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1. 发明申请

US20160114172A1 CONTACT LENS FOR INCREASING TEAR PRODUCTION 有权
标题翻译：联系镜头增加生产力
公开(公告)号：US20160114172A1
公开(公告)日：2016-04-28
申请号：US14920847
申请日：2015-10-22
申请人： Oculeve, Inc.
发明人： James Donald LOUDIN , Manfred FRANKE , Daniel N. HAMILTON , Anand DORAISWAMY , Douglas Michael ACKERMANN
IPC分类号： A61N1/378 , A61N1/36
CPC分类号： A61N1/3787 , A61N1/36046 , A61N1/36121 , B29D11/00038 , B29D11/00826
摘要： Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.
摘要翻译：这里描述了通过刺激角膜，结膜和/或结膜下增加泪液产生的装置，系统和方法。在一些变型中，装置可以是隐形眼镜的形式。隐形眼镜可以包括透镜体和刺激器芯片，其中刺激器芯片嵌入在透镜体中。外部电源将能量无线地传输到刺激器芯片，其中刺激器芯片可以将能量转换成电波形以刺激角膜，结膜和/或结膜下。刺激可以激活泪液反射以增加泪液产生。用于增加泪液生产的装置和系统可以用于治疗干眼症，减少疲劳眼睛的症状，增加隐形眼镜佩戴者的舒适度以及延长隐形眼镜用户可佩戴接触的年数的方法。还描述了制造隐形眼镜的方法。

2. 发明申请

US20160367795A1 NASAL STIMULATION DEVICES AND METHODS 有权
标题翻译： NASAL刺激装置和方法
公开(公告)号：US20160367795A1
公开(公告)日：2016-12-22
申请号：US15256392
申请日：2016-09-02
申请人： Oculeve, Inc.
发明人： Douglas Michael ACKERMANN , James Donald LOUDIN , John WARDLE , Jarren Armond BALDWIN , Daniel N. HAMILTON , Janusz KUZMA , Christopher William STIVERS , Manfred FRANKE
IPC分类号： A61N1/05 , A61N7/00 , A61F7/12 , A61H23/02 , A61N1/36 , A61N1/378
CPC分类号： A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
摘要： Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.
摘要翻译：这里描述了通过向鼻腔或鼻窦组织提供刺激来治疗一种或多种病症（如干眼症）或改善眼部健康的装置，系统和方法。通常，设备可以是手持式的或可植入的。在一些变型中，手持装置可以具有刺激器主体和具有一个或多个鼻插入尖端的刺激器探针。当装置和系统用于治疗干眼症时，可以刺激鼻或鼻窦组织以增加泪液产生，减少干眼症状和/或改善眼部表面的健康。

3. 发明申请

US20160158548A1 NASAL STIMULATION DEVICES AND METHODS 审中-公开
公开(公告)号：US20160158548A1
公开(公告)日：2016-06-09
申请号：US15041916
申请日：2016-02-11
申请人： Oculeve, Inc.
发明人： Douglas Michael ACKERMANN , James Donald LOUDIN
IPC分类号： A61N1/36 , A61N1/04 , A61N1/05
CPC分类号： A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
摘要： Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

4. 发明申请

US20140316310A1 NASAL STIMULATION DEVICES AND METHODS 审中-公开
公开(公告)号：US20140316310A1
公开(公告)日：2014-10-23
申请号：US14256916
申请日：2014-04-18
申请人： Oculeve, Inc.
发明人： Douglas Michael ACKERMANN , James Donald LOUDIN
IPC分类号： A61N1/36 , A61M31/00 , A61F7/12 , A61H1/00
CPC分类号： A61N1/0546 , A61F7/12 , A61H1/00 , A61H9/0071 , A61H21/00 , A61H23/02 , A61H23/0218 , A61H23/0245 , A61H23/0263 , A61H2201/0153 , A61H2201/0173 , A61H2201/0207 , A61H2201/0214 , A61H2201/025 , A61H2201/10 , A61H2201/165 , A61H2201/5002 , A61H2201/5005 , A61H2201/5015 , A61H2201/5035 , A61H2201/5038 , A61H2201/5043 , A61H2205/023 , A61H2205/024 , A61M31/00 , A61N1/0456 , A61N1/36014 , A61N1/36046 , A61N1/36071 , A61N1/36132 , A61N1/36146 , A61N1/3615 , A61N1/36171 , A61N1/36175 , A61N1/3787 , A61N7/00 , A61N2007/0043 , H02J7/0044
摘要： Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

5. 发明申请

US20180064941A1 STIMULATION DEVICES AND METHODS 审中-公开
公开(公告)号：US20180064941A1
公开(公告)日：2018-03-08
申请号：US15802340
申请日：2017-11-02
申请人： Oculeve, Inc. , The Board of Trustees of the Leland Stanford Junior University
发明人： Douglas Michael ACKERMANN , James Donald LOUDIN , Janusz KUZMA , Daniel PALANKER , Scott Franklin WETENKAMP
IPC分类号： A61N1/36 , A61N1/372 , A61N1/375
CPC分类号： A61N1/36046 , A61N1/36057 , A61N1/3606 , A61N1/37205 , A61N1/37211 , A61N1/3756
摘要： Described here are stimulation systems and methods for stimulating one or more anatomical targets in a patient for treatment conditions such as dry eye. The stimulation system may include a controller and a microstimulator. The components of the controller and microstimulator may be implemented in a single unit or in separate devices. When implemented separately, the controller and microstimulator may communicate wirelessly or via a wired connection. The microstimulator may generate pulses from a signal received from the controller and apply the signal via one or more electrodes to an anatomical target. In some variations, the microstimulator may include a passive generation circuit configured to generate a pulse based on a signal received from the controller.

