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1. 发明申请

US20080217557A1 Method and Apparatus For Analyzing a Dynamic Sample 有权
标题翻译：用于分析动态样本的方法和装置
公开(公告)号：US20080217557A1
公开(公告)日：2008-09-11
申请号：US11718788
申请日：2005-12-21
申请人： Patrick Courtney , Robert Alan Hoult , Alistair Fitch , Steve Bush , Shab Ladha , Colin Blackmore
发明人： Patrick Courtney , Robert Alan Hoult , Alistair Fitch , Steve Bush , Shab Ladha , Colin Blackmore
IPC分类号： G01N21/64
CPC分类号： G01N33/582 , G01N21/6428 , G01N21/6456
摘要： A method of analysing a sample of biological material including components (2a to 2d) tagged with respective fluorescent labels (4a to 4d), comprises the steps of identifying a specific labelled component (2d) to be monitored, and irradiating with an energy beam at least one region (8) of the sample which substantially surrounds said specific component. The energy beam modifies the optical properties of labels in the region (8) such that they are distinguishable from the label (4d) associated with said specific component (2d). This assists the tracking of a specific component of interest as it moves through a sample. Apparatus for carrying out the method is also described.
摘要翻译：一种分析生物材料样品的方法，包括用各自的荧光标记（4 a至4 d）标记的组分（2 a至2 d），包括鉴定待监测的特定标记组分（2d）和照射具有能量束，所述能量束基本上围绕所述特定部件的样品的至少一个区域（8）。能量束修改区域（8）中的标签的光学性质，使得它们与与所述特定部件（2d）相关联的标签（4d）区分开。这有助于跟踪特定的感兴趣的组件，因为它通过一个样本。还描述了用于执行该方法的装置。

2. 发明授权

US07521696B2 Method and apparatus for analyzing a dynamic sample 有权
标题翻译：用于分析动态样本的方法和装置
公开(公告)号：US07521696B2
公开(公告)日：2009-04-21
申请号：US11718788
申请日：2005-12-21
申请人： Patrick Courtney , Robert Hoult , Alistair Fitch , Steve Bush , Shab Ladha , Colin Blackmore
发明人： Patrick Courtney , Robert Hoult , Alistair Fitch , Steve Bush , Shab Ladha , Colin Blackmore
IPC分类号： G01N21/64
CPC分类号： G01N33/582 , G01N21/6428 , G01N21/6456
摘要： A method of analysing a sample of biological material including components (2a to 2d) tagged with respective fluorescent labels (4a to 4d), comprises the steps of identifying a specific labeled component (2d) to be monitored, and irradiating with an energy beam at least one region (8) of the sample which substantially surrounds said specific component. The energy beam modifies the optical properties of labels in the region (8) such that they are distinguishable from the label (4d) associated with said specific component (2d). This assists the tracking of a specific component of interest as it moves through a sample. Apparatus for carrying out the method is also described.
摘要翻译：一种分析生物材料样品的方法，包括用各自的荧光标记（4a至4d）标记的成分（2a至2d），包括鉴定待监测的特异性标记组分（2d）和用能量束照射的步骤所述样品的至少一个区域（8）基本上围绕所述特定组分。能量束修改区域（8）中的标签的光学特性，使得它们与与所述特定部件（2d）相关联的标签（4d）区分开。这有助于跟踪特定的感兴趣的组件，因为它通过一个样本。还描述了用于执行该方法的装置。

3. 发明申请

US20080315119A1 Method of Analysing a Sample and Apparatus Therefor 有权
标题翻译：分析样品的方法及其设备
公开(公告)号：US20080315119A1
公开(公告)日：2008-12-25
申请号：US11658829
申请日：2005-08-17
申请人： Colin Blackmore , Patrick Courtney , Alistair Fitch , Shab Ladha
发明人： Colin Blackmore , Patrick Courtney , Alistair Fitch , Shab Ladha
IPC分类号： G01N21/64 , G06F19/00
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/645 , G01N33/5005 , G01N33/582 , G01N2021/6432
摘要： A method for performing photo-modification of a biological sample, the method comprising: (a) irradiating the sample; (b) detecting one or more signals based on the irradiated sample; (c) using one or more processor means to analyze the detected signals and determine one or more irradiation parameters, and, (d) returning to (a) conditioned on the irradiation parameters. Thus modifications may be determined and executed interactively as an experiment progresses, and therefore directed towards specific structures and/or events identified as of particular interest in the course of the experiment.
摘要翻译：一种用于对生物样品进行光修饰的方法，所述方法包括：（a）照射样品; （b）基于被照射样品检测一个或多个信号; （c）使用一个或多个处理器装置来分析检测到的信号并确定一个或多个照射参数，以及（d）返回（a）对照射参数进行调节。因此，随着实验的进行，可以交互地确定和执行修改，并因此针对在实验过程中特别感兴趣的特定结构和/或事件。

