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1. 发明授权

US5192694A Anti-PCI monoclonal antibody 失效
标题翻译：抗PCI单克隆抗体
公开(公告)号：US5192694A
公开(公告)日：1993-03-09
申请号：US116908
申请日：1987-11-05
申请人： Hiroshi Nakao , Takao Nagoya , Yushi Saino
发明人： Hiroshi Nakao , Takao Nagoya , Yushi Saino
IPC分类号： C12N15/02 , C07K1/16 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/435 , C07K14/47 , C07K16/36 , C07K16/38 , C12N5/00 , C12N5/10 , C12N15/00 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577
CPC分类号： C07K16/36 , Y10S436/808 , Y10S530/851
摘要： A monoclonal antibody specific to a human placenta-derived coagulation inhibitor is disclosed. The antibody is produced by culturing a hybridoma which secretes it. A human placenta-derived coagulation inhibitor can be purified by using the monoclonal antibody as an immunoadsorbent. The human placenta-derived coagulation inhibitor can be immunologically assayed by using the monoclonal antibodies.
摘要翻译：公开了一种对人胎盘来源的凝血抑制剂特异性的单克隆抗体。通过培养分泌它的杂交瘤产生抗体。可以通过使用单克隆抗体作为免疫吸附剂来纯化人胎盘来源的凝血抑制剂。可以通过使用单克隆抗体免疫测定人胎盘来源的凝血抑制剂。

2. 发明授权

US06576642B2 Diamide compounds and compositions containing the same 失效
标题翻译：二酰胺化合物和含有它们的组合物
公开(公告)号：US06576642B2
公开(公告)日：2003-06-10
申请号：US09858592
申请日：2001-05-17
申请人： Hiroyuki Ishiwata , Mototsugu Kabeya , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人： Hiroyuki Ishiwata , Mototsugu Kabeya , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号： A61K31165
CPC分类号： C07D213/40 , C07C235/34 , C07C235/36 , C07C235/38 , C07C235/44 , C07C235/56 , C07C237/34 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D207/09 , C07D207/14 , C07D213/75 , C07D213/82
摘要： Compounds having the formula (1): wherein A is a phenyl, naphthyl, dihydronaphthyindeny, pyridyl, indolyl,isoindolyl, quinolyl or isoquinolyl group which are optionally substituted; X is optionally substituted alicyclic, aromatic, imino or heterocyclic groups or —S— or —O—; Y is a single bond or an alkylene group; Z is an unsubstituted aliphatic group or divalent residue of benzene or pyridine, which is optionally substituted; anis hydrogen, lower alkyl, cycloalkyl, aryl or aralkyl; with certain provisos. These compounds exhibit an inhibitory effect on the production of IgE antibodies and are, hence, useful as antiallergic agents.
摘要翻译：具有式（1）的化合物：其中A是任选取代的苯基，萘基，二氢萘并噻吩基，吡啶基，吲哚基，异吲哚基，喹啉基或异喹啉基; X是任选取代的脂环族，芳族，亚氨基或杂环基或-S-或-O-; Y是单键或亚烷基; Z是任选取代的未取代的脂族基团或苯或吡啶的二价残基; 芳烃氢，低级烷基，环烷基，芳基或芳烷基; 具有一定的条件。这些化合物对IgE抗体的产生具有抑制作用，因此可用作抗过敏剂。

3. 发明授权

US06448242B1 Cyclic amide compounds 失效
标题翻译：环状酰胺化合物
公开(公告)号：US06448242B1
公开(公告)日：2002-09-10
申请号：US09622586
申请日：2000-08-21
申请人： Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Yukio Hattori , Makoto Suda , Manabu Shibasaki , Hiroshi Nakao , Takao Nagoya
发明人： Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Yukio Hattori , Makoto Suda , Manabu Shibasaki , Hiroshi Nakao , Takao Nagoya
IPC分类号： A07N4300
CPC分类号： C07D213/70 , C07C2601/14 , C07D211/26 , C07D211/34 , C07D211/58 , C07D213/38 , C07D213/82 , C07D295/185 , C07D295/192 , C07D401/14
摘要： The invention relates to compounds represented by the following general formula (1): wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, or the like, Y is a single bond or the like; Z is a divalent residue of benzene which may be substituted, or the like, and m and n are independently an integer of 1 to 4, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.
摘要翻译：本发明涉及由以下通式（1）表示的化合物：其中A是可被取代的芳族化合物等，B是氮原子或CH，X是可被取代的低级亚烷基，或类似物，Y是单键等; Z是可以被取代的苯的二价残基等，m和n分别是1〜4的整数，以及包含这种化合物的药物。这些化合物对IgE抗体的产生具有优异的抑制作用，因此可用作抗变应性剂等。

