会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明申请
    • Purinenucleoside derivative modified in 8-position and medical use thereof
    • 8位修饰的嘌呤核苷衍生物及其用途
    • US20070179115A1
    • 2007-08-02
    • US11717741
    • 2007-03-13
    • Kazuya TataniYoshinori NonakaNorihiko Kikuchi
    • Kazuya TataniYoshinori NonakaNorihiko Kikuchi
    • A61K31/7076C07H19/16
    • A61K45/06A61K31/7076C07H19/167C07H19/173
    • The present invention provides an 8-modified purinenucleoside derivative which is useful for diseases associated with an abnormality of plasma uric acid level. An 8-modified purinenucleoside derivative represented by the following formula (I), a prodrug thereof or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, is useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like. In the formula, n is 1 or 2; RA is a hydrogen atom or a hydroxyl group; R1 is a hydrogen atom, a hydroxyl group, a thiol group, an amino group or a chlorine atom; ring J represents an optionally substituted 2-naphthyl group, or a group represented by the following general formula (II) wherein Y represents a single bond or a connecting group; ring Z represents an optionally substituted aryl group or heteroaryl group or the like; and R2 to R4, P1 and Q represents a halogen atom, a cyano group or the like.
    • 本发明提供了可用于与血浆尿酸水平异常相关的疾病的8-修饰的嘌呤核苷衍生物。 由下式(I)表示的8-修饰的嘌呤核苷衍生物,其前体药物或其药学上可接受的盐或其水合物或溶剂合物可用于预防或治疗痛风,高尿酸血症,尿结石病,高尿酸性肾病或 类似。 在该式中,n为1或2; R A是氢原子或羟基; R 1是氢原子,羟基,硫醇基,氨基或氯原子; 环J表示任选取代的2-萘基,或由以下通式(II)表示的基团,其中Y表示单键或连接基团; 环Z表示任选取代的芳基或杂芳基等; R 2〜R 4,P 1和Q表示卤素原子,氰基等。
    • 6. 发明授权
    • Polyphenylene ether resin
    • 聚苯醚树脂
    • US5861437A
    • 1999-01-19
    • US930433
    • 1997-10-07
    • Hiromu HaradaYukihiko HoteiHideki HujikuraYoshinori NonakaKoji KamataMitsuhiro IchiharaHiroshi KusamaHumiyasu Satoh
    • Hiromu HaradaYukihiko HoteiHideki HujikuraYoshinori NonakaKoji KamataMitsuhiro IchiharaHiroshi KusamaHumiyasu Satoh
    • C08G65/48C08L71/12A61K31/785
    • C08L71/126C08G65/485
    • A poly(phenylene ether) resin composed of structural units represented by the general formula: ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3 represent each alkyl, cycloalkyl, etc. or H (provided that two or more of R.sup.1, R.sup.2 and R.sup.3 do not represent H at the same time), or one of R.sup.1, R.sup.2 and R.sup.3 represents alkyl or H while the others together form a saturated ring, or R.sup.1, R.sup.2 and R.sup.3 together form an aromatic ring; A represents alkyl; p is an integer of from 3 to 5; and Y.sup.- represents a pharmaceutically acceptable acid residue) and/or structural units represented by the general formula: ##STR2## (wherein R.sup.4, R.sup.5 and R.sup.6 represents each alkyl, cycloalkyl, etc. or H (provided that two or more of R.sup.4, R.sup.5 and R.sup.6 do not represent H at the same time), or one of R.sup.4, R.sup.5 and R.sup.6 represents alkyl or H while the others together form a saturated ring, or R.sup.4, R.sup.5 and R.sup.6 together form an aromatic ring; and A, p and Y.sup.- have same meanings as defined above) and structural units represented by the general formula: ##STR3## (wherein R.sup.7 and R.sup.8 represents each alkyl, cycloalkyl, etc. or together form a saturated ring; q is an integer of from 3 to 20; and A, p, and Y.sup.- have same meanings as defined above) wherein the sum of the contents of the structural units represented by the general formula (I) and the structural units represented by the general formula (II) amounts to 40 to 96% by mole and the content of the structural units represented by the general formula (III) amounts to 4 to 60% by mole based upon the content of phenylene ether component and a process for producing the same. The poly(phenylene ether) resins have the effect of adsorbing bile acids and are useful as a cholesterol reducing agent.