6. 发明申请

US20170368359A1 CONTACT LENS FOR INCREASING TEAR PRODUCTION 审中-公开
公开(公告)号：US20170368359A1
公开(公告)日：2017-12-28
申请号：US15699905
申请日：2017-09-08
申请人： Oculeve, Inc.
发明人： James Donald LOUDIN , Manfred FRANKE , Daniel N. HAMILTON , Anand DORAISWAMY , Douglas Michael ACKERMANN
IPC分类号： A61N1/378 , A61N1/36
CPC分类号： A61N1/3787 , A61N1/36046 , A61N1/3606 , A61N1/36121 , A61N1/3756 , B29D11/00038 , B29D11/00826
摘要： Described here are devices, systems, and methods for increasing tear production by stimulating the cornea, conjunctiva, and/or subconjunctiva. In some variations, the devices may be in the form of a contact lens. The contact lens may comprise a lens body and a stimulator chip, where the stimulator chip is embedded in the lens body. An external power source wirelessly transmits energy to the stimulator chip, where the stimulator chip may convert the energy to an electric waveform to stimulate the cornea, conjunctiva, and/or subconjunctiva. Stimulation may activate the lacrimal reflex to increase tear production. The devices and systems for increasing tear production may be used in methods of treating dry eye, reducing the symptoms of tired eye, increasing comfort for contact lens wearers, and extending the number of years a contact lens user can wear contacts. Also described are methods of manufacturing a contact lens.

7. 发明申请

US20170354536A1 IMPLANT DELIVERY DEVICES, SYSTEMS, AND METHODS 审中-公开
公开(公告)号：US20170354536A1
公开(公告)日：2017-12-14
申请号：US15649364
申请日：2017-07-13
申请人： Oculeve, Inc.
发明人： Janusz KUZMA , Douglas Michael ACKERMANN , Christopher William STIVERS
IPC分类号： A61F9/007 , A61F9/00 , A61F2/14 , A61M31/00 , A61F2/16
摘要： Systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may include a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further include a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.

8. 发明申请

US20140277429A1 IMPLANT DELIVERY DEVICES, SYSTEMS, AND METHODS 有权
标题翻译：植入式装置，系统和方法
公开(公告)号：US20140277429A1
公开(公告)日：2014-09-18
申请号：US14207072
申请日：2014-03-12
申请人： Oculeve, Inc.
发明人： Janusz KUZMA , Douglas Michael ACKERMANN , Christopher William STIVERS
IPC分类号： A61F2/14
CPC分类号： A61F9/007 , A61F2/14 , A61F2/141 , A61F2/148 , A61F2/1662 , A61F9/0017 , A61M31/007 , A61M2210/0612
摘要： Described here are systems, devices, and methods for delivering an implant to the orbit. In some instances, the systems may comprise a delivery device having a tongue member and a handle. The delivery device may further include an ejector configured to deliver an implant from the tongue member. The delivery device may also include a piercing member configured to create an opening in tissue. The systems may further comprise a piercing member for creating an opening in tissue. In some instances, the piercing member may have a first blade member rotatably connected to a second blade member.
摘要翻译：这里描述的是用于将植入物递送到轨道的系统，装置和方法。在一些情况下，系统可以包括具有舌部件和手柄的输送装置。输送装置还可以包括被配置为从舌部件输送植入物的喷射器。输送装置还可以包括构造成在组织中产生开口的刺穿构件。该系统还可以包括用于在组织中形成开口的刺穿构件。在一些情况下，穿刺构件可以具有可旋转地连接到第二叶片构件的第一叶片构件。

9. 发明申请

US20180154137A1 NASAL STIMULATION DEVICES AND METHODS 审中-公开
公开(公告)号：US20180154137A1
公开(公告)日：2018-06-07
申请号：US15851505
申请日：2017-12-21
申请人： Oculeve, Inc.
发明人： Douglas Michael ACKERMANN , James Donald LOUDIN , John WARDLE , Janusz KUZMA
IPC分类号： A61N1/05 , A61H1/00 , A61N1/36 , A61H21/00 , A61H23/02 , A61N7/00 , A61F7/12 , H02J7/00 , A61N1/04 , A61N1/378 , A61H9/00 , A61M31/00
摘要： Described here are devices, systems, and methods for treating one or more conditions (such as dry eye) or improving ocular health by providing stimulation to nasal or sinus tissue. Generally, the devices may be handheld or implantable. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs. When the devices and systems are used to treat dry eye, nasal or sinus tissue may be stimulated to increase tear production, reduce the symptoms of dry eye, and/or improve ocular surface health.

10. 发明申请

US20180153394A1 APPARATUS AND METHOD FOR DRY EYE FORECAST AND TREATMENT RECOMMENDATION 审中-公开
公开(公告)号：US20180153394A1
公开(公告)日：2018-06-07
申请号：US15827683
申请日：2017-11-30
申请人： Oculeve, Inc.
发明人： Manfred FRANKE , Chao LIU , Abirami MURALIDHARAN , James Donald LOUDIN , Douglas Michael ACKERMANN , Michael G. ROGERS
IPC分类号： A61B3/10 , A61B3/00 , G06F19/00
CPC分类号： A61B3/101 , A61B3/0025 , A61B3/0033 , A61B5/6802 , A61B5/742 , A61K9/0048 , G06F19/3418 , G16H15/00 , G16H20/00 , G16H50/20
摘要： Generally, a machine may include a processor and a memory connected to the processor, where the memory stores instructions executed by the processor to determine first and second properties related to dry eye symptoms of a patient. The properties may be used to form a dry eye forecast. A treatment recommendation may be selected based at least in part upon the dry eye forecast. The treatment recommendation may be supplied to a device.

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