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1. 发明授权

US07610942B2 Cell suspension rotating fluidic pump 失效
标题翻译：电池悬浮旋转流体泵
公开(公告)号：US07610942B2
公开(公告)日：2009-11-03
申请号：US10757971
申请日：2004-01-15
申请人： Norio Harui , Michael A. Crawford , Richard J. Esposito , William E. Ortyn
发明人： Norio Harui , Michael A. Crawford , Richard J. Esposito , William E. Ortyn
IPC分类号： B65B1/20 , G01N35/00
CPC分类号： G01N35/1095 , F04B9/02 , F04B13/00 , G01N15/1404 , G01N2015/1413 , Y10T436/11
摘要： A low pulsatility syringe pump including a duplex bearing set rotatingly supporting a lead screw, and a transmission having a first drive train configured to increase a number of motor rotations required for a single rotation of the lead screw, and a second drive train configured to reduce the number of motor rotations required for a single rotation of the lead screw as compared to the first drive train. Another embodiment also includes a motor configured to rotate the syringe about its own axis, independent of the motion of the lead screw. In this other embodiment, the fluid in the syringe barrel includes objects (such as cells, latex beads, etc.) entrained in the fluid. The rate of rotation (e.g., about three revolutions per second) is chosen such that each object traces a substantially circular pathway in the syringe barrel and remains in suspension.
摘要翻译：一种低脉动注射器泵，其包括旋转地支撑导螺杆的双轴承装置，以及具有第一传动系的变速器，其配置成增加所述丝杠的单次旋转所需的电动机转数，以及构造成减小与第一传动系相比，导螺杆的单次旋转所需的电动机转数。另一个实施例还包括电动机，其被配置为独立于导螺杆的运动而围绕其自身的轴线旋转注射器。在该另一个实施例中，注射器筒中的流体包含夹在流体中的物体（例如细胞，乳胶珠等）。选择旋转速率（例如，每秒约三转），使得每个物体在注射器筒中追踪基本上圆形的路径并保持悬浮状态。

2. 发明授权

US06384951B1 High throughput optical scanner 失效
标题翻译：高通量光学扫描仪
公开(公告)号：US06384951B1
公开(公告)日：2002-05-07
申请号：US09551088
申请日：2000-04-18
申请人： David A. Basiji , Gerrit J. van den Engh , Richard J. Esposito
发明人： David A. Basiji , Gerrit J. van den Engh , Richard J. Esposito
IPC分类号： G02B2608
CPC分类号： G01J3/443 , G01J3/45 , G06K7/10801
摘要： A scanning apparatus is provided to obtain automated, rapid and sensitive scanning of substrate fluorescence, optical density or phosphorescence. The scanner uses a constant path length optical train, which enables the combination of a moving beam for high speed scanning with phase-sensitive detection for noise reduction, comprising a light source, a scanning mirror to receive light from the light source and sweep it across a steering mirror, a steering mirror to receive light from the scanning mirror and reflect it to the substrate, whereby it is swept across the substrate along a scan arc, and a photodetector to receive emitted or scattered light from the substrate, wherein the optical path length from the light source to the photodetector is substantially constant throughout the sweep across the substrate. The optical train can further include a waveguide or mirror to collect emitted or scattered light from the substrate and direct it to the photodetector. For phase-sensitive detection the light source is intensity modulated and the detector is connected to phase-sensitive detection electronics. A scanner using a substrate translator is also provided. For two dimensional imaging the substrate is translated in one dimension while the scanning mirror scans the beam in a second dimension. For a high throughput scanner, stacks of substrates are loaded onto a conveyor belt from a tray feeder.
摘要翻译：提供扫描装置以获得对衬底荧光，光密度或磷光的自动，快速和灵敏的扫描。扫描仪使用恒定路径长度的光学列车，其使得用于高速扫描的移动光束与用于降噪的相敏检测的组合包括光源，扫描镜以接收来自光源的光并扫过它转向镜，转向镜，用于接收来自扫描反射镜的光，并将其反射到基板上，由此沿着扫描弧扫过基板;以及光电检测器，用于接收来自基板的发射或散射的光，其中光路在整个扫描过程中，从光源到光电检测器的长度基本恒定。光学系统还可以包括波导或反射镜以收集来自基板的发射或散射的光并将其引导到光电检测器。对于相敏检测，光源进行强度调制，检测器连接到相敏检测电路。还提供了使用基板转换器的扫描仪。对于二维成像，衬底在一个维度上被平移，而扫描镜在第二维度上扫描光束。对于高通量扫描仪，将一堆基板从托盘进料器装载到传送带上。

