专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20070281324A1 Hybrid Nanoparticles With Ln2O3 Core and Carrying Biological Ligands, and Method of Preparation Thereof 有权
标题翻译：具有Ln2O3核心和携带生物配体的混合纳米粒子及其制备方法
公开(公告)号：US20070281324A1
公开(公告)日：2007-12-06
申请号：US10591465
申请日：2005-03-02
申请人： Pascal Perriat , Cedric Louis , Christophe Marquette , Rana Bazzi , Stephane Roux , Olivier Tillement , Gilles Ledoux
发明人： Pascal Perriat , Cedric Louis , Christophe Marquette , Rana Bazzi , Stephane Roux , Olivier Tillement , Gilles Ledoux
IPC分类号： G01N33/58 , G01N33/52 , G01N33/533 , G01N33/553
CPC分类号： G01N33/54346 , A61K41/009 , A61K49/0002 , A61K49/0093 , A61K49/1848 , A61K49/1857 , B82Y5/00 , B82Y30/00 , C01F17/0043 , C01P2002/52 , C01P2004/64 , G01N33/54353
摘要： The invention concerns hybrid nanoparticles containing: a nanosphere, of mean diameter included in the range from 2 to 9 nm, of which at least 90% by weight consists of Ln2O3 where Ln represents a rare earth, optionally doped with a rare earth or an actinide, or a mixture of rare earths, or a rare earth and actinide mixture, in which at least 50% of the metal ions are rare earth ions, a coating around the nanosphere chiefly consisting of functionalized polysiloxane, having a mean thickness included in the range from 0.5 to 10 nm, preferably greater than 2 nm and no more than 10 nm, and at least one biological ligand grafted by covalent bonding to the polysiloxane coating and their method of preparation.
摘要翻译：本发明涉及包含纳米球的混合纳米颗粒，其平均直径包括在2至9nm的范围内，其中至少90重量％由Ln 2 O 3 3 / >其中Ln表示稀土，任选地掺杂有稀土或锕系元素，稀土或稀土和锕系混合物的混合物，其中至少50％的金属离子是稀土离子，涂层围绕主要由官能化聚硅氧烷组成的纳米球，其平均厚度包括在0.5至10nm，优选大于2nm且不大于10nm的范围内，以及至少一种通过共价键接枝至聚硅氧烷涂层的生物配体，以及他们的准备方法。

2. 发明授权

US08357545B2 Hybrid nanoparticles with Ln2O3 core and carrying biological ligands, and method of preparation thereof 有权
标题翻译：具有Ln2O3核心并携带生物配体的杂交纳米颗粒及其制备方法
公开(公告)号：US08357545B2
公开(公告)日：2013-01-22
申请号：US10591465
申请日：2005-03-02
申请人： Pascal Perriat , Cédric Louis , Christophe Marquette , Rana Bazzi , Stéphane Roux , Olivier Tillement , Gilles Ledoux
发明人： Pascal Perriat , Cédric Louis , Christophe Marquette , Rana Bazzi , Stéphane Roux , Olivier Tillement , Gilles Ledoux
IPC分类号： G01N33/553
CPC分类号： G01N33/54346 , A61K41/009 , A61K49/0002 , A61K49/0093 , A61K49/1848 , A61K49/1857 , B82Y5/00 , B82Y30/00 , C01F17/0043 , C01P2002/52 , C01P2004/64 , G01N33/54353
摘要： The invention concerns hybrid nanoparticles containing: a nanosphere, of mean diameter included in the range from 2 to 9 nm, of which at least 90% by weight consists of Ln2O3 where Ln represents a rare earth, optionally doped with a rare earth or an actinide, or a mixture of rare earths, or a rare earth and actinide mixture, in which at least 50% of the metal ions are rare earth ions, a coating around the nanosphere chiefly consisting of functionalized polysiloxane, having a mean thickness included in the range from 0.5 to 10 nm, preferably greater than 2 nm and no more than 10 nm, and at least one biological ligand grafted by covalent bonding to the polysiloxane coating and their method of preparation.
摘要翻译：本发明涉及包含纳米球的混合纳米颗粒，其平均直径包括在2至9nm的范围内，其中至少90重量％由Ln 2 O 3组成，其中Ln表示稀土，任选地掺杂有稀土或锕系元素，或稀土或稀土和锕系混合物的混合物，其中至少50％的金属离子是稀土离子，主要由官能化聚硅氧烷组成的纳米球周围的涂层，其平均厚度包括在该范围内 0.5至10nm，优选大于2nm且不超过10nm，以及至少一种通过与聚硅氧烷涂层共价键接枝的生物配体及其制备方法。

