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1. 发明授权

US08722614B2 Adiponectin production enhancer 有权
标题翻译：脂联素生产增强剂
公开(公告)号：US08722614B2
公开(公告)日：2014-05-13
申请号：US12450286
申请日：2008-03-21
申请人： Norihisa Kato , Kazunobu Tokunaga , Kazuhisa Tsujimoto , Hideyuki Yamada
发明人： Norihisa Kato , Kazunobu Tokunaga , Kazuhisa Tsujimoto , Hideyuki Yamada
IPC分类号： A61K38/00 , A61K38/17
CPC分类号： A61K38/1767 , A23L2/66 , A23L33/17 , A23L33/18 , A23V2002/00 , A61K38/012 , A23V2200/326 , A23V2200/328 , A23V2250/542
摘要： The present invention relates to an adiponectin production enhancer comprising sericin as an active ingredient, and to a pharmaceutical composition and food and drink comprising sericin. These are effective in the prevention and/or amelioration of various diseases caused by reduction of blood adiponectin level such as arteriosclerosis, fatty liver and diabetes associated with obesity. The enhancer, the pharmaceutical composition and the food and drink according to the invention have excellent adiponectin production enhancing effects as well as high safety and are expected to be broadly applied to a variety of pharmaceutical preparations and food and drink.
摘要翻译：本发明涉及包含丝胶蛋白作为活性成分的脂联素生产增强剂，以及包含丝胶蛋白的药物组合物和食品和饮料。这些有效预防和/或改善由血液脂联素水平降低引起的各种疾病，例如动脉硬化，脂肪肝和与肥胖相关的糖尿病。根据本发明的增强剂，药物组合物和食品和饮料具有优异的脂连蛋白生产增强效果以及高安全性，并且预期广泛地应用于各种药物制剂和食品和饮料。

2. 发明申请

US20100035810A1 ADIPONECTIN PRODUCTION ENHANCER 有权
标题翻译： ADIPONECTIN生产增强剂
公开(公告)号：US20100035810A1
公开(公告)日：2010-02-11
申请号：US12450286
申请日：2008-03-21
申请人： Norihisa Kato , Kazunobu Tokunaga , Kazuhisa Tsujimoto , Hideyuki Yamada
发明人： Norihisa Kato , Kazunobu Tokunaga , Kazuhisa Tsujimoto , Hideyuki Yamada
IPC分类号： A61K38/16 , C07K14/00
CPC分类号： A61K38/1767 , A23L2/66 , A23L33/17 , A23L33/18 , A23V2002/00 , A61K38/012 , A23V2200/326 , A23V2200/328 , A23V2250/542
摘要： The present invention relates to an adiponectin production enhancer comprising sericin as an active ingredient, and to a pharmaceutical composition and food and drink comprising sericin. These are effective in the prevention and/or amelioration of various diseases caused by reduction of blood adiponectin level such as arteriosclerosis, fatty liver and diabetes associated with obesity. The enhancer, the pharmaceutical composition and the food and drink according to the invention have excellent adiponectin production enhancing effects as well as high safety and are expected to be broadly applied to a variety of pharmaceutical preparations and food and drink.
摘要翻译：本发明涉及包含丝胶蛋白作为活性成分的脂联素生产增强剂，以及包含丝胶蛋白的药物组合物和食品和饮料。这些有效预防和/或改善由血液脂联素水平降低引起的各种疾病，例如动脉硬化，脂肪肝和与肥胖相关的糖尿病。根据本发明的增强剂，药物组合物和食品和饮料具有优异的脂连蛋白生产增强效果以及高安全性，并且预期广泛地应用于各种药物制剂和食品和饮料。

