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1. 发明授权

US5861437A Polyphenylene ether resin 失效
标题翻译：聚苯醚树脂
公开(公告)号：US5861437A
公开(公告)日：1999-01-19
申请号：US930433
申请日：1997-10-07
申请人： Hiromu Harada , Yukihiko Hotei , Hideki Hujikura , Yoshinori Nonaka , Koji Kamata , Mitsuhiro Ichihara , Hiroshi Kusama , Humiyasu Satoh
发明人： Hiromu Harada , Yukihiko Hotei , Hideki Hujikura , Yoshinori Nonaka , Koji Kamata , Mitsuhiro Ichihara , Hiroshi Kusama , Humiyasu Satoh
IPC分类号： C08G65/48 , C08L71/12 , A61K31/785
CPC分类号： C08L71/126 , C08G65/485
摘要： A poly(phenylene ether) resin composed of structural units represented by the general formula: ##STR1## (wherein R.sup.1, R.sup.2 and R.sup.3 represent each alkyl, cycloalkyl, etc. or H (provided that two or more of R.sup.1, R.sup.2 and R.sup.3 do not represent H at the same time), or one of R.sup.1, R.sup.2 and R.sup.3 represents alkyl or H while the others together form a saturated ring, or R.sup.1, R.sup.2 and R.sup.3 together form an aromatic ring; A represents alkyl; p is an integer of from 3 to 5; and Y.sup.- represents a pharmaceutically acceptable acid residue) and/or structural units represented by the general formula: ##STR2## (wherein R.sup.4, R.sup.5 and R.sup.6 represents each alkyl, cycloalkyl, etc. or H (provided that two or more of R.sup.4, R.sup.5 and R.sup.6 do not represent H at the same time), or one of R.sup.4, R.sup.5 and R.sup.6 represents alkyl or H while the others together form a saturated ring, or R.sup.4, R.sup.5 and R.sup.6 together form an aromatic ring; and A, p and Y.sup.- have same meanings as defined above) and structural units represented by the general formula: ##STR3## (wherein R.sup.7 and R.sup.8 represents each alkyl, cycloalkyl, etc. or together form a saturated ring; q is an integer of from 3 to 20; and A, p, and Y.sup.- have same meanings as defined above) wherein the sum of the contents of the structural units represented by the general formula (I) and the structural units represented by the general formula (II) amounts to 40 to 96% by mole and the content of the structural units represented by the general formula (III) amounts to 4 to 60% by mole based upon the content of phenylene ether component and a process for producing the same. The poly(phenylene ether) resins have the effect of adsorbing bile acids and are useful as a cholesterol reducing agent.
摘要翻译： PCT No.PCT / JP96 / 00931 Sec。 371日期1997年10月7日第 102（e）日期1997年10月7日PCT提交1996年4月5日PCT公布。公开号WO96 / 32435 日期：1996年10月17日由以下通式表示的结构单元构成的聚苯醚树脂：烷基，环烷基等或H（前提是R1，R2和R3中的两个或更多个不表示相同的H 时间），或者R1，R2和R3中的一个表示烷基或H，而另一个一起形成饱和环，或者R1，R2和R3一起形成芳香环; A代表烷基; p是3至5的整数; 和/或由以下通式表示的结构单元：其中R 4，R 5和R 6表示各自的烷基，环烷基等或H（条件是两个或多个 R4，R5和R6不同时表示H），或者R4，R5和R6中的一个表示烷基或H，而另一个共同形成饱和环，或者R4，R5和R6一起形成芳香环; A，p和Y-具有与上述相同的含义）和由通式（III）表示的结构单元（其中R 7和R 8表示各个烷基，环烷基等或一起形成饱和环; q为 3〜20的整数，A，p，Y-具有与上述相同的含义），其中由通式（I）表示的结构单元的含量和由通式（II）表示的结构单元的含量为40〜96摩尔％，通式（I）表示的结构单元的含量 II）相对于亚苯基醚成分的含量为4〜60摩尔％及其制造方法。聚苯醚树脂具有吸附胆汁酸的作用，可用作胆固醇降低剂。

