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1. 发明授权

US06576682B2 Use of reactive amines for the preparation for polyurethane foams 有权
标题翻译：使用活性胺制备聚氨酯泡沫
公开(公告)号：US06576682B2
公开(公告)日：2003-06-10
申请号：US09883666
申请日：2001-06-18
申请人： Oliver Eyrisch , Ralf Hoffmann , Hans-Heinrich Schlöns
发明人： Oliver Eyrisch , Ralf Hoffmann , Hans-Heinrich Schlöns
IPC分类号： C08J904
CPC分类号： C08G18/1825 , C08G18/165 , C08G18/244 , C08G2101/0008 , C08G2101/005 , C08G2101/0083 , C08G2290/00
摘要： The invention relates to a process for preparing polyurethane foams (PUR foams) which uses reactive amines of the formula where n is 1 to 4, R1 and R2 are —(CH2—CH2—O)xH, —(CH2—CH(CH3)—O)xH, or —((CH2—CH(CH2—CH3)—O)xH, and x is 0, 1, 2, 3 or 4, with the proviso that, at least one of the indices in the molecule is greater than 0, in combination with metal salts.
摘要翻译：本发明涉及制备聚氨酯泡沫（PUR泡沫）的方法，其使用公式的反应性胺为1至4，R 1和R 2为 - （CH 2 -CH 2 -O）x H - （CH 2 -CH（CH 3）-O ）xH或 - （（CH 2 -CH（CH 2 -CH 3）-O）x H，且x为0,1,2,3或4，条件是分子中至少一个指数大于0 ，与金属盐组合。

2. 发明授权

US06403664B1 Combination of metal salts of ricinoleic acid with reactive amines in producing polyurethane forms 失效
标题翻译：蓖麻油酸的金属盐与活性胺的组合生产聚氨酯形式
公开(公告)号：US06403664B1
公开(公告)日：2002-06-11
申请号：US09883673
申请日：2001-06-18
申请人： Ralf Hoffmann , Hans-Heinrich Schlöns
发明人： Ralf Hoffmann , Hans-Heinrich Schlöns
IPC分类号： C08J904
CPC分类号： C08G18/1825 , C08G18/244 , C08G2101/0008 , C08G2101/005 , C08G2101/0083 , C08G2290/00
摘要： The invention relates to the combined use of metal salts of ricinoleic acid with reactive amines in the preparation of polyurethane foams (PUR foams) and of their solutions in aqueous or organic solvents in the preparation of polyurethane foams in combination with reactive amines.
摘要翻译：本发明涉及在制备聚氨酯泡沫（PUR泡沫）的过程中将蓖麻油酸与活性胺的金属盐及其在水性或有机溶剂中的溶液与反应性胺的组合制备聚氨酯泡沫体的组合使用。

3. 发明授权

US06194475B1 Use of metal salts of ricinoleic acid in producing polyurethane 有权
标题翻译：使用蓖麻油酸的金属盐生产聚氨酯
公开(公告)号：US06194475B1
公开(公告)日：2001-02-27
申请号：US09464968
申请日：1999-12-16
申请人： Tammo Boinowitz , Georg Burkhart , Ralf Hoffmann , Felix Müller , Hans-Heinrich Schlöns , Andreas Weier , Volker Zellmer , Rainer Ziegler
发明人： Tammo Boinowitz , Georg Burkhart , Ralf Hoffmann , Felix Müller , Hans-Heinrich Schlöns , Andreas Weier , Volker Zellmer , Rainer Ziegler
IPC分类号： C08J904
CPC分类号： C08G18/222 , C08G2101/0008 , C08G2101/005 , C08G2101/0083 , C08G2290/00 , C08J9/0052 , C08J2375/04 , Y10S521/906
摘要： The invention relates to the use of metal salts of ricinoleic acid or solutions thereof in water or in organic solvents in producing polyurethane foams.
摘要翻译：本发明涉及蓖麻油酸金属盐或其溶液在水中或在有机溶剂中用于生产聚氨酯泡沫体的用途。

