专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08394434B2 SCF extract containing cardiac glycoside 有权
标题翻译：含有强心苷的SCF提取物
公开(公告)号：US08394434B2
公开(公告)日：2013-03-12
申请号：US13417686
申请日：2012-03-12
申请人： Otis Crandell Addington , Feng Zhang , John J. Koleng
发明人： Otis Crandell Addington , Feng Zhang , John J. Koleng
IPC分类号： A61K36/13 , A61K36/00
CPC分类号： A61K36/24
摘要： A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.
摘要翻译：提供了含有强心苷的植物体的超临界流体（SCF）提取物。提取物可以包含在含有提取物增溶量的增溶剂的药物组合物中。当通过SCF提取提取含有含有强心苷的植物，例如夹心夹心素时，包含在提取物中。提取物还可以含有一种或多种其它SCF可提取的药理学活性剂。该组合物可用于治疗对心脏糖苷治疗响应的各种各样的疾病。

2. 发明授权

US08173152B2 Stabilized compositions containing alkaline labile drugs 有权
标题翻译：含有碱性不稳定药物的稳定组合物
公开(公告)号：US08173152B2
公开(公告)日：2012-05-08
申请号：US12294367
申请日：2007-03-22
申请人： Michael W. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
发明人： Michael W. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
IPC分类号： A61F13/02
CPC分类号： A61K9/70 , A61K9/0024 , A61K9/006 , A61K9/7023 , A61K9/703 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K31/4468 , A61K31/568 , A61K45/06 , A61K47/10 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/602
摘要： A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and an alkaline thermoplastic matrix-forming material, e.g. polymer. The excipient mixture is formed before blending with an alkaline labile drug. The blend is then hot-melt extruded to form the HME composition. By so doing, the acidic component is able to neutralize or render moderately acidic the excipient mixture. This particular process has been shown to substantially reduce the degradation of an alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during hot-melt extrusion. It can dissolve or not dissolve drug-containing particles during extrusion. Various functional excipients can be included in the carrier system to improve process performance and/or improve the chemical or physical properties of the HME composition.
摘要翻译：提供了含有碱性不稳定药物的稳定的生物粘合剂组合物及其制备方法。在一个方面，组合物是热熔挤出（HME）组合物，其包含预先形成的赋形剂混合物，其包含酸性组分和碱性热塑性基质形成材料，例如，聚合物。赋形剂混合物在与碱性不稳定药物共混之前形成。然后将共混物热熔融挤出以形成HME组合物。通过这样做，酸性成分能够中和或赋予赋形剂混合物中度酸性。已经显示了该特定方法，以显着降低热熔融挤出期间碱性不稳定药物的降解。赋形剂混合物在热熔挤出过程中软化或熔化。在挤出过程中可溶解或不溶解含药颗粒。可以在载体体系中包括各种功能赋形剂以改善工艺性能和/或改善HME组合物的化学或物理性能。

3. 发明授权

US06509028B2 Methods and compositions for treating pain of the mucous membrane 有权
公开(公告)号：US06509028B2
公开(公告)日：2003-01-21
申请号：US10172455
申请日：2002-06-17
申请人： Robert O. Williams , Feng Zhang , John J. Koleng , Gavril W. Pasternak , Yuri A. Kolesnikov
发明人： Robert O. Williams , Feng Zhang , John J. Koleng , Gavril W. Pasternak , Yuri A. Kolesnikov
IPC分类号： A61F1300
CPC分类号： A61K9/006 , A61K9/0043 , A61K31/445 , A61K31/485 , A61K45/06 , Y10S514/817 , Y10S514/818 , A61K2300/00
摘要： Compositions useful for long-lasting pain relief from mucosal damage, such as mucosal inflamation, abrasions, ulcerations, lesions, trauma and incisions, without significant systemic absorption. The compositions of the invention are particularly suitable for application to the mucous membrane of the nasal cavity and buccal cavity. To relieve pain, the compositions or the invention are topically applied directly to the affected area.