2. 发明授权

US07208520B2 Crystals of hydroxynorephedrine derivative 失效
标题翻译：羟基麻黄碱衍生物的晶体
公开(公告)号：US07208520B2
公开(公告)日：2007-04-24
申请号：US10489343
申请日：2002-08-27
申请人： Hidetoshi Isawa , Yukihiko Hotei , Kiyoshi Kasai , Junichi Sonehara , Satoshi Akahane , Hiromu Harada
发明人： Hidetoshi Isawa , Yukihiko Hotei , Kiyoshi Kasai , Junichi Sonehara , Satoshi Akahane , Hiromu Harada
IPC分类号： A01N37/12 , A01N37/44 , A61K31/24
CPC分类号： A61K31/216 , C07B2200/07 , C07C217/60
摘要： The present invention provides ethyl (−)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethylphenoxy]acetate hydrochloride, crystalline forms thereof and pharmaceutical compositions containing them, which have excellent β3-adrenoceptor stimulating effects, therapeutic effects on pollakiuria or urinary incontinence and storage stabilities and are useful as a medicament.
摘要翻译：本发明提供了（ - ） - 2- [4- [2 - [[（1S，2R）-2-羟基-2-（4-羟基苯基）-1-甲基乙基]氨基]乙基] 二甲基苯氧基]乙酸盐酸盐，其结晶形式和含有它们的药物组合物，其具有优异的β3 - 肾上腺素受体刺激作用，对尿频尿失禁和储尿稳定性的治疗作用，并且可用作药物。

3. 发明授权

US5294718A Piperidino-3,4-dihydrocarbostyril compounds 失效
标题翻译：哌啶子基-3,4-二氢喹诺酮类化合物
公开(公告)号：US5294718A
公开(公告)日：1994-03-15
申请号：US101006
申请日：1993-08-03
申请人： Arao Ujiie , Hiromu Harada , Akira Iyobe , Masahiko Uchida , Koji Kamata
发明人： Arao Ujiie , Hiromu Harada , Akira Iyobe , Masahiko Uchida , Koji Kamata
IPC分类号： A61K31/47 , A61P7/02 , C07D401/04 , C07D401/10 , A61K31/445
CPC分类号： C07D401/04
摘要： Piperidino-3,4-dihydrocarbostyril compounds represented by the formula: ##STR1## wherein R.sup.1 represents a hydroxy group or an acyloxy group having 2 to 11 carbon atoms; one of R.sup.2 and R.sup.3 represents a nitro group, a cyano group, an alkoxycarbonyl group having 2 to 7 carbon atoms, an alkyl group having 1 to 4 carbon atoms, a haloalkyl group having 1 to 3 carbons atoms, or a halogen atom, and the other represents a hydrogen atom; and pharmaceutically acceptable salts thereof, exhibit platelet aggregation inhibiting activity and thus being useful as therapeutic agents for the prevention or treatment of cerebral ischemic disorders and arterial ischemic disorders.
摘要翻译：由下式表示的哌啶子基-3,4-二氢喹诺酮化合物：其中R 1表示羟基或具有2至11个碳原子的酰氧基; R 2和R 3中的一个表示硝基，氰基，具有2至7个碳原子的烷氧基羰基，具有1至4个碳原子的烷基，具有1至3个碳原子的卤代烷基或卤素原子，以及另一个表示氢原子; 其药学上可接受的盐具有血小板聚集抑制活性，因此可用作预防或治疗脑缺血障碍和动脉缺血障碍的治疗剂。

4. 发明申请

US20080045741A1 INTERMEDIATES IN PRODUCING PHENOXYACETIC ACID DERIVATIVES AND METHOD OF USING THE SAME 失效
公开(公告)号：US20080045741A1
公开(公告)日：2008-02-21
申请号：US11923149
申请日：2007-10-24
申请人： Nobuyuki Tanaka , Tetsuro Tamai , Harunobu Mukaiyama , Takehiro Ishikawa , Junichi Kobayashi , Satoshi Akahane , Hiromu Harada
发明人： Nobuyuki Tanaka , Tetsuro Tamai , Harunobu Mukaiyama , Takehiro Ishikawa , Junichi Kobayashi , Satoshi Akahane , Hiromu Harada
IPC分类号： C07C69/708
CPC分类号： C07C217/60 , C07C43/315 , C07C69/712 , C07C213/02
摘要： The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates.