3. 发明授权

US5643796A System for sensing droplet formation time delay in a flow cytometer 失效
标题翻译：用于感测流式细胞仪中液滴形成时间延迟的系统
公开(公告)号：US5643796A
公开(公告)日：1997-07-01
申请号：US323358
申请日：1994-10-14
申请人： Ger Van den Engh , Richard J. Esposito
发明人： Ger Van den Engh , Richard J. Esposito
IPC分类号： G01N15/14 , G01N35/00
CPC分类号： G01N15/1404 , G01N2015/149 , Y10T436/11 , Y10T436/115831
摘要： A droplet flow cytometer system which includes a system to optimize the droplet formation time delay based on conditions actually experienced includes an automatic droplet sampler which rapidly moves a plurality of containers stepwise through the droplet stream while simultaneously adjusting the droplet time delay. Through the system sampling of an actual substance to be processed can be used to minimize the effect of the substances variations or the determination of which time delay is optimal. Analysis such as cell counting and the like may be conducted manually or automatically and input to a time delay adjustment which may then act with analysis equipment to revise the time delay estimate actually applied during processing. The automatic sampler can be controlled through a microprocessor and appropriate programming to bracket an initial droplet formation time delay estimate. When maximization counts through volume, weight, or other types of analysis exists in the containers, the increment may then be reduced for a more accurate ultimate setting. This may be accomplished while actually processing the sample without interruption.
摘要翻译：包括基于实际经历的条件来优化液滴形成时间延迟的系统的液滴流式细胞仪系统包括自动液滴采样器，其自动地将多个容器逐步地流过液滴流，同时调节液滴时间延迟。通过对待处理的实际物质的系统采样可以用于最小化物质变化的影响或确定哪个时间延迟是最佳的。可以手动或自动地进行诸如细胞计数等的分析，并输入到时间延迟调整，然后可以与分析设备一起操作以修改在处理期间实际应用的时间延迟估计。自动采样器可以通过微处理器进行控制，并进行适当的编程以支持初始液滴形成时间延迟估计。当最大化通过体积，重量或其他类型的分析计数存在于容器中时，可以减小增量以获得更准确的最终设置。这可以在不间断地实际处理样品的同时完成。

4. 发明授权

US5483469A Multiple sort flow cytometer 失效
标题翻译：多重流式细胞仪
公开(公告)号：US5483469A
公开(公告)日：1996-01-09
申请号：US100762
申请日：1993-08-02
申请人： Ger Van den Engh , Richard J. Esposito
发明人： Ger Van den Engh , Richard J. Esposito
IPC分类号： G01N15/14 , B07C5/344
CPC分类号： G01N15/14 , G01N2015/149
摘要： A flow cytometer utilizes multiple lasers for excitation and respective fluorescence of identified dyes bonded to specific cells or events to identify and verify multiple events to be sorted from a sheath flow and droplet stream. Once identified, verified and timed in the sheath flow, each event is independently tagged upon separation from the flow by an electrical charge of +60, +120, or +180 volts and passed through oppositely charged deflection plates with ground planes to yield a focused six way deflection of at least six events in a narrow plane.
摘要翻译：流式细胞仪利用多个激光器激发和识别结合到特定细胞或事件的识别染料的相应荧光，以鉴定和验证从鞘流和液滴流中分选的多个事件。一旦识别，验证并定时在鞘流中，每个事件在+ 60，+120或+180伏的电荷与流动分离时被独立地标记，并通过带有接地平面的带相反电荷的偏转板，以产生聚焦在狭窄的平面中至少六次事件的六路偏转。

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