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1. 发明授权

US3983152A 9-Oxo-11.alpha.-hydroxymethyl-15.epsilon.-hydroxyprost-13(trans)-enoic acid derivatives and process for the preparation thereof 失效
标题翻译： 9-氧代-11β-羟基甲基-15（68-羟基霜霉素-13（反式） - 烯酸衍生物及其制备方法
公开(公告)号：US3983152A
公开(公告)日：1976-09-28
申请号：US385868
申请日：1973-08-06
申请人： Osamu Oda , Kiyoshi Sakai , Takashi Yusa , Hamako Katano
发明人： Osamu Oda , Kiyoshi Sakai , Takashi Yusa , Hamako Katano
IPC分类号： A61K31/20 , B01J27/00 , B01J31/00 , C07B61/00 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07D317/70 , C07D317/72 , C07D333/32 , C07D335/02 , C07C177/00
CPC分类号： C07D317/72 , C07C405/00 , Y02P20/55
摘要： Prostanoic acid derivatives having the formula ##SPC1##Wherein A represents an alkylene group having from 4 to 8 carbon atoms, R.sup.1 represents an alkyl group having from 4 to 10 carbon atoms, R.sup.2 represents hydrogen atom or an alkyl group having from one to 6 carbon atoms and R.sup.3 represents hydrogen atom or an alkoxycarbonyl group having from one to 6 carbon atoms in the alkyl moiety and the pharmaceutically acceptable salts thereof and also relates to a process for the preparation thereof.The compounds are useful as oxytocic agents and may be prepared by reducing the compound having the formula ##SPC2##Wherein A, R.sup.1, R.sup.2 and R.sup.3 are the same as above and Z represents a carbonyl-protecting group with a metal hydride complex in the presence or absence of an inert organic solvent to give a compound having the formula ##SPC3##Wherein A, R.sup.1, R.sup.2, R.sup.3 and Z are the same as above and removing the carbonyl-protecting group of the latter compound.
摘要翻译：具有下式的前列腺酸衍生物，其中A表示具有4至8个碳原子的亚烷基，R 1表示具有4至10个碳原子的烷基，R 2表示氢原子或具有1至6个碳原子的烷基，R 3 表示氢原子或烷基部分中具有1至6个碳原子的烷氧基羰基及其药学上可接受的盐，并且涉及其制备方法。

2. 发明授权

US4012429A 16,16-Dimethyl 9-oxo-11.alpha.-hydroxymethyl-15.epsilon.-hydroxyprosta-5(cis), 13(trans)-dienoic acid derivatives and process for the preparation thereof 失效
标题翻译： 16,16-二甲基9-氧代-11 {60-羟甲基-15（68-羟基孕甾-5（顺）），13（反） - 二烯酸衍生物及其制备方法
公开(公告)号：US4012429A
公开(公告)日：1977-03-15
申请号：US457564
申请日：1974-04-03
申请人： Kiyoshi Sakai , Osamu Oda , Takashi Yusa , Mitsuo Yamazaki , Masaaki Sasaki , Kazuhiko Sasagawa
发明人： Kiyoshi Sakai , Osamu Oda , Takashi Yusa , Mitsuo Yamazaki , Masaaki Sasaki , Kazuhiko Sasagawa
IPC分类号： C07D335/02 , A61K31/557 , A61K31/5575 , A61P43/00 , B01J31/00 , C07B61/00 , C07C43/174 , C07C51/00 , C07C59/74 , C07C67/00 , C07C401/00 , C07C405/00 , C07D307/93 , C07D307/935 , C07D309/12 , C07C177/00
CPC分类号： C07C43/174 , C07C405/00 , C07D307/93 , C07D309/12 , Y02P20/55
摘要： Prostanoic acid derivatives having the formula ##STR1## wherein A represents a straight or branched alkylene group having from one to 5 carbon atoms, R.sup.1 represents a straight or branched alkyl group having from 4 to 10 carbon atoms and R.sup.2 represents hydrogen atom or a straight or branched alkyl group having from one to 6 carbon atoms and pharmaceutically acceptable salts thereof.The compounds are useful as oxytocic agents and agents inhibiting the secretion of gastric acid and may be prepared by oxidizing a compound having the formula ##STR2## wherein A, R.sup.1 and R.sup.2 are the same as above, R.sup.3 and R.sup.4 are the same or different and each represents a protecting group for the hydroxyl group to give a compound having the formula ##STR3## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same as above, removing the hydroxyl-protecting group from the latter compound and, if appropriate, salifying the product thus obtained.
摘要翻译：具有式“IMAGE”的前列生酸衍生物，其中A表示具有1至5个碳原子的直链或支链亚烷基，R1表示具有4至10个碳原子的直链或支链烷基，R2表示氢原子或直链或支链具有1至6个碳原子的支链烷基及其药学上可接受的盐。

