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1. 发明授权

US07837626B2 Contrast agent manipulation with medical ultrasound imaging 有权
标题翻译：对比剂操作与医学超声成像
公开(公告)号：US07837626B2
公开(公告)日：2010-11-23
申请号：US11197954
申请日：2005-08-05
申请人： James E. Chomas , Ismayil M. Guracar , Patrick J. Phillips , John D. Marshall
发明人： James E. Chomas , Ismayil M. Guracar , Patrick J. Phillips , John D. Marshall
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , G01S7/52022 , G01S15/8927
摘要： Contrast agents are manipulated with acoustic radiation force while ultrasound imaging. Continuous waves for acoustic radiation force are transmitted. Substantially simultaneously, pulsed waves for imaging are transmitted. Low mechanical index continuous and pulsed waves may be used to increase binding efficiency of drug containing contrast agents with the tissue for treatment. Various techniques may be used to minimize the effect of the continuous waves on imaging with the pulsed waves. The acoustic radiation force may be transmitted with an amplitude profile and/or unfocused or defocused.
摘要翻译：对比剂用声辐射力进行超声波成像。传输声辐射力的连续波。基本上同时传输用于成像的脉冲波。可以使用低机械指数的连续脉冲波和脉冲波来增加含有药物的造影剂与用于治疗的组织的结合效率。可以使用各种技术来最小化连续波对脉冲波成像的影响。声辐射力可以以幅度分布和/或未聚焦或散焦来传输。

2. 发明授权

US08177719B2 Contrast agent imaging with agent specific ultrasound detection 有权
标题翻译：对比剂成像与特异性超声检测
公开(公告)号：US08177719B2
公开(公告)日：2012-05-15
申请号：US11152521
申请日：2005-06-14
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.
摘要翻译：可以通过处理立方基本信息来获得容器中诸如冠状动脉之间的流动的高度特异性测量。通过显示具有高度对比组织特异性的血管中的流动，基于超声的基于3D造影剂的冠状动脉血管造影可能是可能的。与三次基本能量的显示同时提供来自三次基本信号的试剂速度的测量和显示，例如提供由能量和速度两者分度的显示图。结合长速度测量间隔的三次基波检测的高脉冲重复频率（PRF）可以提高低速度灵敏度和测量精度。脉冲波（PW）多普勒可以通过使用立方基本敏感脉冲序列来改善。使用三维基本敏感技术与其他运动估计技术（如二维速度估计或斑点跟踪）相比，使用其他造影剂检测技术的操作可能比实际上减少的杂波更好。

3. 发明申请

US20090082671A1 Contrast Agent Imaging With Agent Specific Ultrasound Detection 有权
公开(公告)号：US20090082671A1
公开(公告)日：2009-03-26
申请号：US12233940
申请日：2008-09-19
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.

4. 发明授权

US08491483B2 Contrast agent imaging with agent specific ultrasound detection 有权
标题翻译：对比剂成像与特异性超声检测
公开(公告)号：US08491483B2
公开(公告)日：2013-07-23
申请号：US12233940
申请日：2008-09-19
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14 , A61B8/00
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.
摘要翻译：可以通过处理立方基本信息来获得容器中诸如冠状动脉之间的流动的高度特异性测量。通过显示具有高度对比组织特异性的血管中的流动，基于超声的基于3D造影剂的冠状动脉血管造影可能是可能的。与三次基本能量的显示同时提供来自三次基本信号的试剂速度的测量和显示，例如提供由能量和速度两者分度的显示图。结合长速度测量间隔的三次基波检测的高脉冲重复频率（PRF）可以提高低速度灵敏度和测量精度。脉冲波（PW）多普勒可以通过使用立方基本敏感脉冲序列来改善。使用三维基本敏感技术与其他运动估计技术（如二维速度估计或斑点跟踪）相比，使用其他造影剂检测技术的操作可能比实际上减少的杂波更好。

5. 发明申请

US20090082672A1 Contrast Agent Imaging With Agent Specific Ultrasound Detection 审中-公开
公开(公告)号：US20090082672A1
公开(公告)日：2009-03-26
申请号：US12234422
申请日：2008-09-19
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.

