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1. 发明授权

US08530679B2 Delta 9—tetrahydrocannabinol processing 有权
标题翻译：三角洲9-四氢大麻酚加工
公开(公告)号：US08530679B2
公开(公告)日：2013-09-10
申请号：US12528077
申请日：2008-02-19
申请人： Parveen Bhatarah , Alan Kenneth Greenwood , Derek McHattie , Jerome Thomas Garfield Carr-Brion
发明人： Parveen Bhatarah , Alan Kenneth Greenwood , Derek McHattie , Jerome Thomas Garfield Carr-Brion
IPC分类号： C07D311/80 , C07D311/82 , B01D11/00 , B01D3/24 , B01D15/00
CPC分类号： A61K9/08 , A61K9/1688 , A61K31/353 , A61K47/02 , A61K47/06 , A61K47/08
摘要： The present invention provides a process for handling Δ9-THC, which comprises preparing a solution of Δ9-THC in a solvent which exists as a gas at room temperature and atmospheric pressure. The invention also provides solutions of Δ9-THC in the solvent and solid preparations of Δ9-THC.
摘要翻译：本发明提供了一种处理Delta9-THC的方法，其包括在室温和大气压下作为气体存在的溶剂中制备Delta9-THC溶液。本发明还提供Delta9-THC在Delta9-THC溶剂和固体制剂中的溶液。

2. 发明申请

US20110171300A1 DELTA 9 TETRAHYDROCANNABINOL DERIVATIVES 审中-公开
标题翻译： DELTA 9四氯氰菊酯衍生物
公开(公告)号：US20110171300A1
公开(公告)日：2011-07-14
申请号：US12527183
申请日：2008-02-14
申请人： Parveen Bhatarah , Kevin John Batchelor , Derek Mchattie , Alan Kenneth Greenwood
发明人： Parveen Bhatarah , Kevin John Batchelor , Derek Mchattie , Alan Kenneth Greenwood
IPC分类号： A61K9/64 , C07D311/80 , A61K31/353 , A61P1/08
CPC分类号： C07D311/80
摘要： A compound of formula (I) wherein R is selected from (i) a 5 to 7 membered heterocyclic ring containing 1 to 3 heteroatoms independently selected from nitrogen, oxygen and sulfur, which is optionally substituted by one or more groups independently selected from halo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl; (ii) (C1-C6)alkyl, which is optionally substituted by one or more substituents each independently selected from halo, oxo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl; (iii) (C1-C6)alkyl substituted by (C3-C13)cycloalkyl, which is optionally substituted by one or more substituents each independently selected from halo, oxo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl; and (iv) (C3-C13)cycloalkyl, which is optionally substituted by one or more substituents each independently selected from halo, oxo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl.
摘要翻译：式（I）化合物，其中R选自（i）含有1至3个独立地选自氮，氧和硫的杂原子的5至7元杂环，其任选被一个或多个独立地选自以下的基团取代：卤素， CN，NO 2，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基和苯基; （C 1 -C 6）烷基，（C 1 -C 6）烷基，其任选被一个或多个各自独立地选自卤素，氧代，CN，NO 2，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基和苯基的取代基取代; （C 3 -C 13）环烷基取代的（C 3 -C 13）烷基，其任选被一个或多个独立地选自卤素，氧代，CN，NO 2，（C 1 -C 6）烷基，（C 1 -C 6））烷氧基和苯基; 任选被一个或多个独立地选自卤素，氧代，CN，NO 2，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基和苯基的取代基取代的（ⅳ）（C 3 -C 13）环烷基。

3. 发明申请

US20110046213A1 Production of Delta 9 Tetrahydrocannabinol 审中-公开
标题翻译： Delta 9四氢大麻酚的生产
公开(公告)号：US20110046213A1
公开(公告)日：2011-02-24
申请号：US12990387
申请日：2009-05-01
申请人： Parveen Bhatarah , Derek McHattie , Alan Kenneth Greenwood
发明人： Parveen Bhatarah , Derek McHattie , Alan Kenneth Greenwood
IPC分类号： A61K31/352 , C07D311/80 , A61P25/00 , A61P1/08
CPC分类号： C07D311/80
摘要： Δ9 THC is obtained by extracting Δ9 THC and Δ9 THC carboxylic acid from plant material using a non-polar solvent and decarboxylating the Δ9 THC acid into Δ9 THC in the same solvent, without a solvent swap, in the presence of aqueous base. The Δ9 THC is then washed to remove inorganic impurities, still in the same original solvent.
摘要翻译：＆Dgr; 9 THC通过使用非极性溶剂从植物材料中提取＆Dgr; 9 THC和＆Dgr; 9 THC羧酸并在相同溶剂中将Dgr; 9 THC酸脱羧成Dgr; 9 THC，而无需溶剂交换在碱水溶液存在下进行。然后洗涤＆Dgr; 9 THC以除去仍然在相同的原始溶剂中的无机杂质。