4. 发明授权

US08946580B2 Contact bridge with blow magnets 有权
标题翻译：接触桥与吹塑磁铁
公开(公告)号：US08946580B2
公开(公告)日：2015-02-03
申请号：US13139208
申请日：2009-12-04
申请人： Ralf Hoffmann , Matthias Kroeker
发明人： Ralf Hoffmann , Matthias Kroeker
IPC分类号： H01H1/54 , H01H9/44 , H01H1/20 , H01H50/54
CPC分类号： H01H1/54 , H01H1/20 , H01H9/443 , H01H50/546 , H01H2001/545
摘要： The present invention relates to contactors for unidirectional DC operation with permanent magnetic arc extinguishing. In addition to the blow magnets, the contactors are equipped with compensatory permanent magnets for compensating the magnetic field in the vicinity of the contact bridge in order to prevent contact levitation, i.e., an uncontrolled opening of the contacts that is due to a magnetic force generated by a strong current flowing through the contact bridge. To this end, the compensatory permanent magnets are arranged in the vicinity of the contact bridge and polarized in the opposite direction of the blow magnets. The magnetic field of the compensatory magnets and the current flowing through the contact bridge are generating a magnetic force that acts on the contact bridge and tends to keep the electrical contacts closed.
摘要翻译：本发明涉及用于具有永久磁性灭弧的单向直流操作的接触器。除了吹制磁体之外，接触器还配备有补偿永磁体，用于补偿接触桥附近的磁场，以防止接触悬浮，即由于产生的磁力引起的触头的不受控的打开通过流过接触桥的强电流。为此，补偿永久磁铁布置在接触桥附近，并沿着吹塑磁体的相反方向极化。补偿磁体的磁场和流过接触桥的电流产生作用在接触桥上的磁力，并且趋向于保持电触点闭合。

5. 发明申请

US20140309161A1 Modified antibiotic peptides having variable systemic release 有权
标题翻译：具有可变系统释放的改良抗生素肽
公开(公告)号：US20140309161A1
公开(公告)日：2014-10-16
申请号：US14128083
申请日：2012-06-20
申请人： Ralf Hoffmann , Nicole Berthold , Friederike Nollmann
发明人： Ralf Hoffmann , Nicole Berthold , Friederike Nollmann
IPC分类号： A61K47/48 , A01N25/22 , A61K38/10
CPC分类号： C07K14/43572 , A01N25/22 , A01N37/46 , A01N63/02 , A61K38/00 , A61K38/10 , A61K38/16 , A61K38/1767 , A61K47/60 , C07K7/08 , C07K11/00 , C07K14/43563 , C12Q1/37
摘要： The invention relates to modified antibiotic peptides, in particular derivatives of apidaecin and oncocin, preferably having increased stability, reduced immunoreaction, and improved pharmacokinetics. In the invention, the peptide antibiotics are reversibly protected by means of a linker having the polymer polyethylene glycol (PEG). The peptide linker contains a recognition sequence for trypsin-like serum proteases. In the apidaecin derivatives, the linker and the PEG are bonded to a side chain. In the serum, the linker is cut by serum proteases and PEG is separated off. The released peptide still contains remnants of the linker, which are still bonded to the amino group in the side chain. Astonishingly, said remaining remnants of the linker impair the activity of the antimicrobial peptide only a little or not at all.
摘要翻译：本发明涉及修饰的抗生素肽，特别是apidaecin和oncocin的衍生物，优选具有增加的稳定性，降低的免疫反应和改善的药代动力学。在本发明中，肽抗生素通过具有聚合物聚乙二醇（PEG）的接头可逆地保护。肽接头包含胰蛋白酶样血清蛋白酶的识别序列。在apidaecin衍生物中，接头和PEG与侧链结合。在血清中，用血清蛋白酶切割接头，分离出PEG。释放的肽仍然含有仍然与侧链中的氨基键合的接头残基。令人惊讶的是，所述接头的剩余残留物仅仅少量地损害了抗微生物肽的活性。

