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1. 发明授权

US09346832B2 Gold complexes for use in the treatment of cancer 有权
标题翻译：用于治疗癌症的金配合物
公开(公告)号：US09346832B2
公开(公告)日：2016-05-24
申请号：US13704894
申请日：2011-06-14
申请人： Orde Quentin Munro , Kate Julie Akerman , Piers Akerman
发明人： Orde Quentin Munro , Kate Julie Akerman , Piers Akerman
IPC分类号： C07F1/12 , A61K31/28 , C01G7/00 , C07C209/16 , C07C213/02 , C07D401/12 , C07D487/22 , C07C209/68 , C07C209/86 , C07C213/06 , C07D207/335
CPC分类号： C07F1/12 , C01G7/00 , C07C209/16 , C07C209/68 , C07C209/86 , C07C213/02 , C07C213/06 , C07D207/335 , C07D401/12 , C07D487/22 , C07C211/15 , C07C217/42
摘要： The invention provides compounds of the Formula (I), in which W is independently selected from W1, W2, W3, W4, W5, or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Zn—Zn′ bonds (n=4-17; n′=n+1) are optionally of any whole or partial bond order, Y is Y1 or Y represents a pair of substituents independently selected from H, C1-C6 alkyl, Z5 or Z6 aryl, or Y is optionally a bridging structure that may comprise one or more C1-C6 amide, C1-C6 ether, or C1-C6 ester groups, R—R39 are independently selected from no substituent, a lone pair of electrons, H, halogen, C5-C6 aryl, C1-C12 alkyl, amine, C1-C6 alkylamine, C1-C6 amide, nitro, cyano, carboxyl, C1-C6 ester, phosphane, thiol, C1-C6 thioether, OR40, and suitable pairs of adjacent R groups (R—R39) may optionally together form part of a C5 or C6 aryl ring, a Z5 or Z6 ring, R40 is independently selected from H, C1-C6 alkyl, Z5 or Z6 aryl, C1-C6 ester, poly(—C2O—), amine, and C1-C6 alkylamine, Z—Z24 are independently selected from C, N, P, O, and S, and X− is a pharmaceutically acceptable anion, for the treatment of cancer.
摘要翻译：本发明提供式（I）化合物，其中W独立地选自W 1，W 2，W 3，W 4，W 5或W表示独立地选自H，烷基，芳基或酰胺的一对取代基，其中酰胺是任选地部分连接链，Zn-Zn'键（n = 4-17; n'= n + 1）任选地具有任何全部或部分键合顺序，Y是Y1或Y表示独立选择的一对取代基由H，C 1 -C 6烷基，Z 5或Z 6芳基，或Y任选是可以包含一个或多个C 1 -C 6酰胺，C 1 -C 6醚或C 1 -C 6酯基团的桥连结构，R-R 39独立地选自无取代基，孤对电子，H，卤素，C5-C6芳基，C1-C12烷基，胺，C1-C6烷基胺，C1-C6酰胺，硝基，氰基，羧基，C1-C6酯， C1-C6硫醚，OR40和适当的相邻R基团（R-R39）可以任选地一起形成C5或C6芳基环，Z5或Z6环的一部分，R40独立地选自H，C1-C6烷基， Z5 或Z6芳基，C1-C6酯，聚（-C2O-），胺和C1-C6烷基胺，Z-Z24独立地选自C，N，P，O和S，X-是药学上可接受的阴离子，用于治疗癌症。

2. 发明申请

US20130090472A1 GOLD COMPLEXES FOR USE IN THE TREATMENT OF CANCER 有权
标题翻译：用于治疗癌症的黄金复合物
公开(公告)号：US20130090472A1
公开(公告)日：2013-04-11
申请号：US13704894
申请日：2011-06-14
申请人： Orde Quentin Munro , Kate Julie Akerman , Piers Akerman
发明人： Orde Quentin Munro , Kate Julie Akerman , Piers Akerman
IPC分类号： C07F1/12 , C07C209/86 , C07D207/335 , C07C213/06 , C07C209/68
CPC分类号： C07F1/12 , C01G7/00 , C07C209/16 , C07C209/68 , C07C209/86 , C07C213/02 , C07C213/06 , C07D207/335 , C07D401/12 , C07D487/22 , C07C211/15 , C07C217/42
摘要： The invention provides compounds of the Formula (I), in which W is independently selected from W1, W2, W3, W4, W5, or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Zn—Zn bonds (n=4-17; n′=n+1) are optionally of any whole or partial bond order, Y is Y1 or Y represents a pair of substituents independently selected from H, C-1-C6 alkyl, Z5 or Z6 aryl, or Y is optionally a bridging structure that may comprise one or more C-1-C6 amide, C-1-C6 ether, or C-1-C6 ester groups, R-R39 are independently selected from no substituent, a lone pair of electrons, H, halogen, C5-C6 aryl, C1- C-12 alkyl, amine, C-1-C6 alkylamine, C-1-C6 amide, nitro, cyano, carboxyl, C-1-C6 ester, phosphane, thiol, C-1-C6 thioether, OR′, and suitable pairs of adjacent R groups (R-R39) may optionally together form part of a C5 or C6 aryl ring, a Z5 or Z6 ring, R′ is independently selected from H, C-1-C6 alkyl, Z5 or Z6 aryl, C-1-C6 ester, poly(—C2O—), amine, and C-1-C6 alkylamine, Z-Z24 are independently selected from C, N, P, O, and S, and X− is a pharmaceutically acceptable anion, for the treatment of cancer.
摘要翻译：本发明提供式（I）化合物，其中W独立地选自W 1，W 2，W 3，W 4，W 5或W表示独立地选自H，烷基，芳基或酰胺的一对取代基，其中酰胺是任选地部分连接链，并且Zn-Zn键（n = 4-17; n'= n + 1）任选地具有任何全部或部分键合顺序，Y是Y 1或Y表示一对独立地选自 H，C 1 -C 6烷基，Z 5或Z 6芳基，或Y任选是可以包含一个或多个C 1 -C 6酰胺，C 1 -C 6醚或C 1 -C 6酯基团的桥连结构， R-R39独立地选自无取代基，孤对电子，H，卤素，C 5 -C 6芳基，C 1 -C 12烷基，胺，C 1 -C 6烷基胺，C 1 -C 6酰胺，硝基，氰基，羧基，C-1-C6酯，膦，硫醇，C-1-C6硫醚，OR'，合适的相邻R基团（R-R39）可任选地一起形成C5或C6芳环的一部分， Z5或Z6环，R'独立地选自H，C-1-C6烷基 C 1 -C 6烷基，C 1 -C 6烷基胺，Z-Z 2，Z 5或Z 6芳基，C 1 -C 6酯，聚（C 2 O - ），胺和C 1 -C 6烷基胺，Z-Z 24独立地选自C，N，P，O和S， X-是药学上可接受的阴离子，用于治疗癌症。

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