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1. 发明申请

US20090191610A1 Microorganisms With Increased Efficiency for Methionine Synthesis 审中-公开
标题翻译：提高甲硫氨酸合成效率的微生物
公开(公告)号：US20090191610A1
公开(公告)日：2009-07-30
申请号：US11989369
申请日：2006-08-18
申请人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
发明人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
IPC分类号： C12N1/21 , C12N15/10 , C12N1/19 , G01N33/48 , C12N5/10
CPC分类号： C12N15/52 , C12P13/12
摘要： The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
摘要翻译：本发明涉及用于生产具有增加甲硫氨酸合成效率的微生物的方法，提高甲硫氨酸合成效率的微生物以及确定生物相对于甲硫氨酸合成的最佳代谢通量的方法。

2. 发明申请

US20090298136A1 Methionine producing recombinant microorganisms 审中-公开
标题翻译：产生甲硫氨酸的重组微生物
公开(公告)号：US20090298136A1
公开(公告)日：2009-12-03
申请号：US11988962
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Corinna Klopprogge , Hartwig Schroder , Andrea Herold , Thomas A. Patterson , Theron Hermann , R. Rogers Yocum , Mark K. William , Janice G. Pero
发明人： Oskar Zelder , Stefan Haefner , Corinna Klopprogge , Hartwig Schroder , Andrea Herold , Thomas A. Patterson , Theron Hermann , R. Rogers Yocum , Mark K. William , Janice G. Pero
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , C12N15/52
摘要： This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.
摘要翻译：本发明涉及产生甲硫氨酸的重组微生物。具体而言，本发明涉及棒状杆菌的重组菌株，其与野生型对应物相比产生较高水平的甲硫氨酸，并且还涉及产生这种微生物的方法。

3. 发明申请

US20090281353A1 Use of dimethyl disulfide for methionine production in microoragnisms 有权
标题翻译：二甲基二硫化物用于微生物中的甲硫氨酸生产
公开(公告)号：US20090281353A1
公开(公告)日：2009-11-12
申请号：US11988971
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
发明人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
IPC分类号： C12P13/12 , C07C323/03 , C12N1/21 , C12N15/31 , C12Q1/68 , C12N9/00
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，DeltametF生物体或DeltametE AmetH生物体，例如谷氨酸棒状杆菌或大肠杆菌的突变体可以使用甲基封端的硫化物源，例如二甲基二硫醚（DMDS）作为硫和甲基，绕过MetH / MetE和MetF活性的需要，需要还原硫酸盐，用于合成甲硫氨酸。该专利中还描述的是涉及MetY（也称为MetZ）作为将甲基封端的硫化物源例如DMDS掺入甲硫氨酸的酶的数据。谷氨酸棒状病毒的DeltametF DeltametB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基两者的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过量产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

4. 发明授权

US08399214B2 Use of dimethyl disulfide for methionine production in microoraganisms 有权
标题翻译：用二甲基二硫化物在微生物激素中生产甲硫氨酸
公开(公告)号：US08399214B2
公开(公告)日：2013-03-19
申请号：US11988971
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
发明人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
IPC分类号： C12P1/00
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，一种有机蛋白（MetF）生物体或一种具有谷氨酸棒状杆菌或大肠杆菌的突变体的MetE生物体可以使用例如二甲基二硫醚（DMDS）的甲基封端硫化物源作为硫和甲基，绕过MetH / MetE和MetF活性的需要，需要还原硫酸盐，用于合成甲硫氨酸。该专利中还描述的是涉及MetY（也称为MetZ）作为将甲基封端的硫化物源例如DMDS掺入甲硫氨酸的酶的数据。 A＆Dgr; metF＆Dgr;谷氨酸棒杆菌的metB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过量产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

5. 发明授权

US08048651B2 Methods for the preparation of lysine by fermentation of Corynebacterium glutamicum 有权
标题翻译：谷氨酸棒杆菌发酵制备赖氨酸的方法
公开(公告)号：US08048651B2
公开(公告)日：2011-11-01
申请号：US12533677
申请日：2009-07-31
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P13/06 , C12P13/08 , C12P13/10 , C12P13/12 , C12P23/00 , C12N9/16 , C12N15/70 , C12N1/20 , C12N15/74 , C07H21/04
CPC分类号： C12P13/08 , C12N9/16
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译：本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。

6. 发明申请

US20080160585A1 Methods for the Preparation of Lysine by Fermentation of Corynebacterium Glutamicum 审中-公开
标题翻译：通过发酵谷氨酸棒杆菌制备赖氨酸的方法
公开(公告)号：US20080160585A1
公开(公告)日：2008-07-03
申请号：US12021081
申请日：2008-01-28
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P13/08 , C12N15/74 , C12N1/20 , C12N9/16 , C12P1/00
CPC分类号： C12P13/08 , C12N9/16
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译：本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。

7. 发明申请

US20080032374A1 Method for the Preparation of Lysine by Fermentation of Corynebacterium Glutamicum 审中-公开
标题翻译：通过发酵谷氨酸棒杆菌制备赖氨酸的方法
公开(公告)号：US20080032374A1
公开(公告)日：2008-02-07
申请号：US10579690
申请日：2004-12-17
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P1/04 , C12N1/00 , C12N1/21 , C12N9/16
CPC分类号： C12P13/08 , C12N9/16
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译：本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。

8. 发明申请

US20080038787A1 Methods for the Preparation of a Fine Chemical by Fermentation 审中-公开
标题翻译：通过发酵制备精细化学品的方法
公开(公告)号：US20080038787A1
公开(公告)日：2008-02-14
申请号：US10579693
申请日：2004-12-17
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P13/08 , C12N1/21
CPC分类号： C12P13/08
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译：本发明的特征在于通过使酶编码基因失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产的方法，即甘油激酶。在优选的实施方案中，本发明提供了通过增加甘油激酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。

9. 发明申请

US20100015674A1 Methods For The Preparation of Lysine By Fermentation Of Corynebacterium Glutamicum 有权
标题翻译：通过发酵谷氨酸棒杆菌制备赖氨酸的方法
公开(公告)号：US20100015674A1
公开(公告)日：2010-01-21
申请号：US12533677
申请日：2009-07-31
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Häfner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Häfner , Burkhard Kröger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P13/08
CPC分类号： C12P13/08 , C12N9/16
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译：本发明的特征在于通过使酶编码基因（即果糖-1,6-二磷酸酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。在优选的实施方案中，本发明提供了通过增加果糖-1,6-二磷酸酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。

10. 发明申请

US20070134768A1 Methods for the preparation of a fine chemical by fermentation 审中-公开
标题翻译：通过发酵制备精细化学品的方法
公开(公告)号：US20070134768A1
公开(公告)日：2007-06-14
申请号：US10579648
申请日：2004-12-17
申请人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
发明人： Oskar Zelder , Corinna Klopprogge , Hartwig Schroder , Stefan Hafner , Burkhard Kroger , Patrick Kiefer , Elmar Heinzle , Christoph Wittmann
IPC分类号： C12P13/04 , C12N15/74 , C12N1/21
CPC分类号： C12N9/0006 , C12P13/08
摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., lactate dehydrogenase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of the expression of lactate dehydrogenase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.
摘要翻译：本发明的特征在于通过使酶编码基因（即乳酸脱氢酶）失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产方法。在优选的实施方案中，本发明提供通过乳酸脱氢酶活性的表达增加谷氨酸棒杆菌中赖氨酸的产生的方法。本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。

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