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1. 发明授权

US06399568B1 Cyclic tetrapeptide derivatives and medicinal use thereof 失效
标题翻译：环状四肽衍生物及其医药用途
公开(公告)号：US06399568B1
公开(公告)日：2002-06-04
申请号：US09486783
申请日：2000-03-01
申请人： Norikazu Nishino , Minoru Yoshida , Sueharu Horinouchi , Yasuhiko Komatsu , Tsutomu Mimoto
发明人： Norikazu Nishino , Minoru Yoshida , Sueharu Horinouchi , Yasuhiko Komatsu , Tsutomu Mimoto
IPC分类号： A61K3812
CPC分类号： C07K5/126 , A61K38/00
摘要： A cyclic tetrapeptide derivative represented by the general formula (I): wherein: R11, R12, R21 and R22 independently denote a monovalent group selected from hydrogen, a linear or branched alkyl group with 6 or less carbon atoms, benzyl group, 4-methoxybenzyl group, 3-indolylmethyl group, (N-methoxy-3-indolyl) methyl group, (N-formyl-3-indolyl)methyl group, etc.; R3 denotes a divalent group selected from a linear chained hydrocarbon group with 3 or 4 carbon atoms, or the linear branched hydrocarbon group having a branched chain added to the chain, or a divalent group substituted with a heteroatom; R4 denotes a divalent chained hydrocarbon group with 4 to 6 carbon atoms, or a divalent group derived from said hydrocarbon group by addition etc. of a branched chain on said chain; and a pharmaceutically acceptable salt thereof, or an analogous cyclic tetrapeptide derivative compound; as well as a histone deacetylase enzyme inhibitor, an MHC class-I molecule expression promoting agent and a pharmaceutical composition that comprise said cyclic tetrapeptide derivative as an effective ingredient.
摘要翻译：由通式（I）表示的环状四肽衍生物：其中：R11，R12，R21和R22独立地表示选自氢，碳原子数6以下的直链或支链烷基，苄基，4-甲氧基苄基（3-甲氧基-3-吲哚基）甲基，（N-甲酰基-3-吲哚基）甲基等。 R3表示选自具有3或4个碳原子的直链状烃基或者在该链上添加有支链的直链支链烃基或被杂原子取代的二价基团的二价基团; R4表示二价链状烃基或含有4〜6个碳原子的二价基团，或通过所述链上的支链的加成等衍生自所述烃基的二价基团; 和其药学上可接受的盐，或类似的环状四肽衍生物化合物; 以及组蛋白脱乙酰酶酶抑制剂，MHC class I分子表达促进剂和包含所述环状四肽衍生物作为有效成分的药物组合物。

2. 发明授权

US06825317B2 Cyclic tetrapeptide derivatives and pharmaceutical uses thereof 失效
标题翻译：环状四肽衍生物及其药物用途
公开(公告)号：US06825317B2
公开(公告)日：2004-11-30
申请号：US09945237
申请日：2001-08-31
申请人： Norikazu Nishino , Minoru Yoshida , Sueharu Horinouchi , Yasuhiko Komatsu
发明人： Norikazu Nishino , Minoru Yoshida , Sueharu Horinouchi , Yasuhiko Komatsu
IPC分类号： C07K752
CPC分类号： C07K5/126 , A61K38/00
摘要： The present invention provides a cyclic tetrapeptide derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof: wherein each of R21 and R22 independently denotes hydrogen, a linear C1-C6-alkyl group to which a non-aromatic cycloalkyl group or an optionally substituted aromatic ring may be attached, or a branched C3-C6-alkyl group to which a non-aromatic cycloalkyl group or an optionally substituted aromatic ring may be attached; and each of R1 and R3 independently denotes a linear C1-C5-alkylene group which may have a C1-C6 side chain, in which the side chain may form a condensed ring structure on the alkylene chain. The present invention also provides a histone deacetylase inhibitor, an MHC class-I molecule expression-promoting agent and a pharmaceutical composition, each of which comprises the above cyclic tetrapeptide derivative or pharmaceutically acceptable salt thereof as an active ingredient.
摘要翻译：本发明提供由以下通式（I）表示的环状四肽衍生物或其药学上可接受的盐：R21和R22独立地表示氢，非芳香族环烷基的直链C 1 -C 6 - 烷基或可以连接任选取代的芳环，或者可以连接非芳族环烷基或任选取代的芳环的支链C 3 -C 6 - 烷基; R 1和R 3的每一个独立地表示可以具有C 1 -C 6侧链的直链C 1 -C 5亚烷基，其中侧链可以在亚烷基链上形成稠环结构。本发明还提供组蛋白脱乙酰酶抑制剂，MHC I类分子表达促进剂和药物组合物，其各自包含上述环状四肽衍生物或其药学上可接受的盐作为活性成分。