4. 发明授权

US07671345B2 Method of analysing a sample and apparatus therefor 有权
标题翻译：分析样品及其设备的方法
公开(公告)号：US07671345B2
公开(公告)日：2010-03-02
申请号：US11658829
申请日：2005-08-17
申请人： Colin Blackmore , Patrick Courtney , Alistair Fitch , Shab Ladha
发明人： Colin Blackmore , Patrick Courtney , Alistair Fitch , Shab Ladha
IPC分类号： G01J1/58
CPC分类号： G01N21/6458 , G01N21/6428 , G01N21/645 , G01N33/5005 , G01N33/582 , G01N2021/6432
摘要： A method for performing photo-modification of a biological sample, the method comprising: (a) irradiating the sample; (b) detecting one or more signals based on the irradiated sample; (c) using one or more processor means to analyze the detected signals and determine one or more irradiation parameters, and, (d) returning to (a) conditioned on the irradiation parameters. Thus modifications may be determined and executed interactively as an experiment progresses, and therefore directed towards specific structures and/or events identified as of particular interest in the course of the experiment.
摘要翻译：一种用于对生物样品进行光修饰的方法，所述方法包括：（a）照射样品; （b）基于被照射样品检测一个或多个信号; （c）使用一个或多个处理器装置来分析检测到的信号并确定一个或多个照射参数，以及（d）返回（a）对照射参数进行调节。因此，随着实验的进行，可以交互地确定和执行修改，并因此针对在实验过程中特别感兴趣的特定结构和/或事件。

5. 发明申请

US20090298114A1 APPARATUS AND METHODS FOR IMAGING AND MODIFICATION OF BIOLOGICAL SAMPLES 审中-公开
标题翻译：生物样品成像和修改的装置和方法
公开(公告)号：US20090298114A1
公开(公告)日：2009-12-03
申请号：US12162444
申请日：2007-02-28
申请人： Patrick Courtney , Alistair Fitch
发明人： Patrick Courtney , Alistair Fitch
IPC分类号： C12Q1/02 , C12N13/00 , C12M3/00
CPC分类号： G01N21/6458 , G01N21/6408
摘要： This invention relates to enrichment of a biological sample comprising a plurality of cells to assist further analysis thereof. It provides a technique comprising the steps of: (a) providing a sample comprising a plurality of cells which include a photosensitive compound that can be induced by light irradiation to inactivate or kill at least part of the respective cell; (b) acquiring an image of at least a portion of the sample; (c) identifying cells of interest in the sample image; (d) selecting cells other than the cells identified in step (c); and (e) irradiating only those cells selected in step (d) with a light beam so as induce the photosensitive compound therein to inactivate or kill at least part of those cells, and thereby enrich the sample with respect to the cells of interest for further analysis.
摘要翻译：本发明涉及包含多个细胞的生物样品的富集以辅助其进一步分析。它提供了一种技术，其包括以下步骤：（a）提供包含多个细胞的样品，所述细胞包括可通过光照射诱导的光敏化合物，以灭活或杀死相应细胞的至少一部分; （b）获取所述样品的至少一部分的图像; （c）识别样本图像中感兴趣的细胞; （d）选择除步骤（c）中鉴定的细胞以外的细胞; 和（e）仅用光束照射步骤（d）中选择的那些细胞，以便诱导其中的光敏化合物灭活或杀死这些细胞的至少一部分，从而使样品相对于感兴趣的细胞富集进一步分析。

6. 发明授权

US10429304B2 Apparatus and methods for imaging and modification of biological samples 有权
公开(公告)号：US10429304B2
公开(公告)日：2019-10-01
申请号：US12162444
申请日：2007-02-28
申请人： Patrick Courtney , Alistair Fitch
发明人： Patrick Courtney , Alistair Fitch
IPC分类号： C12Q1/02 , G01N21/64
摘要： This invention relates to enrichment of a biological sample comprising a plurality of cells to assist further analysis thereof. It provides a technique comprising the steps of: (a) providing a sample comprising a plurality of cells which include a photosensitive compound that can be induced by light irradiation to inactivate or kill at least part of the respective cell; (b) acquiring an image of at least a portion of the sample; (c) identifying cells of interest in the sample image; (d) selecting cells other than the cells identified in step (c); and (e) irradiating only those cells selected in step (d) with a light beam so as induce the photosensitive compound therein to inactivate or kill at least part of those cells, and thereby enrich the sample with respect to the cells of interest for further analysis.

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