4. 发明申请

US20100087518A1 DELTA 9 - TETRAHYDROCANNABINOL PROCESSING 有权
标题翻译： DELTA 9 - 四氢胞嘧啶加工
公开(公告)号：US20100087518A1
公开(公告)日：2010-04-08
申请号：US12528077
申请日：2008-02-19
申请人： Parveen Bhatarah , Alan Kenneth Greenwood , Derek Mchattie , Jerome Thomas Garfield Carr-Brion
发明人： Parveen Bhatarah , Alan Kenneth Greenwood , Derek Mchattie , Jerome Thomas Garfield Carr-Brion
IPC分类号： A61K31/352 , C07D311/80 , A61P25/00
CPC分类号： A61K9/08 , A61K9/1688 , A61K31/353 , A61K47/02 , A61K47/06 , A61K47/08
摘要： The present invention provides a process for handling Δ9-THC, which comprises preparing a solution of Δ9-THC in a solvent which exists as a gas at room temperature and atmospheric pressure. The invention also provides solutions of Δ9-THC in the solvent and solid preparations of Δ9-THC.
摘要翻译：本发明提供了一种处理D-9-THC的方法，其包括在室温和大气压下作为气体存在的溶剂中制备＆Dgr.9-THC的溶液。本发明还提供了在D-9-THC的溶剂和固体制剂中的＆Dgr。9-THC的溶液。

5. 发明授权

US07339060B2 Preparation of cabergoline 失效
标题翻译：卡麦角林的制备
公开(公告)号：US07339060B2
公开(公告)日：2008-03-04
申请号：US11268118
申请日：2005-11-07
申请人： Alan Kenneth Greenwood , Derek McHattie , Parveen Bhatarah , Mahmoud Aloui
发明人： Alan Kenneth Greenwood , Derek McHattie , Parveen Bhatarah , Mahmoud Aloui
IPC分类号： C07D457/04 , C07D457/02
CPC分类号： C07D457/06
摘要： A method of preparing cabergoline Form I, comprising forming a solvate including cabergoline and a p-disubstituted benzene of formula (A) or 1,3,5-trimethylbenzene and obtaining cabergoline Form I from the solvate. Another aspect of the present invention provides a method for preparing cabergoline Form I comprising dissolving cabergoline in p-disubstituted benzene or 1,3,5-trimethylbenzene and recovering the cabergoline Form I polymorph, suitably by direct crystallization of Form I or by recovery of a solvate which can be converted to Form I. Another aspect of the present invention provides a novel cabergoline polymorph designated cabergoline Form FB and a method of preparing said polymorph by dissolving or forming a solvate of cabergoline in fluorobenzene and recovering cabergoline Form FB.
摘要翻译：制备卡麦角林型I的方法，包括形成包含卡麦角林和式（A）的对二取代的苯或1,3,5-三甲基苯的溶剂合物，并从溶剂合物中获得卡麦角林I型。本发明的另一方面提供了一种制备卡麦角林型I的方法，其包括将卡麦角林溶解在对二取代的苯或1,3,5-三甲基苯中，并适当地通过形式I的直接结晶或通过回收本发明的另一方面提供了一种新颖的卡麦角林多晶型物，称为卡麦角林型F B B，以及通过溶解或形成卡麦角林溶剂化物在氟苯中制备所述多晶型物的方法，以及恢复卡麦角林F型B。

6. 发明申请

US20100197646A1 SOLVENT-BASED STERILISATION OF PHARMACEUTICALS 审中-公开
标题翻译：基于溶剂的药物灭菌
公开(公告)号：US20100197646A1
公开(公告)日：2010-08-05
申请号：US12759483
申请日：2010-04-13
申请人： Parveen Bhatarah , Alan Kenneth Greenwood
发明人： Parveen Bhatarah , Alan Kenneth Greenwood
IPC分类号： A61K31/58 , C07J71/00 , A61P11/06
CPC分类号： A61K9/0078 , A61K9/14 , A61L2/0011 , A61L2/0017 , A61L2/0088 , Y10T428/2982
摘要： A sterile composition of a pharmaceutical compound is prepared by combining solvent with a non-sterile pharmaceutical compound to form a solution and filtering to yield a sterile pharmaceutical compound, optionally removing all or part of the solvent, and under sterile conditions combining the compound with a pharmaceutically acceptable carrier.
摘要翻译：通过将溶剂与非无菌药物化合物结合以形成溶液并过滤以产生无菌药物化合物，任选地除去全部或部分溶剂，并在无菌条件下将化合物与药学上可接受的载体。