3. 发明授权

US07488712B2 Histone deacetylase inhibitors and methods for producing the same 失效
标题翻译：组蛋白脱乙酰酶抑制剂及其制备方法
公开(公告)号：US07488712B2
公开(公告)日：2009-02-10
申请号：US10505380
申请日：2003-02-20
申请人： Minoru Yoshida , Norikazu Nishino , Sueharu Horinouchi
发明人： Minoru Yoshida , Norikazu Nishino , Sueharu Horinouchi
IPC分类号： A61K38/00
CPC分类号： C07K5/126 , A61K38/00
摘要： Compounds represented by formula (1) have strong inhibitory activity that is selective towards HDAC1 and HDAC4. Therefore, the compounds of the present invention are useful as pharmaceutical agents for treating or preventing diseases caused by HDAC1 and HDAC4.
摘要翻译：由式（1）表示的化合物具有对HDAC1和HDAC4具有选择性的强抑制活性。因此，本发明的化合物可用作治疗或预防HDAC1和HDAC4引起的疾病的药剂。

4. 发明授权

US07056884B2 Reduced FK228 and use thereof 有权
标题翻译：减少FK228及其使用
公开(公告)号：US07056884B2
公开(公告)日：2006-06-06
申请号：US10333063
申请日：2001-07-09
申请人： Hidenori Nakajima , Akito Tanaka , Minoru Yoshida , Sueharu Horinouchi
发明人： Hidenori Nakajima , Akito Tanaka , Minoru Yoshida , Sueharu Horinouchi
IPC分类号： A61K38/00 , C07K16/00
CPC分类号： C07K11/02 , A61K38/00 , C07K5/101 , Y02P20/55
摘要： The present invention relates to reduced FK228 of the formula (I) wherein R1 and R2 are the same or different and each is a hydrogen atom or a thiol-protecting group, or a salt thereof, and a histone deacetylase inhibitor containing this compound, an expression potentiator and a reactivation promoter of a transgene, and pharmaceutical agents containing them as active ingredients. The reduced FK228 or a salt thereof has a strong histone deacetylase inhibitory activity and this compound can be used for the prophylaxis or treatment of various diseases, in which histone deacetylation is involved, and for the gene therapy of such diseases.
摘要翻译：本发明涉及式（I）的还原型FK228，其中R 1和R 2相同或不同，各自为氢原子或硫醇保护基或其盐，以及含有该化合物的组蛋白脱乙酰酶抑制剂，转基因的表达增强子和再活化启动子以及含有它们作为有效成分的药剂。还原的FK228或其盐具有强的组蛋白脱乙酰酶抑制活性，该化合物可用于预防或治疗涉及组蛋白脱乙酰化的各种疾病和用于这些疾病的基因治疗。

