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    • 10. 发明申请
    • CONTRAST AGENT CONTAINING SILSESQUIOXANE
    • 对比剂含有SILSESQUIOXANE
    • US20100256404A1
    • 2010-10-07
    • US12733464
    • 2008-09-03
    • Yoshiki ChujoKazuo TanakaKensuke Naka
    • Yoshiki ChujoKazuo TanakaKensuke Naka
    • C07F7/21
    • C07F7/21A61K49/124
    • The present invention provides a contrast agent which ensures 1) high contrast performance, 2) low toxicity, and 3) a simple production process.The present invention provides a contrast agent containing a silsesquioxane represented by General Formula (I), wherein R1, the same or different, is a substituent bonded to Si through a carbon atom, the substituent having, at its terminal, a group represented by General Formula (II), wherein p represents an integer of from 1 to 5; q is the same or different, and represents an integer of from 1 to 5; R2 is the same or different, and represents hydrogen atom, alkyl group, aralkyl group or acyl group, or a group represented by General Formula (III), wherein p, q and R2 are the same as above.
    • 本发明提供了一种造影剂,其确保1)高对比度性能,2)低毒性,和3)简单的生产过程。 本发明提供含有通式(I)表示的倍半硅氧烷的造影剂,其中R1,相同或不同,是通过碳原子与Si键合的取代基,该取代基在其末端具有由通式 式(II),其中p表示1〜5的整数; q相同或不同,表示1〜5的整数, R2相同或不同,表示氢原子,烷基,芳烷基或酰基,或由通式(III)表示的基团,其中p,q和R2与上述相同。