3. 发明授权

US3971825A Pharmaceutically useful prostenoic acid derivatives 失效
标题翻译：药用有用的前列腺酸衍生物
公开(公告)号：US3971825A
公开(公告)日：1976-07-27
申请号：US527353
申请日：1974-11-26
申请人： Kiyoshi Sakai , Takashi Yusa , Kenji Inoue
发明人： Kiyoshi Sakai , Takashi Yusa , Kenji Inoue
IPC分类号： C07C67/00 , C07C401/00 , C07C405/00 , C07D307/935 , C07D309/12 , C07C61/38 , C07C69/74
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12 , Y02P20/55
摘要： New prostaglandin-like compounds, having brochodilating activity, of formula ##SPC1##(wherein A represents a direct bond or an alkylene group and R.sup.1 represents an alkyl group) and their pharmaceutically acceptable salts are prepared by oxidizing compounds of formula ##SPC2##(wherein R.sup.2 represents hydrogen or a carboxyl-protecting group, and R.sup.3 represents a hydroxyl-protecting group), removing protecting groups from the product and, when appropriate, salifying the compound obtained.
摘要翻译：具有通式（WHEREIN A代表直接键或亚烷基并且R 1表示烷基）的具有通菌活性的新的前列腺素样化合物及其药学上可接受的盐通过氧化式（WHEREIN R2表示氢或羧基）保护基，R3表示羟基保护基），从产物中除去保护基，适当时将所得化合物进行成盐。

4. 发明授权

US3996263A 9-Oxo-11.alpha.-methyl-15.EPSILON.-hyroxyprost-13(trans)-enoic acid derivatives and process for the preparaion thereof 失效
标题翻译： 9-氧代-11 {60-甲基-15 {69-羟基霜霉素-13（反） - 烯酸衍生物及其制备方法
公开(公告)号：US3996263A
公开(公告)日：1976-12-07
申请号：US574376
申请日：1975-05-05
申请人： Kiyoshi Sakai , Takashi Yusa , Junya Ide , Mitsuo Yamazaki , Shinsaku Kobayashi
发明人： Kiyoshi Sakai , Takashi Yusa , Junya Ide , Mitsuo Yamazaki , Shinsaku Kobayashi
IPC分类号： C07C405/00 , C07D307/93 , C07D307/935 , C07D317/72 , C07C177/00
CPC分类号： C07D307/935 , C07C405/00 , C07D307/93 , C07D317/72
摘要： Prostanoic acid derivatives having the formula ##STR1## wherein A represents an alkylene group having from 4 to 8 carbon atoms, R.sup.1 represents an alkyl group having from one to 5 carbon atoms, R.sup.2 and R.sup.3 may be the same or different and each represents hydrogen atom or an alkyl group having from one to 4 carbon atoms and R.sup.4 represents hydrogen atom or an alkyl group having from one to 4 carbon atoms and the pharmaceutically acceptable salts thereof and also relates to a process for the preparation thereof.The compounds are useful as anti-ulcerogenic agents and may be prepared by reducing a compound having the formula ##STR2## wherein A, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are the same above and Z represents a carbonyl-protecting group to give a compound having the formula ##STR3## wherein A, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and Z are the same as above and removing the carbonyl-protecting group from the latter compound.
摘要翻译：具有式的前列生酸衍生物，其中A表示具有4至8个碳原子的亚烷基，R 1表示具有1至5个碳原子的烷基，R 2和R 3可以相同或不同，各自表示氢原子或具有1至4个碳原子的烷基和R 4表示氢原子或具有1至4个碳原子的烷基及其药学上可接受的盐，并且涉及其制备方法。

