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1. 发明授权

US08602958B1 Methods and assemblies for collecting liquid by centrifugation 有权
标题翻译：通过离心收集液体的方法和组件
公开(公告)号：US08602958B1
公开(公告)日：2013-12-10
申请号：US12324655
申请日：2008-11-26
申请人： Patrick D. Kinney , Michele E. Wisniewski , Jon A. Hoshizaki , David M. Liu , Joon Mo Yang
发明人： Patrick D. Kinney , Michele E. Wisniewski , Jon A. Hoshizaki , David M. Liu , Joon Mo Yang
IPC分类号： B01D21/26
CPC分类号： B01L3/5025 , B01L2200/025 , B01L2200/0673 , B01L2300/0829 , B01L2400/0409
摘要： Assemblies for and methods of coupling a microtiter plate and receptacle for centrifugation of liquid from the microtiter plate to the receptacle are provided. In some embodiments, a coupling frame can be used. In other embodiments, the microtiter plate couples directly to the receptacle. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-y plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the x-z plane. In some embodiments, relative motion between the receptacle and the microtiter plate is limited in the y-z plane.
摘要翻译：提供了用于将微量滴定板和容器耦合的组件和方法，用于将液体从微量滴定板离心到容器。在一些实施例中，可以使用联接框架。在其他实施方案中，微量滴定板直接连接到容器。在一些实施例中，容器和微量滴定板之间的相对运动在x-y平面中受到限制。在一些实施例中，容器和微量滴定板之间的相对运动在x-z平面中受到限制。在一些实施例中，容器和微量滴定板之间的相对运动在y-z平面中受到限制。

2. 发明授权

US08597590B2 Systems and methods for multiple analyte detection 有权
标题翻译：多个分析物检测的系统和方法
公开(公告)号：US08597590B2
公开(公告)日：2013-12-03
申请号：US12789363
申请日：2010-05-27
申请人： Min Yue , David M. Liu , Joy Roy , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John R. Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Maryam Shariati , Umberto Ulmanella
发明人： Min Yue , David M. Liu , Joy Roy , Yuh-Min Chiang , Joon Mo Yang , Dennis Lehto , Charles S. Vann , Nigel P. Beard , Ian A. Harding , John R. Van Camp , Alexander Dromaretsky , Sergey V. Ermakov , Mark F. Oldham , Maryam Shariati , Umberto Ulmanella
IPC分类号： G01N21/75
CPC分类号： C12Q1/6806 , B01J2219/00317 , B01J2219/00722 , B01L3/502707 , B01L3/502723 , B01L3/50853 , B01L2200/0684 , B01L2200/0689 , B01L2200/16 , B01L2300/041 , B01L2300/048 , B01L2300/0636 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0694 , G01N35/028 , Y10T436/2575
摘要： Systems and methods for multiple analyte detection include a system for distribution of a biological sample that includes a substrate, wherein the substrate includes a plurality of sample chambers, a sample introduction channel for each sample chamber, and a venting channel for each sample chamber. The system may further include a preloaded reagent contained in each sample chamber and configured for nucleic acid analysis of a biological sample that enters the substrate and a sealing instrument configured to be placed in contact with the substrate to seal each sample chamber so as to substantially prevent sample contained in each sample chamber from flowing out of each sample chamber. The substrate can be constructed of detection-compatible and assay-compatible materials.
摘要翻译：用于多个分析物检测的系统和方法包括用于分配包括基底的生物样品的系统，其中所述基底包括多个样品室，用于每个样品室的样品引入通道和用于每个样品室的排气通道。该系统可以进一步包括包含在每个样品室中并被配置用于进入基底的生物样品的核酸分析的预加载试剂和被配置为与基底接触以密封每个样品室以便基本上防止每个样品室中包含的样品从每个样品室流出。底物可以由检测相容和测定相容的材料构成。