4. 发明授权

US5290915A Placenta-derived coagulation inhibitor 失效
标题翻译：胎盘来源凝血抑制剂
公开(公告)号：US5290915A
公开(公告)日：1994-03-01
申请号：US820004
申请日：1992-01-13
申请人： Hiroshi Nakao , Takao Nagoya , Yushi Saino , Masahiro Maki , Hideo Tani
发明人： Hiroshi Nakao , Takao Nagoya , Yushi Saino , Masahiro Maki , Hideo Tani
IPC分类号： C12N15/02 , C07K1/16 , C07K1/22 , C07K14/005 , C07K14/195 , C07K14/435 , C07K14/47 , C07K16/36 , C07K16/38 , C12N5/00 , C12N5/10 , C12N15/00 , C12P21/00 , C12P21/08 , C12R1/91 , G01N33/53 , G01N33/577 , C07K15/06 , A61K37/24
CPC分类号： C07K16/36 , Y10S436/808 , Y10S530/851
摘要： A monoclonal antibody specific to a human placenta-derived coagulation inhibitor is disclosed. The antibody is produced by culturing a hybridoma which secretes it. A human placenta-derived coagulation inhibitor can be purified by using the monoclonal antibody as an immunoadsorbent. The human placenta-derived coagulation inhibitor can be immunologically assayed by using the monoclonal antibodies.
摘要翻译：公开了一种对人胎盘来源的凝血抑制剂特异性的单克隆抗体。通过培养分泌它的杂交瘤产生抗体。可以通过使用单克隆抗体作为免疫吸附剂来纯化人胎盘来源的凝血抑制剂。可以通过使用单克隆抗体免疫测定人胎盘来源的凝血抑制剂。

5. 发明授权

US06645957B2 Cyclic amide compound 失效
标题翻译：环状酰胺化合物
公开(公告)号：US06645957B2
公开(公告)日：2003-11-11
申请号：US10173670
申请日：2002-06-19
申请人： Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Yukio Hattori , Makoto Suda , Manabu Shibasaki , Hiroshi Nakao , Takao Nagoya
发明人： Hiroyuki Ishiwata , Seiichi Sato , Mototsugu Kabeya , Soichi Oda , Yukio Hattori , Makoto Suda , Manabu Shibasaki , Hiroshi Nakao , Takao Nagoya
IPC分类号： C07D20902
CPC分类号： C07D213/70 , C07C2601/14 , C07D211/26 , C07D211/34 , C07D211/58 , C07D213/38 , C07D213/82 , C07D295/185 , C07D295/192 , C07D401/14
摘要： The invention relates to compounds represented by the following general formula (1): wherein A is an aromatic compound which may be substituted, or the like, B is a nitrogen atom or CH, X is a lower alkylene group which may be substituted, or the like, Y is a single bond or the like; Z is a divalent residue of benzene which may be substituted, or the like, and m and n are independently an integer of 1 to 4, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.
摘要翻译：本发明涉及由以下通式（1）表示的化合物：其中A是可被取代的芳族化合物等，B是氮原子或CH，X是可被取代的低级亚烷基，或类似物，Y是单键等; Z是可以被取代的苯的二价残基等，m和n分别是1〜4的整数，以及包含这种化合物的药物。这些化合物对IgE抗体的产生具有优异的抑制作用，因此可用作抗变应性剂等。