7. 发明授权

US07524881B2 Production of Δ 9 tetrahydrocannabinol 有权
标题翻译：生产Delta 9四氢大麻酚
公开(公告)号：US07524881B2
公开(公告)日：2009-04-28
申请号：US10503082
申请日：2003-02-03
申请人： Neil John Goodwin , Nicolas James Archer , Christopher Murray , Alan Kenneth Greenwood , Derek Mchattie
发明人： Neil John Goodwin , Nicolas James Archer , Christopher Murray , Alan Kenneth Greenwood , Derek Mchattie
IPC分类号： A61K31/352 , C07D311/72
CPC分类号： C07D311/80 , A61K36/00 , A61K36/185 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , A61K2300/00
摘要： Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is then converted to Δ9 THC which is further purified and combined with a carrier for pharmaceutical use.
摘要翻译： Delta9 THC酸从植物材料获得，并在pH控制条件下萃取到含水溶剂中。将酸转化成盐，将盐萃取到极性溶剂中，产生高纯度的酸。然后将Delta9 THC酸转化成Delta9 THC，进一步纯化并与用于药物用途的载体组合。

8. 发明申请

US20090253783A1 Production of Delta 9 Tetrahydrocannabinol 审中-公开
标题翻译： Delta 9四氢大麻酚的生产
公开(公告)号：US20090253783A1
公开(公告)日：2009-10-08
申请号：US12487185
申请日：2009-06-18
申请人： Neil John Goodwin , Nicolas James Archer , Christopher Murray , Alan Kenneth Greenwood , Derek Mchattie
发明人： Neil John Goodwin , Nicolas James Archer , Christopher Murray , Alan Kenneth Greenwood , Derek Mchattie
IPC分类号： A61K31/352 , C07D311/82 , A61P25/22
CPC分类号： C07D311/80 , A61K36/00 , A61K36/185 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , A61K2300/00
摘要： The present invention provides isolated, purified Δ9 THC. In another embodiment, the invention provides pharmaceutical compositions comprising isolated, purified Δ9 THC and a pharmaceutically acceptable carrier. In another embodiment, the invention provides methods of preparing pharmaceutical compositions comprising isolated, purified Δ9 THC and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供了分离的纯化的Delta9 THC。在另一个实施方案中，本发明提供包含分离的纯化的Delta9THC和药学上可接受的载体的药物组合物。在另一个实施方案中，本发明提供了制备包含分离的纯化的Delta9THC和药学上可接受的载体的药物组合物的方法。

9. 发明授权

US07498458B2 Process for the preparation of prostaglandins and analogues thereof 失效
标题翻译：制备前列腺素及其类似物的方法
公开(公告)号：US07498458B2
公开(公告)日：2009-03-03
申请号：US11189985
申请日：2005-07-27
申请人： Alan Kenneth Greenwood , Derek McHattie , David George Thompson , Derek Clissold
发明人： Alan Kenneth Greenwood , Derek McHattie , David George Thompson , Derek Clissold
IPC分类号： C07C69/74
CPC分类号： C08F295/00 , C07C405/00 , C07D307/935 , C07F7/1804 , C07F7/1892
摘要： Disclosed are processes for the synthesis and purification of prostaglandins and analogues thereof, especially analogues of PGF2α.
摘要翻译：公开了前列腺素及其类似物，特别是PGF2α的类似物的合成和纯化的方法。

10. 发明授权

US07268239B2 Process for the preparation of prostaglandins and analogues thereof 有权
标题翻译：制备前列腺素及其类似物的方法
公开(公告)号：US07268239B2
公开(公告)日：2007-09-11
申请号：US11189986
申请日：2005-07-27
申请人： Alan Kenneth Greenwood , Derek McHattie , David George Thompson , Derek Clissold
发明人： Alan Kenneth Greenwood , Derek McHattie , David George Thompson , Derek Clissold
IPC分类号： C07D307/935
CPC分类号： C08F295/00 , C07C405/00 , C07D307/935 , C07F7/1804 , C07F7/1892
摘要： Disclosed are processes for the synthesis and purification of prostaglandins and analogues thereof, especially analogues of PGF2α.
摘要翻译：公开了前列腺素及其类似物的合成和纯化的方法，特别是PGF2α的类似物。

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