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1. 发明申请

US20090191610A1 Microorganisms With Increased Efficiency for Methionine Synthesis 审中-公开
标题翻译：提高甲硫氨酸合成效率的微生物
公开(公告)号：US20090191610A1
公开(公告)日：2009-07-30
申请号：US11989369
申请日：2006-08-18
申请人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
发明人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
IPC分类号： C12N1/21 , C12N15/10 , C12N1/19 , G01N33/48 , C12N5/10
CPC分类号： C12N15/52 , C12P13/12
摘要： The present invention relates to methods for the production of microorganisms with increased efficiency for methionine synthesis, microorganisms with increased efficiency for methionine synthesis, and methods for determining the optimal metabolic flux for organisms with respect to methionine synthesis.
摘要翻译：本发明涉及用于生产具有增加甲硫氨酸合成效率的微生物的方法，提高甲硫氨酸合成效率的微生物以及确定生物相对于甲硫氨酸合成的最佳代谢通量的方法。

2. 发明授权

US08148117B2 Microorganism and process for the preparation of L-methionine 失效
标题翻译：微生物和L-甲硫氨酸的制备方法
公开(公告)号：US08148117B2
公开(公告)日：2012-04-03
申请号：US12091948
申请日：2006-10-23
申请人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
发明人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
IPC分类号： C12P13/12 , C12N9/00 , C12N15/00 , C12N1/21
CPC分类号： C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
摘要翻译：本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。

3. 发明申请

US20090298137A1 MICROORGANISM AND PROCESS FOR THE PREPARATION OF L-METHIONINE 失效
标题翻译：用于制备L-甲硫氨酸的微生物和方法
公开(公告)号：US20090298137A1
公开(公告)日：2009-12-03
申请号：US12091948
申请日：2006-10-23
申请人： Oskar Zelder , Andreas Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
发明人： Oskar Zelder , Andreas Herold , Corinna Klopprogge , Hartwig Schröder , Stefan Haefner , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice G. Pero , R. Rogers Yocum , Thomas A. Patterson , Mark Williams , Theron Herman
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , A23K10/16 , A23K20/142 , A23K40/10 , C12N15/52
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-amino acids such as L-methionine. In particular, the present invention relates to microorganisms and processes in which the formation and/or accumulation of homolanthionine in the methionine pathway is reduced and/or prevented.
摘要翻译：本发明涉及用于有效制备L-氨基酸如L-甲硫氨酸的微生物和方法。特别地，本发明涉及微生物和其中甲硫氨酸途径中高山ion素的形成和/或积累减少和/或预防的方法。

4. 发明申请

US20090298136A1 Methionine producing recombinant microorganisms 审中-公开
标题翻译：产生甲硫氨酸的重组微生物
公开(公告)号：US20090298136A1
公开(公告)日：2009-12-03
申请号：US11988962
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Corinna Klopprogge , Hartwig Schroder , Andrea Herold , Thomas A. Patterson , Theron Hermann , R. Rogers Yocum , Mark K. William , Janice G. Pero
发明人： Oskar Zelder , Stefan Haefner , Corinna Klopprogge , Hartwig Schroder , Andrea Herold , Thomas A. Patterson , Theron Hermann , R. Rogers Yocum , Mark K. William , Janice G. Pero
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , C12N15/52
摘要： This invention relates to methionine producing recombinant microorganisms. Specifically, this invention relates to recombinant strains of Corynebacterium that produce increased levels of methionine compared to their wild-type counterparts and further to methods of generating such microorganisms.
摘要翻译：本发明涉及产生甲硫氨酸的重组微生物。具体而言，本发明涉及棒状杆菌的重组菌株，其与野生型对应物相比产生较高水平的甲硫氨酸，并且还涉及产生这种微生物的方法。

5. 发明申请

US20100003727A1 Coryneform Bacteria with Formate-THF-Synthetase and/or Glycine Cleavage Activity 审中-公开
标题翻译：具有甲酸-THF合成酶和/或甘氨酸裂解活性的棒状杆菌细菌
公开(公告)号：US20100003727A1
公开(公告)日：2010-01-07
申请号：US12519909
申请日：2008-02-14
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson , R. Rogers Yocum , Janice G. Pero
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , Thomas A. Patterson , R. Rogers Yocum , Janice G. Pero
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , C12N15/52
摘要： The present invention relates to microorganisms, in particular C. glutamicum in which the formation of N5,N10-methylene-THF is increased.The present invention also relates to the use of such microorganisms for producing methionine.
摘要翻译：本发明涉及增加N5，N10-亚甲基-THF的形成的微生物，特别是谷氨酸棒杆菌。本发明还涉及这种微生物用于产生甲硫氨酸的用途。

6. 发明申请

US20100009416A1 Process for the Preparation of L-Methionine 审中-公开
标题翻译： L-甲硫氨酸的制备方法
公开(公告)号：US20100009416A1
公开(公告)日：2010-01-14
申请号：US12301279
申请日：2007-05-24
申请人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice Pero , Rogers Yocum , Thomas Patterson , Mark Williams , Theron Hermann
发明人： Oskar Zelder , Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Elmar Heinzle , Christoph Wittmann , Jens Kroemer , Janice Pero , Rogers Yocum , Thomas Patterson , Mark Williams , Theron Hermann
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12
摘要： The present invention relates to microorganisms and processes for the efficient preparation of L-methionine. In particular, the present invention relates to processes in which the amount of serine available for the metabolism of the microorganism is increased.
摘要翻译：本发明涉及用于L-甲硫氨酸有效制备的微生物和方法。特别地，本发明涉及其中可用于微生物代谢的丝氨酸量增加的方法。

