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1. 发明申请

US20110106062A1 System and Method For In Vivo Delivery of Antibodies and Fragments Thereof 审中-公开
标题翻译：用于体内递送抗体及其片段的系统和方法
公开(公告)号：US20110106062A1
公开(公告)日：2011-05-05
申请号：US12940090
申请日：2010-11-05
申请人： Osiris Marroquin , Patrick Aebischer , Maurizio Molinari , Nicolas Bouche
发明人： Osiris Marroquin , Patrick Aebischer , Maurizio Molinari , Nicolas Bouche
IPC分类号： A61M37/00
CPC分类号： A61M5/14276 , A61K9/0024 , A61K9/0085 , A61K9/0092
摘要： The present invention is directed to devices and methods for in situ delivering an antibody or a fragment thereof to a host. In particular, the invention relates to devices and methods for in situ delivering an antibody or a fragment thereof to patient suffering for a neurodegenerative disorder or other diseases treated by antibody administration.
摘要翻译：本发明涉及将抗体或其片段原位递送至宿主的装置和方法。特别地，本发明涉及将抗体或其片段原位递送给患有神经退行性疾病或通过抗体给药治疗的其它疾病的患者的装置和方法。

2. 发明申请

US20110275885A1 RECOVERABLE INTRA-UTERINE SYSTEM 审中-公开
标题翻译：可恢复的内脏系统
公开(公告)号：US20110275885A1
公开(公告)日：2011-11-10
申请号：US12735811
申请日：2009-02-13
申请人： Nicolas Bouche
发明人： Nicolas Bouche
IPC分类号： A61B17/435 , A61B17/43
CPC分类号： A61B17/425 , A61B17/43 , A61B17/435 , A61B2017/00867 , A61B2090/08021
摘要： A recoverable intra-uterine system comprises a receptacle (10) designed to contain one or more elements chosen from the group comprising an embryo, male and/or female gametes, a fertilized oocyte, an unfertilized ovum, and a combination of these elements, and a retaining device (20) for retaining the recoverable intra-uterine system in the uterus. The retaining device (20) comprises a deformable element (21) designed to be retained by bearing in the neck of the uterus. Use in artificial insemination techniques.
摘要翻译：可恢复的子宫内系统包括设计成容纳从包括胚胎，雄性和/或雌性配子，受精卵母细胞，未受精卵和这些元素的组合的组中选择的一种或多种元件的容器（10），以及用于将可恢复的子宫内系统保持在子宫中的保持装置（20）。保持装置（20）包括可变形元件（21），该可变形元件被设计成通过支承在子宫的颈部中。用于人工授精技术。

3. 发明授权

US09390187B2 Method for enriching content of a web page with presence information 有权
标题翻译：利用存在信息丰富网页内容的方法
公开(公告)号：US09390187B2
公开(公告)日：2016-07-12
申请号：US12675251
申请日：2008-08-20
申请人： Paul Labrogere , Vincent Billault , Nicolas Bouche
发明人： Paul Labrogere , Vincent Billault , Nicolas Bouche
IPC分类号： H04L29/06 , G06F17/30 , H04L29/08
CPC分类号： G06F17/30887 , G06F17/30893 , H04L65/1016 , H04L67/02 , H04L67/24
摘要： Method for enriching content of a web page (2) displayed for a user on a computer (3) connected to a computerized network (5) and provided with a web browser (4), said method comprising the steps of: the web browser (4) sending a request for a web page (2) to a distant web server (6), upon receipt of the web page (2) from the web server (6), the web browser (4) parsing the web page (2) for contact information, upon detection of contact information within the web page (2), the web browser (4) sending a request for presence information (8) associated with said contact information to at least one presence server (7), upon receipt of the presence information (8) from the presence server(s) (7), the web browser (4) displaying the web page (2) on the computer (3) together with the presence information (8).
摘要翻译：一种用于丰富在连接到计算机网络（5）并且具有网络浏览器（4）的计算机（3）上为用户显示的网页（2）的内容的方法，所述方法包括以下步骤：网页浏览器 4）在从web服务器（6）接收到网页（2）时，向远程Web服务器（6）发送对网页（2）的请求，网页浏览器（4）解析网页（2）），用于联系信息，当检测到网页（2）中的联系人信息时，网络浏览器（4）在收到时向与至少一个在场服务器（7）发送与所述联系人信息相关联的存在信息请求（8）来自存在服务器（7）的存在信息（8），网络浏览器（4）与存在信息（8）一起在计算机（3）上显示网页（2）。