5. 发明授权

US5948883A Human CRM1 Protein 失效
标题翻译：人类CRM1蛋白
公开(公告)号：US5948883A
公开(公告)日：1999-09-07
申请号：US975527
申请日：1997-11-20
申请人： Minoru Yoshida , Sueharu Horinouchi , Kazunori Nishi
发明人： Minoru Yoshida , Sueharu Horinouchi , Kazunori Nishi
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12
CPC分类号： C07K14/4703 , A61K38/00
摘要： A protein which comprises the sane or substantially the same amino acid sequence as that represented by SEQ ID NO:1, its partial peptide and their salts are disclosed. DNA encoding the protein or its partial peptide is also disclosed. The protein, its partial peptide or a salt thereof is an inhibitory factor of a transcription factor and, therefore, it is useful as medicine such as prophylactic and therapeutic drugs of, for example, tumors. The DNA is useful as a gene diagnosing drug. The antibody against the protein, etc. is also disclosed. The antibody is used for, for example, quantitative determination of the protein, etc. in a specimen fluid. The protein, etc. are also useful as a reagent for screening for compounds or their salts which promote the function of the protein, etc.
摘要翻译：公开了包含与SEQ ID NO：1所示的基本相同的氨基酸序列的蛋白质，其部分肽及其盐。还公开了编码蛋白质或其部分肽的DNA。蛋白质，其部分肽或其盐是转录因子的抑制因子，因此可用作例如肿瘤的预防和治疗药物等药物。该DNA可用作诊断药物的基因。还公开了针对蛋白质等的抗体。抗体用于例如样品流体中蛋白质等的定量测定。蛋白质等也可用作筛选促进蛋白质等功能的化合物或其盐的试剂。

6. 发明授权

US5654180A Hybrid plasmid vectors, recombinant plasmids containing genes encoding nitrile degrading enzymes, transformants containing the recombinant plasmids and methods of producing amides and acids using the transformants 失效
标题翻译：杂交质粒载体，含有编码腈降解酶的基因的重组质粒，含有重组质粒的转化体和使用转化体产生酰胺和酸的方法
公开(公告)号：US5654180A
公开(公告)日：1997-08-05
申请号：US344683
申请日：1994-11-17
申请人： Teruhiko Beppu , Sueharu Horinouchi , Makoto Nishiyama , Fujio Yu , Yoshihiro Hashimoto
发明人： Teruhiko Beppu , Sueharu Horinouchi , Makoto Nishiyama , Fujio Yu , Yoshihiro Hashimoto
IPC分类号： C12N1/21 , C12N9/78 , C12N15/55 , C12N15/74 , C12P13/02 , C12N1/20 , C12P7/40
CPC分类号： C12N15/74 , C12N9/78
摘要： The present invention provides a recombinant plasmid comprising combining a hybrid plasmid vector with the isolated DNA sequences of one or more genes encoding nitrile degrading enzymes which are derived from bacteria belonging to the genus Rhodococcus, said hybrid plasmid vector comprising an isolated DNA sequence which confers on the vector the ability to replicate and amplify in the cells of bacteria belonging to the genus Rhodococcus, and an isolated DNA sequence which confers on the vector the ability to replicate and amplify in the cells of bacteria belonging to Escherichia coli, and an isolated DNA sequence containing a drug resistance gene.
摘要翻译：本发明提供了一种重组质粒，其包含将杂交质粒载体与编码来自属于红球菌属的细菌的腈降解酶的一个或多个基因的分离的DNA序列组合，所述杂交质粒载体包含赋予的分离的DNA序列载体能够在属于红球菌属的细菌的细胞中复制和扩增的能力，以及赋予载体在分离的DNA序列的细胞中复制和扩增能力的分离的DNA序列含有耐药性基因。

7. 发明授权

US5130235A DNA encoding polypeptide having nitrile hydratase activity and method for producing amides from nitriles with transformant containing the same 失效
标题翻译：具有NITRILE HYDRATASE活性的DNA编码多肽和从含有其的转化体的NITRILES生产氨基的方法
公开(公告)号：US5130235A
公开(公告)日：1992-07-14
申请号：US372449
申请日：1989-06-28
申请人： Teruhiko Beppu , Sueharu Horinouchi , Osamu Ikehata , Takakazu Endo
发明人： Teruhiko Beppu , Sueharu Horinouchi , Osamu Ikehata , Takakazu Endo
IPC分类号： C12N1/21 , C12N9/78 , C12N9/88 , C12N15/09 , C12N15/55 , C12P13/02 , C12R1/15 , C12R1/19
CPC分类号： C12P13/02 , C12N9/78
摘要： A DNA which encodes polypeptide carrying two specific amino acid sequences and having nitrile hydratase activity; a method for producing nitrile hydratase by incubating a transformant made by the transformation with a recombinant DNA prepared by integrating the foregoing DNA into a vector in a medium and harvesting nitrile hydratase accumulated in the medium; and a method for producing amides by incubating the foregoing transformant and then converting nitriles into corresponding amides by the action of the obtained nitrile hydratase or by making a culture solution, isolates, treated cells or their immobilized products act upon nitriles to produce corresponding amides.
摘要翻译：编码携带两个特定氨基酸序列并具有腈水合酶活性的多肽的DNA; 通过将通过转化制备的转化体与通过将上述DNA整合到培养基中的载体并收获在培养基中积累的腈水合酶而制备的重组DNA来生产腈水合酶的方法; 以及通过温育上述转化体然后通过所得腈水合酶的作用将腈转化为相应的酰胺或通过使培养液，分离物，经处理的细胞或其固定化产物作用于腈以产生相应的酰胺的方法来生产酰胺。

