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1. 发明授权

US5047503A Thrombin-binding substance and process for its preparation 失效
标题翻译：凝血酶结合物质及其制备方法
公开(公告)号：US5047503A
公开(公告)日：1991-09-10
申请号：US72051
申请日：1987-07-10
申请人： Nobuo Aoki , Shigeru Kimura , Masami Shiratsuchi
发明人： Nobuo Aoki , Shigeru Kimura , Masami Shiratsuchi
IPC分类号： A61K38/00 , C07K14/745 , C07K16/40
CPC分类号： C07K14/7455 , C07K16/40 , A61K38/00 , Y10S530/834
摘要： Thrombin-binding substances are obtained by fractionating human urine by ion-exchange chromatography, affinity chromatography using a thrombin-bound carrier, immune adsorption column chromatography, gel filtration, and/or molecular-weight fractionation. One of the substances has a molecular weight of 46,500.+-.6,000 in reduced condition and 39,000.+-.10,000 in unreduced condition by SDS PAGE and an isoelectric point at pH 5.0-5.3, while the other has a molecular weight of 40,000.+-.8,000 in reduced condition and 31,000.+-.10,000 in unreduced condition by SDS PAGE and an isoelectric point at pH 4.9-5.7. They have strong affinity to thrombin. They are capable of promoting the thrombin catalyzed activation of protein C and prolong clotting time. They are stable to denaturing agents (urea and sodium dodecylsulfate).
摘要翻译：凝血酶结合物质通过离子交换色谱法，使用凝血酶结合载体的亲和层析，免疫吸附柱色谱法，凝胶过滤和/或分子量分级法分级人尿获得。其中一种物质在还原条件下的分子量为46,500 +/- 6,000，通过SDS PAGE分析为39,000 +/- 10,000，在pH 5.0-5.3时为等电点，而另一种的分子量为40,000+ / -8,000的还原条件和31,000 +/- 10,000的未降解条件下通过SDS PAGE和等电点在pH 4.9-5.7。它们对凝血酶具有很强的亲和力。它们能够促进凝血酶催化蛋白C的活化并延长凝血时间。它们对变性剂（尿素和十二烷基硫酸钠）是稳定的。

2. 发明授权

US5043425A Thrombin-binding protein substance and process for preparing the same 失效
标题翻译：凝血酶结合蛋白质物质及其制备方法
公开(公告)号：US5043425A
公开(公告)日：1991-08-27
申请号：US394715
申请日：1989-08-16
申请人： Nobuo Aoki , Shigeru Kimura , Masami Shiratsuchi
发明人： Nobuo Aoki , Shigeru Kimura , Masami Shiratsuchi
IPC分类号： C12P21/00 , A61K38/00 , A61P7/02 , C07K1/00 , C07K1/16 , C07K1/22 , C07K14/00 , C07K14/47 , C07K14/745 , C12R1/91
CPC分类号： C07K14/7455 , A61K38/00 , Y10S530/834
摘要： Novel thrombin-binding substances (A) and (B) are disclosed. The thrombin-binding substances have the following characteristics:(a) molecular weight:Thrombin-binding substance (A):90,000-92,000 under reduced conditions55,000-58,000 under unreduced conditionsThrombin-binding substance (B):98,000-105,000 under reduced conditions60,000-65,000 under unreduced conditions(b) isoelectric point:Thrombin-binding substance (A): pH 6.0-6.8Thrombin-binding substance (B): pH 5.8-6.5(c) affinity: strong affinity to thrombin(d) activity:(1) capable of promoting the thrombin catalyzed activation of protein C(2) prolongs clotting time; and(e) stability: stable to denaturing agents (sodium dodecylsulfate and urea).The thrombin-binding substances are useful as a medicine for curing thrombosis.