5. 发明申请

US20130195991A1 Composition for Treatment of Damaged Part 审中-公开
标题翻译：治疗损伤部位的组成
公开(公告)号：US20130195991A1
公开(公告)日：2013-08-01
申请号：US13637107
申请日：2011-03-25
申请人： Minoru Ueda , Yoichi Yamada , Katsumi Ebisawa , Akihito Yamamoto , Kiyoshi Sakai , Kohki Matsubara , Hisashi Hattori , Masahiko Sugiyama , Takanori Inoue
发明人： Minoru Ueda , Yoichi Yamada , Katsumi Ebisawa , Akihito Yamamoto , Kiyoshi Sakai , Kohki Matsubara , Hisashi Hattori , Masahiko Sugiyama , Takanori Inoue
IPC分类号： A61K35/12
CPC分类号： A61K35/12 , A61K35/28 , A61K35/30 , A61K35/32 , A61K35/545 , A61K38/18 , A61K38/1833 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/30 , C12N5/0664 , A61K2300/00
摘要： The present invention provides a damaged part treatment composition for repairing a damaged part of a target tissue that includes a stem cell-conditioned medium obtained by culturing stem cells; a damaged part treatment method for repairing or restoring a damaged part of a target tissue that includes administering the damaged part treatment composition to a patient having the target tissue for the damaged part treatment composition in an amount therapeutically effective for repairing the damaged part of the target tissue; a method of treating cerebral infarction that includes administering the damaged part treatment composition to a cerebral infarct patient in an amount effective for repairing a damaged part of the brain; and a method of treating a CNS disease that includes administering, as a CNS disease treatment composition, the damaged part treatment composition to a CNS disease patient in a therapeutically effective amount.
摘要翻译：本发明提供一种用于修复目标组织的损伤部分的损伤部分处理组合物，其包括通过培养干细胞获得的干细胞条件培养基; 用于修复或恢复目标组织的损伤部分的损坏部分处理方法，包括将损伤的部分处理组合物施用于具有损伤部分处理组合物的目标组织的患者，其量以治疗有效的量修复靶的损伤部分组织; 一种治疗脑梗死的方法，其包括以有效修复脑损伤部分的量将损伤的部分治疗组合物给予脑梗死患者; 以及治疗CNS疾病的方法，其包括以治疗有效量向CNS疾病患者施用所述损伤的部分治疗组合物作为CNS疾病治疗组合物。

6. 发明申请

US20070217510A1 VIDEO CODING METHOD, VIDEO CODING APPARATUS AND VIDEO CODING PROGRAM 有权
标题翻译：视频编码方法，视频编码设备和视频编码程序
公开(公告)号：US20070217510A1
公开(公告)日：2007-09-20
申请号：US11460260
申请日：2006-07-27
申请人： Akihiro Yamori , Akira Nakagawa , Kiyoshi Sakai
发明人： Akihiro Yamori , Akira Nakagawa , Kiyoshi Sakai
IPC分类号： H04N7/12 , H04N11/04
CPC分类号： H04N19/157 , H04N19/109 , H04N19/176 , H04N19/52 , H04N19/61
摘要： The present invention provides a video coding method which includes, as one of a plurality of coding modes, a direct mode generating a piece of motion information of each of Macro Blocks, which are obtained by dividing a first picture, by predicting from motion information of a coded Macro Block of other plurality of second pictures, including: a first step for selecting the direct mode as the coding mode by using a variable selection criterion; and a second step for coding the Macro Blocks based on the selected coding mode.
摘要翻译：本发明提供一种视频编码方法，其包括作为多个编码模式之一的直接模式，通过从第一图像的运动信息预测生成通过划分第一图像获得的每个宏块的运动信息，其它多个第二图像的编码宏块，包括：通过使用变量选择准则来选择直接模式作为编码模式的第一步骤; 以及用于基于所选择的编码模式对宏块进行编码的第二步骤。