4. 发明授权

US08333688B2 Recoverable intra-uterine system 有权
标题翻译：可恢复子宫内系统
公开(公告)号：US08333688B2
公开(公告)日：2012-12-18
申请号：US12374290
申请日：2007-06-26
申请人： Pascal Mock , Nicolas Bouche , Philippe Le Goff
发明人： Pascal Mock , Nicolas Bouche , Philippe Le Goff
IPC分类号： A61B17/43 , A61F6/06 , A61F6/14
CPC分类号： A61F6/144 , A61B17/43 , A61B17/435
摘要： The recoverable intra-uterine system comprises a housing capable of containing one or a plurality of elements selected from among the group comprising an embryo, male and/or female gametes, a fertilized oocyte, and unfertilized ovum and a combination of these elements, the housing having along an axis a distal end and a proximal end, and a device for holding the recoverable intra-uterine device in the uterus. The holding device is arranged at the proximal end of the housing and includes at least one holding arm in the uterine cavity capable of taking at least two positions: —one free position in which at least one holding arm is separated from the axis; and —a retracted position in which at least one holding arm is substantially parallel to the axis. Use in medically assisted reproduction techniques.
摘要翻译：可恢复的子宫内系统包括能够包含选自包括胚，雄和/或雌配子，受精卵母细胞和未受精卵的组中的一种或多种元件的壳体和这些元件的组合，所述壳体沿着轴线具有远端和近端，以及用于将可恢复的子宫内装置保持在子宫中的装置。保持装置设置在壳体的近端处，并且在子宫腔中包括至少一个保持臂，其能够至少采取两个位置： - 一个自由位置，其中至少一个保持臂与轴线分离; 和 - 至少一个保持臂基本上平行于所述轴线的缩回位置。用于医疗辅助生殖技术。

5. 发明申请

US20110208799A1 METHOD FOR ENRICHING CONTENT OF A WEB PAGE WITH PRESENCE INFORMATION 有权
标题翻译：增强网页内容与现有信息的方法
公开(公告)号：US20110208799A1
公开(公告)日：2011-08-25
申请号：US12675251
申请日：2008-08-20
申请人： Paul Labrogere , Vincent Billault , Nicolas Bouche
发明人： Paul Labrogere , Vincent Billault , Nicolas Bouche
IPC分类号： G06F15/16
CPC分类号： G06F17/30887 , G06F17/30893 , H04L65/1016 , H04L67/02 , H04L67/24
摘要： Method for enriching content of a web page (2) displayed for a user on a computer (3) connected to a computerized network (5) and provided with a web browser (4), said method comprising the steps of: the web browser (4) sending a request for a web page (2) to a distant web server (6), upon receipt of the web page (2) from the web server (6), the web browser (4) parsing the web page (2) for contact information, upon detection of contact information within the web page (2), the web browser (4) sending a request for presence information (8) associated with said contact information to at least one presence server (7), upon receipt of the presence information (8) from the presence server(s) (7), the web browser (4) displaying the web page (2) on the computer (3) together with the presence information (8).
摘要翻译：一种用于丰富在连接到计算机网络（5）并且具有网络浏览器（4）的计算机（3）上为用户显示的网页（2）的内容的方法，所述方法包括以下步骤：网页浏览器 4）在从web服务器（6）接收到网页（2）时，向远程Web服务器（6）发送对网页（2）的请求，网页浏览器（4）解析网页（2）），用于联系信息，当检测到网页（2）中的联系人信息时，网络浏览器（4）在收到时向与至少一个在场服务器（7）发送与所述联系人信息相关联的存在信息请求（8）来自存在服务器（7）的存在信息（8），网络浏览器（4）与存在信息（8）一起在计算机（3）上显示网页（2）。

