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1. 发明授权

US07524881B2 Production of Δ 9 tetrahydrocannabinol 有权
标题翻译：生产Delta 9四氢大麻酚
公开(公告)号：US07524881B2
公开(公告)日：2009-04-28
申请号：US10503082
申请日：2003-02-03
申请人： Neil John Goodwin , Nicolas James Archer , Christopher Murray , Alan Kenneth Greenwood , Derek Mchattie
发明人： Neil John Goodwin , Nicolas James Archer , Christopher Murray , Alan Kenneth Greenwood , Derek Mchattie
IPC分类号： A61K31/352 , C07D311/72
CPC分类号： C07D311/80 , A61K36/00 , A61K36/185 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , A61K2300/00
摘要： Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is then converted to Δ9 THC which is further purified and combined with a carrier for pharmaceutical use.
摘要翻译： Delta9 THC酸从植物材料获得，并在pH控制条件下萃取到含水溶剂中。将酸转化成盐，将盐萃取到极性溶剂中，产生高纯度的酸。然后将Delta9 THC酸转化成Delta9 THC，进一步纯化并与用于药物用途的载体组合。

2. 发明申请

US20090253783A1 Production of Delta 9 Tetrahydrocannabinol 审中-公开
标题翻译： Delta 9四氢大麻酚的生产
公开(公告)号：US20090253783A1
公开(公告)日：2009-10-08
申请号：US12487185
申请日：2009-06-18
申请人： Neil John Goodwin , Nicolas James Archer , Christopher Murray , Alan Kenneth Greenwood , Derek Mchattie
发明人： Neil John Goodwin , Nicolas James Archer , Christopher Murray , Alan Kenneth Greenwood , Derek Mchattie
IPC分类号： A61K31/352 , C07D311/82 , A61P25/22
CPC分类号： C07D311/80 , A61K36/00 , A61K36/185 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , A61K2300/00
摘要： The present invention provides isolated, purified Δ9 THC. In another embodiment, the invention provides pharmaceutical compositions comprising isolated, purified Δ9 THC and a pharmaceutically acceptable carrier. In another embodiment, the invention provides methods of preparing pharmaceutical compositions comprising isolated, purified Δ9 THC and a pharmaceutically acceptable carrier.
摘要翻译：本发明提供了分离的纯化的Delta9 THC。在另一个实施方案中，本发明提供包含分离的纯化的Delta9THC和药学上可接受的载体的药物组合物。在另一个实施方案中，本发明提供了制备包含分离的纯化的Delta9THC和药学上可接受的载体的药物组合物的方法。

3. 发明申请

US20110171300A1 DELTA 9 TETRAHYDROCANNABINOL DERIVATIVES 审中-公开
标题翻译： DELTA 9四氯氰菊酯衍生物
公开(公告)号：US20110171300A1
公开(公告)日：2011-07-14
申请号：US12527183
申请日：2008-02-14
申请人： Parveen Bhatarah , Kevin John Batchelor , Derek Mchattie , Alan Kenneth Greenwood
发明人： Parveen Bhatarah , Kevin John Batchelor , Derek Mchattie , Alan Kenneth Greenwood
IPC分类号： A61K9/64 , C07D311/80 , A61K31/353 , A61P1/08
CPC分类号： C07D311/80
摘要： A compound of formula (I) wherein R is selected from (i) a 5 to 7 membered heterocyclic ring containing 1 to 3 heteroatoms independently selected from nitrogen, oxygen and sulfur, which is optionally substituted by one or more groups independently selected from halo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl; (ii) (C1-C6)alkyl, which is optionally substituted by one or more substituents each independently selected from halo, oxo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl; (iii) (C1-C6)alkyl substituted by (C3-C13)cycloalkyl, which is optionally substituted by one or more substituents each independently selected from halo, oxo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl; and (iv) (C3-C13)cycloalkyl, which is optionally substituted by one or more substituents each independently selected from halo, oxo, CN, NO2, (C1-C6)alkyl, (C1-C6)alkoxy and phenyl.
摘要翻译：式（I）化合物，其中R选自（i）含有1至3个独立地选自氮，氧和硫的杂原子的5至7元杂环，其任选被一个或多个独立地选自以下的基团取代：卤素， CN，NO 2，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基和苯基; （C 1 -C 6）烷基，（C 1 -C 6）烷基，其任选被一个或多个各自独立地选自卤素，氧代，CN，NO 2，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基和苯基的取代基取代; （C 3 -C 13）环烷基取代的（C 3 -C 13）烷基，其任选被一个或多个独立地选自卤素，氧代，CN，NO 2，（C 1 -C 6）烷基，（C 1 -C 6））烷氧基和苯基; 任选被一个或多个独立地选自卤素，氧代，CN，NO 2，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基和苯基的取代基取代的（ⅳ）（C 3 -C 13）环烷基。