3. 发明申请

US20090081768A1 Devices and Methods for Thermally Isolating Chambers of an Assay Card 审中-公开
标题翻译：测定卡热隔离室的设备和方法
公开(公告)号：US20090081768A1
公开(公告)日：2009-03-26
申请号：US11859180
申请日：2007-09-21
申请人： Joon Mo Yang , David M. Liu , Yuh-Min Chiang , Carol Schrembri , Aldrich N.K. Lau , Umberto Ulmanella , Nigel P. Beard , Maryam Shariati , James C. Nurse , Douwe D. Haga , Ian A. Harding , Julio P. Focaracci
发明人： Joon Mo Yang , David M. Liu , Yuh-Min Chiang , Carol Schrembri , Aldrich N.K. Lau , Umberto Ulmanella , Nigel P. Beard , Maryam Shariati , James C. Nurse , Douwe D. Haga , Ian A. Harding , Julio P. Focaracci
IPC分类号： C12M1/34 , B29C59/02 , B29C59/16
CPC分类号： B01L3/502707 , B01L7/52 , B01L2200/141 , B01L2300/0816 , B01L2300/1805 , B01L2300/1861 , B01L2400/0677
摘要： An assay card and devices and methods for isolating chambers on the assay card are described. The assay card comprises a substrate formed of one or more materials, e.g., plastic, having a softening temperature, the substrate defining channels communicating with respective reaction chambers. The assay card may be heated in a region of the channels to at least the softening temperature. The softened plastic may be deformed, e.g., with a tool which may or may not also provide the heat for softening the substrate. In this manner, the plastic of the substrate may be caused to at least partially obstruct the channels, thereby isolating the reaction chambers. The invention also relates to a method of manufacturing a tool device that includes pins for heating and deforming an assay card.
摘要翻译：描述了用于在测试卡上隔离室的测定卡和装置和方法。测定卡包括由一种或多种具有软化温度的材料（例如塑料）形成的衬底，衬底限定通道与各个反应室连通。测定卡可以在通道的区域中被加热到至少软化温度。软化的塑料可能变形，例如用可能也可能不提供用于软化基底的热量的工具。以这种方式，可以使衬底的塑料至少部分地阻碍通道，从而隔离反应室。本发明还涉及一种制造工具装置的方法，该工具装置包括用于加热和变形分析卡的销。

4. 发明申请

US20070280856A1 Devices and Methods for Controlling Bubble Formation in Microfluidic Devices 审中-公开
标题翻译：用于控制微流控装置中气泡形成的装置和方法
公开(公告)号：US20070280856A1
公开(公告)日：2007-12-06
申请号：US11422057
申请日：2006-06-02
申请人： Umberto Ulmanella , Eric S. Nordman , Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Min Yue , Carol Schembri , David Liu
发明人： Umberto Ulmanella , Eric S. Nordman , Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Min Yue , Carol Schembri , David Liu
IPC分类号： B01L3/02
CPC分类号： B01L3/502746 , B01L3/502723 , B01L3/502784 , B01L2200/0642 , B01L2200/0673 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B01L2400/086
摘要： A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers. At least some of the sample chambers may include a dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.
摘要翻译：微流体装置可以包括样品分配网络，其包括多个样品室，其被配置为装载用于生物样品的生物样品的生物样品，而在样品室中，生物样品具有在加载期间在样品室内移动的弯液面。样品分配网络还可以包括多个入口通道，每个入口通道与生物样品流动连通并配置成将生物样品流动到相应的样品室，以及多个出口通道，每个出口通道流动连通并且被配置为从相应的样品室流动生物样品。至少一些样品室可以包括物理修改，其被配置为控制弯液面的运动，以便控制至少一些样品室内的气泡形成。至少一些样品室可以包括位于与至少一些样品室流动连通的入口通道附近的至少一些样品室内的干燥试剂。

5. 发明授权

US08426209B2 Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network 有权
标题翻译：用于在微流体通道网络中使用光开关分选细胞的方法和装置
公开(公告)号：US08426209B2
公开(公告)日：2013-04-23
申请号：US12825037
申请日：2010-06-28
申请人： William Frank Butler , Mirianas Chachisvilis , Robert Dees , Norbert Hagen , Philippe Marchand , Daniel E. Raymond , Eugene Tu , Mark M. Wang , Joon Mo Yang , Rong Yang , Haichuan Zhang
发明人： William Frank Butler , Mirianas Chachisvilis , Robert Dees , Norbert Hagen , Philippe Marchand , Daniel E. Raymond , Eugene Tu , Mark M. Wang , Joon Mo Yang , Rong Yang , Haichuan Zhang
IPC分类号： G01N33/48
CPC分类号： G01N15/1459 , B01L3/502707 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0415 , B01L2400/0454 , B01L2400/0487 , G01N2015/149 , Y10T436/2575
摘要： Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.
摘要翻译：为微型荧光激活细胞分选器提供基于光学开关的装置和方法，用于通过微流体通道网络快速，主动地控制细胞路由。该分选机能够对小数量细胞群体（即1000-100,000个细胞）进行低应激，高效分选。本发明包括将微流体通道网络包装在独立的塑料盒中，使得微流体通道网络能够以无菌的一次性格式进行大规模的仪器互连。

