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1. 发明授权

US08361488B2 Methods and compositions for controlled release oral dosage of a vitamin D compound 有权
标题翻译：口服维生素D化合物口服剂量的方法和组合物
公开(公告)号：US08361488B2
公开(公告)日：2013-01-29
申请号：US12109983
申请日：2008-04-25
申请人： Charles W. Bishop , Samir P. Tabash , Sammy Asiamah Agudoawu , Jay A. White , Keith H. Crawford , Eric J. Messner , P. Martin Petkovich
发明人： Charles W. Bishop , Samir P. Tabash , Sammy Asiamah Agudoawu , Jay A. White , Keith H. Crawford , Eric J. Messner , P. Martin Petkovich
IPC分类号： A61K31/59 , A61L15/16 , A61F13/02
CPC分类号： A61K9/48 , A61K9/0019 , A61K9/0053 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/59 , A61K31/593 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/44
摘要： A stable, controlled release formulation for oral dosing of vitamin D compounds is disclosed. The formulation is prepared by incorporating one or more vitamin D compounds into a solid or semi-solid mixture of waxy materials. Oral dosage forms can be prepared by melt-blending the components described herein and filling gelatin capsules with the formulation.
摘要翻译：公开了用于口服给药维生素D化合物的稳定的控释制剂。通过将一种或多种维生素D化合物掺入蜡质材料的固体或半固体混合物中来制备制剂。口服剂型可以通过将本文所述的组分熔融共混并用制剂填充明胶胶囊来制备。

2. 发明授权

US08592401B2 Methods and compounds for vitamin D therapy 有权
标题翻译：维生素D治疗方法和化合物
公开(公告)号：US08592401B2
公开(公告)日：2013-11-26
申请号：US12597224
申请日：2008-04-25
申请人： P. Martin Petkovich , Charles W. Bishop , Eric J. Messner , Keith H. Crawford
发明人： P. Martin Petkovich , Charles W. Bishop , Eric J. Messner , Keith H. Crawford
IPC分类号： A61K31/59
CPC分类号： A61K31/592 , A61K9/0019 , A61K9/0053 , A61K47/14 , A61K47/44
摘要： Methods and compositions comprising 1,25-dihydroxyvitamin D2 are disclosed. A method for lowering or maintaining lowered serum parathyroid hormone in human patients including administering to said patients an effective amount of 1,25-dihydroxyvitamin D2 to lower or maintain lowered serum parathyroid hormone levels is disclosed. Dosage forms and dosing regimens are also disclosed.
摘要翻译：公开了包含1,25-二羟基维生素D2的方法和组合物。一种用于降低或维持人类患者血清甲状旁腺激素降低或降低的方法，包括向所述患者施用有效量的1,25-二羟维生素D 2以降低或维持血清甲状旁腺激素水平的降低。还公开了剂量形式和给药方案。

3. 发明申请

US20100204189A1 Methods and Compounds for Vitamin D Therapy 有权
标题翻译：维生素D治疗方法与化合物
公开(公告)号：US20100204189A1
公开(公告)日：2010-08-12
申请号：US12597224
申请日：2008-04-25
申请人： P. Martin Petkovich , Charles W. Bishop , Eric J. Messner , Keith H. Crawford
发明人： P. Martin Petkovich , Charles W. Bishop , Eric J. Messner , Keith H. Crawford
IPC分类号： A61K31/592 , A61P5/18
CPC分类号： A61K31/592 , A61K9/0019 , A61K9/0053 , A61K47/14 , A61K47/44
摘要： Methods and compositions comprising 1,25-dihydroxyvitamin D2 are disclosed. A method for lowering or maintaining lowered serum parathyroid hormone in human patients including administering to said patients an effective amount of 1,25-dihydroxyvitamin D2 to lower or maintain lowered serum parathyroid hormone levels is disclosed. Dosage forms and dosing regimens are also disclosed.
摘要翻译：公开了包含1,25-二羟基维生素D2的方法和组合物。一种用于降低或维持人类患者血清甲状旁腺激素降低或降低的方法，包括向所述患者施用有效量的1,25-二羟维生素D 2以降低或维持血清甲状旁腺激素水平的降低。还公开了剂量形式和给药方案。

4. 发明授权

US08207149B2 Method for treating secondary hyperparathyroidism in CKD 有权
标题翻译：治疗CKD继发性甲状旁腺功能亢进的方法
公开(公告)号：US08207149B2
公开(公告)日：2012-06-26
申请号：US13244945
申请日：2011-09-26
申请人： Samir P. Tabash , Jay A. White , Charles W. Bishop , Sammy A. Agudoawu , Eric J. Messner , P. Martin Petkovich
发明人： Samir P. Tabash , Jay A. White , Charles W. Bishop , Sammy A. Agudoawu , Eric J. Messner , P. Martin Petkovich
IPC分类号： A61K31/593 , A61K31/592 , A61P5/18
CPC分类号： A61K9/48 , A61K9/0019 , A61K9/0053 , A61K9/4825 , A61K9/4858 , A61K9/4866 , A61K31/59 , A61K31/593 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/44
摘要： A stable, controlled release formulation for oral dosing of vitamin D compounds is disclosed. The formulation is prepared by incorporating one or more vitamin D compounds into a solid or semi-solid mixture of waxy materials. Oral dosage forms can be prepared by melt-blending the components described herein and filling gelatin capsules with the formulation.
摘要翻译：公开了用于口服给药维生素D化合物的稳定的控释制剂。通过将一种或多种维生素D化合物掺入蜡质材料的固体或半固体混合物中来制备制剂。口服剂型可以通过将本文所述的组分熔融共混并用制剂填充明胶胶囊来制备。