5. 发明授权

US07329771B2 Intermediates in producing phenoxyacetic acid derivatives and method of using the same 失效
标题翻译：制备苯氧基乙酸衍生物的中间体及其使用方法
公开(公告)号：US07329771B2
公开(公告)日：2008-02-12
申请号：US10526660
申请日：2002-09-05
申请人： Nobuyuki Tanaka , Tetsuro Tamai , Harunobu Mukaiyama , Takehiro Ishikawa , Junichi Kobayashi , Satoshi Akahane , Hiromu Harada
发明人： Nobuyuki Tanaka , Tetsuro Tamai , Harunobu Mukaiyama , Takehiro Ishikawa , Junichi Kobayashi , Satoshi Akahane , Hiromu Harada
IPC分类号： C07C69/76 , A01N37/10 , A61K31/235
CPC分类号： C07C217/60 , C07C43/315 , C07C69/712 , C07C213/02
摘要： The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates.
摘要翻译：本发明提供由通式（I）等表示的新型中间体，其用于制备具有β3肾上腺素受体刺激活性并用于治疗或预防肥胖的通式（X）表示的苯氧基乙酸衍生物或其药学上可接受的盐，高血糖症，由肠蠕动过多引起的疾病，尿尿症，尿失禁，抑郁症或胆道结石。本发明还提供了制备所述中间体的方法和使用所述中间体的方法。

6. 发明授权

US4461905A Imidazole derivatives 失效
标题翻译：咪唑衍生物
公开(公告)号：US4461905A
公开(公告)日：1984-07-24
申请号：US413204
申请日：1982-08-30
申请人： Kinji Iizuka , Tetsuhide Kamijo , Ryoji Yamamoto , Hiromu Harada
发明人： Kinji Iizuka , Tetsuhide Kamijo , Ryoji Yamamoto , Hiromu Harada
IPC分类号： C07D233/54 , C07D233/60 , C07D521/00
CPC分类号： C07D233/64 , C07D231/12 , C07D233/56 , C07D249/08
摘要： The imidazole derivatives of the general formula: ##STR1## wherein A and B may be the same or different, and each is a straight- or branched-chain alkylene or alkenylene group having 1 to 8 carbon atoms, D is an acyl group having 2 to 10 carbon atoms, an alkoxycarbonyl group having 2 to 7 carbon atoms or a dialkoxymethyl group having 3 to 13 carbon atoms, Q is a cyano group or an alkoxycarbonyl group having 2 to 7 carbon atoms, X is a halogen atom, Z is ##STR2## (wherein E is a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms or an alkoxy group having 1 to 6 carbon atoms, Y is an oxygen atom or a sulfur atom and may be connected with either A or B), n is zero or 1, with the proviso that n is 1 when Y connects with B.These compounds are novel compounds and are useful as intermediates in producing 1-substituted imidazole derivatives which possess strong and specific inhibitory effects on thromboxane synthetase and thus are useful as therapeutically active agents for treatment of diseases caused by thromboxane A.sub.2.
摘要翻译：具有以下通式的咪唑衍生物：其中A和B可以相同或不同，并且各自是具有1至8个碳原子的直链或支链亚烷基或亚烯基，D是具有2个碳原子数为2〜7的烷氧基羰基或碳原子数3〜13的二烷氧基甲基，Q为氰基或碳原子数2〜7的烷氧基羰基，X为卤素原子，Z为< IMAGE>（其中E是氢原子，卤素原子，具有1至6个碳原子的烷基或具有1至6个碳原子的烷氧基，Y是氧原子或硫原子，并且可以与A 或B），n为0或1，条件是当Y与B连接时n为1。这些化合物是新化合物，可用作生产1-取代咪唑衍生物的中间体，其具有对凝血恶烷合成酶的强和特异性抑制作用因此可用作治疗活性剂治疗由血栓素A2引起的疾病。

7. 发明申请

US20080045739A1 INTERMEDIATES IN PRODUCING PHENOXYACETIC ACID DERIVATIVES AND METHOD OF USING THE SAME 失效
标题翻译：生产苯氧基酸衍生物的中间体及其使用方法
公开(公告)号：US20080045739A1
公开(公告)日：2008-02-21
申请号：US11923067
申请日：2007-10-24
申请人： Nobuyuki Tanaka , Tetsuro Tamai , Harunobu Mukaiyama , Takehiro Ishikawa , Junichi Kobayashi , Satoshi Akahane , Hiromu Harada
发明人： Nobuyuki Tanaka , Tetsuro Tamai , Harunobu Mukaiyama , Takehiro Ishikawa , Junichi Kobayashi , Satoshi Akahane , Hiromu Harada
IPC分类号： C07C229/02
CPC分类号： C07C217/60 , C07C43/315 , C07C69/712 , C07C213/02
摘要： The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates.
摘要翻译：本发明提供由通式（I）等表示的新型中间体，其用于制备具有β3肾上腺素受体刺激活性并用于治疗或预防肥胖的通式（X）表示的苯氧基乙酸衍生物或其药学上可接受的盐，高血糖症，由肠蠕动过多引起的疾病，尿尿症，尿失禁，抑郁症或胆道结石。本发明还提供了制备所述中间体的方法和使用所述中间体的方法。