3. 发明授权

US4748156A Thrombin-binding substance and process for preparing the same 失效
标题翻译：凝血酶结合物质及其制备方法
公开(公告)号：US4748156A
公开(公告)日：1988-05-31
申请号：US3465
申请日：1987-01-15
申请人： Nobuo Aoki , Masami Shiratsuchi , Shigeru Kimura
发明人： Nobuo Aoki , Masami Shiratsuchi , Shigeru Kimura
IPC分类号： A61K35/50 , A61K38/16 , C07G99/00 , C07K3/20 , C07K3/28
CPC分类号： A61K35/50
摘要： A novel thrombin-binding substance having the characteristics of (a) molecular weight: 47,000.+-.6,000 in reduced condition and 38,000.+-.6,000 in unreduced condition, (b) isoelectric point: pH 4.9-5.7, (c) affinity: strong affinity to thrombin, (d) activity: (1) capable of promoting the thrombin catalyzed activation of protein C, (2) prolongs clotting time; and (e) stability: stable to denaturing agents (urea sodium and dodecylsulfate), can be prepared from a human placenta by means of extraction, fractionation using ion exchange chromatography and affinity chromatography, and/or gel filtration, followed by electrophoresis. The substance is useful as a medicine for the treatment of thrombosis.
摘要翻译：一种具有以下特性的新型凝血酶结合物质：（a）分解质量为47,000 +/- 6,000，还原条件为38,000 +/- 6,000，（b）等电点：pH 4.9-5.7，（c）亲和力：（d）活性：（1）能促进凝血酶催化蛋白C的活化，（2）延长凝血时间; 和（e）稳定性：对变性剂（尿素钠和十二烷基硫酸盐）稳定，可以通过提取，使用离子交换层析和亲和层析分离，和/或凝胶过滤，然后电泳从人胎盘制备。该物质可用作治疗血栓形成的药物。

4. 发明授权

US5098829A Anti-thrombin-binding substance monoclonal antibodies, hybridomas producing same, as well as purification process and assay of thrombin-binding substance making use of said monoclonal antibodies 失效
标题翻译：抗血栓形成物质单克隆抗体，其制备的混合物，以及作为纯化过程的硫蛋白结合物质的测定以及使用单一抗体的方法
公开(公告)号：US5098829A
公开(公告)日：1992-03-24
申请号：US560275
申请日：1990-07-30
申请人： Nobuo Aoki , Takao Nagoya , Shigeru Kimura
发明人： Nobuo Aoki , Takao Nagoya , Shigeru Kimura
IPC分类号： C07K1/22 , C07K14/00 , C07K14/435 , C07K16/00 , C07K16/18 , C07K16/36 , C07K19/00 , C12N5/10 , C12N15/02 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/36 , C07K16/18
摘要： The present invention provides a monoclonal antibody specific to a thrombin-binding substance (TM), hybridomas producing the monoclonal antibody, a purification process of TM featuring the use of the monoclonal antibody as an immunoadsorbent, as well as an immunoassay of TM featuring the use of the monoclonal antibody.

5. 发明授权

US07513756B2 Fuel supply pump and tappet structure body 有权
标题翻译：燃油泵和挺杆结构体
公开(公告)号：US07513756B2
公开(公告)日：2009-04-07
申请号：US11018220
申请日：2004-12-21
申请人： Nobuo Aoki , Kazuya Kubota , Takeshi Terada , Noriyuki Kobayashi
发明人： Nobuo Aoki , Kazuya Kubota , Takeshi Terada , Noriyuki Kobayashi
IPC分类号： F04B19/00 , F01B31/10
CPC分类号： F02M63/0225 , F02M47/027 , F02M57/025 , F02M59/102 , F02M59/105
摘要： A fuel supply pump with a large fuel discharge amount and a tappet structure body, which are suitably used for an accumulated pressure-type fuel injection device that mechanically amplifies pressure, is provided. A fuel supply pump has a tappet structural body and a spring sheet, wherein a penetration portion for allowing passage of a lubricant or a fuel for lubrication therethrough by coordinating the tappet structure and the spring sheet is provided between a spring-holding chamber for holding a spring to be used for pulling up a plunger and a cam chamber for housing a cam to be used for moving the plunger up and down.
摘要翻译：提供了具有大的燃料排出量的燃料供给泵和挺杆结构体，其适用于机械地放大压力的积压式燃料喷射装置。燃料供给泵具有挺杆结构体和弹簧片，其特征在于，在所述挺杆结构体和弹簧片的弹簧保持室之间设置用于通过配合所述挺杆结构和所述弹簧片而使润滑剂或用于润滑的燃料通过的贯通部用于拉起柱塞的弹簧和用于容纳用于上下移动柱塞的凸轮的凸轮室。