    • PCT No.PCT / JP96 / 00931 Sec。 371日期1997年10月7日第 102(e)日期1997年10月7日PCT提交1996年4月5日PCT公布。 公开号WO96 / 32435 日期:1996年10月17日由以下通式表示的结构单元构成的聚苯醚树脂:烷基,环烷基等或H(前提是R1,R2和R3中的两个或更多个不表示相同的H 时间),或者R1,R2和R3中的一个表示烷基或H,而另一个一起形成饱和环,​​或者R1,R2和R3一起形成芳香环; A代表烷基; p是3至5的整数; 和/或由以下通式表示的结构单元:其中R 4,R 5和R 6表示各自的烷基,环烷基等或H(条件是两个或多个 R4,R5和R6不同时表示H),或者R4,R5和R6中的一个表示烷基或H,而另一个共同形成饱和环,​​或者R4,R5和R6一起形成芳香环; A,p和Y-具有与上述相同的含义)和由通式(III)表示的结构单元(其中R 7和R 8表示各个烷基,环烷基等或一起形成饱和环; q为 3〜20的整数,A,p,Y-具有与上述相同的含义),其中由通式(I)表示的结构单元的含量和由通式 (II)表示的结构单元的含量为40〜96摩尔%,通式(I)表示的结构单元的含量 II)相对于亚苯基醚成分的含量为4〜60摩尔%及其制造方法。 聚苯醚树脂具有吸附胆汁酸的作用,可用作胆固醇降低剂。
    • 9. 发明授权
    • Purine nucleoside derivative modified in 8-position and medical use thereof
    • 8位修饰的嘌呤核苷衍生物及其用途
    • US07795236B2
    • 2010-09-14
    • US11717741
    • 2007-03-13
    • Kazuya TataniYoshinori NonakaNorihiko Kikuchi
    • Kazuya TataniYoshinori NonakaNorihiko Kikuchi
    • A01N43/04A61K31/70C07H19/00C07H19/16
    • A61K45/06A61K31/7076C07H19/167C07H19/173
    • The present invention provides an 8-modified purinenucleoside derivative which is useful for diseases associated with an abnormality of plasma uric acid level. An 8-modified purinenucleoside derivative represented by the following formula (I), a prodrug thereof or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, is useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like.In the formula, n is 1 or 2; RA is a hydrogen atom or a hydroxyl group; R1 is a hydrogen atom, a hydroxyl group, a thiol group, an amino group or a chlorine atom; ring J represents an optionally substituted 2-naphthyl group, or a group represented by the following general formula (II) wherein Y represents a single bond or a connecting group; ring Z represents an optionally substituted aryl group or heteroaryl group or the like; and R2 to R4, P1 and Q represents a halogen atom, a cyano group or the like.
    • 本发明提供了可用于与血浆尿酸水平异常相关的疾病的8-修饰的嘌呤核苷衍生物。 由下式(I)表示的8-修饰的嘌呤核苷衍生物,其前体药物或其药学上可接受的盐或其水合物或溶剂合物可用于预防或治疗痛风,高尿酸血症,尿结石病,高尿酸性肾病或 类似。 在该式中,n为1或2; RA是氢原子或羟基; R1是氢原子,羟基,硫醇基,氨基或氯原子; 环J表示任选取代的2-萘基,或由以下通式(II)表示的基团,其中Y表示单键或连接基团; 环Z表示任选取代的芳基或杂芳基等; R2和R4,P1和Q表示卤原子,氰基等。