4. 发明申请

US20100087518A1 DELTA 9 - TETRAHYDROCANNABINOL PROCESSING 有权
标题翻译： DELTA 9 - 四氢胞嘧啶加工
公开(公告)号：US20100087518A1
公开(公告)日：2010-04-08
申请号：US12528077
申请日：2008-02-19
申请人： Parveen Bhatarah , Alan Kenneth Greenwood , Derek Mchattie , Jerome Thomas Garfield Carr-Brion
发明人： Parveen Bhatarah , Alan Kenneth Greenwood , Derek Mchattie , Jerome Thomas Garfield Carr-Brion
IPC分类号： A61K31/352 , C07D311/80 , A61P25/00
CPC分类号： A61K9/08 , A61K9/1688 , A61K31/353 , A61K47/02 , A61K47/06 , A61K47/08
摘要： The present invention provides a process for handling Δ9-THC, which comprises preparing a solution of Δ9-THC in a solvent which exists as a gas at room temperature and atmospheric pressure. The invention also provides solutions of Δ9-THC in the solvent and solid preparations of Δ9-THC.
摘要翻译：本发明提供了一种处理D-9-THC的方法，其包括在室温和大气压下作为气体存在的溶剂中制备＆Dgr.9-THC的溶液。本发明还提供了在D-9-THC的溶剂和固体制剂中的＆Dgr。9-THC的溶液。

5. 发明申请

US20050171361A1 Production of delta 9 tetrahydrocannabinol 有权
标题翻译：生产δ9四氢大麻酚
公开(公告)号：US20050171361A1
公开(公告)日：2005-08-04
申请号：US10503082
申请日：2003-02-03
申请人： Neil Goodwin , Nicolas Archer , Christopher Murray , Alan Greenwood , Derek Mchattie
发明人： Neil Goodwin , Nicolas Archer , Christopher Murray , Alan Greenwood , Derek Mchattie
IPC分类号： A61K31/352 , A61K36/00 , A61K36/18 , A61P1/08 , B01D11/02 , C07D311/80 , C07D311/82
CPC分类号： C07D311/80 , A61K36/00 , A61K36/185 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , A61K2300/00
摘要： Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is t5en converted to Δ9 THC which is further purified and combined with a carrier for pharmaceutical use.
摘要翻译： Delta9 THC酸从植物材料获得，并在pH控制条件下萃取到含水溶剂中。将酸转化成盐，将盐萃取到极性溶剂中，产生高纯度的酸。将Delta9THC酸转化为Delta9 THC，进一步纯化并与用于药物用途的载体组合。

6. 发明申请

US20050049298A1 Production of Delta 9 tetrahydrocannabinol 有权
标题翻译：生产Delta 9四氢大麻酚
公开(公告)号：US20050049298A1
公开(公告)日：2005-03-03
申请号：US10902698
申请日：2004-07-30
申请人： Neil Goodwin , Nicolas Archer , Christopher Murray , Alan Greenwood , Derek Mchattie
发明人： Neil Goodwin , Nicolas Archer , Christopher Murray , Alan Greenwood , Derek Mchattie
IPC分类号： A61K31/352 , A61K36/00 , A61K36/18 , A61P1/08 , B01D11/02 , C07D311/80 , A61K31/353
CPC分类号： C07D311/80 , A61K36/00 , A61K36/185 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , A61K2300/00
摘要： Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is t5hen converted to Δ9 THC which is further purified and combined with a carrier for pharmaceutical use.
摘要翻译： Delta9 THC酸从植物材料获得，并在pH控制条件下萃取到含水溶剂中。将酸转化成盐，将盐萃取到极性溶剂中，产生高纯度的酸。 Delta9 THC酸被转化为Delta9 THC，进一步纯化并与用于药物用途的载体组合。

7. 发明授权

US07592468B2 Production of Δ 9 tetrahydrocannabinol 有权
公开(公告)号：US07592468B2
公开(公告)日：2009-09-22
申请号：US10902698
申请日：2004-07-30
申请人： Neil J Goodwin , Nicolas J. Archer , Christopher Murray , Alan K. Greenwood , Derek Mchattie
发明人： Neil J Goodwin , Nicolas J. Archer , Christopher Murray , Alan K. Greenwood , Derek Mchattie
IPC分类号： C07D311/82 , G01N1/18 , B01D3/10 , B01D3/00
CPC分类号： C07D311/80 , A61K36/00 , A61K36/185 , Y10T436/142222 , Y10T436/25375 , Y10T436/255 , A61K2300/00
摘要： Δ9 THC acid is obtained from plant material and extracted into an aqueous solvent under conditions of pH control. The acid is converted to a salt and the salt extracted into a polar solvent, yielding acid of high purity. The Δ9 THC acid is then converted to Δ9 THC which is further purified and combined with a carrier for pharmaceutical use.

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