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1. 发明授权

US09646812B2 MALDI sample preparation methods and targets 有权
公开(公告)号：US09646812B2
公开(公告)日：2017-05-09
申请号：US14234772
申请日：2012-07-25
申请人： Oliver J. Schmitz , Volker Wulf , Lukas Hyzak , Michaela Wirtz , David Melchior , Hans Willi Kling , Siegmar Gäb , Ursula Gäb
发明人： Oliver J. Schmitz , Volker Wulf , Lukas Hyzak , Michaela Wirtz , David Melchior , Hans Willi Kling , Siegmar Gäb
IPC分类号： H01J49/00 , H01J49/04 , G01N1/38 , H01J49/16
CPC分类号： H01J49/0031 , G01N1/38 , H01J49/0036 , H01J49/0418 , H01J49/0459 , H01J49/164
摘要： The present invention is concerned with a method of preparing a MALDI sample, the method comprising the steps of: (a) mixing a solid sample precursor comprising sample and matrix to form a solid sample mixture; (b) applying the solid sample mixture to a sample cavity of a MALDI target; and (c) compressing the solid sample mixture in the sample cavity so as to form a MALDI sample surface for laser desorption. The present invention also provides a MALDI target comprising a sample cavity for receiving a MALDI sample, the sample cavity having (a) a desorption end portion comprising an aperture, such that a portion of the MALDI sample exposed at the aperture is in use subjected to laser desorption; and wherein the sample cavity also has (b) a compression end portion adapted to permit compression of a solid sample mixture towards the desorption end portion in the sample cavity by applying a compression force to the solid sample mixture via the compression end portion.

2. 发明申请

US20150162176A1 MALDI SAMPLE PREPARATION METHODS AND TARGETS 审中-公开
标题翻译： MALDI样品制备方法和目标
公开(公告)号：US20150162176A1
公开(公告)日：2015-06-11
申请号：US14234772
申请日：2012-07-25
申请人： Ursula Gäb
发明人： Oliver J. Schmitz , Volker Wulf , Lukas Hyzak , Michaela Wirtz , David Melchior , Hans Willi Kling , Siegmar Gäb
IPC分类号： H01J49/00 , H01J49/16 , G01N1/38
CPC分类号： H01J49/0031 , G01N1/38 , H01J49/0036 , H01J49/0418 , H01J49/0459 , H01J49/164
摘要： The present invention is concerned with a method of preparing a MALDI sample, the method comprising the steps of: (a) mixing a solid sample precursor comprising sample and matrix to form a solid sample mixture; (b) applying the solid sample mixture to a sample cavity of a MALDI target; and (c) compressing the solid sample mixture in the sample cavity so as to form a MALDI sample surface for laser desorption. The present invention also provides a MALDI target comprising a sample cavity for receiving a MALDI sample, the sample cavity having (a) a desorption end portion comprising an aperture, such that a portion of the MALDI sample exposed at the aperture is in use subjected to laser desorption; and wherein the sample cavity also has (b) a compression end portion adapted to permit compression of a solid sample mixture towards the desorption end portion in the sample cavity by applying a compression force to the solid sample mixture via the compression end portion.
摘要翻译：本发明涉及一种制备MALDI样品的方法，该方法包括以下步骤：（a）将包含样品和基质的固体样品前体混合以形成固体样品混合物; （b）将固体样品混合物施加到MALDI靶的样品腔中; 和（c）压缩样品腔中的固体样品混合物，以便形成用于激光解吸的MALDI样品表面。本发明还提供了一种MALDI靶，其包括用于接收MALDI样品的样品腔，所述样品腔具有（a）包含孔的解吸端部，使得在所述孔处露出的部分MALDI样品在使用中受到激光解吸; 并且其中所述样品腔还具有（b）压缩端部，其适于通过经由所述压缩端部向所述固体样品混合物施加压缩力而使固体样品混合物朝向所述样品腔中的解吸端部压缩。

3. 发明申请

US20080296485A1 Method and Device for Mass Spectrometry Examination of Analytes 审中-公开
标题翻译：分析物质谱检测方法与装置
公开(公告)号：US20080296485A1
公开(公告)日：2008-12-04
申请号：US11569145
申请日：2005-05-24
申请人： Thorsten Benter , Klaus-Josef Brockman , Marc Constapel , Siegmar Gab , Ronald Giese , Oliver J. Schmitz
发明人： Thorsten Benter , Klaus-Josef Brockman , Marc Constapel , Siegmar Gab , Ronald Giese , Oliver J. Schmitz
IPC分类号： H01J49/26
CPC分类号： H01J49/162
摘要： The invention relates to a method for the mass spectrometry examination of at least one analyte, wherein an analyte to be examined is photoionized and the mass of the ions produced is determined in a mass spectrometer. The analyte to be examined is ionized at normal atmospheric ambient pressure by means of laser light using multiphoton ionization, especially resonant multiphoton ionization. The invention also relates to a device which comprises an ionization chamber in which an analyte to be examined is ionized at normal atmospheric ambient pressure using resonant multiphoton ionization and is transferred into a mass spectrometer. Said device can be used as an interface between a device for the chromatographic or electrophoretic separation of analytes and a mass spectrometer.
摘要翻译：本发明涉及一种用于对至少一种分析物进行质谱检测的方法，其中待测试的分析物被光电离并且在质谱仪中测定产生的离子的质量。待测分析物通过使用多光子电离，特别是共振多光子电离的激光在正常大气环境压力下离子化。本发明还涉及一种装置，其包括电离室，其中使用共振多光子电离在正常大气环境压力下将待检测的被分析物离子化并转移到质谱仪中。所述装置可用作分析物的色谱或电泳分离装置与质谱仪之间的界面。

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