4. 发明申请

US20120214777A1 STABILIZED COMPOSITIONS CONTAINING ALKALINE LABILE DRUGS 有权
标题翻译：包含碱性可溶性药物的稳定组合物
公开(公告)号：US20120214777A1
公开(公告)日：2012-08-23
申请号：US13463375
申请日：2012-05-03
申请人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
发明人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
IPC分类号： A61K31/4468 , A61P5/24 , A61K31/568
CPC分类号： A61K9/70 , A61K9/0024 , A61K9/006 , A61K9/7023 , A61K9/703 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K31/4468 , A61K31/568 , A61K45/06 , A61K47/10 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/602
摘要： A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and an alkaline thermoplastic matrix-forming material, e.g. polymer. The excipient mixture is formed before blending with an alkaline labile drug. The blend is then hot-melt extruded to form the HME composition. By so doing, the acidic component is able to neutralize or render moderately acidic the excipient mixture. This particular process has been shown to substantially reduce the degradation of an alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during hot-melt extrusion. It can dissolve or not dissolve drug-containing particles during extrusion. Various functional excipients can be included in the carrier system to improve process performance and/or improve the chemical or physical properties of the HME composition.
摘要翻译：提供了含有碱性不稳定药物的稳定的生物粘合剂组合物及其制备方法。在一个方面，组合物是热熔挤出（HME）组合物，其包含预先形成的赋形剂混合物，其包含酸性组分和碱性热塑性基质形成材料，例如，聚合物。赋形剂混合物在与碱性不稳定药物共混之前形成。然后将共混物热熔融挤出以形成HME组合物。通过这样做，酸性成分能够中和或赋予赋形剂混合物中度酸性。已经显示了该特定方法，以显着降低热熔融挤出期间碱性不稳定药物的降解。赋形剂混合物在热熔挤出过程中软化或熔化。在挤出过程中可溶解或不溶解含药颗粒。可以在载体体系中包括各种功能赋形剂以改善工艺性能和/或改善HME组合物的化学或物理性能。

5. 发明申请

US20090264385A1 STABILIZED COMPOSITIONS CONTAINING ALKALINE LABILE DRUGS 有权
标题翻译：包含碱性可溶性药物的稳定组合物
公开(公告)号：US20090264385A1
公开(公告)日：2009-10-22
申请号：US12294367
申请日：2007-03-22
申请人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
发明人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
IPC分类号： A61K31/60 , A61K31/56 , A61K31/485 , A61K31/445 , A61K31/4439 , A61K31/216 , A61K47/30
CPC分类号： A61K9/70 , A61K9/0024 , A61K9/006 , A61K9/7023 , A61K9/703 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K31/4468 , A61K31/568 , A61K45/06 , A61K47/10 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/602
摘要： A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and an alkaline thermoplastic matrix-forming material, e.g. polymer. The excipient mixture is formed before blending with an alkaline labile drug. The blend is then hot-melt extruded to form the HME composition. By so doing, the acidic component is able to neutralize or render moderately acidic the excipient mixture. This particular process has been shown to substantially reduce the degradation of an alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during hot-melt extrusion. It can dissolve or not dissolve drug-containing particles during extrusion. Various functional excipients can be included in the carrier system to improve process performance and/or improve the chemical or physical properties of the HME composition.
摘要翻译：提供了含有碱性不稳定药物的稳定的生物粘合剂组合物及其制备方法。在一个方面，组合物是热熔挤出（HME）组合物，其包含预先形成的赋形剂混合物，其包含酸性组分和碱性热塑性基质形成材料，例如，聚合物。赋形剂混合物在与碱性不稳定药物共混之前形成。然后将共混物热熔融挤出以形成HME组合物。通过这样做，酸性成分能够中和或赋予赋形剂混合物中度酸性。已经显示了该特定方法，以显着降低热熔融挤出期间碱性不稳定药物的降解。赋形剂混合物在热熔挤出过程中软化或熔化。在挤出过程中可溶解或不溶解含药颗粒。可以在载体体系中包括各种功能赋形剂以改善工艺性能和/或改善HME组合物的化学或物理性能。

