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1. 发明授权

US07985781B2 PVA hydrogel 有权
标题翻译： PVA水凝胶
公开(公告)号：US07985781B2
公开(公告)日：2011-07-26
申请号：US12170303
申请日：2008-07-09
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Jeffrey W. Ruberti , Niels A. Abt
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Jeffrey W. Ruberti , Niels A. Abt
IPC分类号： A61K27/14 , A61K24/04 , C08L29/00 , C08L39/00 , C08F116/06 , C08F116/34 , C08F118/08 , C08F126/10 , A61F2/02
CPC分类号： C08J3/28 , C08J2329/04 , Y10S524/916
摘要： The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.
摘要翻译：本发明提供了制备具有有利物理性质的共价交联的乙烯基聚合物水凝胶和通过这些方法制备的共价交联的乙烯基聚合物水凝胶组合物的方法，以及包含这种共价交联的乙烯基聚合物水凝胶组合物的制品。所产生的水凝胶的物理性质可以通过改变受控参数来调节，例如物理缔合的比例，聚合物的浓度和施加的辐射量。根据加工条件，这种共价交联的乙烯基聚合物水凝胶可以制成半透明的，优选透明的或不透明的。所制备的乙烯基聚合物水凝胶的物理性质的稳定性可以通过控制共价交联剂的量来增强。

2. 发明申请

US20090131548A1 PVA HYDROGEL 有权
公开(公告)号：US20090131548A1
公开(公告)日：2009-05-21
申请号：US12170303
申请日：2008-07-09
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Jeffrey W. Ruberti , Niels A. Abt
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Jeffrey W. Ruberti , Niels A. Abt
IPC分类号： C08J3/28
CPC分类号： C08J3/28 , C08J2329/04 , Y10S524/916
摘要： The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.
摘要翻译：本发明提供了制备具有有利物理性质的共价交联的乙烯基聚合物水凝胶和通过这些方法制备的共价交联的乙烯基聚合物水凝胶组合物的方法，以及包含这种共价交联的乙烯基聚合物水凝胶组合物的制品。所产生的水凝胶的物理性质可以通过改变受控参数来调节，例如物理缔合的比例，聚合物的浓度和施加的辐射量。根据加工条件，这种共价交联的乙烯基聚合物水凝胶可以制成半透明的，优选透明的或不透明的。所制备的乙烯基聚合物水凝胶的物理性质的稳定性可以通过控制共价交联剂的量来增强。

3. 发明授权

US07235592B2 PVA hydrogel 失效
标题翻译： PVA水凝胶
公开(公告)号：US07235592B2
公开(公告)日：2007-06-26
申请号：US10962975
申请日：2004-10-12
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Jeffrey W. Ruberti , Niels Abt
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Jeffrey W. Ruberti , Niels Abt
IPC分类号： C08F2/46
CPC分类号： C08J3/28 , C08J2329/04 , Y10S524/916
摘要： The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.
摘要翻译：本发明提供了制备具有有利物理性质的共价交联的乙烯基聚合物水凝胶和通过这些方法制备的共价交联的乙烯基聚合物水凝胶组合物的方法，以及包含这种共价交联的乙烯基聚合物水凝胶组合物的制品。所产生的水凝胶的物理性质可以通过改变受控参数来调节，例如物理缔合的比例，聚合物的浓度和施加的辐射量。根据加工条件，这种共价交联的乙烯基聚合物水凝胶可以制成半透明的，优选透明的或不透明的。所制备的乙烯基聚合物水凝胶的物理性质的稳定性可以通过控制共价交联剂的量来增强。

4. 发明授权

US09962463B2 Cross-linking of antioxidant-containing polymers 有权
公开(公告)号：US09962463B2
公开(公告)日：2018-05-08
申请号：US15184228
申请日：2016-06-16
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg
IPC分类号： A61L27/16 , A61L27/44 , A61L27/50 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08J3/22 , C08J3/28 , C08J3/24 , C08K5/1545
CPC分类号： A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L2430/02 , C08J3/226 , C08J3/247 , C08J3/28 , C08J2323/06 , C08J2423/00 , C08K5/1545 , C08K2201/012 , C08L23/06 , C08L2666/02 , C08K5/005
摘要： The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.

5. 发明授权

US08968628B2 Methods for making oxidation resistant polymeric material 有权
公开(公告)号：US08968628B2
公开(公告)日：2015-03-03
申请号：US12987399
申请日：2011-01-10
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg
IPC分类号： B29C35/08 , A61L27/16 , A61L27/50 , B29C43/00 , C08K5/00 , C08K5/1545 , A61L29/04 , A61L29/14 , A61L31/04 , A61L31/14 , C08J3/28 , C08L23/06
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.