6. 发明申请

US20050106049A1 Fuel supply pump and tappet structure body 有权
标题翻译：燃油泵和挺杆结构体
公开(公告)号：US20050106049A1
公开(公告)日：2005-05-19
申请号：US11018220
申请日：2004-12-21
申请人： Nobuo Aoki , Kazuya Kubota , Takeshi Terada , Noriyuki Kobayashi
发明人： Nobuo Aoki , Kazuya Kubota , Takeshi Terada , Noriyuki Kobayashi
IPC分类号： F02M47/02 , F02M57/02 , F02M59/10 , F02M59/36 , F02M59/46 , F02M63/02 , F04B1/00
CPC分类号： F02M63/0225 , F02M47/027 , F02M57/025 , F02M59/102 , F02M59/105
摘要： A fuel supply pump with a large fuel discharge amount and a tappet structure body, which are suitably used for an accumulated pressure-type fuel injection device that mechanically amplifies pressure, is provided. A fuel supply pump has a tappet structural body and a spring sheet, wherein a penetration portion for allowing passage of a lubricant or a fuel for lubrication therethrough by coordinating the tappet structure and the spring sheet is provided between a spring-holding chamber for holding a spring to be used for pulling up a plunger and a cam chamber for housing a cam to be used for moving the plunger up and down.
摘要翻译：提供了具有大的燃料排出量的燃料供给泵和挺杆结构体，其适用于机械地放大压力的积压式燃料喷射装置。燃料供给泵具有挺杆结构体和弹簧片，其特征在于，在所述挺杆结构体和弹簧片的弹簧保持室之间设置用于通过配合所述挺杆结构和所述弹簧片而使润滑剂或用于润滑的燃料通过的贯通部用于拉起柱塞的弹簧和用于容纳用于上下移动柱塞的凸轮的凸轮室。

7. 发明授权

US5354487A Solid lubricant and composition 失效
标题翻译：固体润滑剂和组成
公开(公告)号：US5354487A
公开(公告)日：1994-10-11
申请号：US681874
申请日：1991-04-05
申请人： Nobuo Aoki , Shinichiro Suzuki , Hisatake Sato
发明人： Nobuo Aoki , Shinichiro Suzuki , Hisatake Sato
IPC分类号： C08K5/01 , C08L19/00 , C08L21/00 , C08L101/00 , C10M107/14 , C10M107/38 , C10M111/04 , C10M147/02 , C10M169/04 , C08L5/00
CPC分类号： C08L21/00 , C08K5/01 , C08L101/00 , C08L19/003 , C10M107/14 , C10M107/38 , C10M111/04 , C10M147/02 , C10M169/041 , C08L2205/06 , C08L69/00 , C08L7/00 , C10M2203/06 , C10M2205/026 , C10M2205/028 , C10M2205/14 , C10M2205/16 , C10M2205/17 , C10M2207/04 , C10M2207/281 , C10M2207/282 , C10M2207/283 , C10M2207/286 , C10M2207/34 , C10M2209/00 , C10M2209/02 , C10M2209/10 , C10M2209/104 , C10M2209/105 , C10M2211/06 , C10M2213/00 , C10M2213/02 , C10M2213/023 , C10M2213/043 , C10M2213/0606 , C10M2213/062 , C10M2213/0623 , C10M2217/026 , C10M2223/041 , C10N2250/121
摘要： Compositions of high lubrication and light coloration are disclosed in which a selected class of resins and rubbers is blended with a specified cured polybutadiene product. The cured product results from crosslinking more than 10% of vinyl bonds in a butadiene polymer having a vinyl bond content of not less 20% by mol in terms of its monomer unit. Also disclosed are solid lubricants comprising a specified fluorinated cured polybutadiene and compositions containing the solid lubricant.
摘要翻译：公开了高润滑性和浅色组合物，其中所选类别的树脂和橡胶与指定的固化聚丁二烯产品共混。固化产物是由乙烯键含量以单体单位计不少于20摩尔％的丁二烯聚合物交联10％以上的乙烯基键。还公开了包含指定的氟化固化的聚丁二烯和含有固体润滑剂的组合物的固体润滑剂。