6. 发明申请

US20090136555A1 PROCESS FOR THE PREPARATION OF A HOT-MELT EXTRUDED LAMINATE 有权
标题翻译：制备高熔点挤出层压板的方法
公开(公告)号：US20090136555A1
公开(公告)日：2009-05-28
申请号：US12294372
申请日：2007-03-22
申请人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
发明人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
IPC分类号： A61F2/04 , A61K9/70 , A61K31/56 , A61K9/00
CPC分类号： A61K9/7007 , A61K9/006 , A61K9/7069 , B29C47/0019 , B29C47/0021 , B29C47/065 , B29C47/0816 , B29C47/145 , B29C47/16 , B29K2105/0097 , B29K2995/0092 , B29K2995/0093
摘要： A process for the preparation of a bioadhesive laminate comprising a hot-melt extruded reservoir layer and a hot-melt extruded backing layer is provided. The reservoir layer comprises a thermoplastic bioadhesive composition containing an active agent. An active agent-containing thermoplastic bioadhesive hydrophilic composition is hot-melt coextruded with a hydrophobic composition to form at least a bi-layered laminate. The hydrophilic composition and the hydrophobic composition have at least one polymer in common. In addition, the melt flow index of the hydrophobic composition is within 50% of the melt flow index of the hydrophilic composition. As a result, the laminate has a uniform transverse cross-section and/or a uniform longitudinal cross-section throughout a major of the length of the laminate. Moreover, when the laminate is divided into unit doses of approximately the same size, they have a high degree of content uniformity with respect to the active agent(s) present therein.
摘要翻译：提供了一种用于制备包含热熔挤压储存层和热熔挤出背衬层的生物粘合层压材料的方法。储层包含含有活性剂的热塑性生物粘合剂组合物。将含活性剂的热塑性生物粘附性亲水性组合物与疏水组合物热熔共挤出以形成至少双层层压体。亲水组合物和疏水组合物具有至少一种共聚物。此外，疏水性组合物的熔体流动指数在亲水性组合物的熔体流动指数的50％以内。结果，层压体在层压体的整个长度上具有均匀的横截面和/或均匀的纵向横截面。此外，当将层压体分成大致相同尺寸的单位剂量时，它们相对于其中存在的活性剂具有高度的均匀度。

7. 发明授权

US08883187B2 Stabilized compositions containing alkaline labile drugs 有权
标题翻译：含有碱性不稳定药物的稳定组合物
公开(公告)号：US08883187B2
公开(公告)日：2014-11-11
申请号：US13463375
申请日：2012-05-03
申请人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
发明人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
IPC分类号： A61F2/02 , A61K9/00 , A61K31/568 , A61K9/70
CPC分类号： A61K9/70 , A61K9/0024 , A61K9/006 , A61K9/7023 , A61K9/703 , A61K9/7069 , A61K9/7084 , A61K9/7092 , A61K31/4468 , A61K31/568 , A61K45/06 , A61K47/10 , A61L15/44 , A61L27/54 , A61L31/16 , A61L2300/602
摘要： A stabilized bioadhesive composition containing an alkaline labile drug and a method for its preparation are provided. In one aspect, the composition is a hot-melt extruded (HME) composition comprising a preformed excipient mixture comprising an acidic component and an alkaline thermoplastic matrix-forming material, e.g. polymer. The excipient mixture is formed before blending with an alkaline labile drug. The blend is then hot-melt extruded to form the HME composition. By so doing, the acidic component is able to neutralize or render moderately acidic the excipient mixture. This particular process has been shown to substantially reduce the degradation of an alkaline labile drug during hot-melt extrusion. The excipient mixture softens or melts during hot-melt extrusion. It can dissolve or not dissolve drug-containing particles during extrusion. Various functional excipients can be included in the carrier system to improve process performance and/or improve the chemical or physical properties of the HME composition.
摘要翻译：提供了含有碱性不稳定药物的稳定的生物粘合剂组合物及其制备方法。在一个方面，组合物是热熔挤出（HME）组合物，其包含预先形成的赋形剂混合物，其包含酸性组分和碱性热塑性基质形成材料，例如，聚合物。赋形剂混合物在与碱性不稳定药物共混之前形成。然后将共混物热熔融挤出以形成HME组合物。通过这样做，酸性成分能够中和或赋予赋形剂混合物中度酸性。已经显示了该特定方法，以显着降低热熔融挤出期间碱性不稳定药物的降解。赋形剂混合物在热熔挤出过程中软化或熔化。在挤出过程中可溶解或不溶解含药颗粒。可以在载体体系中包括各种功能赋形剂以改善工艺性能和/或改善HME组合物的化学或物理性能。