3. 发明授权

US07329726B2 Physiologically active peptides 失效
标题翻译：生理活性肽
公开(公告)号：US07329726B2
公开(公告)日：2008-02-12
申请号：US11010800
申请日：2004-12-13
申请人： Shigeru Nakamori , Hiroshi Takagi , Masakazu Takahashi , Kazuhisa Tsujimoto , Hideyuki Yamada
发明人： Shigeru Nakamori , Hiroshi Takagi , Masakazu Takahashi , Kazuhisa Tsujimoto , Hideyuki Yamada
IPC分类号： C07K7/06 , A61K38/08 , C12N5/02
CPC分类号： C07K14/43586 , C12N5/0018 , C12N5/0601 , C12N2501/998 , C12N2501/999
摘要： A peptide according to the present invention is selected from the group consisting of: (a) a peptide having the amino acid sequence represented by SEQ ID NO: 1; (b) a peptide having a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having cell death-preventing activity and/or cell growth-promoting activity; and (c) a peptide which has an amino acid sequence having at least 80% homology with the peptide consisting of the amino acid sequence described in (a) above and has cell death-preventing activity and/or cell growth-promoting activity. The peptide has cell death-preventing activity and/or cell growth-promoting activity, is highly safe, and can be produced without difficulty. The peptide is useful as a culture supplement or as an effective component for a cell culture medium.
摘要翻译：根据本发明的肽选自：（a）具有由SEQ ID NO：1表示的氨基酸序列的肽; （b）具有上述（a）中所述的氨基酸序列的修饰氨基酸序列的肽，其中一个或多个氨基酸残基被缺失，取代，插入或添加并具有细胞死亡预防活性和/或细胞生长促进活性; 和（c）具有与由上述（a）中所述的氨基酸序列组成的肽具有至少80％同源性的氨基酸序列并具有细胞死亡预防活性和/或细胞生长促进活性的肽。肽具有细胞死亡预防活性和/或细胞生长促进活性，是高度安全的，可以毫无困难地制备。该肽可用作培养物补充物或作为细胞培养基的有效成分。

4. 发明申请

US20090232911A1 Use of sericin for improving feeling in use of denture 审中-公开
标题翻译：使用丝胶来改善使用义齿的感觉
公开(公告)号：US20090232911A1
公开(公告)日：2009-09-17
申请号：US11887027
申请日：2006-03-24
申请人： Yoichi Kato , Kazuhisa Tsujimoto , Hideyuki Yamada , Taizo Hamada , Sadayuki Yuda , Koichi Okano
发明人： Yoichi Kato , Kazuhisa Tsujimoto , Hideyuki Yamada , Taizo Hamada , Sadayuki Yuda , Koichi Okano
IPC分类号： A61K36/00 , C07K14/47 , A61K38/17
CPC分类号： A61C13/0025 , A61K6/0026 , A61K8/64 , A61Q11/00 , C08L1/00 , C08L3/00 , C08L5/00 , C08L89/04
摘要： The purpose is to prevent, ameliorate or relieve various conditions induced in the dried oral cavity or to improve the stability of a denture during use. A solution for treating a denture or a denture stabilizer comprising sericin can be used.
摘要翻译：目的是防止，改善或缓解在干燥的口腔中引起的各种病症，或改善使用期间义齿的稳定性。可以使用用于治疗包括丝胶蛋白的义齿或义齿稳定剂的溶液。

5. 发明申请

US20050196861A1 Physiologically active peptides 失效
标题翻译：生理活性肽
公开(公告)号：US20050196861A1
公开(公告)日：2005-09-08
申请号：US11010800
申请日：2004-12-13
申请人： Shigeru Nakamori , Hiroshi Takagi , Masakazu Takahashi , Kazuhisa Tsujimoto , Hideyuki Yamada
发明人： Shigeru Nakamori , Hiroshi Takagi , Masakazu Takahashi , Kazuhisa Tsujimoto , Hideyuki Yamada
IPC分类号： C07K7/06 , C07K14/435 , C12N5/00 , C12N5/07 , A61K38/18 , C07K14/475 , C12N5/02
CPC分类号： C07K14/43586 , C12N5/0018 , C12N5/0601 , C12N2501/998 , C12N2501/999
摘要： A peptide according to the present invention is selected from the group consisting of: (a) a peptide having the amino acid sequence represented by SEQ ID NO: 1; (b) a peptide having a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having cell death-preventing activity and/or cell growth-promoting activity; and (c) a peptide which has an amino acid sequence having at least 80% homology with the peptide consisting of the amino acid sequence described in (a) above and has cell death-preventing activity and/or cell growth-promoting activity. The peptide has cell death-preventing activity and/or cell growth-promoting activity, is highly safe, and can be produced without difficulty. The peptide is useful as a culture supplement or as an effective component for a cell culture medium.
摘要翻译：根据本发明的肽选自：（a）具有由SEQ ID NO：1表示的氨基酸序列的肽; （b）具有上述（a）中所述的氨基酸序列的修饰氨基酸序列的肽，其中一个或多个氨基酸残基被缺失，取代，插入或添加并具有细胞死亡预防活性和/或细胞生长促进活性; 和（c）具有与由上述（a）中所述的氨基酸序列组成的肽具有至少80％同源性的氨基酸序列并具有细胞死亡预防活性和/或细胞生长促进活性的肽。肽具有细胞死亡预防活性和/或细胞生长促进活性，是高度安全的，可以毫无困难地制备。该肽可用作培养物补充物或作为细胞培养基的有效成分。