3. 发明申请

US20070275383A1 Novel Hybrid Probes with Heightened Luminescence 审中-公开
标题翻译：具有增加发光的新型混合探针
公开(公告)号：US20070275383A1
公开(公告)日：2007-11-29
申请号：US10581052
申请日：2004-11-26
申请人： Francis Vocanson , Roger Lamartine , Pierre Debouttiere , Christophe Marquette , Loic Blum , Stephane Roux , Olivier Tillement , Pascal Perriat
发明人： Francis Vocanson , Roger Lamartine , Pierre Debouttiere , Christophe Marquette , Loic Blum , Stephane Roux , Olivier Tillement , Pascal Perriat
IPC分类号： C12Q1/68 , C12Q1/00 , G01N33/53
CPC分类号： G01N33/54346 , B01J13/0043 , B82Y5/00 , C12Q1/6816 , C12Q2563/155
摘要： Hybrid probe particles comprising a nanoparticle of gold of diameter in the range extending from 2 to 30 nm on the surface of which, on the one hand, at least one, and preferably from one to 100, organic probe molecules are grafted by gold-sulphur bonds and on the other hand, at least 10, and preferably 10 to 10000, molecules with luminescent activity, as well as their preparation process.
摘要翻译：包含直径在2至30nm范围内的金的纳米颗粒的混合探针颗粒表面上，一方面至少一个，优选1至100个有机探针分子由金 - 硫接枝另一方面，具有至少10个，优选10到10000个具有发光活性的分子，以及它们的制备方法。

4. 发明授权

US09260957B2 Use of nanoparticles for labelling oil field injection waters 有权
标题翻译：使用纳米颗粒标记油田注射水
公开(公告)号：US09260957B2
公开(公告)日：2016-02-16
申请号：US13518827
申请日：2010-12-22
申请人： Annie Commarieu , Fabrice Aubertin , Nicolas Crowther , Cédric Louis , Pascal Perriat , Matteo Martini , Olivier Tillement
发明人： Annie Commarieu , Fabrice Aubertin , Nicolas Crowther , Cédric Louis , Pascal Perriat , Matteo Martini , Olivier Tillement
IPC分类号： G01N21/64 , E21B47/00 , C09K8/03 , C09K8/58 , E21B47/10 , C09K11/59 , B82Y15/00
CPC分类号： E21B47/00 , B82Y15/00 , C09K8/03 , C09K8/58 , C09K11/06 , C09K11/592 , E21B47/1015 , G01N21/64 , Y10S977/773 , Y10S977/902
摘要： The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well.The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs.This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10−7, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.
摘要翻译：本发明涉及示踪流体的开发，更一般地说，旨在在储油器中例如从注入井到生产井的压力下注入含水液体。本发明的目的是提出一种通过所述固体介质通过扩散含有示踪剂的液体（即注射水）的固体介质，即储油器的研究的新方法，所述固体介质易于实施和经济，并且其中弥补了油藏注射水已知示踪剂的缺点。该方法基本上包括在该固体培养基中注入含有平均尺寸在20和200nm之间的纳米颗粒型示踪剂的注射液，其可以通过少于或等于10- 7，适于在盐水介质中形成稳定的胶体悬浮液，其至少一部分由芯和具有可调亲水亲油平衡（HLB）的涂层构成，并且包含至少一种有机和/或有机硅组分 ; 回收扩散的液体; 并且通过检测信号或信号S来分析扩散的液体以测量示踪剂的量。

