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1. 发明申请

US20210180124A1 COUPLING METHOD 有权
公开(公告)号：US20210180124A1
公开(公告)日：2021-06-17
申请号：US17094571
申请日：2020-11-10
申请人： Oxford Nanopore Technologies Limited
发明人： James Anthony Clarke , James White , John Milton , Clive Gavin Brown
IPC分类号： C12Q1/6869 , G01N27/447 , G01N33/487 , B82Y15/00
摘要： The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

2. 发明申请

US20200024654A1 METHOD FOR NUCLEIC ACID DETECTION BY GUIDING THROUGH A NANOPORE 审中-公开
公开(公告)号：US20200024654A1
公开(公告)日：2020-01-23
申请号：US16338399
申请日：2017-09-29
申请人： Oxford Nanopore Technologies Limited
发明人： Andrew John Heron , James Edward Graham , Richard Alexander Gutierrez , Rebecca Victoria Bowen , James White , Clive Gavin Brown , Daniel George Fordham
IPC分类号： C12Q1/6869 , C12Q1/6876 , G01N33/487
摘要： The invention provides a method of detecting a target polynucleotide in a sample comprising: (a) contacting the sample with a guide polynucleotide that binds to a sequence in the target polynucleotide and a polynucleotide-guided effector protein, wherein the guide polynucleotide and polynucleotide-guided effector protein form a complex with any target polynucleotide present in the sample; (b) contacting the sample with a membrane comprising a transmembrane pore; (c) applying a potential to the membrane; and (d) monitoring for the presence or absence of an effect resulting from the interaction of the complex with the transmembrane pore to determine the presence or absence of the complex, thereby detecting the target polynucleotide in the sample.

3. 发明授权

US09651519B2 Biochemical analysis instrument 有权
公开(公告)号：US09651519B2
公开(公告)日：2017-05-16
申请号：US14812510
申请日：2015-07-29
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： Clive Gavin Brown , James Peter Willcocks
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48 , G01N27/447 , G01N33/487 , C12Q1/68
CPC分类号： G01N27/44756 , C12Q1/6869 , G01N33/48721
摘要： An analysis instrument comprises plural modules connected together over a data network, each module comprising an analysis apparatus operable to perform biochemical analysis of a sample. Each module comprises a control unit that controls the operation of the analysis apparatus. The control units are addressable to select an arbitrary number of modules to operate as a cluster for performing a common biochemical analysis. The control units communicate over the data network, repeatedly during the performance of the common biochemical analysis, to determine the operation of the analysis apparatus of each module required to meet the global performance targets, on the basis of measures of performance derived from the output data produced by the modules. The arrangement of the instrument as modules interacting in this manner provides a scalable analysis instrument.

4. 发明申请

US20150265994A1 FORMATION OF ARRAY OF MEMBRANES AND APPARATUS THEREFOR 审中-公开
标题翻译：形成膜片及其装置
公开(公告)号：US20150265994A1
公开(公告)日：2015-09-24
申请号：US14438705
申请日：2013-10-23
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： Jason Robert Hyde , Pedro Miguel Ortiz Bahamon , Clive Gavin Brown , Andrew John Heron , Paul Raymond Mackett
IPC分类号： B01J19/00 , G01N33/573 , C12Q1/68
摘要： An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.
摘要翻译：使用包括限定隔室阵列的支架的装置形成包含两亲分子的膜阵列。包含极性介质的体积被设置在相应的隔室内，并且提供包括非极性介质的层，其跨越具有体积的开口延伸。极性介质流过载体以置换非极性介质并形成与体积接触的层，在界面处形成包含两亲性分子的膜。在该装置的一个结构中，支撑件包括包括内部部分和外部部分的隔板。内部部分限定内部凹部，其之间没有间隙，其能够约束包含相邻内凹部中的极性介质的体积彼此接触。外部部分从内部部分向外延伸并且具有允许非极性介质流过基板的间隙。

5. 发明申请

US20210095337A1 COUPLING METHOD 有权
公开(公告)号：US20210095337A1
公开(公告)日：2021-04-01
申请号：US17064633
申请日：2020-10-07
申请人： Oxford Nanopore Technologies Limited
发明人： James Anthony Clarke , James White , John Milton , Clive Gavin Brown
IPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/487 , G01N27/447
摘要： The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

6. 发明申请

US20210087623A1 COUPLING METHOD 有权
公开(公告)号：US20210087623A1
公开(公告)日：2021-03-25
申请号：US17064628
申请日：2020-10-07
申请人： Oxford Nanopore Technologies Limited
发明人： James Anthony Clarke , James White , John Milton , Clive Gavin Brown
IPC分类号： C12Q1/6869 , B82Y15/00 , G01N33/487 , G01N27/447
摘要： The invention relates to a new method of determining the presence, absence or characteristics of an analyte. The analyte is coupled to a membrane. The invention also relates to nucleic acid sequencing.