6. 发明授权

US08686113B2 Antibiotic peptides 有权
标题翻译：抗生素肽
公开(公告)号：US08686113B2
公开(公告)日：2014-04-01
申请号：US13147095
申请日：2010-01-29
申请人： Ralf Hoffmann , Daniel Knappe , Anna Klara Brigitte Hansen
发明人： Ralf Hoffmann , Daniel Knappe , Anna Klara Brigitte Hansen
IPC分类号： A61K38/10 , A61P31/04 , C07K1/00 , C07K7/08
CPC分类号： C07K7/08 , A01N47/44 , A61K38/00 , A61K38/10 , A61K47/48246 , A61K47/64 , C07K14/43563 , C12Q1/18 , G01N2500/10 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/481 , Y02A50/483
摘要： The invention relates to a peptide or peptide derivative having the general formula: Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17/Y17-N18-N19-X4-Sub2, wherein X1 is a non-polar, hydrophobic group or a positively charged group, D2 is asparagine or glutamine, K3, X2, and X4 are positively charged groups, X3 is a positively charged group, proline, or a proline derivative; L7 and I16 are non-polar, hydrophobic groups, Y6 and Y17 are tyrosine, R9 and R14 are arginine, N18 and N19 are asparagine or glutamine, P4, P5, P8, P10, P12, P13, and P17 are proline, hydroxyproline, or derivatives thereof, wherein possibly one or two of the groups selected from D2, P4, P5, P8, P10, P12, P13, P17, and Y17 are replaced by an arbitrary group and/or P13 and R14 are exchanged, Sub1 is the free or modified N-terminus, and Sub2 is the free or modified C-terminus. The invention further relates to the use of the peptides and peptide derivatives in medicine, as an antibiotic, in a disinfectant or cleaning agent, as a preservative or in a packaging material, in pharmaceutical research, or in a screening method.
摘要翻译：本发明涉及具有以下通式的肽或肽衍生物：Sub1-X1-D2K3-P4-P5-Y6-L7-P8-R9-P10-X2-P12-P13-R14-X3-I16-P17 / Y17- N18-N19-X4-Sub2，其中X1是非极性疏水基团或带正电荷的基团，D2是天冬酰胺或谷氨酰胺，K 3，X 2和X 4是带正电荷的基团，X 3是带正电荷的基团，或脯氨酸衍生物; L7和I16是非极性疏水基团，Y6和Y17是酪氨酸，R9和R14是精氨酸，N18和N19是天冬酰胺或谷氨酰胺，P4，P5，P8，P10，P12，P13和P17是脯氨酸，羟脯氨酸，或其衍生物，其中可选地一个或两个选自D2，P4，P5，P8，P10，P12，P13，P17和Y17的基团被任意基团替代和/或P13和R14被交换，Sub1是游离或修饰的N末端，Sub2是游离或修饰的C-末端。本发明还涉及肽和肽衍生物在药物，作为抗生素，在消毒剂或清洁剂中，作为防腐剂或在包装材料中，在药物研究中或在筛选方法中的用途。

7. 发明授权

US08050477B2 Radiation therapy flanning procedure 有权
标题翻译：放射治疗方法
公开(公告)号：US08050477B2
公开(公告)日：2011-11-01
申请号：US12162671
申请日：2007-01-22
申请人： Lothar Spies , Helga Hummel , Carolina Ribbing , Ralf Hoffmann , Peter Klaus Bachmann
发明人： Lothar Spies , Helga Hummel , Carolina Ribbing , Ralf Hoffmann , Peter Klaus Bachmann
IPC分类号： A61N5/10
CPC分类号： A61N5/1031
摘要： An improved radiation therapy planning procedure is suggested. The procedure comprises the steps of specifying and determining the absolute grade of cell degeneracy by in-vitro tests, whereby marker(s) indicative for specific cell degeneracy are detected and quantified, establishing a biology-based segmentation of areas with similar grade of relative cell degeneracy and applying the absolute grade of cell degeneracy to the biology-based segmentation data, thereby establishing an improved radiation therapy planning procedure. Moreover, the present invention suggests a system for an improved radiation therapy planning procedure and its use in procedures of diagnosis and/or therapy management of cancer.
摘要翻译：建议采用改进的放射治疗计划程序。该方法包括以下步骤：通过体外测试来指定和确定细胞退化的绝对等级，由此检测和量化指示特异性细胞退化的标志物，建立具有相似等级的相对细胞的区域的基于生物学的分割退化并将绝对等级的细胞退化应用于基于生物学的分割数据，从而建立改进的放射治疗计划程序。此外，本发明提出了一种改进的放射治疗计划程序及其在癌症诊断和/或治疗管理程序中的应用的系统。