6. 发明申请

US20140178571A1 RESIN SUBSTRATE HAVING METAL FILM PATTERN FORMED THEREON 有权
标题翻译：具有金属薄膜图案的树脂基材
公开(公告)号：US20140178571A1
公开(公告)日：2014-06-26
申请号：US14122797
申请日：2012-05-17
申请人： Akimitsu Bamba , Kazuhisa Tsujimoto , Hideyuki Yamada , Kouichi Kugimiya
发明人： Akimitsu Bamba , Kazuhisa Tsujimoto , Hideyuki Yamada , Kouichi Kugimiya
IPC分类号： H05K3/18
CPC分类号： H05K3/182 , B05D1/28 , B05D5/12 , B05D7/52 , B41M1/30 , C23C18/1608 , C23C18/1651 , C23C18/2086 , C23C18/30 , C23C18/36 , C23C18/405 , H05K2201/0154 , H05K2203/0793
摘要： The purpose of the present invention is to provide a method for using a metal ion solution of low concentration to efficiently form a metal film pattern of excellent accuracy and reliable adhesion on a resin substrate. A resin substrate having a metal film pattern formed thereon is produced by a method that includes the following steps (a) to (e): (a) a step for pattern-printing of a latent image agent (2) onto the surface of a resin substrate (1) ; (b) a step for bringing the area imprinted with the latent image agent (2) into contact with a solution containing metal ions, and forming a metal salt (3); (c) a step for bringing the metal salt (3) into contact with an acidic treatment liquid containing a reducing agent, and reducing the metal salt; (d) a step for forming an electroless nickel plating film (5) on the area imprinted with the latent image agent; and (e) a step for precipitating an electroless copper plating (6) onto the surface of the nickel plating film (5).
摘要翻译：本发明的目的是提供一种使用低浓度的金属离子溶液来有效地形成在树脂基板上具有优异的精度和可靠的粘附性的金属膜图案的方法。通过包括以下步骤（a）至（e）的方法制备其上形成有金属膜图案的树脂基板：（a）将潜像剂（2）图案印刷到表面上的步骤树脂基板（1）; （b）使潜像剂（2）印刷的区域与含有金属离子的溶液接触并形成金属盐（3）的步骤; （c）使金属盐（3）与含有还原剂的酸性处理液接触并还原金属盐的工序; （d）在印有潜像剂的区域上形成化学镀镍膜（5）的步骤; 和（e）将化学镀铜（6）析出到镀镍膜（5）的表面上的步骤。

7. 发明授权

US07314745B2 Protein and DNA encoding the same 失效
标题翻译：蛋白质和DNA编码相同
公开(公告)号：US07314745B2
公开(公告)日：2008-01-01
申请号：US10469486
申请日：2002-03-01
申请人： Shigeru Nakamori , Hiroshi Takagi , Masakazu Takahashi , Kazuhisa Tsujimoto , Hideyuki Yamada
发明人： Shigeru Nakamori , Hiroshi Takagi , Masakazu Takahashi , Kazuhisa Tsujimoto , Hideyuki Yamada
IPC分类号： C12N9/64 , C12N15/57 , C12N15/79 , C12N15/85
CPC分类号： C12N9/64 , C12N9/6402
摘要： An objective of the present invention is to provide a new protein derived from the silkworm middle silk gland and a DNA encoding said protein. The present invention relates to a protein of the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 1; (b) a protein comprising a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having protease activity.
摘要翻译：本发明的目的是提供一种来自蚕丝绸的新蛋白质和编码所述蛋白质的DNA。本发明涉及以下（a）或（b）的蛋白质：（a）包含SEQ ID NO：1所示的氨基酸序列的蛋白质; （b）包含上述（a）中描述的氨基酸序列的修饰氨基酸序列的蛋白质，其中一个或多个氨基酸残基被缺失，取代，插入或添加并具有蛋白酶活性。