6. 发明授权

US08318065B2 Methods for making oxidation resistant polymeric material 有权
标题翻译：制造耐氧化聚合材料的方法
公开(公告)号：US08318065B2
公开(公告)日：2012-11-27
申请号：US12904481
申请日：2010-10-14
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg
IPC分类号： C08J3/28
CPC分类号： A61L27/16 , A61L27/505 , C08L23/06 , C08L23/10 , C08L27/06 , C08L67/00 , C08L77/00 , C08L2312/06
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion, post-doping annealing, and materials used therein.
摘要翻译：本发明涉及制备抗氧化医疗器械的方法，其包括聚合材料，例如超高分子量聚乙烯（UHMWPE）。本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散掺杂含有交联的UHMWPE与维生素E的医疗装置，后掺杂退火和其中使用的材料。

7. 发明申请

US20120082860A1 High Modulus Crosslinked Polyethylene with Reduced Residual Free Radical Concentration Prepared Below the Melt 审中-公开
标题翻译：高模量交联聚乙烯，在熔体下方制备残留的自由基浓度降低
公开(公告)号：US20120082860A1
公开(公告)日：2012-04-05
申请号：US13314586
申请日：2011-12-08
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Gareth H. Mckinley
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Gareth H. Mckinley
IPC分类号： B32B15/08 , C08J3/28 , B32B27/08 , C08F110/02
CPC分类号： C08J3/28 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61L27/16 , B29B13/08 , B29C71/04 , B29C2035/085 , B29C2035/0877 , B29K2023/06 , B29K2023/0683 , B29K2995/0087 , B29L2031/7532 , C08J3/24 , C08J7/12 , C08J2323/06 , C08L23/06 , C08L23/0815 , C08L2312/06 , Y10T428/31692 , Y10T428/31909
摘要： The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
摘要翻译：本发明提供一种包含还原自由基的辐照交联聚乙烯，优选基本上不含残留的自由基。公开了通过在低于熔点的高温下照射聚乙烯与感光环境接触来制造照射的交联聚乙烯的方法，以便将残余自由基的浓度降低至不可检测的水平。本文还公开了通过在低于聚乙烯熔点的温度（任选在敏化环境中）使聚乙烯机械变形来制备具有降低的自由基含量的辐照交联聚乙烯组合物，优选基本上不含残余自由基的方法。。

8. 发明授权

US07906064B2 Methods for making oxidation resistant polymeric material 有权
公开(公告)号：US07906064B2
公开(公告)日：2011-03-15
申请号：US11564594
申请日：2006-11-29
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg
IPC分类号： B29B13/08
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.

9. 发明授权

US07507774B2 High modules crosslinked polyethylene with reduced residual free radical concentration prepared below the melt 有权
标题翻译：高分子量交联聚乙烯，在熔体下制备残留的自由基浓度降低
公开(公告)号：US07507774B2
公开(公告)日：2009-03-24
申请号：US11873853
申请日：2007-10-17
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Gareth H. McKinley
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg , Gareth H. McKinley
IPC分类号： C08F2/46 , A61F2/00 , A61F2/02 , A61F2/30
CPC分类号： C08J3/28 , A61F2/3094 , A61F2/32 , A61F2/38 , A61F2/3804 , A61F2/4202 , A61L27/16 , B29B13/08 , B29C71/04 , B29C2035/085 , B29C2035/0877 , B29K2023/06 , B29K2023/0683 , B29K2995/0087 , B29L2031/7532 , C08J3/24 , C08J7/12 , C08J2323/06 , C08L23/06 , C08L23/0815 , C08L2312/06 , Y10T428/31692 , Y10T428/31909
摘要： The present invention provides an irradiated crosslinked polyethylene containing reduced free radicals, preferably containing substantially no residual free radical. Disclosed is a process of making irradiated crosslinked polyethylene by irradiating the polyethylene in contact with a sensitizing environment at an elevated temperature that is below the melting point, in order to reduce the concentration of residual free radicals to an undetectable level. A process of making irradiated crosslinked polyethylene composition having reduced free radical content, preferably containing substantially no residual free radicals, by mechanically deforming the polyethylene at a temperature that is below the melting point of the polyethylene, optionally in a sensitizing environment, is also disclosed herein.
摘要翻译：本发明提供一种包含还原自由基的辐照交联聚乙烯，优选基本上不含残留的自由基。公开了通过在低于熔点的高温下照射聚乙烯与感光环境接触来制造照射的交联聚乙烯的方法，以便将残余自由基的浓度降低至不可检测的水平。本文还公开了通过在低于聚乙烯熔点的温度（任选在敏化环境中）使聚乙烯机械变形来制备具有降低的自由基含量的辐照交联聚乙烯组合物，优选基本上不含残余自由基的方法。。

10. 发明授权

US07431874B2 Methods for making oxidation resistant polymeric material 有权
标题翻译：制造耐氧化聚合材料的方法
公开(公告)号：US07431874B2
公开(公告)日：2008-10-07
申请号：US10757551
申请日：2004-01-15
申请人： Orhun K. Muratoglu , Stephen H. Spiegelberg
发明人： Orhun K. Muratoglu , Stephen H. Spiegelberg
IPC分类号： B29C71/02 , B29C35/08 , A61F2/34 , A61F2/38 , B29C43/02
CPC分类号： B29C35/0805 , A61L27/16 , A61L27/505 , A61L29/041 , A61L29/143 , A61L31/048 , A61L31/143 , B29C43/003 , C08J3/28 , C08K5/005 , C08K5/1545 , C08L23/06 , C08L2312/06 , Y10T29/49 , Y10T29/49995 , Y10T428/31855
摘要： The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
摘要翻译：本发明涉及制备抗氧化医疗器械的方法，其包括聚合物材料，例如超高分子量聚乙烯（UHMWPE）。本发明还提供了制备抗氧化剂掺杂医疗植入物的方法，例如，通过扩散和其中使用的材料掺杂含有与维生素E的交联UHMWPE的医疗装置。

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