7. 发明授权

US08163532B2 Microorganisms with a reactivation system for cob(I)alamin-dependent methionine synthase 失效
标题翻译：具有cob（I）氨基酸依赖性甲硫氨酸合酶活化系统的微生物
公开(公告)号：US08163532B2
公开(公告)日：2012-04-24
申请号：US12472432
申请日：2009-05-27
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , R. Rogers Yocum , Thomas A. Patterson , Mark Williams
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , R. Rogers Yocum , Thomas A. Patterson , Mark Williams
IPC分类号： C12N1/20 , C12N15/00 , C12N15/74 , C12P21/06 , C12P13/12 , C07H21/04
CPC分类号： C12P13/12 , C12N9/1007
摘要： The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.
摘要翻译：本发明涉及通过MetH酶的再活化来生产甲硫氨酸的微生物和方法。

8. 发明申请

US20090311756A1 Microorganisms with a Reactivation System for cob(I)Alamin-Dependent Methionine Synthase 失效
标题翻译：具有重组酶活性的微生物（I）Alamin依赖性甲硫氨酸合成酶
公开(公告)号：US20090311756A1
公开(公告)日：2009-12-17
申请号：US12472432
申请日：2009-05-27
申请人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , R. Rogers Yocum , Thomas A. Patterson , Mark Williams
发明人： Oskar Zelder , Hartwig Schröder , Corinna Klopprogge , Andrea Herold , Stefan Haefner , R. Rogers Yocum , Thomas A. Patterson , Mark Williams
IPC分类号： C12P13/12 , C12N1/21
CPC分类号： C12P13/12 , C12N9/1007
摘要： The present invention relates to microorganisms and methods for producing methionine by reactivation of the MetH enzyme.
摘要翻译：本发明涉及通过MetH酶的再活化来生产甲硫氨酸的微生物和方法。

9. 发明申请

US20090281353A1 Use of dimethyl disulfide for methionine production in microoragnisms 有权
标题翻译：二甲基二硫化物用于微生物中的甲硫氨酸生产
公开(公告)号：US20090281353A1
公开(公告)日：2009-11-12
申请号：US11988971
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
发明人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
IPC分类号： C12P13/12 , C07C323/03 , C12N1/21 , C12N15/31 , C12Q1/68 , C12N9/00
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，DeltametF生物体或DeltametE AmetH生物体，例如谷氨酸棒状杆菌或大肠杆菌的突变体可以使用甲基封端的硫化物源，例如二甲基二硫醚（DMDS）作为硫和甲基，绕过MetH / MetE和MetF活性的需要，需要还原硫酸盐，用于合成甲硫氨酸。该专利中还描述的是涉及MetY（也称为MetZ）作为将甲基封端的硫化物源例如DMDS掺入甲硫氨酸的酶的数据。谷氨酸棒状病毒的DeltametF DeltametB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基两者的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过量产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

10. 发明授权

US08399214B2 Use of dimethyl disulfide for methionine production in microoraganisms 有权
标题翻译：用二甲基二硫化物在微生物激素中生产甲硫氨酸
公开(公告)号：US08399214B2
公开(公告)日：2013-03-19
申请号：US11988971
申请日：2006-07-18
申请人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
发明人： Oskar Zelder , Stefan Haefner , Andrea Herold , Corinna Klopprogge , Hartwig Schroder , R. Rogers Yocum , Mark K. Williams
IPC分类号： C12P1/00
CPC分类号： C12P13/12
摘要： The present invention features improved processes and organisms for the production of methionine. The invention demonstrates that a ΔmetF organism or a ΔmetE AmetH organism, for example, mutants of C. glutamicum or E. coli, can use a methyl capped sulfide source, e.g., dimethyl disulfide (DMDS), as a source of both sulfur and a methyl group, bypassing the need for MetH/MetE and MetF activity and the need to reduce sulfate, for the synthesis of methionine. Also described in this patent are data implicating MetY (also called MetZ) as an enzyme that incorporates a methyl capped sulfide source, e.g., DMDS, into methionine. A ΔmetF ΔmetB strain of C. glutamicum can use a methyl capped sulfide source, e.g., DMDS, as a source of both sulfide and a methyl group. Furthermore, methionine production by engineered prototrophic organisms that overproduce O-acetyl-homoserine was improved by the addition of a methyl capped sulfide source, e.g., DMDS.
摘要翻译：本发明的特征在于用于生产甲硫氨酸的改进方法和生物体。本发明证明，一种有机蛋白（MetF）生物体或一种具有谷氨酸棒状杆菌或大肠杆菌的突变体的MetE生物体可以使用例如二甲基二硫醚（DMDS）的甲基封端硫化物源作为硫和甲基，绕过MetH / MetE和MetF活性的需要，需要还原硫酸盐，用于合成甲硫氨酸。该专利中还描述的是涉及MetY（也称为MetZ）作为将甲基封端的硫化物源例如DMDS掺入甲硫氨酸的酶的数据。 A＆Dgr; metF＆Dgr;谷氨酸棒杆菌的metB菌株可以使用甲基封端的硫化物源，例如DMDS，作为硫化物和甲基的来源。此外，通过加入甲基封端的硫化物源（例如DMDS），改善过量产生O-乙酰高丝氨酸的工程化原养殖生物体的甲硫氨酸生产。

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