8. 发明授权

US5343103A Power supplying unit for submerged motor 失效
标题翻译：潜水电机供电装置
公开(公告)号：US5343103A
公开(公告)日：1994-08-30
申请号：US651413
申请日：1990-12-12
申请人： Nobuo Aoki , Ikuo Aizawa , Keisuke Yokoi , Hideo Negishi
发明人： Nobuo Aoki , Ikuo Aizawa , Keisuke Yokoi , Hideo Negishi
IPC分类号： H01B17/26 , H01B17/30 , H02G3/22 , H02K5/10 , H02G15/02
CPC分类号： H01B17/30 , H01B17/26
摘要： Power supplying unit to be used for supplying power to such a load as the motor for driving a submerged pump that scoops liquid out of a tank storing low temperature liquid like LNG and so forth. The power supplying unit has a ceramic sleeve fixed to the flange, a penetrating conductor inserted into this ceramic sleeve, and the ceramic sleeve and the penetrating conductor are coupled air-tightly to each other inside the flange (inside the tank) sealed outside the flange with a bellows of semi-mountain construction in cross section. The bellows has an elasticity and is mounted, when the ceramic sleeve and the penetrating conductor are linearly expanded at the maximum temperature during practical or normal use, or at the temperature slightly higher than the said level. The bellows is mounted between the ceramic sleeve and the penetrating conductor in a state where it is displaced to its maximum length due to its self elasticity. The bellows has been structured in such that it may absorb the reaction force being generated, when the penetrating conductor has linearly expanded, as a compression onto the side of ceramic sleeve for preventing it from acting as an tensile stress.
摘要翻译： PCT No.PCT / JP90 / 00269 Sec。 371 1990年12月12日第 102（e）日期1990年12月12日PCT 1990年3月1日PCT公布。出版物WO90 / 10330 日期1990年9月7日。供电单元用于向用于驱动潜水泵的电动机提供动力，该潜水泵将液体从储存诸如LNG之类的低温液体等的罐中舀出。供电单元具有固定到凸缘的陶瓷套筒，插入该陶瓷套筒中的穿透导体，陶瓷套筒和穿透导体在密封在凸缘外部的凸缘（内部）内彼此气密地联接横断面半山建筑的波纹管。波纹管具有弹性，并且当陶瓷套筒和穿透导体在实际或正常使用期间在最高温度下线性膨胀时，或者在略高于所述水平的温度下安装。波纹管由于其自身弹性而被置于其最大长度的状态下安装在陶瓷套筒和穿透导体之间。波纹管已经被构造成使得当穿透导体线性膨胀时，其可以吸收产生的反作用力作为压缩到陶瓷套筒的侧面上，以防止其作为拉伸应力。