5. 发明申请

US20130195766A1 ULTRAFINE NANOPARTICLES COMPRISING A FUNCTIONALIZED POLYORGANOSILOXANE MATRIX AND INCLUDING METAL COMPLEXES; METHOD FOR OBTAINING SAME AND USES THEREOF IN MEDICAL IMAGING AND/OR THERAPY 审中-公开
标题翻译：包含官能化聚硅氧烷基质并包括金属络合物的超纳米纳米粒子; 用于获得其的方法及其在医学成像和/或治疗中的用途
公开(公告)号：US20130195766A1
公开(公告)日：2013-08-01
申请号：US13695090
申请日：2011-05-02
申请人： François Lux , Olivier Tillement , Maxime Saint Jean , Pierre Mowat , Pascal Perriat , Stéphane Roux , Anna Mignot
发明人： François Lux , Olivier Tillement , Maxime Saint Jean , Pierre Mowat , Pascal Perriat , Stéphane Roux , Anna Mignot
IPC分类号： A61K49/18 , A61K9/14
摘要： The invention relates to novel biocompatible hybrid nanoparticles of very small size, useful in particular for diagnostics and/or therapy.The purpose of the invention is to offer novel nanoparticles which are useful in particular as contrast agents in imaging (e.g. MRI) and/or in other diagnostic techniques and/or as therapeutic agents, which give better performance than the known nanoparticles of the same type and which combine both a small size (for example less than 20 nm) and a high loading with metals (e.g. rare earths), in particular so as to have, in imaging (e.g. MRI), strong intensification and a correct response (increased relaxivity) at high frequencies.Thus, the nanoparticles according to the invention, with diameter d1 between 1 and 20 nm, each comprise a polyorganosiloxane (POS) matrix including gadolinium cations optionally associated with doping cations; a chelating graft C1 DTPABA (diethylenetriaminepentaacetic acid bisanhydride) bound to the POS matrix by an —Si—C— covalent bond, and present in sufficient quantity to be able to complex all the gadolinium cations; and optionally another functionalizing graft Gf* bound to the POS matrix by an —Si—C— covalent bond (where Gf* can be derived from a hydrophilic compound (PEG); from a compound having an active ingredient PA1; from a targeting compound; from a luminescent compound (fluorescein).The method for the production of these nanoparticles and the applications thereof in imaging and in therapy also form part of the invention.
摘要翻译：本发明涉及非常小尺寸的新型生物相容性杂合纳米粒子，特别适用于诊断和/或治疗。本发明的目的是提供新颖的纳米颗粒，其特别用作成像（例如MRI）和/或其它诊断技术和/或作为治疗剂的造影剂，其比具有相同类型的已知纳米颗粒更好的性能并且其结合了小尺寸（例如小于20nm）和高负载金属（例如稀土），特别是在成像（例如MRI）中，具有强烈的强化和正确的响应（增加的弛豫性）在高频率。因此，直径d1在1和20nm之间的根据本发明的纳米颗粒各自包含聚有机硅氧烷（POS）基质，其包含任选与掺杂阳离子相关的钆阳离子; 通过-Si-C-共价键与POS基质结合的螯合接枝C1DTPABA（二亚乙基三胺五乙酸双酐），并且以足够的量存在以能够使所有的钆阳离子复合; 和任选的通过-Si-C-共价键（其中Gf *可以衍生自亲水性化合物（PEG））与POS基质结合的另一个官能化移植物Gf *;具有活性成分PA1的化合物;来自靶向化合物; 来自发光化合物（荧光素）的方法。用于制备这些纳米颗粒的方法及其在成像和治疗中的应用也构成本发明的一部分。

6. 发明申请

US20140323363A1 NANOTRACERS FOR LABELING OIL FIELD INJECTION WATERS 审中-公开
标题翻译：用于标记油田注射水的纳米加工器
公开(公告)号：US20140323363A1
公开(公告)日：2014-10-30
申请号：US14128194
申请日：2012-06-22
申请人： Pascal Perriat , Nicolas Crowther , Matteo Martini , Olivier Tillement , Thomas Brichart , Nicolas Agenet
发明人： Pascal Perriat , Nicolas Crowther , Matteo Martini , Olivier Tillement , Thomas Brichart , Nicolas Agenet
IPC分类号： C09K8/588
CPC分类号： C09K8/588 , B01J13/0039 , B01J13/0043 , B01J13/18 , B82Y30/00 , B82Y40/00 , E21B47/1015
摘要： This invention relates to the development of nanoparticles, which can be used as tracers, in order to track the movement of fluids injected into an oil reservoir. The injected fluids diffuse through a solid geological medium which constitutes the oil reservoir, thus making it possible to study this latter by following the path of the injected fluids. The objective is in particular to monitor the flows between the injection well(s) and the production well(s) and/or to evaluate the volumes of oil in reserve and water in the reservoir and ultimately to optimize oil exploration and exploitation.
摘要翻译：本发明涉及可以用作示踪剂的纳米颗粒的开发，以便跟踪注入油藏的流体的运动。注入的流体通过构成储油器的固体地质介质扩散，从而可以通过遵循注入流体的路径来研究后者。目的是监测注入井和生产井之间的流量和/或评估储层中储备油和水中的油量，最终优化石油勘探开采。