7. 发明授权

US10739341B2 Aptamer method 有权
公开(公告)号：US10739341B2
公开(公告)日：2020-08-11
申请号：US14378929
申请日：2013-02-14
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： Daniel John Turner , Daniel George Fordham , Roger Charles Gill , Clive Gavin Brown , Stuart Reid , James Anthony Clarke , James White
IPC分类号： G01N33/00 , G01N33/543 , G01N33/53 , C12N15/115 , C07H21/04
摘要： The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

8. 发明申请

US20150285781A1 DROPLET INTERFACES 有权
标题翻译： DROPLET接口
公开(公告)号：US20150285781A1
公开(公告)日：2015-10-08
申请号：US14438670
申请日：2013-10-23
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： Andrew John Heron , Jason Robert Hyde , Clive Gavin Brown
IPC分类号： G01N33/487 , B01D71/70 , B01D67/00
CPC分类号： G01N33/48721 , B01D67/0023 , B01D69/122 , B01D71/26 , B01D71/32 , B01D71/58 , B01D71/70 , B01D71/80 , B01D2323/35 , B01D2325/36 , B01D2325/38 , C12Q1/6869 , G01N33/50 , Y10T436/145555 , C12Q2565/631
摘要： The invention provides a method of forming a membrane between a first volume of polar medium and a second volume of polar medium, which method comprises: (a) providing a first volume comprising polar medium and a second volume comprising polar medium which are separated from one another by an apolar medium, wherein at least one of said first and second volumes comprises a layer comprising amphipathic molecules, at the interface between the polar medium and the apolar medium, wherein each of the amphipathic molecules comprises a first outer hydrophilic group, a hydrophobic core group, and a second outer hydrophilic group, wherein each of the first and second outer hydrophilic groups is linked to the hydrophobic core group; and (b) causing the first and second volumes to come into contact with one another to form a membrane comprising said amphipathic molecules between the first and second volumes. The invention also provides a system comprising a membrane between a first volume of a polar medium; and a second volume of a polar medium, which membrane comprises the amphipathic molecules, and wherein the first volume of polar medium is within an apolar medium.
摘要翻译：本发明提供了一种在第一体积的极性介质和第二体积的极性介质之间形成膜的方法，该方法包括：（a）提供包含极性介质的第一体积和包含极性介质的第二体积，所述第二体积与极性介质分离，另一个通过非极性介质，其中所述第一和第二体积中的至少一个包含在极性介质和非极性介质之间的界面处的包含两亲性分子的层，其中每个两亲性分子包含第一外部亲水基团，疏水性核心基团和第二外部亲水基团，其中第一和第二外部亲水基团中的每一个连接到疏水性核心基团; 和（b）使第一和第二体积彼此接触以形成包含第一和第二体积之间的所述两亲分子的膜。本发明还提供一种系统，其包括在第一体积的极性介质之间的膜; 和第二体积的极性介质，所述膜包含两亲性分子，并且其中所述第一体积的极性介质在非极性介质内。

9. 发明申请

US20210018500A1 APTAMER METHOD 有权
公开(公告)号：US20210018500A1
公开(公告)日：2021-01-21
申请号：US16916305
申请日：2020-06-30
申请人： Oxford Nanopore Technologies Limited
发明人： Daniel John Turner , Daniel George Fordham , Roger Charles Gill , Clive Gavin Brown , Stuart Reid , James Anthony Clarke , James White
IPC分类号： G01N33/543 , G01N33/53 , C12N15/115
摘要： The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

10. 发明申请

US20160251710A1 METHOD OF CHARACTERIZING A TARGET RIBONUCLEIC ACID (RNA) COMPRISING FORMING A COMPLEMENTARY POLYNUCLEOTIDE WHICH MOVES THROUGH A TRANSMEMBRANE PORE 审中-公开
标题翻译：表征包含形成通过转移核心移动的互补多核苷酸的靶向赖氨酸（RNA）的方法
公开(公告)号：US20160251710A1
公开(公告)日：2016-09-01
申请号：US15028637
申请日：2014-10-17
申请人： OXFORD NANOPORE TECHNOLOGIES LIMITED
发明人： Clive Gavin Brown , Daniel John , James White
IPC分类号： C12Q1/68 , G01N27/416
CPC分类号： C12Q1/6869 , C12Q1/6883 , C12Q2600/118 , C12Q2600/158 , C12Q2600/178 , G01N27/4166 , C12Q2565/607 , C12Q2565/631
摘要： The invention relates to a new method of characterising a target ribonucleic acid (RNA) involving forming a complementary polynucleotide. The method uses a transmembrane pore.
摘要翻译：本发明涉及表征涉及形成互补多核苷酸的靶核糖核酸（RNA）的新方法。该方法使用跨膜孔。

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