8. 发明授权

US08465759B2 Process for the preparation of a hot-melt extruded laminate 有权
标题翻译：制备热熔挤出层压板的方法
公开(公告)号：US08465759B2
公开(公告)日：2013-06-18
申请号：US12294372
申请日：2007-03-22
申请人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
发明人： Michael M. Crowley , Justin M. Keen , John J. Koleng , Feng Zhang
IPC分类号： A61F13/00 , A61K47/00 , A61L15/00 , B29C47/06 , B32B37/00
CPC分类号： A61K9/7007 , A61K9/006 , A61K9/7069 , B29C47/0019 , B29C47/0021 , B29C47/065 , B29C47/0816 , B29C47/145 , B29C47/16 , B29K2105/0097 , B29K2995/0092 , B29K2995/0093
摘要： A process for the preparation of a bioadhesive laminate comprising a hot-melt extruded reservoir layer and a hot-melt extruded backing layer is provided. The reservoir layer comprises a thermoplastic bioadhesive composition containing an active agent. An active agent-containing thermoplastic bioadhesive hydrophilic composition is hot-melt coextruded with a hydrophobic composition to form at least a bi-layered laminate. The hydrophilic composition and the hydrophobic composition have at least one polymer in common. In addition, the melt flow index of the hydrophobic composition is within 50% of the melt flow index of the hydrophilic composition. As a result, the laminate has a uniform transverse cross-section and/or a uniform longitudinal cross-section throughout a major of the length of the laminate. Moreover, when the laminate is divided into unit doses of approximately the same size, they have a high degree of content uniformity with respect to the active agent(s) present therein.
摘要翻译：提供了一种用于制备包含热熔挤压储存层和热熔挤出背衬层的生物粘合层压材料的方法。储层包含含有活性剂的热塑性生物粘合剂组合物。将含活性剂的热塑性生物粘附性亲水性组合物与疏水组合物热熔共挤出以形成至少双层层压体。亲水组合物和疏水组合物具有至少一种共聚物。此外，疏水性组合物的熔体流动指数在亲水性组合物的熔体流动指数的50％以内。结果，层压体在层压体的整个长度上具有均匀的横截面和/或均匀的纵向横截面。此外，当将层压体分成大致相同尺寸的单位剂量时，它们相对于其中存在的活性剂具有高度的均匀度。

9. 发明申请

US20120219620A1 SCF Extract Containing Cardiac Glycoside 有权
标题翻译：含有心脏糖苷的SCF提取物
公开(公告)号：US20120219620A1
公开(公告)日：2012-08-30
申请号：US13417686
申请日：2012-03-12
申请人： O.Cradell Addington , Feng Zhang , John J. Koleng
发明人： O.Cradell Addington , Feng Zhang , John J. Koleng
IPC分类号： A61K36/24 , A61P31/12 , A61P35/00 , A61K9/48 , A61K31/704
CPC分类号： A61K36/24
摘要： A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.
摘要翻译：提供了含有强心苷的植物体的超临界流体（SCF）提取物。提取物可以包含在含有提取物增溶量的增溶剂的药物组合物中。当通过SCF提取提取含有含有强心苷的植物，例如夹心夹心素时，包含在提取物中。提取物还可以含有一种或多种其它SCF可提取的药理学活性剂。该组合物可用于治疗对心脏糖苷治疗响应的各种各样的疾病。

10. 发明申请

US20080131504A1 Short Term Slow Release Drug Delivery System 审中-公开
标题翻译：短期缓释药物输送系统
公开(公告)号：US20080131504A1
公开(公告)日：2008-06-05
申请号：US11565846
申请日：2006-12-01
申请人： Neill B. Walsdorf, Sr. , Jon C. Taylor , Feng Zhang , Francis K. Sherwood , John J. Koleng
发明人： Neill B. Walsdorf, Sr. , Jon C. Taylor , Feng Zhang , Francis K. Sherwood , John J. Koleng
IPC分类号： A61K9/20 , A61K33/00 , A61K33/32
CPC分类号： A61K33/14 , A61K9/2081 , A61K9/5015 , A61K33/00
摘要： The present invention is directed to a novel short term slow release drug delivery system, preferably for solid oral dosage forms of water-soluble, alkaline salts of alkali metals and alkaline earth metals comprising polyvinylpyrrolidone and CPAA and preferably a wax component.
摘要翻译：本发明涉及一种新型的短期缓释药物递送系统，优选用于包含聚乙烯吡咯烷酮和CPAA，优选蜡组分的碱金属和碱土金属的水溶性碱性盐的固体口服剂型。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式