7. 发明申请

US20150001385A1 MEMORY EFFECT TRACER FLUIDS FOR THE STUDY OF AN OIL RESERVOIR 审中-公开
标题翻译：用于研究油储层的记忆效应追踪器流体
公开(公告)号：US20150001385A1
公开(公告)日：2015-01-01
申请号：US14128323
申请日：2012-06-22
申请人： Pascal Perriat , Nicolas Crowther , Matteo Martini , Olivier Tillement , Thomas Brichart , Nicolas Agenet
发明人： Pascal Perriat , Nicolas Crowther , Matteo Martini , Olivier Tillement , Thomas Brichart , Nicolas Agenet
IPC分类号： G01V8/02 , G01N21/64
CPC分类号： G01V8/02 , C09K8/58 , C09K8/70 , E21B47/1015 , E21B49/00 , E21B49/008 , G01N21/64 , G01N2021/6497
摘要： The fluid tracers according to the invention have the advantage of producing a memory effect fluorescent signal, that is to say a signal modified as a function of the physico-chemical conditions encountered in the medium through which the nanoparticles pass after injection into the geological underground area. The analysis of fluorescent signals in the fluids collected after diffusion makes it possible to deduce therefrom information on the characteristics of the oil reservoir.
摘要翻译：根据本发明的流体示踪剂具有产生记忆效应荧光信号的优点，也就是说，根据在注入地质地下区域之后纳米粒子经过的介质中遇到的物理化学条件而改变的信号。在扩散后收集的流体中的荧光信号的分析使得可以从其中推导出油藏特征的信息。

8. 发明申请

US20130084643A1 USE OF NANOPARTICLES FOR LABELLING OIL FIELD INJECTION WATERS 有权
标题翻译：用于标记油田注射水的纳米颗粒的使用
公开(公告)号：US20130084643A1
公开(公告)日：2013-04-04
申请号：US13518827
申请日：2010-12-22
申请人： Annie Commarieu , Fabrice Aubertin , Nicolas Crowther , Cédric Louis , Pascal Perriat , Matteo Martini , Olivier Tillement
发明人： Annie Commarieu , Fabrice Aubertin , Nicolas Crowther , Cédric Louis , Pascal Perriat , Matteo Martini , Olivier Tillement
IPC分类号： E21B47/00 , G01N21/64 , C09K11/59
CPC分类号： E21B47/00 , B82Y15/00 , C09K8/03 , C09K8/58 , C09K11/06 , C09K11/592 , E21B47/1015 , G01N21/64 , Y10S977/773 , Y10S977/902
摘要： The present invention relates to the development of tracer fluids, more generally, that of aqueous liquids, intended to be injected under pressure in an oil reservoir, for example from an injection well up to a production well.The object of the invention is to propose a new method of study of a solid medium, i.e. an oil reservoir, by diffusion of a liquid (i.e. injection waters) containing tracers, through said solid medium, which is simple to implement and economical and which remedies the drawbacks of the known tracers for injection waters of oil reservoirs.This method essentially consisting of injecting, in this solid medium, an injection liquid comprising a nanoparticle-based tracer having average dimensions comprised between 20 and 200 nm, detectable by means of one or several S signals at dilutions of less than or equal to 10−7, adapted to form a stable colloidal suspension in a saline medium, at least a portion of which is constituted of a core and a coating provided with an adjustable hydrophilic-lipophilic balance (HLB) and comprising at least one organic and/or organosilicon component; recovering the liquid having diffused; and analyzing this liquid having diffused to measure the quantity of tracer by detection of the signal or signals S.
摘要翻译：本发明涉及示踪流体的开发，更一般地说，旨在在储油器中例如从注入井到生产井的压力下注入含水液体。本发明的目的是提出一种通过所述固体介质通过扩散含有示踪剂的液体（即注射水）的固体介质，即储油器的研究的新方法，所述固体介质易于实施和经济，并且其中弥补了油藏注射水已知示踪剂的缺点。该方法基本上包括在该固体培养基中注入含有平均尺寸在20和200nm之间的纳米颗粒型示踪剂的注射液，其可以通过少于或等于10- 7，适于在盐水介质中形成稳定的胶体悬浮液，其至少一部分由芯和具有可调亲水亲油平衡（HLB）的涂层构成，并且包含至少一种有机和/或有机硅组分 ; 回收扩散的液体; 并且通过检测信号或信号S来分析扩散的液体来测量示踪剂的量。