8. 发明授权

US08035468B2 Magnet system extrusion coating for a relay 有权
标题翻译：用于继电器的磁体系统挤压涂层
公开(公告)号：US08035468B2
公开(公告)日：2011-10-11
申请号：US10535052
申请日：2003-11-06
申请人： Ralf Hoffmann , Heinz Stadler
发明人： Ralf Hoffmann , Heinz Stadler
IPC分类号： H01H67/02
CPC分类号： H01H50/042 , H01H49/00 , H01H50/26 , H01H50/36
摘要： A relay has a magnet system with a core partially enclosed by a coil. A yoke has a first yoke leg attached to a first end of the core and a second yoke leg extending parallel to the core. The second yoke leg has an armature mounting portion formed on an upper side of the second yoke leg remote from the coil. A pole has a first pole leg connected to a second end of the core and a second pole leg extending parallel to the core. The second pole leg has an upper surface substantially aligned with the armature mounting portion. A fixed contact is arranged on a fixed contact carrier substantially aligned with the second pole leg. The arrangement of the magnet system ensures precise positional alignment during extrusion coating with a plastic material.
摘要翻译：继电器具有磁体系统，其中芯部被线圈部分地包围。轭具有附接到芯的第一端的第一轭腿和平行于芯延伸的第二轭腿。第二轭腿具有形成在远离线圈的第二轭腿的上侧上的电枢安装部分。杆具有连接到芯的第二端的第一极腿和平行于芯延伸的第二极腿。第二极腿具有与电枢安装部分大致对准的上表面。固定触点布置在基本上与第二极腿对齐的固定触点支架上。磁体系统的布置确保了在用塑料材料的挤出涂覆期间精确的位置对准。

9. 发明申请

US20110045989A1 SELECTIVE ENRICHMENT OF N-TERMINALLY MODIFIED PEPTIDES FROM COMPLEX SAMPLES 审中-公开
标题翻译：从复制样品中选择性地增加N-末端修饰的肽
公开(公告)号：US20110045989A1
公开(公告)日：2011-02-24
申请号：US12936417
申请日：2009-04-02
申请人： Ralf Hoffmann , Hugo Matthieu Visser , Edwin Peter Romijn
发明人： Ralf Hoffmann , Hugo Matthieu Visser , Edwin Peter Romijn
IPC分类号： C40B10/00
CPC分类号： C07K1/13 , C07K1/36
摘要： The present invention relates to methods allowing the selective enrichment of N-terminal fragments of polypeptides and/or peptides from complex samples by combining a particular polypeptide/peptide labeling and fractionation strategy with specific chemical and/or enzymatic reactions targeting the N-terminal fragments to be analyzed.
摘要翻译：本发明涉及通过将特定的多肽/肽标记和分级分离策略与针对N末端片段的特定化学和/或酶反应组合而允许从复杂样品中选择性富集多肽和/或肽的N-末端片段的方法分析。

10. 发明申请

US20100304493A1 SELECTIVE ENRICHMENT OF POST-TRANSLATIONALLY MODIFIED PROTEINS AND/OR PEPTIDES FROM COMPLEX SAMPLES 审中-公开
标题翻译：复制样品中经过翻译后修饰的蛋白质和/或肽的选择性增殖
公开(公告)号：US20100304493A1
公开(公告)日：2010-12-02
申请号：US12744486
申请日：2008-11-17
申请人： Ralf Hoffmann , Hugo M. Visser , Edwin P. Romijn
发明人： Ralf Hoffmann , Hugo M. Visser , Edwin P. Romijn
IPC分类号： G01N33/68 , C07K1/14
CPC分类号： C07K1/14
摘要： The present invention relates to the selective enrichment of post-translationally modified proteins and/or peptides from complex samples by combining a particular protein/peptide labeling and fractionation strategy with specific chemical and/or enzymatic reactions targeting the post-translational modification to be analyzed. More specifically, the invention relates to methods for the enrichment and/or separation of phospho-proteins and/or -peptides, and particularly for the discrimination between different subsets of phospho-proteins and/or -peptides in complex samples.
摘要翻译：本发明涉及通过将特定的蛋白质/肽标记和分级分离策略与针对待分析的翻译后修饰的特定化学和/或酶反应结合从复杂样品中选择性富集翻译后修饰的蛋白质和/或肽。更具体地，本发明涉及用于富集和/或分离磷酸蛋白和/或肽的方法，特别是用于鉴定复杂样品中磷酸蛋白和/或肽的不同子集之间的差异。

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