9. 发明授权

US5221738A cDNA and genomic DNA encoding the amino acid sequence of human .alpha..sub.2 -plasmin inhibition 失效
标题翻译：编码人α2-纤溶酶抑制的氨基酸序列的cDNA和基因组DNA
公开(公告)号：US5221738A
公开(公告)日：1993-06-22
申请号：US803896
申请日：1991-12-09
申请人： Yoshihiko Sumi , Yataro Ichikawa , Masami Murakami , Nobuo Aoki
发明人： Yoshihiko Sumi , Yataro Ichikawa , Masami Murakami , Nobuo Aoki
IPC分类号： C07K14/81 , C12N15/55
CPC分类号： C07K14/8121
摘要： cDNA encoding a human .alpha..sub.2 -plasmin inhibitor precursor protein represented by an amino acid sequence from the -39th Met to the 452nd Lys in FIG. 1 of the accompanying drawings; an amino acid sequence of a human .alpha..sub.2 -plasmin inhibitor precursor represented by an amino acid sequence from the -39th Met to the 452nd Lys in FIG. 1 of the accompanying drawings; and genomic DNA encoding a human .alpha..sub.2 -plasmin inhibitor protein which is composed of exons II, III, IV, V, VI, VII, VIII, IX and X in FIG. 4 of the accompanying drawings, said exons being bonded to one another via introns.
摘要翻译：编码人α2-纤溶酶原抑制物前体蛋白的cDNA，由图3中的第39位Met至第452位Lys的氨基酸序列表示。附图1; 由图3中的第39位Met至第452位Lys的氨基酸序列表示的人α2-纤溶酶抑制剂前体的氨基酸序列。附图1; 以及编码图2中由外显子II，III，IV，V，VI，VII，VIII，IX和X组成的人α2-纤溶酶抑制蛋白的基因组DNA。附图4中，所述外显子通过内含子彼此结合。

10. 发明授权

US5049926A Image recording apparatus having a mechanism for varying copying magnification 失效
标题翻译：具有用于改变复印倍率的机构的图像记录装置
公开(公告)号：US5049926A
公开(公告)日：1991-09-17
申请号：US470899
申请日：1990-01-26
申请人： Michitoshi Akao , Katsuyoshi Sonobe , Kazuichi Sakaida , Nobuo Aoki , Satoshi Uchiyama , Hiroshi Igarashi
发明人： Michitoshi Akao , Katsuyoshi Sonobe , Kazuichi Sakaida , Nobuo Aoki , Satoshi Uchiyama , Hiroshi Igarashi
IPC分类号： G03B27/32 , G03B27/34 , G03F7/00 , G03G15/041
CPC分类号： G03G15/041 , G03B27/32 , G03B27/34 , G03F7/0022 , G03B2227/325
摘要： An image recording apparatus for recording an image corresponding to an original on a photosensitive recording medium by irradiating light onto the original and converging light from the original onto the photosensitive recording medium. The apparatus includes a lens unit vertically movably supported by the frame, a plurality of position setting holes arrayed in a vertical direction of the frame, position setting means provided on the lens unit and capable of being inserted into one of the position setting holes for fixing the lens unit to the frame, urging means provided on the lens unit for urging the position setting means toward the frame to project the position setting means, actuating means provided on the lens unit for actuating the position setting means so that the position setting means retracts and moves away from the frame against urging force of the urging means when electric current is supplied to the actuating means. The apparatus further includes control means for controlling the actuating means so that when an error is detected during movement of the lens unit, electric current to the actuating means is cut off to project the position setting means by the urging force of the urging means and to fix the lens unit to the frame.
摘要翻译：一种图像记录装置，用于通过将光照射到原稿上并将来自原稿的光会聚到感光记录介质上，将与原稿对应的图像记录在感光记录介质上。该装置包括由框架上下移动地支撑的透镜单元，沿着框架的垂直方向排列的多个位置设定孔，设置在透镜单元上的位置设定装置，能够插入到固定位置设定孔透镜单元到框架，设置在透镜单元上的推动装置用于将位置设定装置推向框架以突出位置设定装置，设置在透镜单元上的致动装置，用于致动位置设定装置，使得位置设定装置缩回并且当电流被供应到致动装置时，抵抗推动装置的推动力而远离框架移动。该装置还包括用于控制致动装置的控制装置，使得当在透镜单元的移动期间检测到误差时，切断对致动装置的电流，以通过推动装置的推动力使位置设定装置突出，并且将镜头单元固定到框架上。

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