9. 发明申请

US20110027375A1 USE OF LANTHANIDE-BASED NANOPARTICLES AS RADIOSENSITIZING AGENTS 审中-公开
标题翻译：使用作为放射增敏剂的基于兰氢化合物的纳米粒子
公开(公告)号：US20110027375A1
公开(公告)日：2011-02-03
申请号：US12738191
申请日：2008-10-14
申请人： Olivier Tillement , Stéphane Roux , Pascal Perriat , Géraldine Leduc , Céline Mandon , Brice Mutelet , Christophe Alric , Claire Billotey , Marc Janier , Cédric Louis
发明人： Olivier Tillement , Stéphane Roux , Pascal Perriat , Géraldine Leduc , Céline Mandon , Brice Mutelet , Christophe Alric , Claire Billotey , Marc Janier , Cédric Louis
IPC分类号： A61K9/14 , A61K33/24 , A61P35/00
CPC分类号： A61K41/0038 , A61K9/0019
摘要： The invention relates to the use of nanoparticles with dimensions comprised between 1 and 50 nm, at least one portion of which consists of at least one oxide and/or one oxohydroxide of at least one lanthanide, said nanoparticles: either consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide, or in the form of nanoparticles comprising a core consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide, and a coating consisting of polysiloxane, with possibly organic molecules grafted at the surface or comprised inside it, as a radio-sensitizing agent in the making of an injectable composition intended to improve the efficiency of the treatment of a tumor by X or gamma irradiations. It also relates to nanoparticles particularly suitable for the use above, consisting of a core consisting of at least one oxide and/or one oxohydroxide of at least one lanthanide and of a coating in polysiloxane comprising 1 to 5 silicon atoms per lanthanide and at least 10% of the silicon atoms of which are bound to hydrophilic organic molecules with molar masses of less than 450 g/mol.
摘要翻译：本发明涉及使用尺寸为1至50nm的纳米颗粒，其至少一部分由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物组成，所述纳米颗粒由至少一种氧化物或至少一种镧系元素的一种氧代氢氧化物，或纳米颗粒的形式，其包含由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物构成的核心，以及由聚硅氧烷组成的涂层，可能的有机分子被接枝在表面或其内部，作为用于通过X或γ照射提高肿瘤治疗效率的可注射组合物的放射性增感剂。它还涉及特别适合于上述用途的纳米颗粒，其由至少一种镧系元素的至少一种氧化物和/或一种氧代氢氧化物和每镧系元素含有1至5个硅原子的聚硅氧烷中的涂层和至少10个其硅原子的％与摩尔质量小于450g / mol的亲水性有机分子结合。

10. 发明授权

US06670515B1 Material constituted by ultrafine metallic and oxide particles 失效
标题翻译：材料由超细金属和氧化物颗粒构成
公开(公告)号：US06670515B1
公开(公告)日：2003-12-30
申请号：US09807927
申请日：2001-08-16
申请人： Jean-Marie Dubois , Yves Fort , Olivier Tillement
发明人： Jean-Marie Dubois , Yves Fort , Olivier Tillement
IPC分类号： C07C510
CPC分类号： B01J37/031 , B01J35/0013
摘要： A material composed of ultrafine particles, comprising at least a metal element M having catalytic properties and at least a metal element M′ having a standard oxidation potential less than that of M, part at least of M′ atoms being in oxidized form, the average size of the particles being less than 50 nm, at least 80% in number of the particles having an average size less than 10 nm. One particle of the material is constituted by at least a metal element M with oxidation level 0, or by at least a metal element M′ in oxidized form, or by at least a metal element M′ with oxidation level 0, or by the combination of at least two species selected from the three previous species. The material is useful as a catalyst for hydrogenation or coupling reactions.
摘要翻译：由超细颗粒组成的材料至少包含具有催化性能的金属元素M和至少具有小于M的标准氧化电位的金属元素M'，至少M'原子部分为氧化形式，平均值颗粒尺寸小于50nm，平均尺寸小于10nm的颗粒数至少为80％。该材料的一个颗粒由至少具有氧化水平为0的金属元素M或至少一种氧化形式的金属元素M'或至少具有氧化水平为0的金属元素M'或由组合至少有两种物种选自三种以前的物种。该材料可用作氢化或偶联反应的催化剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式