6. 发明授权

US5723465A Inhibitors for cell adhesion and cellular infiltration 失效
标题翻译：抑制细胞粘附和细胞浸润
公开(公告)号：US5723465A
公开(公告)日：1998-03-03
申请号：US746811
申请日：1996-11-18
申请人： Hiroshi Nakao , Michihisa Umetani , Makoto Suda , Takao Nagoya
发明人： Hiroshi Nakao , Michihisa Umetani , Makoto Suda , Takao Nagoya
IPC分类号： C07D243/08 , A61K31/495 , A61K31/55 , A61P9/10 , A61P11/00 , A61P29/00 , A61P37/08 , A61P43/00 , C07D295/08
CPC分类号： A61K31/551 , A61K31/495
摘要： The present invention is directed to a cell adhesion inhibitory agent, cellular infiltration inhibitory agent, antiallergic agent, antiasthmatic agent, and antiphlogistic, which contains a compound of the following formula (1): ##STR1## wherein each of R.sup.1 through R.sup.6 represents H, a halogen atom, a hydroxyl group, a lower alkyl group, or a lower alkoxy group, m represents a number of 1 from 3 inclusive, and n represents 2 or 3.
摘要翻译：本发明涉及含有下式（1）的化合物的细胞粘附抑制剂，细胞浸润抑制剂，抗过敏剂，抗哮喘药和消炎剂，其中每种 R 1至R 6表示H，卤素原子，羟基，低级烷基或低级烷氧基，m表示包含3的数，1表示2或3。

7. 发明授权

US5360789A Therapeutic agent for skin or corneal disease 失效
标题翻译：皮肤或角膜疾病治疗剂
公开(公告)号：US5360789A
公开(公告)日：1994-11-01
申请号：US50330
申请日：1993-05-20
申请人： Hiroshi Nakao , Takao Nagoya , Yushi Saino
发明人： Hiroshi Nakao , Takao Nagoya , Yushi Saino
IPC分类号： A61K38/00 , A61K38/17 , A61K37/02
CPC分类号： A61K38/1709
摘要： A therapeutic agent for skin or corneal diseases containing CPB-I (calphobindin-I) or recombinant CPB-I as the active ingredient. The CPB-I or recombinant CPB-I have excellent activities in promoting regeneration of granulation tissue, migration of corneal endothelial and epithelial cells, etc., and lowering PKC activity. Because the agent has an action mechanism different from that of the conventional agent, it can be used together with the conventional agent to enhance the therapeutic effect, thus being remarkably useful for treating all sorts of the skin and corneal diseases, in particular, wound and psoriasis.
摘要翻译： PCT No.PCT / JP91 / 01587第 371日期：1993年5月20日 102（e）日期1993年5月20日PCT 1991年11月19日PCT公布。出版物WO92 / 08475 日期：1992年5月29日。含有CPB-1（钙调蛋白-1）或重组CPB-1作为活性成分的皮肤或角膜疾病治疗剂。 CPB-I或重组CPB-I在促进肉芽组织再生，角膜内皮和上皮细胞迁移等方面具有优异的活性，降低PKC活性。由于该药剂具有与常规药剂不同的作用机理，因此可以与常规药物一起使用以增强治疗效果，因此对于治疗各种皮肤和角膜疾病，特别是伤口和银屑病。

8. 发明授权

US06828316B2 Diamide compound and medicine containing the same 失效
标题翻译：二酰胺化合物和含有它的药物
公开(公告)号：US06828316B2
公开(公告)日：2004-12-07
申请号：US09978102
申请日：2001-10-17
申请人： Hiroyuki Ishiwata , Mototsugu Kabeya , Hiromichi Shigyo , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人： Hiroyuki Ishiwata , Mototsugu Kabeya , Hiromichi Shigyo , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号： A61K3155
CPC分类号： C07D213/69 , C07D213/56 , C07D213/70 , C07D213/82 , C07D215/12 , C07D231/12 , C07D233/56 , C07D241/04 , C07D241/42 , C07D243/08 , C07D249/08 , C07D295/185 , C07D471/04 , C07D487/04
摘要： The present invention relates to diamide derivatives represented by the following general formula (1): wherein A is a phenyl group or the like, which may be substituted, B is —CH═CH—, —C≡C—, —(CH═CH)2—, —C≡C—CH═CH—, —CH═CH—C≡C—, phenylene or the like, and W is and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.
摘要翻译：本发明涉及由以下通式（1）表示的二酰胺衍生物：其中A是可被取代的苯基等，B是-CH = CH-，-C = C-， - （CH = CH）2 - ， - C = C-CH = CH - ， - CH = CH-C = C-，亚苯基等，W为包含这种化合物的药物。这些化合物对IgE抗体的产生具有优异的抑制作用，因此可用作抗变应性剂等。

