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    • 3. 发明授权
    • Use of nanoparticles for labelling oil field injection waters
    • 使用纳米颗粒标记油田注射水
    • US09260957B2
    • 2016-02-16
    • US13518827
    • 2010-12-22
    • Annie CommarieuFabrice AubertinNicolas CrowtherCédric LouisPascal PerriatMatteo MartiniOlivier Tillement
    • Annie CommarieuFabrice AubertinNicolas CrowtherCédric LouisPascal PerriatMatteo MartiniOlivier Tillement
    • G01N21/64E21B47/00C09K8/03C09K8/58E21B47/10C09K11/59B82Y15/00
    • E21B47/00B82Y15/00C09K8/03C09K8/58C09K11/06C09K11/592E21B47/1015G01N21/64Y10S977/773Y10S977/902
    • The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well.The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs.This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10−7, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.
    • 本发明涉及示踪流体的开发,更一般地说,旨在在储油器中例如从注入井到生产井的压力下注入含水液体。 本发明的目的是提出一种通过所述固体介质通过扩散含有示踪剂的液体(即注射水)的固体介质,即储油器的研究的新方法,所述固体介质易于实施和经济,并且其中 弥补了油藏注射水已知示踪剂的缺点。 该方法基本上包括在该固体培养基中注入含有平均尺寸在20和200nm之间的纳米颗粒型示踪剂的注射液,其可以通过少于或等于10- 7,适于在盐水介质中形成稳定的胶体悬浮液,其至少一部分由芯和具有可调亲水亲油平衡(HLB)的涂层构成,并且包含至少一种有机和/或有机硅组分 ; 回收扩散的液体; 并且通过检测信号或信号S来分析扩散的液体以测量示踪剂的量。
    • 4. 发明申请
    • USE OF NANOPARTICLES FOR LABELLING OIL FIELD INJECTION WATERS
    • 用于标记油田注射水的纳米颗粒的使用
    • US20130084643A1
    • 2013-04-04
    • US13518827
    • 2010-12-22
    • Annie CommarieuFabrice AubertinNicolas CrowtherCédric LouisPascal PerriatMatteo MartiniOlivier Tillement
    • Annie CommarieuFabrice AubertinNicolas CrowtherCédric LouisPascal PerriatMatteo MartiniOlivier Tillement
    • E21B47/00G01N21/64C09K11/59
    • E21B47/00B82Y15/00C09K8/03C09K8/58C09K11/06C09K11/592E21B47/1015G01N21/64Y10S977/773Y10S977/902
    • The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well.The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs.This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10−7, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.
    • 本发明涉及示踪流体的开发,更一般地说,旨在在储油器中例如从注入井到生产井的压力下注入含水液体。 本发明的目的是提出一种通过所述固体介质通过扩散含有示踪剂的液体(即注射水)的固体介质,即储油器的研究的新方法,所述固体介质易于实施和经济,并且其中 弥补了油藏注射水已知示踪剂的缺点。 该方法基本上包括在该固体培养基中注入含有平均尺寸在20和200nm之间的纳米颗粒型示踪剂的注射液,其可以通过少于或等于10- 7,适于在盐水介质中形成稳定的胶体悬浮液,其至少一部分由芯和具有可调亲水亲油平衡(HLB)的涂层构成,并且包含至少一种有机和/或有机硅组分 ; 回收扩散的液体; 并且通过检测信号或信号S来分析扩散的液体来测量示踪剂的量。
    • 5. 发明申请
    • ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES; METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY
    • 包含官能化聚硅氧烷基质并包括金属络合物的超纳米纳米粒子; 用于获得其的方法及其在医学成像和/或治疗中的用途
    • US20130195766A1
    • 2013-08-01
    • US13695090
    • 2011-05-02
    • François LuxOlivier TillementMaxime Saint JeanPierre MowatPascal PerriatStéphane RouxAnna Mignot
    • François LuxOlivier TillementMaxime Saint JeanPierre MowatPascal PerriatStéphane RouxAnna Mignot
    • A61K49/18A61K9/14
    • The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein).The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.
    • 本发明涉及非常小尺寸的新型生物相容性杂合纳米粒子,特别适用于诊断和/或治疗。 本发明的目的是提供新颖的纳米颗粒,其特别用作成像(例如MRI)和/或其它诊断技术和/或作为治疗剂的造影剂,其比具有相同类型的已知纳米颗粒更好的性能 并且其结合了小尺寸(例如小于20nm)和高负载金属(例如稀土),特别是在成像(例如MRI)中,具有强烈的强化和正确的响应(增加的弛豫性 )在高频率。 因此,直径d1在1和20nm之间的根据本发明的纳米颗粒各自包含聚有机硅氧烷(POS)基质,其包含任选与掺杂阳离子相关的钆阳离子; 通过-Si-C-共价键与POS基质结合的螯合接枝C1DTPABA(二亚乙基三胺五乙酸双酐),并且以足够的量存在以能够使所有的钆阳离子复合; 和任选的通过-Si-C-共价键(其中Gf *可以衍生自亲水性化合物(PEG))与POS基质结合的另一个官能化移植物Gf *;具有活性成分PA1的化合物;来自靶向化合物; 来自发光化合物(荧光素)的方法。用于制备这些纳米颗粒的方法及其在成像和治疗中的应用也构成本发明的一部分。