7. 发明授权

US06725003B2 Image forming apparatus having a supporting device for supporting imaging units 失效
标题翻译：图像形成装置具有用于支撑成像单元的支撑装置
公开(公告)号：US06725003B2
公开(公告)日：2004-04-20
申请号：US09964584
申请日：2001-09-28
申请人： Yasuyuki Shinkai , Kiyoshi Sakai , Satoru Tomita , Mamoru Kiyota , Kohji Ichimiya , Yuichiro Kanoshima , Nekka Matsuura
发明人： Yasuyuki Shinkai , Kiyoshi Sakai , Satoru Tomita , Mamoru Kiyota , Kohji Ichimiya , Yuichiro Kanoshima , Nekka Matsuura
IPC分类号： G03G1500
CPC分类号： G03G21/1619 , G03G15/0194 , G03G2221/1684
摘要： An image forming apparatus including a plurality of imaging units each for forming an image on a recording medium, an image carrier provided in each of the plurality of imaging unit, a development unit for visualizing an electrostatic latent image on the image carrier by toner in each of the plurality of imaging units, and a supporting device configured to integrate at least two imaging units of the plurality of imaging units into a unit, wherein the supporting device has a plurality of pressing members configured to press upper portions of the at least two imaging units, respectively, and a plurality of supporting members configured to support lower portions of the at least two imagining units, respectively.
摘要翻译：一种图像形成装置，包括：用于在记录介质上形成图像的多个成像单元;设置在所述多个成像单元中的每一个中的图像载体;显影单元，用于通过各自中的调色剂使所述图像载体上的静电潜像可视化以及支撑装置，其被配置为将所述多个成像单元中的至少两个成像单元集成为一个单元，其中所述支撑装置具有多个按压构件，所述多个按压构件构造成按压所述至少两个成像的上部以及分别配置成支撑所述至少两个想象单元的下部的多个支撑构件。

8. 发明授权

US06207151B1 Aqueous solution of t-PA 失效
标题翻译： t-PA的水溶液
公开(公告)号：US06207151B1
公开(公告)日：2001-03-27
申请号：US08259152
申请日：1994-06-13
申请人： Yukio Shimazaki , Nobuhiro Kawashima , Miki Suzuki , Yasuhito Tanaka , Ryo Tanaka , Kiyoshi Sakai , Hisahiro Ishiwari
发明人： Yukio Shimazaki , Nobuhiro Kawashima , Miki Suzuki , Yasuhito Tanaka , Ryo Tanaka , Kiyoshi Sakai , Hisahiro Ishiwari
IPC分类号： A61K3849
CPC分类号： A61K38/49 , A61K47/34 , A61K47/36 , A61K47/42
摘要： Aqueous protein-containing solutions, in which a protein is dissolved at a high concentration at a pH near the isoelectric point of the protein by adding an anionic polymer or a salt thereof to the solution. Pharmaceutical formulations using a physiologically active protein are prepared using this technique.
摘要翻译：含有蛋白质的溶液，其中蛋白质通过向溶液中加入阴离子聚合物或其盐，在接近蛋白质等电点的pH下以高浓度溶解。使用该技术制备使用生理活性蛋白质的药物制剂。