8. 发明授权

US4623724A Method for the production of nuclear substituted cinnamoylanthranilic acid salts 失效
标题翻译：制备核取代肉桂酰邻氨基苯甲酸盐的方法
公开(公告)号：US4623724A
公开(公告)日：1986-11-18
申请号：US640588
申请日：1984-08-14
申请人： Kinji Iizuka , Tetsuhide Kamijo , Ryoji Yamamoto , Hiromu Harada
发明人： Kinji Iizuka , Tetsuhide Kamijo , Ryoji Yamamoto , Hiromu Harada
IPC分类号： C07C231/00 , C07C231/12 , C07C235/38 , C07D295/02 , C07D295/027 , C07D295/00
CPC分类号： C07D295/027
摘要： The present invention provides an improved method for producing a nuclear substituted cinnamoylanthranilic acid compound.Illustrative of the process is the reaction of 3,4-dimethoxybenzaldehyde with 2-carboxymalonanilic acid in an inert solvent medium in the presence of piperidine to provide an intermediate salt precipitate, and the salt is treated with an acidic reagent to yield N-(3,4-dimethoxycinnamoyl)anthranilic acid product.

9. 发明授权

US4486597A Method for the production of nuclear substituted cinnamoylanthranilic acid derivatives 失效
标题翻译：制备核取代肉桂酰邻氨基苯甲酸衍生物的方法
公开(公告)号：US4486597A
公开(公告)日：1984-12-04
申请号：US577758
申请日：1984-02-07
申请人： Kinji Iizuka , Tetsuhide Kamino , Ryoji Yamamoto , Hiromu Harada
发明人： Kinji Iizuka , Tetsuhide Kamino , Ryoji Yamamoto , Hiromu Harada
IPC分类号： C07C231/00 , C07C231/12 , C07C235/38 , C07D295/02 , C07D295/027 , C07C99/00
CPC分类号： C07D295/027
摘要： The present invention provides an improved method for producing a nuclear substituted cinnamoylanthranilic acid compound.Illustrative of the process is the reaction of 3,4-dimethoxybenzaldehyde with 2-carboxymalonanilic acid in an inert solvent medium in the presence of piperidine to provide an intermediate salt precipitate, and the salt is treated with an acidic reagent to yield N-(3,4-dimethoxycinnamoyl)anthranilic acid product.
摘要翻译：本发明提供了制备核取代肉桂酰邻氨基苯甲酸化合物的改进方法。该方法的实例是在哌啶存在下，在惰性溶剂介质中3,4-二甲氧基苯甲醛与2-羧基丙二酸的反应，得到中间体盐沉淀物，盐用酸性试剂处理，得到N-（3 ，4-二甲氧基肉桂酰基）邻氨基苯甲酸产物。

10. 发明授权

US07402692B2 Intermediates in producing phenoxyacetic acid derivatives and method of using the same 失效
标题翻译：制备苯氧基乙酸衍生物的中间体及其使用方法
公开(公告)号：US07402692B2
公开(公告)日：2008-07-22
申请号：US11923067
申请日：2007-10-24
申请人： Nobuyuki Tanaka , Tetsuro Tamai , Harunobu Mukaiyama , Takehiro Ishikawa , Junichi Kobayashi , Satoshi Akahane , Hiromu Harada
发明人： Nobuyuki Tanaka , Tetsuro Tamai , Harunobu Mukaiyama , Takehiro Ishikawa , Junichi Kobayashi , Satoshi Akahane , Hiromu Harada
IPC分类号： C07C229/00 , C07C69/76
CPC分类号： C07C217/60 , C07C43/315 , C07C69/712 , C07C213/02
摘要： The present invention provides novel intermediates represented by general formula (I) etc. for preparing a phenoxyacetic acid derivative represented by general formula (X) or a pharmaceutically acceptable salt thereof, which has β3-adrenoceptor stimulating activity and are useful for treating or preventing obesity, hyperglycemia, diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression or biliary calculus. The present invention also provides a process for preparing said intermediates and a method of using said intermediates
摘要翻译：本发明提供由通式（I）等表示的新型中间体，其用于制备具有β3肾上腺素受体刺激活性并用于治疗或预防肥胖的通式（X）表示的苯氧基乙酸衍生物或其药学上可接受的盐，高血糖症，由肠蠕动过多引起的疾病，尿尿症，尿失禁，抑郁症或胆道结石。本发明还提供了制备所述中间体的方法和使用所述中间体的方法

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