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1. 发明授权

US06984815B2 Electronic pulse detection apparatus and electronic pulse detection chip 失效
标题翻译：电子脉冲检测装置和电子脉冲检测芯片
公开(公告)号：US06984815B2
公开(公告)日：2006-01-10
申请号：US10489422
申请日：2002-09-26
申请人： Takayoshi Yumii , Kyoji Doi , Noriaki Kimura
发明人： Takayoshi Yumii , Kyoji Doi , Noriaki Kimura
IPC分类号： H01J40/14
CPC分类号： H04N5/32 , H04N5/374
摘要： An electronic pulse detection device includes: an MCP in which a plurality of capillaries configured to increase the number of electrons are arranged in matrix; and an electronic pulse reading chip 30 disposed on an output side of the MCP. The electronic pulse detection chip 30 includes anodes 32 and detection transistors 34 both provided so as to correspond to the respective capillaries. Electronic pulses are incident on the anodes 32 from the MCP. Drains of the detection transistors 34 are connected to the corresponding anodes. The detection transistors 34 on the same row are connected to one another at gates thereof and turned on/off as a unit, and sources of the detection transistors 34 on the same column are connected to a corresponding switch circuit 80 as a unit to be connected to a current-voltage conversion resistance RL via the switch circuit 80. The current-voltage conversion resistance RL converts a current, which flows therethrough when the electronic pulses are incident on the anodes 32, to a voltage and inputs the voltage to an operational amplifier 90. This makes it possible to detect feeble light and radiation ray two dimensionally.
摘要翻译：电子脉冲检测装置包括：MCP，其中配置成增加电子数量的多个毛细管布置成矩阵; 以及设置在MCP的输出侧的电子脉冲读取芯片30。电子脉冲检测芯片30包括阳极32和检测晶体管34，两者均设置成对应于相应的毛细管。电子脉冲从MCP入射到阳极32上。检测晶体管34的漏极连接到相应的阳极。同一行的检测晶体管34在其栅极处彼此连接并作为单元导通/截止，并且同一列上的检测晶体管34的源极连接到相应的开关电路80作为要连接的单元经由开关电路80到达电流 - 电压转换电阻R L L。电流 - 电压转换电阻R L将在电子脉冲入射到阳极32上时流经的电流转换成电压并将电压输入到运算放大器90。这使得可以二维地检测微弱的光和辐射线。

2. 发明授权

US07326900B2 Two-dimensional weak radiation detector with a detection means based on orthogonal modulation 有权
标题翻译：具有基于正交调制的检测手段的二维弱辐射检测器
公开(公告)号：US07326900B2
公开(公告)日：2008-02-05
申请号：US10533469
申请日：2002-11-18
申请人： Noriaki Kimura , Takayoshi Yumii
发明人： Noriaki Kimura , Takayoshi Yumii
IPC分类号： H01J40/14
CPC分类号： G01N21/6456 , G01N21/6428 , G01N21/6452 , G01N2021/6463 , G01N2021/6473 , H01J31/507 , H01J43/045 , H01J43/243
摘要： A weak light detector (40) which can detect two-dimensional weak radiation at a high speed with high precision. The fluorescence from the DNA chip (46) is incident on a detection part (56) of a detection unit (52). The detection unit (56) has a detection module with a number of detection transistors being placed to correspond to cells of the DNA chip (46). The detection part (56) performs photoelectric conversion of the incident fluorescence (photon) to emit electrons, and amplifies the electrons to make them incident on the detection module. The detection transistors are switched based the Hadamard matrix to operate. A data processing unit (54) reads an output signal of the detection part (56), then performs Hadamard inversion, and determines the detection transistor which outputs the signal.
摘要翻译：弱光检测器（40）可高精度检测二维弱辐射。来自DNA芯片（46）的荧光入射到检测单元（52）的检测部分（56）上。检测单元（56）具有检测模块，多个检测晶体管被放置成对应于DNA芯片（46）的单元。检测部（56）进行入射荧光（光子）的光电转换，发射电子，放大电子，使其入射到检测模块上。检测晶体管基于Hadamard矩阵进行切换操作。数据处理单元（54）读取检测部分（56）的输出信号，然后执行哈达玛反转，并确定输出该信号的检测晶体管。