9. 发明授权

US06340682B1 Diamide compound and drugs containing the same 失效
标题翻译：二酰胺化合物和含有相同药物
公开(公告)号：US06340682B1
公开(公告)日：2002-01-22
申请号：US09147711
申请日：1999-02-23
申请人： Hiroyuki Ishiwata , Mototsugu Kabeya , Hiromichi Shigyo , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人： Hiroyuki Ishiwata , Mototsugu Kabeya , Hiromichi Shigyo , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号： A61K31495
CPC分类号： C07D213/69 , C07D213/56 , C07D213/70 , C07D213/82 , C07D215/12 , C07D231/12 , C07D233/56 , C07D241/04 , C07D241/42 , C07D243/08 , C07D249/08 , C07D295/185 , C07D471/04 , C07D487/04
摘要： The present invention provides diamide derivatives represented by the following general formula (1): wherein A is a phenyl group or the like, which may be substituted, B is —CH═CH—, —C═C—, —(CH═CH)2—, —C≡C—CH═CH—, —CH═CH—C≡C—, phenylene or the like, and W is or and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.
摘要翻译：本发明提供由以下通式（1）表示的二酰胺衍生物：其中A是可以被取代的苯基等，B是-CH = CH-，-C = C-， - （CH = CH ）2-，-C = C-CH = CH-，-CH = CH-C = C-，亚苯基等，以及含有这种化合物的W异构体药物。这些化合物对IgE抗体的产生具有优异的抑制作用，因此可用作抗变应性剂等。

10. 发明授权

US06297283B1 Diamide compounds and compositions containing the same 失效
标题翻译：二酰胺化合物和含有它们的组合物
公开(公告)号：US06297283B1
公开(公告)日：2001-10-02
申请号：US09269764
申请日：1999-04-09
申请人： Hiroyuki Ishiwata , Mototsugu Kabeya , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
发明人： Hiroyuki Ishiwata , Mototsugu Kabeya , Masami Shiratsuchi , Yukio Hattori , Hiroshi Nakao , Takao Nagoya , Seiichi Sato , Soichi Oda , Makoto Suda , Manabu Shibasaki
IPC分类号： A61K31165
CPC分类号： C07D213/40 , C07C235/34 , C07C235/36 , C07C235/38 , C07C235/44 , C07C235/56 , C07C237/34 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07D207/09 , C07D207/14 , C07D213/75 , C07D213/82
摘要： The present invention relates to compounds represented by the following general formula (1): wherein A is a phenyl, naphthyl, dihydronaphthyl, indenyl, pyridyl, indolyl, isoindolyl, quinolyl or isoquinolyl group which may be substituted; X is a lower alkylene group which may be substituted, or the like; Y is a single bond or an alkylene group; Z is a group of —CH═CH—, —C≡C—, —(CH═CH)2—, —C≡C—CH═CH— or —CH═CH—C≡C—, or the like; and R is a hydrogen atom, a lower alkyl group or the like, and medicines comprising such a compound. These compounds have an excellent inhibitory effect on the production of an IgE antibody and are hence useful as antiallergic agents and the like.
摘要翻译：本发明涉及由以下通式（1）表示的化合物：其中A为可被取代的苯基，萘基，二氢萘基，茚基，吡啶基，吲哚基，异吲哚基，喹啉基或异喹啉基; X是可以被取代的低级亚烷基等; Y是单键或亚烷基; Z是-CH = CH-，-C = C - ， - （CH = CH）2 - ， - C = C-CH = CH-或-CH = CH-C = C - 等的基团; R为氢原子，低级烷基等，以及含有该化合物的药物。这些化合物对IgE抗体的产生具有优异的抑制作用，因此可用作抗变应性剂等。

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