6. 发明申请

US20100304429A1 METHODS AND APPARATUS FOR SORTING CELLS USING AN OPTICAL SWITCH IN A MICROFLUIDIC CHANNEL NETWORK 有权
标题翻译：在微流通道网络中使用光开关分选细胞的方法和装置
公开(公告)号：US20100304429A1
公开(公告)日：2010-12-02
申请号：US12825037
申请日：2010-06-28
申请人： William Frank Butler , Mirianas Chachisvilis , Robert Dees , Norbert Hagen , Philippe Marchand , Daniel E. Raymond , Eugene Tu , Mark M. Wang , Joon Mo Yang , Rong Yang , Haichuan Zhang
发明人： William Frank Butler , Mirianas Chachisvilis , Robert Dees , Norbert Hagen , Philippe Marchand , Daniel E. Raymond , Eugene Tu , Mark M. Wang , Joon Mo Yang , Rong Yang , Haichuan Zhang
IPC分类号： C12Q1/04
CPC分类号： G01N15/1459 , B01L3/502707 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0415 , B01L2400/0454 , B01L2400/0487 , G01N2015/149 , Y10T436/2575
摘要： Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.
摘要翻译：为微型荧光激活细胞分选器提供基于光学开关的装置和方法，用于通过微流体通道网络快速，主动地控制细胞路由。该分选机能够对小数量细胞群体（即1000-100,000个细胞）进行低应激，高效分选。本发明包括将微流体通道网络包装在独立的塑料盒中，使得微流体通道网络能够以无菌的一次性格式进行大规模的仪器互连。

7. 发明申请

US20100206731A1 DEVICES AND METHODS FOR OPTOELECTRONIC MANIPULATION OF SMALL PARTICLES 有权
标题翻译：用于光电子操作小颗粒的装置和方法
公开(公告)号：US20100206731A1
公开(公告)日：2010-08-19
申请号：US12702137
申请日：2010-02-08
申请人： Aldrich N.K. Lau , Joon Mo Yang , Huan L. Phan , Steven W. Sherwood , Hans A. Fuernkranz
发明人： Aldrich N.K. Lau , Joon Mo Yang , Huan L. Phan , Steven W. Sherwood , Hans A. Fuernkranz
IPC分类号： B03C11/00
CPC分类号： B03C5/026 , B03C5/005 , B03C5/028 , C07K1/26 , G01N27/305
摘要： A method for sorting cells in a biological sample comprising a first type of cells and a second type of cells may comprise introducing the biological sample into a chamber comprising a first surface and a second surface, wherein the first surface is associated with a transparent electrode and the second surface is associated with a photoconductive portion of an electrode. The method may further comprise moving incident light and the photoconductive portion relative to one another so as to illuminate regions of the photoconductive portion and modulate an electric field in the chamber in proximity to the illuminated regions. The method may further comprise separating the first type of cells from the second type of cells in the chamber via dielectrophoretic movement of the first type of cells and the second type of cells caused by the modulated electric field, wherein a dielectrophoretic characteristic of at least one of the first type of cells and the second type of cells has been modified.
摘要翻译：用于分选生物样品中包含第一类型细胞和第二类型细胞的细胞的方法可以包括将生物样品引入包含第一表面和第二表面的室中，其中第一表面与透明电极相关联，第二表面与电极的光电导部分相关联。该方法还可以包括相对于彼此移动入射光和光电导部分，以照射光电导部分的区域并且调制在邻近照明区域的室中的电场。该方法还可以包括通过由调制电场引起的第一类型的细胞和第二类型的细胞的介电电泳运动，将第一类型的细胞与腔室中的第二类型的细胞分离，其中至少一种的介电电泳特性的第一类型的细胞和第二类型的细胞已被修改。

8. 发明授权

US07745221B2 Methods and apparatus for sorting cells using an optical switch in a microfluidic channel network 有权
标题翻译：用于在微流体通道网络中使用光开关分选细胞的方法和装置
公开(公告)号：US07745221B2
公开(公告)日：2010-06-29
申请号：US10928650
申请日：2004-08-27
申请人： William Frank Butler , Mirianas Chachisvilis , Robert Dees , Norbert Hagen , Philippe Marchand , Daniel E. Raymond , Eugene Tu , Mark M. Wang , Joon Mo Yang , Rong Yang , Haichuan Zhang
发明人： William Frank Butler , Mirianas Chachisvilis , Robert Dees , Norbert Hagen , Philippe Marchand , Daniel E. Raymond , Eugene Tu , Mark M. Wang , Joon Mo Yang , Rong Yang , Haichuan Zhang
IPC分类号： G01N33/48
CPC分类号： G01N15/1459 , B01L3/502707 , B01L3/502761 , B01L3/502776 , B01L2200/0636 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0415 , B01L2400/0454 , B01L2400/0487 , G01N2015/149 , Y10T436/2575
摘要： Apparatus and Methods are provided for a microfabricated fluorescence activated cell sorter based on an optical switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells). The invention includes packaging of the microfluidic channel network in a self-contained plastic cartridge that enables microfluidic channel network to macro-scale instrument interconnect, in a sterile, disposable format.
摘要翻译：为微型荧光激活细胞分选器提供基于光学开关的装置和方法，用于通过微流体通道网络快速，主动地控制细胞路由。该分选机能够对小数量细胞群体（即1000-100,000个细胞）进行低应激，高效分选。本发明包括将微流体通道网络包装在独立的塑料盒中，使得微流体通道网络能够以无菌的一次性格式进行大规模的仪器互连。