8. 发明授权

US5792630A Cellulose-producing microorganism transformed with a gene for an enzyme involved in sucrose metabolism 失效
标题翻译：用参与蔗糖代谢的酶的基因转化的产生纤维素的微生物
公开(公告)号：US5792630A
公开(公告)日：1998-08-11
申请号：US578536
申请日：1996-03-29
申请人： Naoto Tonouchi , Takayasu Tsuchida , Fumihiro Yoshinaga , Sueharu Horinouchi , Teruhiko Beppu , Hideshi Yanase , Takahisa Hayashi
发明人： Naoto Tonouchi , Takayasu Tsuchida , Fumihiro Yoshinaga , Sueharu Horinouchi , Teruhiko Beppu , Hideshi Yanase , Takahisa Hayashi
IPC分类号： C12N1/21 , C12N9/10 , C12P19/04 , C12N1/12 , C12N1/20 , C12N15/00
CPC分类号： C12N9/1051 , C12N9/1062 , C12P19/04 , Y10S435/823
摘要： A method for the production of a cellulosic product, which comprises: culturing a cellulose-producing microorganism transformed with a gene for an enzyme involved in sucrose metabolism in a medium containing sucrose, allowing the cellulosic product to be produced and accumulated in the medium, and collecting the cellulosic product. By the present method, the cellulosic product can be produced efficiently and economically.
摘要翻译： PCT No.PCT / JP95 / 00961 Sec。 371日期：1996年3月29日 102（e）1996年3月29日PCT PCT 1995年5月19日PCT公布。公开号WO95 / 32279 日期：1995年11月30日一种纤维素产品的制造方法，其特征在于，在含有蔗糖的培养基中，培养用参与蔗糖代谢的酶的基因转化的纤维素生成微生物，使其生产和累积纤维素产物在培养基中，并收集纤维素产品。通过本方法，可以有效且经济地制造纤维素产品。

9. 发明授权

US5580782A Acetic acid bacterium, plasmid derived from said bacterium and shuttle vectors constructed with said plasmid 失效
标题翻译：乙酸菌，源自所述细菌的质粒和用所述质粒构建的穿梭载体
公开(公告)号：US5580782A
公开(公告)日：1996-12-03
申请号：US331488
申请日：1994-12-23
申请人： Teruhiko Beppu , Naoto Tonouchi , Sueharu Horinouchi , Takayasu Tsuchida
发明人： Teruhiko Beppu , Naoto Tonouchi , Sueharu Horinouchi , Takayasu Tsuchida
IPC分类号： C12N1/21 , C12N15/74 , C12N1/20 , C12N15/00
CPC分类号： C12N15/74
摘要： Acetobacter sp. strain BPR 2001, an endogeneous plasmid named pAH4 derived from said strain as well as shuttle vectors constructed from said plasmid and an E. coli-derived plasmid are disclosed.These shuttle vectors can be advantageously used for gene recombination of cellulose-producing acetic acid bacteria.
摘要翻译： PCT No.PCT / JP94 / 00315 Sec。 371日期1994年12月23日第 102（e）日期1994年12月23日PCT 1994年2月28日PCT PCT。公开号WO94 / 20626 日期1994年9月15日公开了菌株BPR 2001，从所述菌株衍生的命名为pAH4的内源性质粒以及由所述质粒构建的穿梭载体和来自大肠杆菌的质粒。这些穿梭载体可以有利地用于产生乙酸的细菌的基因重组。

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