专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080200401A1 SCF Extract Containing Cardiac Glycoside 有权
标题翻译：含有心脏糖苷的SCF提取物
公开(公告)号：US20080200401A1
公开(公告)日：2008-08-21
申请号：US12019435
申请日：2008-01-24
申请人： Otis Crandell ADDINGTON
发明人： Otis Crandell ADDINGTON
IPC分类号： A61K31/70 , C07G3/00 , C12N5/06
CPC分类号： A61K36/24
摘要： A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.
摘要翻译：提供了含有强心苷的植物体的超临界流体（SCF）提取物。提取物可以包含在含有提取物增溶量的增溶剂的药物组合物中。当通过SCF提取提取含有含有强心苷的植物，例如夹心夹心素时，包含在提取物中。提取物还可以含有一种或多种其它SCF可提取的药理学活性剂。该组合物可用于治疗对心脏糖苷治疗响应的各种各样的疾病。

2. 发明授权

US08367363B2 Method of determining the probability of a therapeutic response in cancer chemotherapy with cardiac glycoside 有权
标题翻译：用强心苷确定癌症化疗中治疗反应概率的方法
公开(公告)号：US08367363B2
公开(公告)日：2013-02-05
申请号：US12773540
申请日：2010-05-04
申请人： Otis Crandell Addington , Robert A. Newman , Peiying Yang
发明人： Otis Crandell Addington , Robert A. Newman , Peiying Yang
IPC分类号： C12Q1/34
CPC分类号： G01N33/573 , A61K31/513 , A61K31/58 , A61K31/7008 , A61K31/704 , A61K31/7048 , A61K36/24 , A61K45/06 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , C12Y306/01003 , G01N33/574 , G01N33/6872 , G01N2333/914 , G01N2800/52 , G01N2800/7023 , G01N2800/7028 , G06F19/12
摘要： A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the α subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside.
摘要翻译：提供预后测定法和试剂盒及其使用方法。该试剂盒和测定法用于确定具有与过量细胞增殖相关的病因的疾病中用强心苷治疗的治疗反应的患病细胞或组织的可能性。试剂盒和测定用于测定从患病细胞或组织获得的Na，K-ATP酶的α亚基的同种型的比例。该试剂盒可用于预测受试者用强心苷治疗的癌症或肿瘤的治疗反应性。试剂盒和测定法可以掺入一种用包含强心苷的组合物治疗与过量细胞增殖相关的病因的疾病或病症的方法。

3. 发明授权

US08187644B2 SCF extract containing cardiac glycoside 有权
标题翻译：含有强心苷的SCF提取物
公开(公告)号：US08187644B2
公开(公告)日：2012-05-29
申请号：US12019435
申请日：2008-01-24
申请人： Otis Crandell Addington
发明人： Otis Crandell Addington
IPC分类号： A61K36/13 , A61K36/00
CPC分类号： A61K36/24
摘要： A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.
摘要翻译：提供了含有强心苷的植物体的超临界流体（SCF）提取物。提取物可以包含在含有提取物增溶量的增溶剂的药物组合物中。当通过SCF提取提取含有含有强心苷的植物，例如夹心夹心素时，包含在提取物中。提取物还可以含有一种或多种其它SCF可提取的药理学活性剂。该组合物可用于治疗对心脏糖苷治疗响应的各种各样的疾病。

4. 发明申请

US20100317541A1 Method of Determining the Probability of a Therapeutic Response in Cancer Chemotherapy With Cardiac Glycoside 有权
标题翻译：确定癌症化疗与心脏糖苷治疗反应概率的方法
公开(公告)号：US20100317541A1
公开(公告)日：2010-12-16
申请号：US12773540
申请日：2010-05-04
申请人： Otis Crandell ADDINGTON , Robert A. NEWMAN , Peiying YANG
发明人： Otis Crandell ADDINGTON , Robert A. NEWMAN , Peiying YANG
IPC分类号： C40B30/04 , C12Q1/34 , G01N33/573 , C12Q1/68
CPC分类号： G01N33/573 , A61K31/513 , A61K31/58 , A61K31/7008 , A61K31/704 , A61K31/7048 , A61K36/24 , A61K45/06 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , C12Y306/01003 , G01N33/574 , G01N33/6872 , G01N2333/914 , G01N2800/52 , G01N2800/7023 , G01N2800/7028 , G06F19/12
摘要： A prognostic assay and kit and method of use thereof are provided. The kit and assay are used to determine the likelihood of a diseased cell or tissue having a therapeutic response to treatment with a cardiac glycoside in a disease having an etiology associated with excessive cell proliferation. The kit and assay are used to determine the ratio of isoforms of the α subunit of Na, K-ATPase obtained from the diseased cell or tissue. The kit can be used to predict the therapeutic responsiveness of cancer or tumor in a subject to treatment with a cardiac glycoside. The kit and assay can be incorporated in a method of treating a disease or disorder having an etiology associated with excessive cell proliferation with a composition comprising a cardiac glycoside.
摘要翻译：提供预后测定法和试剂盒及其使用方法。该试剂盒和测定法用于确定具有与过量细胞增殖相关的病因的疾病中用强心苷治疗的治疗反应的患病细胞或组织的可能性。试剂盒和测定用于测定从患病细胞或组织获得的Na，K-ATP酶的α亚基的同种型的比例。该试剂盒可用于预测受试者用强心苷治疗的癌症或肿瘤的治疗反应性。试剂盒和测定法可以掺入一种用包含强心苷的组合物治疗与过量细胞增殖相关的病因的疾病或病症的方法。

5. 发明授权

US08394434B2 SCF extract containing cardiac glycoside 有权
标题翻译：含有强心苷的SCF提取物
公开(公告)号：US08394434B2
公开(公告)日：2013-03-12
申请号：US13417686
申请日：2012-03-12
申请人： Otis Crandell Addington , Feng Zhang , John J. Koleng
发明人： Otis Crandell Addington , Feng Zhang , John J. Koleng
IPC分类号： A61K36/13 , A61K36/00
CPC分类号： A61K36/24
摘要： A supercritical fluid (SCF) extract of a cardiac glycoside-containing plant mass is provided. The extract can be included in a pharmaceutical composition containing an extract-solubilizing amount of solubilizer. Oleandrin is included within the extract when a cardiac glycoside-containing plant, such as Nerium oleander, is extracted by SCF extraction. The extract can also contain one or more other SCF extractable pharmacologically active agents. The composition can be used to treat a wide range of disorders that are therapeutically responsive to a cardiac glycoside.
摘要翻译：提供了含有强心苷的植物体的超临界流体（SCF）提取物。提取物可以包含在含有提取物增溶量的增溶剂的药物组合物中。当通过SCF提取提取含有含有强心苷的植物，例如夹心夹心素时，包含在提取物中。提取物还可以含有一种或多种其它SCF可提取的药理学活性剂。该组合物可用于治疗对心脏糖苷治疗响应的各种各样的疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式