9. 发明申请

US20070280857A1 Devices and Methods for Positioning Dried Reagent In Microfluidic Devices 审中-公开
标题翻译：微流控装置中干燥试剂定位的装置和方法
公开(公告)号：US20070280857A1
公开(公告)日：2007-12-06
申请号：US11422058
申请日：2006-06-02
申请人： Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Yuh-Min Chiang , Roy H. Tan , Carol Schembri
发明人： Maengseok Song , Joon Mo Yang , Julie C. Lee , Nigel P. Beard , Yuh-Min Chiang , Roy H. Tan , Carol Schembri
IPC分类号： B01L3/02
CPC分类号： B01L3/502723 , B01L3/502746 , B01L3/502784 , B01L2200/0642 , B01L2200/0673 , B01L2200/0684 , B01L2200/16 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B01L2400/086 , C12Q1/6806 , Y10T436/2575
摘要： A microfluidic device may include a sample distribution network including a plurality of sample chambers configured to be loaded with biological sample for biological testing of the biological sample while in the sample chambers, the biological sample having a meniscus that moves within the sample chambers during loading. The sample distribution network may further include a plurality of inlet channels, each inlet channel being in flow communication with and configured to flow biological sample to a respective sample chamber, and a plurality of outlet channels, each outlet channel being in flow communication and configured to flow biological sample from a respective sample chamber. At least some of the sample chambers may include a physical modification configured to control the movement of the meniscus so as to control bubble formation within the at least some sample chambers. At least some of the sample chambers may include a dried reagent positioned within the at least some sample chambers proximate the inlet channels in flow communication with the at least some sample chambers.
摘要翻译：微流体装置可以包括样品分配网络，其包括多个样品室，其被配置为装载用于生物样品的生物样品的生物样品，而在样品室中，生物样品具有在加载期间在样品室内移动的弯液面。样品分配网络还可以包括多个入口通道，每个入口通道与生物样品流动连通并配置成将生物样品流动到相应的样品室，以及多个出口通道，每个出口通道流动连通并且被配置为从相应的样品室流动生物样品。至少一些样品室可以包括物理修改，其被配置为控制弯液面的运动，以便控制至少一些样品室内的气泡形成。至少一些样品室可以包括位于与至少一些样品室流动连通的入口通道附近的至少一些样品室内的干燥试剂。

10. 发明申请

US20070095669A1 Devices and Methods for Optoelectronic Manipulation of Small Particles 审中-公开
标题翻译：小粒子光电子操作的装置和方法
公开(公告)号：US20070095669A1
公开(公告)日：2007-05-03
申请号：US11552853
申请日：2006-10-25
申请人： Aldrich Lau , Joon Mo Yang , Huan Phan , Steven Sherwood , Hans Fuernkranz
发明人： Aldrich Lau , Joon Mo Yang , Huan Phan , Steven Sherwood , Hans Fuernkranz
IPC分类号： B03C5/02
CPC分类号： B03C5/026 , B03C5/005 , B03C5/028 , C07K1/26 , G01N27/305
摘要： A method for sorting cells in a biological sample comprising a first type of cells and a second type of cells may comprise introducing the biological sample into a chamber comprising a first surface and a second surface, wherein the first surface is associated with a transparent electrode and the second surface is associated with a photoconductive portion of an electrode. The method may further comprise moving incident light and the photoconductive portion relative to one another so as to illuminate regions of the photoconductive portion and modulate an electric field in the chamber in proximity to the illuminated regions. The method may further comprise separating the first type of cells from the second type of cells in the chamber via dielectrophoretic movement of the first type of cells and the second type of cells caused by the modulated electric field, wherein a dielectrophoretic characteristic of at least one of the first type of cells and the second type of cells has been modified.
摘要翻译：用于分选生物样品中包含第一类型细胞和第二类型细胞的细胞的方法可以包括将生物样品引入包含第一表面和第二表面的室中，其中第一表面与透明电极相关联，第二表面与电极的光电导部分相关联。该方法还可以包括相对于彼此移动入射光和光电导部分，以照射光电导部分的区域并且调制在邻近照明区域的室中的电场。该方法还可以包括通过由调制电场引起的第一类型的细胞和第二类型的细胞的介电电泳运动，将第一类型的细胞与腔室中的第二类型的细胞分离，其中至少一种的介电电泳特性的第一类型的细胞和第二类型的细胞已被修改。

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