3. 发明授权

US07822558B2 Fluorescence detecting device and fluorescence detecting method 有权
标题翻译：荧光检测装置和荧光检测方法
公开(公告)号：US07822558B2
公开(公告)日：2010-10-26
申请号：US11816244
申请日：2006-02-15
申请人： Noriaki Kimura , Kyoji Doi , Takayoshi Yumii , Takashi Yoshida , Shigeyuki Nakada , Hironori Hayashi , Kazuteru Hoshishima
发明人： Noriaki Kimura , Kyoji Doi , Takayoshi Yumii , Takashi Yoshida , Shigeyuki Nakada , Hironori Hayashi , Kazuteru Hoshishima
IPC分类号： G06F19/00
CPC分类号： G01N21/274 , G01N15/1459 , G01N21/6408 , G01N21/6428 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6482
摘要： A fluorescence detecting device irradiates an object to be measured with a laser beam, receives fluorescence generated from the object and processes a fluorescence signal generated when receiving the fluorescence. The device includes a laser light source section outputting the laser beam for irradiating the object, a light receiving section outputting the fluorescence signal of the fluorescence generated by the irradiated object, a light source control section generates a modulation signal having a frequency in order to time-modulate an intensity of the laser beam, and a processing section that calculates a fluorescence relaxation time of the fluorescence of the object based on the fluorescence signal output from the light receiving section. From the detection values acquired by the device including the phase information on the fluorescence, the intensity of the fluorescence is calculated.
摘要翻译：荧光检测装置用激光束照射待测物体，接收从物体产生的荧光，并处理在接收荧光时产生的荧光信号。该装置包括输出用于照射物体的激光束的激光光源部分，输出被照射物体产生的荧光的荧光信号的光接收部分，光源控制部分产生具有频率的调制信号以便时间 - 调制激光束的强度，以及处理部，其基于从光接收部输出的荧光信号，计算对象的荧光的荧光弛豫时间。根据由包括荧光的相位信息的装置获取的检测值，计算荧光强度。

4. 发明申请

US20090012721A1 FLUORESCENCE DETECTING DEVICE AND FLUORESCENCE DETECTING METHOD 有权
标题翻译：荧光检测装置和荧光检测方法
公开(公告)号：US20090012721A1
公开(公告)日：2009-01-08
申请号：US11816244
申请日：2006-02-15
申请人： Noriaki Kimura , Kyoji Doi , Takayoshi Yumii , Takashi Yoshida , Shigeyuki Nakada , Hironori Hayashi , Kazuteru Hoshishima
发明人： Noriaki Kimura , Kyoji Doi , Takayoshi Yumii , Takashi Yoshida , Shigeyuki Nakada , Hironori Hayashi , Kazuteru Hoshishima
IPC分类号： G01N21/64 , G06F19/00
CPC分类号： G01N21/274 , G01N15/1459 , G01N21/6408 , G01N21/6428 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6439 , G01N2021/6482
摘要： A fluroescene detecting device irradiates an object to be measured with a laser beam, receives fluroescene generated from the object and processes a fluorescence signal generated when receiving the fluroescene. The device includes a laser light source section outputting the laser beam for irradiating the object, a light receiving section outputting the fluorescene signal of the fluorescene generated by the irradiated object, a light source control section generates a modulatioon signal having a frequency in order to time-modulate an intensity of the laser beam, and a processing section that calculates a flurescene relaxation time of the fluorescene of the object based on the fluorescene relaxation time of the fluorescene of the object based on the fluorescene relaxation time of the fluorescene of the object based on the fluorescene signal output from the light receiving section. From the detection values acquired by the device including the phase information on the fluorescene, the intensity of the fluorescene is calculated.
摘要翻译：氟草醚检测装置用激光束照射待测物体，接收从物体产生的氟草醚，并处理接收氟草醚时产生的荧光信号。该装置包括输出用于照射物体的激光束的激光光源部分，输出由照射物体产生的荧光的荧光信号的光接收部分，光源控制部分产生具有频率的模数信号以便时间 - 调制激光束的强度，以及处理部，其基于物体的荧光的荧光弛豫时间，基于物体的荧光的荧光弛豫时间，计算物体的荧光的荧光弛豫时间在从光接收部分输出的荧光信号上。从包括荧光相位信息的装置获取的检测值，计算出荧光的强度。

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