ultrasound imaging. Continuous waves for acoustic radiation force are transmitted. Substantially simultaneously, pulsed waves for imaging are transmitted. Low mechanical index continuous and pulsed waves may be used to increase binding efficiency of drug containing contrast agents with the tissue for treatment. Various techniques may be used to minimize the effect of the continuous waves on imaging with the pulsed waves. The acoustic radiation force may be transmitted with an amplitude profile and/or unfocused or defocused.
摘要翻译：对比剂用声辐射力进行超声波成像。传输声辐射力的连续波。基本上同时传输用于成像的脉冲波。可以使用低机械指数的连续脉冲波和脉冲波来增加含有药物的造影剂与用于治疗的组织的结合效率。可以使用各种技术来最小化连续波对脉冲波成像的影响。声辐射力可以以幅度分布和/或未聚焦或散焦来传输。

7. 发明授权

US08177719B2 Contrast agent imaging with agent specific ultrasound detection 有权
标题翻译：对比剂成像与特异性超声检测
公开(公告)号：US08177719B2
公开(公告)日：2012-05-15
申请号：US11152521
申请日：2005-06-14
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.
摘要翻译：可以通过处理立方基本信息来获得容器中诸如冠状动脉之间的流动的高度特异性测量。通过显示具有高度对比组织特异性的血管中的流动，基于超声的基于3D造影剂的冠状动脉血管造影可能是可能的。与三次基本能量的显示同时提供来自三次基本信号的试剂速度的测量和显示，例如提供由能量和速度两者分度的显示图。结合长速度测量间隔的三次基波检测的高脉冲重复频率（PRF）可以提高低速度灵敏度和测量精度。脉冲波（PW）多普勒可以通过使用立方基本敏感脉冲序列来改善。使用三维基本敏感技术与其他运动估计技术（如二维速度估计或斑点跟踪）相比，使用其他造影剂检测技术的操作可能比实际上减少的杂波更好。

8. 发明申请

US20090082671A1 Contrast Agent Imaging With Agent Specific Ultrasound Detection 有权
公开(公告)号：US20090082671A1
公开(公告)日：2009-03-26
申请号：US12233940
申请日：2008-09-19
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.

9. 发明申请

US20080125657A1 Automated contrast agent augmented ultrasound therapy for thrombus treatment 审中-公开
标题翻译：自动造影剂增强超声治疗血栓治疗
公开(公告)号：US20080125657A1
公开(公告)日：2008-05-29
申请号：US11528882
申请日：2006-09-27
申请人： James E. Chomas , Anming He Cai , Richard M. Bennett , Ismayil M. Guracar
发明人： James E. Chomas , Anming He Cai , Richard M. Bennett , Ismayil M. Guracar
IPC分类号： A61B8/14
CPC分类号： A61N7/00 , A61B8/06 , A61B8/0833 , A61B8/13 , A61B8/481 , A61B2090/378
摘要： Control of the sonothrombolysis treatment is automated based on feedback from ultrasound. The region to be treated may be tracked to provide ongoing treatment at the desired location. The treatment may be triggered based on detection of sufficient perfusion. The number or intensity of destructive ultrasound pulses may adapt to the number of remaining contrast agents. The treatment may be ceased or modified based on the efficacy.
摘要翻译：基于超声反馈自动控制溶栓治疗。可以跟踪被治疗的区域以在期望的位置提供持续的治疗。可以基于足够灌注的检测来触发治疗。破坏性超声脉冲的数量或强度可适应剩余造影剂的数量。治疗可以基于功效停止或修改。

10. 发明申请

US20080097206A1 Enhanced contrast agent augmented ultrasound thrombus treatment 审中-公开
标题翻译：增强造影剂增强超声血栓治疗
公开(公告)号：US20080097206A1
公开(公告)日：2008-04-24
申请号：US11528915
申请日：2006-09-27
申请人： James E. Chomas , Anming He Cai , Richard M. Bennett , Ismayil M. Guracar
发明人： James E. Chomas , Anming He Cai , Richard M. Bennett , Ismayil M. Guracar
IPC分类号： A61N7/00
CPC分类号： A61B8/481 , A61B8/06 , A61B8/0833 , A61B8/13 , A61B2090/378 , A61N7/00
摘要： Contrast agents may more effectively clear a clot if they are as close to the clot as possible. Radiation force may effectively push and/or pull the contrast agents next to the clot and away from the middle of any flow channels. By transmitting driving acoustic energy, the contrast agents may be positioned for treatment that is more effective by destruction.
摘要翻译：如果血块尽可能接近凝块，造影剂可以更有效地清除凝块。辐射力可以有效地推动和/或拉动凝块旁边的造影剂并远离任何流动通道的中间。通过传输驱动声能，造影剂可以定位成通过破坏更有效的治疗。

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