5. 发明授权

US11672809B2 Methods and compositions for reducing parathyroid levels 有权
公开(公告)号：US11672809B2
公开(公告)日：2023-06-13
申请号：US13638845
申请日：2011-03-29
申请人： Eric J. Messner , P. Martin Petkovich , Jay A. White , Samir P. Tabash , Joel Z. Melnick , Charles W. Bishop
发明人： Eric J. Messner , P. Martin Petkovich , Jay A. White , Samir P. Tabash , Joel Z. Melnick , Charles W. Bishop
IPC分类号： A61K31/593 , A61K31/592 , A61K9/48
CPC分类号： A61K31/593 , A61K9/4858 , A61K31/592 , A61K31/593 , A61K2300/00 , A61K31/592 , A61K2300/00 , A61K31/592 , A61K2300/00 , A61K31/593 , A61K2300/00
摘要： Methods and compositions for reducing serum parathyroid levels in, for example, chronic kidney disease patients are disclosed. In these methods, an effective amount of a modified release formulation of 25-hydroxy vitamin D is orally administered to a patient suffering from secondary hyperparathyroidism to lower the patient's serum intact parathyroid hormone (iPTH) level, while avoiding a surge in serum total 25-hydroxy vitamin D.

6. 发明申请

US20130137663A1 METHODS AND COMPOSITIONS FOR REDUCING PARATHYROID LEVELS 审中-公开
标题翻译：减少PARATHYROID水平的方法和组合物
公开(公告)号：US20130137663A1
公开(公告)日：2013-05-30
申请号：US13638845
申请日：2011-03-29
申请人： Eric J. Messner , P. Martin Petkovich , Jay A. White , Samir P. Tabash , Joel Z. Melnick , Charles W. Bishop
发明人： Eric J. Messner , P. Martin Petkovich , Jay A. White , Samir P. Tabash , Joel Z. Melnick , Charles W. Bishop
IPC分类号： A61K31/593 , A61K31/592
CPC分类号： A61K31/593 , A61K9/4858 , A61K31/592 , A61K2300/00
摘要： Methods and compositions for reducing serum parathyroid levels in, for example, chronic kidney disease patients are disclosed. In these methods, an effective amount of a modified release formulation of 25-hydroxy vitamin D is orally administered to a patient suffering from secondary hyperparathyroidism to lower the patient's serum intact parathyroid hormone (iPTH) level, while avoiding a surge in serum total 25-hydroxy vitamin D.
摘要翻译：公开了用于降低例如慢性肾脏病患者血清甲状旁腺水平的方法和组合物。在这些方法中，向患有继发性甲状旁腺功能亢进的患者口服施用有效量的25-羟基维生素D的调释释放制剂，以降低患者的血清完整甲状旁腺激素（iPTH）水平，同时避免血清总25- 羟基维生素D.

7. 发明授权

US08426391B2 Treating vitamin D insufficiency and deficiency with 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 有权
公开(公告)号：US08426391B2
公开(公告)日：2013-04-23
申请号：US12278053
申请日：2007-02-02
申请人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner
发明人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner
IPC分类号： A01N45/00 , A61K31/59 , A61K38/37 , A61K9/52 , C07K14/755
CPC分类号： A61K31/593 , A61K9/00 , A61K9/0019 , A61K9/16 , A61K9/48 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K31/592 , A61K47/26
摘要： Methods and compositions for treating 25-hydroxyvitamin D insufficiency and deficiency in a patient are described herein. The method includes orally administering to the patient a delayed, sustained release formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, or it includes gradually administering to the patient a sterile intravenous formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3.

8. 发明申请

US20090311316A1 TREATING VITAMIN D INSUFFICIENCY AND DEFICIENCY WITH 25-HYDROXYVITAMIN D2 AND 25-HYDROXYVITAMIN D3 有权
标题翻译：用25羟维生素D2和25-羟维生素D3处理维生素D缺乏症和缺乏症
公开(公告)号：US20090311316A1
公开(公告)日：2009-12-17
申请号：US12278053
申请日：2007-02-02
申请人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner
发明人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner
IPC分类号： A61K31/59 , A61K9/52
CPC分类号： A61K31/593 , A61K9/00 , A61K9/0019 , A61K9/16 , A61K9/48 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K31/592 , A61K47/26
摘要： Methods and compositions for treating 25-hydroxyvitamin D insufficiency and deficiency in a patient are described herein. The method includes orally administering to the patient a delayed, sustained release formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, or it includes gradually administering to the patient a sterile intravenous formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3.
摘要翻译：本文描述了用于治疗患者的25-羟基维生素D不足和缺乏症的方法和组合物。该方法包括向患者口服给予延迟的持续释放制剂，其包括选自由25-羟基维生素D2,25-羟基维生素D3或25-羟基维生素D 2和25-羟基维生素D 3组合组成的组的第一成分，或其包括向患者逐渐施用无菌静脉内制剂，其包含选自由25-羟基维生素D2,25-羟基维生素D3或25-羟基维生素D 2和25-羟基维生素D3的组合组成的组的第一成分。

