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    • 1. 发明授权
    • Gold complexes for use in the treatment of cancer
    • 用于治疗癌症的金配合物
    • US09346832B2
    • 2016-05-24
    • US13704894
    • 2011-06-14
    • Orde Quentin MunroKate Julie AkermanPiers Akerman
    • Orde Quentin MunroKate Julie AkermanPiers Akerman
    • C07F1/12A61K31/28C01G7/00C07C209/16C07C213/02C07D401/12C07D487/22C07C209/68C07C209/86C07C213/06C07D207/335
    • C07F1/12C01G7/00C07C209/16C07C209/68C07C209/86C07C213/02C07C213/06C07D207/335C07D401/12C07D487/22C07C211/15C07C217/42
    • The invention provides compounds of the Formula (I), in which W is independently selected from W1, W2, W3, W4, W5, or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Zn—Zn′ bonds (n=4-17; n′=n+1) are optionally of any whole or partial bond order, Y is Y1 or Y represents a pair of substituents independently selected from H, C1-C6 alkyl, Z5 or Z6 aryl, or Y is optionally a bridging structure that may comprise one or more C1-C6 amide, C1-C6 ether, or C1-C6 ester groups, R—R39 are independently selected from no substituent, a lone pair of electrons, H, halogen, C5-C6 aryl, C1-C12 alkyl, amine, C1-C6 alkylamine, C1-C6 amide, nitro, cyano, carboxyl, C1-C6 ester, phosphane, thiol, C1-C6 thioether, OR40, and suitable pairs of adjacent R groups (R—R39) may optionally together form part of a C5 or C6 aryl ring, a Z5 or Z6 ring, R40 is independently selected from H, C1-C6 alkyl, Z5 or Z6 aryl, C1-C6 ester, poly(—C2O—), amine, and C1-C6 alkylamine, Z—Z24 are independently selected from C, N, P, O, and S, and X− is a pharmaceutically acceptable anion, for the treatment of cancer.
    • 本发明提供式(I)化合物,其中W独立地选自W 1,W 2,W 3,W 4,W 5或W表示独立地选自H,烷基,芳基或酰胺的一对取代基,其中酰胺是 任选地部分连接链,Zn-Zn'键(n = 4-17; n'= n + 1)任选地具有任何全部或部分键合顺序,Y是Y1或Y表示独立选择的一对取代基 由H,C 1 -C 6烷基,Z 5或Z 6芳基,或Y任选是可以包含一个或多个C 1 -C 6酰胺,C 1 -C 6醚或C 1 -C 6酯基团的桥连结构,R-R 39独立地选自 无取代基,孤对电子,H,卤素,C5-C6芳基,C1-C12烷基,胺,C1-C6烷基胺,C1-C6酰胺,硝基,氰基,羧基,C1-C6酯, C1-C6硫醚,OR40和适当的相邻R基团(R-R39)可以任选地一起形成C5或C6芳基环,Z5或Z6环的一部分,R40独立地选自H,C1-C6烷基, Z5 或Z6芳基,C1-C6酯,聚(-C2O-),胺和C1-C6烷基胺,Z-Z24独立地选自C,N,P,O和S,X-是药学上可接受的阴离子 ,用于治疗癌症。
    • 2. 发明申请
    • GOLD COMPLEXES FOR USE IN THE TREATMENT OF CANCER
    • 用于治疗癌症的黄金复合物
    • US20130090472A1
    • 2013-04-11
    • US13704894
    • 2011-06-14
    • Orde Quentin MunroKate Julie AkermanPiers Akerman
    • Orde Quentin MunroKate Julie AkermanPiers Akerman
    • C07F1/12C07C209/86C07D207/335C07C213/06C07C209/68
    • C07F1/12C01G7/00C07C209/16C07C209/68C07C209/86C07C213/02C07C213/06C07D207/335C07D401/12C07D487/22C07C211/15C07C217/42
    • The invention provides compounds of the Formula (I), in which W is independently selected from W1, W2, W3, W4, W5, or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Zn—Zn bonds (n=4-17; n′=n+1) are optionally of any whole or partial bond order, Y is Y1 or Y represents a pair of substituents independently selected from H, C-1-C6 alkyl, Z5 or Z6 aryl, or Y is optionally a bridging structure that may comprise one or more C-1-C6 amide, C-1-C6 ether, or C-1-C6 ester groups, R-R39 are independently selected from no substituent, a lone pair of electrons, H, halogen, C5-C6 aryl, C1- C-12 alkyl, amine, C-1-C6 alkylamine, C-1-C6 amide, nitro, cyano, carboxyl, C-1-C6 ester, phosphane, thiol, C-1-C6 thioether, OR′, and suitable pairs of adjacent R groups (R-R39) may optionally together form part of a C5 or C6 aryl ring, a Z5 or Z6 ring, R′ is independently selected from H, C-1-C6 alkyl, Z5 or Z6 aryl, C-1-C6 ester, poly(—C2O—), amine, and C-1-C6 alkylamine, Z-Z24 are independently selected from C, N, P, O, and S, and X− is a pharmaceutically acceptable anion, for the treatment of cancer.
    • 本发明提供式(I)化合物,其中W独立地选自W 1,W 2,W 3,W 4,W 5或W表示独立地选自H,烷基,芳基或酰胺的一对取代基,其中酰胺是 任选地部分连接链,并且Zn-Zn键(n = 4-17; n'= n + 1)任选地具有任何全部或部分键合顺序,Y是Y 1或Y表示一对独立地选自 H,C 1 -C 6烷基,Z 5或Z 6芳基,或Y任选是可以包含一个或多个C 1 -C 6酰胺,C 1 -C 6醚或C 1 -C 6酯基团的桥连结构, R-R39独立地选自无取代基,孤对电子,H,卤素,C 5 -C 6芳基,C 1 -C 12烷基,胺,C 1 -C 6烷基胺,C 1 -C 6酰胺,硝基, 氰基,羧基,C-1-C6酯,膦,硫醇,C-1-C6硫醚,OR',合适的相邻R基团(R-R39)可任选地一起形成C5或C6芳环的一部分, Z5或Z6环,R'独立地选自H,C-1-C6烷基 C 1 -C 6烷基,C 1 -C 6烷基胺,Z-Z 2,Z 5或Z 6芳基,C 1 -C 6酯,聚(C 2 O - ),胺和C 1 -C 6烷基胺,Z-Z 24独立地选自C,N,P,O和S, X-是药学上可接受的阴离子,用于治疗癌症。