9. 发明授权

US5844611A Image coding system which limits number of variable length code words 失效
标题翻译：限制可变长度码字数量的图像编码系统
公开(公告)号：US5844611A
公开(公告)日：1998-12-01
申请号：US452834
申请日：1995-05-30
申请人： Takashi Hamano , Kiyoshi Sakai , Kiichi Matsuda
发明人： Takashi Hamano , Kiyoshi Sakai , Kiichi Matsuda
IPC分类号： G06T9/00 , H03M7/42 , H04N19/126 , H04N19/136 , H04N19/152 , H04N19/196 , H04N19/42 , H04N19/423 , H04N19/50 , H04N19/503 , H04N19/60 , H04N19/61 , H04N19/625 , H04N19/85 , H04N19/91 , H04N7/30
CPC分类号： H04N19/00 , H03M7/42 , H04N19/124 , H04N19/152 , H04N19/176 , H04N19/60 , H04N19/61 , H04N19/13 , H04N19/146 , H04N19/50 , H04N19/91
摘要： An image encoding control system includes an orthogonal transform encoder for carrying out orthogonal transform coding for each block which includes transform coefficients related to a plurality of blocks, each block obtained by dividing one picture of an input image signal into the plurality of blocks, a code control for controlling the transform coefficients obtained for each block so that the number of variable-length code words obtained for each block is equal to or smaller than a predetermined number of variable-length code words, a variable-length encoder for converting the transform coefficients obtained for each block into variable-length code words, and a buffer memory for temporarily storing the variable-length code words output by the variable-length encoder for each block.
摘要翻译：图像编码控制系统包括正交变换编码器，用于对包括与多个块相关的变换系数的每个块执行正交变换编码，每个块通过将输入图像信号的一个图像分成多个块而获得;块用于控制为每个块获得的变换系数，使得为每个块获得的可变长度码字的数量等于或小于预定数量的可变长度码字;可变长度编码器，用于将变换系数对于每个块获得的可变长度码字;以及缓冲存储器，用于临时存储由每个块由可变长度编码器输出的可变长度码字。

10. 发明授权

US5719963A Two-dimensional discrete cosine transform computing circuit 失效
标题翻译：二维离散余弦变换计算电路
公开(公告)号：US5719963A
公开(公告)日：1998-02-17
申请号：US454867
申请日：1995-05-31
申请人： Kimihiko Kazui , Kiyoshi Sakai , Kiichi Matsuda , Akira Nakagawa
发明人： Kimihiko Kazui , Kiyoshi Sakai , Kiichi Matsuda , Akira Nakagawa
IPC分类号： H04N7/30 , G06F17/14 , G06T1/20 , G06T9/00 , H03M7/30 , H04N1/41 , G06K9/20 , G06F15/00 , G06K9/38
CPC分类号： G06F17/147 , G06T9/007
摘要： A two-dimensional discrete cosine transform computing circuit has a transform block, formed by a multiplication unit and a Hadamard transform unit, which performs computations in a sequence of Hadamard transforms followed by multiplications in a two-dimensional discrete cosine transform, and in a sequence of multiplication followed by Hadamard transforms in an inverse two-dimensional discrete cosine transform. A memory block temporarily stores input/output data of the transform block; an input/output processing block performs pre-processing and post-processing such as cumulative addition and subtraction of input/output data of the transform block. A control block controls, when performing processing for either a two-dimensional discrete cosine transform or inverse two-dimensional discrete cosine transform, multiplications of coefficients in the transform block, read/write of the memory block, and the input/output processing block. This configuration achieves high-speed processing and a reduction in scale of the circuitry.
摘要翻译：二维离散余弦变换计算电路具有由乘法单元和Hadamard变换单元形成的变换块，该单元在Hadamard变换序列中进行计算，随后在二维离散余弦变换中进行乘法，并以序列的乘法，然后是逆二维离散余弦变换中的Hadamard变换。存储块临时存储变换块的输入/输出数据; 输入/输出处理块执行诸如变换块的输入/输出数据的累积加法和减法的预处理和后处理。当执行二维离散余弦变换或反向二维离散余弦变换的处理时，控制块控制变换块中的系数乘法，存储块的读/写和输入/输出处理块。该配置实现了高速处理和电路规模的缩小。

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