9. 发明授权

US08906410B2 Oral dosage form of 25-hydroxyvitamin D 有权
标题翻译： 25-羟基维生素D的口服剂型
公开(公告)号：US08906410B2
公开(公告)日：2014-12-09
申请号：US13848982
申请日：2013-03-22
申请人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner
发明人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner
IPC分类号： A61K31/593 , A61K9/16 , A61K9/48 , A61K31/592 , A61K9/00 , A61K47/26
CPC分类号： A61K31/593 , A61K9/00 , A61K9/0019 , A61K9/16 , A61K9/48 , A61K9/4808 , A61K9/4858 , A61K9/4866 , A61K9/4875 , A61K31/592 , A61K47/26
摘要： Methods and compositions for treating 25-hydroxyvitamin D insufficiency and deficiency in a patient are described herein. The method includes orally administering to the patient a delayed, sustained release formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3, or it includes gradually administering to the patient a sterile intravenous formulation including a first ingredient selected from the group consisting of 25-hydroxyvitamin D2, 25-hydroxyvitamin D3, or a combination of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3.
摘要翻译：本文描述了用于治疗患者的25-羟基维生素D不足和缺乏症的方法和组合物。该方法包括向患者口服给予延迟的持续释放制剂，其包括选自由25-羟基维生素D2,25-羟基维生素D3或25-羟基维生素D 2和25-羟基维生素D 3组合组成的组的第一成分，或其包括向患者逐渐施用无菌静脉内制剂，其包含选自由25-羟基维生素D2,25-羟基维生素D3或25-羟基维生素D 2和25-羟基维生素D 3组合组成的组的第一成分。

10. 发明授权

US08329677B2 Method of treating and preventing secondary hyperparathyroidism 有权
标题翻译：治疗和预防继发性甲状旁腺功能亢进的方法
公开(公告)号：US08329677B2
公开(公告)日：2012-12-11
申请号：US12305572
申请日：2007-06-21
申请人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner , Martin P. Petkovich , Christian F. Helvig
发明人： Charles W. Bishop , Keith H. Crawford , Eric J. Messner , Martin P. Petkovich , Christian F. Helvig
IPC分类号： A61K31/59
CPC分类号： A61K31/593 , A61K9/48 , A61K31/59 , A61K31/592
摘要： The a method of treating elevated blood levels of iPTH by increasing or maintaining blood concentrations of both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in a patient by administering, as necessary, both Vitamin D repletion and Vitamin D hormone replacement therapies, is disclosed. The blood concentrations of 25-hydroxyvitamin D are increased to and maintained at or above 30 ng/mL, and blood concentrations of 1,25-dihydroxyvitamin D are increased to or maintained within a patient's normal historical physiological range for 1,25-dihydroxyvitamin D without causing substantially increased risk of hypercalcemia, hyperphosphatemia or over suppression of plasma iPTH in the patient. The blood levels of 25-hydroxyvitamin D are maintained at or above 30 ng/mL between doses of Vitamin D repletion therapies, and the blood levels of 1,25-dihydroxyvitamin D are maintained in the patient's normal historical physiological range between doses of Vitamin D hormone replacement therapies. In one aspect, the disclosure includes methods wherein the blood concentration of 25-hydroxyvitamin D during treatment comprises predominantly 25-hydroxyvitamin D3, and/or wherein the method includes administering predominantly or solely 25-hydroxyvitamin D3 for 25-hydroxyvitamin D repletion and/or maintenance.
摘要翻译：通过根据需要施用维生素D补充剂和维生素D激素替代疗法，通过增加或维持患者的25-羟基维生素D和1,25-二羟基维生素D的血液浓度来治疗iPTH升高的血液水平的方法是披露 25-羟基维生素D的血液浓度增加并保持在30ng / mL以上，1,25-二羟基维生素D的血液浓度增加至1,25-二羟基维生素D的患者正常的历史生理范围内而不会导致患者高钙血症，高磷血症或过度抑制血浆iPTH的风险显着增加。在维生素D补充疗法的剂量之间，25-羟基维生素D的血液水平维持在或高于30ng / mL，1,25-二羟基维生素D的血液水平维持在维生素D剂量之间的患者正常的历史生理范围内激素替代疗法。一方面，本公开内容包括其中治疗期间25-羟基维生素D的血液浓度主要包含25-羟基维生素D3和/或其中所述方法包括主要或单独使用25-羟基维生素D补充的25-羟基维生素D3用于25-羟基维生素D补充和/或保养。

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