6. 发明申请

US20090012352A1 RECOVERABLE INTRA-UTERINE DEVICE 审中-公开
标题翻译：可恢复的内脏器官
公开(公告)号：US20090012352A1
公开(公告)日：2009-01-08
申请号：US12159374
申请日：2006-12-26
申请人： Pascal Mock , Nicolas Bouche , Philippe Le Goff
发明人： Pascal Mock , Nicolas Bouche , Philippe Le Goff
IPC分类号： A61B17/435
CPC分类号： A61B17/435
摘要： A recoverable intra-uterine device comprising a housing containing one or several elements selected from a group containing an embryo, male and/or female gametes, a fertilised oocyte, an unfertilised egg and the combination thereof, wherein said housing is provided with a wall made of a biocompatible material. The wall is provided with a series of perforations whose size is sufficient in order to bring the intra-uterine medium into a cellular contact with the housing and to keep the elements therein. The inventive device is provided with a system for loading and unloading one or several elements selected from the group containing an embryo, male and/or female gametes, a fertilised oocyte, an unfertilised egg and the combination thereof.
摘要翻译：一种可恢复的子宫内装置，其包括含有选自包含胚胎，雄性和/或雌性配子，受精卵母细胞，未受精的卵及其组合的组中的一种或几种元件的壳体，其中所述壳体设置有壁的生物相容性材料。壁具有一系列穿孔，其尺寸足以使子宫内介质进入与壳体的细胞接触并将元件保持在其中。本发明的装置设置有用于装载和卸载选自包含胚胎，雄性和/或雌性配子，受精卵母细胞，未受精的卵及其组合的组中的一种或几种元件的系统。

7. 发明申请

US20090299129A1 RECOVERABLE INTRA-UTERINE SYSTEM 有权
标题翻译：可恢复的内脏系统
公开(公告)号：US20090299129A1
公开(公告)日：2009-12-03
申请号：US12374290
申请日：2007-06-26
申请人： Pascal Mock , Nicolas Bouche , Philippe Le Goff
发明人： Pascal Mock , Nicolas Bouche , Philippe Le Goff
IPC分类号： A61B17/435 , A61B17/43
CPC分类号： A61F6/144 , A61B17/43 , A61B17/435
摘要： The recoverable intra-uterine system comprises a housing capable of containing one or a plurality of elements selected from among the group comprising an embryo, male and/or female gametes, a fertilized oocyte, and unfertilized ovum and a combination of these elements, the housing having along an axis a distal end and a proximal end, and a device for holding the recoverable intra-uterine device in the uterus. The holding device is arranged at the proximal end of the housing and includes at least one holding arm in the uterine cavity capable of taking at least two positions: —one free position in which at least one holding arm is separated from the axis; and —a retracted position in which at least one holding arm is substantially parallel to the axis. Use in medically assisted reproduction techniques.
摘要翻译：可恢复的子宫内系统包括能够包含选自包括胚，雄和/或雌配子，受精卵母细胞和未受精卵的组中的一种或多种元件的壳体和这些元件的组合，所述壳体沿着轴线具有远端和近端，以及用于将可恢复的子宫内装置保持在子宫中的装置。保持装置设置在壳体的近端处，并且在子宫腔中包括至少一个保持臂，其能够至少采取两个位置： - 一个自由位置，其中至少一个保持臂与轴线分离; 和 - 至少一个保持臂基本上平行于所述轴线的缩回位置。用于医疗辅助生殖技术。

8. 发明授权

US06383830B2 Optical component having a chemically etched guide with a ridge structure and its method of manufacture 有权
标题翻译：具有具有脊结构的化学蚀刻导向器的光学部件及其制造方法
公开(公告)号：US06383830B2
公开(公告)日：2002-05-07
申请号：US09789826
申请日：2001-02-22
申请人： Nicolas Bouche , Stéphane Lovisa
发明人： Nicolas Bouche , Stéphane Lovisa
IPC分类号： H01L2100
CPC分类号： G02B6/136 , G02B6/122 , G02B2006/12097 , G02B2006/12119
摘要： The present invention concerns an optical component having at least one guide with a ridge structure obtained by chemical etching on a substrate made of semiconductor material, the ridge having a base and a top face, the guide having an outline with at least one curved section, the tangent at any point on the outline defining the local orientation (&bgr;) of the guide. According to the invention, the width of the base (weff) of the ridge is substantially constant all along the guide and the width of the top face (w) of the ridge varies according to the local orientation (&bgr;) of the guide with respect to the reference crystallographic direction (R) of the substrate.
摘要翻译：本发明涉及一种光学部件，其具有至少一个引导件，该引导件具有通过在由半导体材料制成的基板上进行化学蚀刻获得的脊状结构，所述脊具有基部和顶面，所述引导件具有至少一个弯曲部分的轮廓，轮廓上的任何一点上的切线定义了指南的局部方向（β）。根据本发明，脊的基部的宽度（weff）基本上是恒定的，并且脊的顶面（w）的宽度根据引导件的局部取向（β）而变化，相对于到基板的参考晶体方向（R）。

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