6. 发明授权

US07998076B2 Advanced characterization of contrast agents with ultrasound 有权
标题翻译：超声造影剂的高级特征
公开(公告)号：US07998076B2
公开(公告)日：2011-08-16
申请号：US11237221
申请日：2005-09-27
申请人： Patrick J. Phillips , James E. Chomas , Ismayil M. Guracar
发明人： Patrick J. Phillips , James E. Chomas , Ismayil M. Guracar
IPC分类号： A61B8/14 , A61B8/00 , G06K9/00
CPC分类号： G01S15/8981 , A61B8/481 , G01S7/52039
摘要： Contrast agents are characterized with ultrasound. Flowing or unbound contrast agents are distinguished automatically from bound or relatively stationary contrast agents. The bound or relatively stationary contrast agents are highlighted on a display. A processor distinguishes different types of contrast agents or contrast agents in different binding states with relative signal strength or velocity. Attached contrast agents are differentiated from phagocytosed contrast agents. Monitoring absolute signal strength as a function of time may indicate binding. Any one or more of these features may be used.
摘要翻译：造影剂用超声波表征。流动或未结合的造影剂自动与界定或相对静止的造影剂区分开。绑定或相对静止的造影剂在显示器上突出显示。处理器将不同类型的造影剂或造影剂以相对信号强度或速度区别在不同的结合状态。附着的造影剂与吞噬的造影剂不同。监测绝对信号强度作为时间的函数可能表示绑定。可以使用这些特征中的一个或多个。

7. 发明申请

US20090012400A1 Contrast Agent Imaging With Agent Specific Ultrasound Detection 审中-公开
标题翻译：对比剂成像与特定特定超声检测
公开(公告)号：US20090012400A1
公开(公告)日：2009-01-08
申请号：US12234448
申请日：2008-09-19
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.
摘要翻译：可以通过处理立方基本信息来获得容器中诸如冠状动脉之间的流动的高度特异性测量。通过显示具有高度对比组织特异性的血管中的流动，基于超声的基于3D造影剂的冠状动脉血管造影可能是可能的。与三次基本能量的显示同时提供来自三次基本信号的试剂速度的测量和显示，例如提供由能量和速度两者分度的显示图。结合长速度测量间隔的三次基波检测的高脉冲重复频率（PRF）可以提高低速度灵敏度和测量精度。脉冲波（PW）多普勒可以通过使用立方基本敏感脉冲序列来改善。使用三维基本敏感技术与其他运动估计技术（如二维速度估计或斑点跟踪）相比，使用其他造影剂检测技术的操作可能比实际上减少的杂波更好。

8. 发明授权

US07004906B1 Contrast agent imaging with agent specific ultrasound detection 有权
公开(公告)号：US07004906B1
公开(公告)日：2006-02-28
申请号：US10899803
申请日：2004-07-26
申请人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
发明人： Ismayil M. Guracar , James E. Chomas , Patrick J. Phillips
IPC分类号： A61B8/00
CPC分类号： A61B8/481 , A61B8/483
摘要： Highly specific measurements of flow in vessels, such as the coronary artery, can be obtained by processing cubic fundamental information. By showing flow in vessels with a high degree of contrast-to-tissue specificity, ultrasound based 3D contrast agent based coronary artery angiograms may be possible. Measurement and display of the velocity of agent from the cubic fundamental signal is provided simultaneously with display of cubic fundamental energy, such as providing a display map indexed by both energy and velocity. High pulse repetition frequency (PRF) for cubic fundamental detection in conjunction with long velocity measurement intervals may increase low velocity sensitivity and measurement precision. Pulsed wave (PW) Doppler may be improved by using a cubic fundamental sensitive pulse sequence. Using cubic fundamental sensitive techniques with other motion estimation techniques, such as two-dimensional velocity estimation or speckle tracking, may operate better than using other contrast agent detection techniques because of substantially reduced clutter.