8. 发明授权

US07763448B2 Porous body formed of sericin 有权
标题翻译：多孔体形成丝胶蛋白
公开(公告)号：US07763448B2
公开(公告)日：2010-07-27
申请号：US10593608
申请日：2005-03-17
申请人： Yoichi Kato , Kazuhisa Tsujimoto , Hideyuki Yamada
发明人： Yoichi Kato , Kazuhisa Tsujimoto , Hideyuki Yamada
IPC分类号： C12N11/02 , C07K17/02
CPC分类号： A61L27/227 , A61L27/56 , Y10S530/812
摘要： The present invention provides a porous body high in safety against environment and living bodies and having a strength high enough to withstand practical use, said porous body comprising, as a skeleton constituent thereof, sericin with an average molecular weight of 30000 to 400000, and having a recovery rate of 10 to 100% after 50% compression.
摘要翻译：本发明提供一种对环境和生物体的安全性高的多孔体，其强度足够高以抵抗实际应用，所述多孔体作为骨架组分包含平均分子量为30000至400000的丝胶蛋白，并且具有 50％压缩后的回收率为10〜100％。

9. 发明授权

US09578751B2 Method for producing a resin substrate having a metal film pattern formed thereon 有权
标题翻译：用于制造其上形成有金属膜图案的树脂基板的方法
公开(公告)号：US09578751B2
公开(公告)日：2017-02-21
申请号：US14122797
申请日：2012-05-17
申请人： Akimitsu Bamba , Kazuhisa Tsujimoto , Hideyuki Yamada , Kouichi Kugimiya
发明人： Akimitsu Bamba , Kazuhisa Tsujimoto , Hideyuki Yamada , Kouichi Kugimiya
IPC分类号： B05D5/12 , C23C18/30 , H05K3/18 , B41M1/30 , C23C18/16 , C23C18/20 , B05D7/00 , B05D1/28 , C23C18/36 , C23C18/40
CPC分类号： H05K3/182 , B05D1/28 , B05D5/12 , B05D7/52 , B41M1/30 , C23C18/1608 , C23C18/1651 , C23C18/2086 , C23C18/30 , C23C18/36 , C23C18/405 , H05K2201/0154 , H05K2203/0793
摘要： The purpose of the present invention is to provide a method for using a metal ion solution of low concentration to efficiently form a metal film pattern of excellent accuracy and reliable adhesion on a resin substrate. A resin substrate having a metal film pattern formed thereon is produced by a method that includes the following steps (a) to (e): (a) a step for pattern-printing of a latent image agent (2) onto the surface of a resin substrate (1) ; (b) a step for bringing the area imprinted with the latent image agent (2) into contact with a solution containing metal ions, and forming a metal salt (3); (c) a step for bringing the metal salt (3) into contact with an acidic treatment liquid containing a reducing agent, and reducing the metal salt; (d) a step for forming an electroless nickel plating film (5) on the area imprinted with the latent image agent; and (e) a step for precipitating an electroless copper plating (6) onto the surface of the nickel plating film (5).
摘要翻译：本发明的目的是提供一种使用低浓度的金属离子溶液来有效地形成在树脂基板上具有优异的精度和可靠的粘附性的金属膜图案的方法。通过包括以下步骤（a）至（e）的方法制备其上形成有金属膜图案的树脂基板：（a）将潜像剂（2）图案印刷到表面上的步骤树脂基板（1）; （b）使潜像剂（2）印刷的区域与含有金属离子的溶液接触并形成金属盐（3）的步骤; （c）使金属盐（3）与含有还原剂的酸性处理液接触并还原金属盐的工序; （d）在印有潜像剂的区域上形成化学镀镍膜（5）的步骤; 和（e）将化学镀铜（6）析出到镀镍膜（5）的表面上的步骤。

10. 发明授权

US08097285B2 Use of sericin for improving the feeling in use of denture 失效
标题翻译：使用丝胶来改善使用义齿的感觉
公开(公告)号：US08097285B2
公开(公告)日：2012-01-17
申请号：US12861265
申请日：2010-08-23
申请人： Yoichi Kato , Kazuhisa Tsujimoto , Hideyuki Yamada , Taizo Hamada , Sadayuki Yuda , Koichi Okano
发明人： Yoichi Kato , Kazuhisa Tsujimoto , Hideyuki Yamada , Taizo Hamada , Sadayuki Yuda , Koichi Okano
IPC分类号： A61K35/64
CPC分类号： A61C13/0025 , A61K6/0026 , A61K8/64 , A61Q11/00 , C08L1/00 , C08L3/00 , C08L5/00 , C08L89/04
摘要： The purpose is to prevent, ameliorate or relieve various conditions induced in the dried oral cavity or to improve the stability of a denture during use. A solution for treating a denture or a denture stabilizer comprising sericin can be used.
摘要翻译：目的是防止，改善或缓解在干燥的口腔中引起的各种病症，或改善使用期间义齿的稳定性。可以使用用于治疗包括丝胶蛋白的义齿或义齿稳定剂的溶液。

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