9. 发明授权

US06899681B1 Automated power level for contrast agent imaging 有权
标题翻译：造影剂成像自动功率水平
公开(公告)号：US06899681B1
公开(公告)日：2005-05-31
申请号：US10077499
申请日：2002-02-15
申请人： Patrick J. Phillips , Ismayil M. Guracar , Robert W. Steins
发明人： Patrick J. Phillips , Ismayil M. Guracar , Robert W. Steins
IPC分类号： A61B8/00 , G01S7/52 , G03B42/06 , A61B8/14
CPC分类号： G01S7/52096 , G01S7/52026 , G03B42/06
摘要： Automated determination and setting of an ultrasound system transmit power level is provided for contrast agent imaging. Low mechanical index imaging of contrast agents allows substantially continuous imaging of contrast agents without destruction. By comparing data associated with different transmit power levels, different delays between acquisition or different acquisition sequences, a contrast agent imaging transmit power generally minimizing destruction of contrast agents and maximizing signal-to-noise ratio is automatically determined.
摘要翻译：提供超声系统发射功率水平的自动确定和设置用于造影剂成像。造影剂的低机械指数成像允许对比剂的基本连续成像而不破坏。通过比较与不同发射功率电平相关联的数据，可以自动确定采集或不同采集序列之间的不同延迟，通常最小化对比剂的破坏和最大化信噪比的造影剂成像发射功率。

10. 发明授权

US07993273B2 Adaptive contrast agent medical imaging 有权
标题翻译：自适应造影剂医学成像
公开(公告)号：US07993273B2
公开(公告)日：2011-08-09
申请号：US12129544
申请日：2008-05-29
申请人： Patrick J. Phillips , Ismayil M. Guracar
发明人： Patrick J. Phillips , Ismayil M. Guracar
IPC分类号： A61B8/14
CPC分类号： A61B8/481 , A61B8/467
摘要： System parameters for contrast agent medical imaging are conveniently set. A simplified contrast agent configuration is provided where an appropriate contrast agent detection technique and/or contrast agent imaging parameters are achieved consistently and more often then exists with current methods. Examination workflow is improved for contrast agent studies by offering one contrast agent imaging mode or configuration that is dynamically determined and optimized based on the user's selected transmit level and/or a real-time measurement of the contrast agent signals. A simplified user interface provides one contrast agent imaging mode without a need to switch between multiple modes or contrast agent detection techniques and associated contrast agent imaging parameters. The contrast agent detection technique and imaging parameters are adjusting or selected based on changes in the transmit levels for contrast agent imaging. Either a single user input control or real time measurements are used to select a transmit level, resulting in automatic selection of adjustment of the detection technique and/or imaging parameters. Appropriate contrast agent detection techniques and imaging parameters are selected for each given transmit level without the user having to switch the mode or configuration of the system during an imaging session. As a result, contrast agent examinations are simplified while minimizing suboptimal selection by a user.
摘要翻译：造影剂医学成像的系统参数设置方便。提供了一种简化的造影剂配置，其中一致地实现适当的造影剂检测技术和/或造影剂成像参数，并且随后以当前方法存在。通过提供基于用户选择的发射电平和/或造影剂信号的实时测量动态确定和优化的一种造影剂成像模式或配置，对造影剂研究的检查工作流程得到改善。简化的用户界面提供一种造影剂成像模式，而无需在多种模式或造影剂检测技术和相关的造影剂成像参数之间进行切换。造影剂检测技术和成像参数根据造影剂成像的传输水平的变化进行调整或选择。使用单个用户输入控制或实时测量来选择发射电平，导致自动选择检测技术和/或成像参数的调整。为每个给定的传输级别选择适当的造影剂检测技术和成像参数，而用户不必在成像会话期间切换系统的模式或配置。因此，简化了造影剂检查，同时使用户的次优选择最小化。

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