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1. 发明授权

US08927579B2 Male contraceptive 有权
标题翻译：男性避孕
公开(公告)号：US08927579B2
公开(公告)日：2015-01-06
申请号：US12504287
申请日：2009-07-16
申请人： Nnae-Meka Ikechukwu Amobi , Christopher Smith
发明人： Nnae-Meka Ikechukwu Amobi , Christopher Smith
IPC分类号： A01N43/00 , A61K31/445 , A01N43/64 , A61K31/41 , A01N31/14 , A61K31/075 , A01N33/18 , A01N33/24 , A61K31/04 , C07C211/27 , C07C211/45 , C07C217/16 , C07D207/09 , C07D209/08 , C07D211/12 , C07D211/14 , C07D211/26 , C07D215/06 , C07D215/12 , C07D217/10 , C07D221/04 , C07D279/26 , C07D279/28 , C07D295/03 , C07D401/06 , C07D417/06
CPC分类号： C07C211/27 , C07C211/45 , C07C217/16 , C07C2603/26 , C07D207/09 , C07D209/08 , C07D211/12 , C07D211/14 , C07D211/26 , C07D215/06 , C07D215/12 , C07D217/10 , C07D221/04 , C07D279/26 , C07D279/28 , C07D295/03 , C07D401/06 , C07D417/06
摘要： A compound having formula I. R1, R2, R3 and R4 are independently H or lower alkyl. R5 is aryl, heteroaryl, cycloalkyl, heterocycloalkyl, aryloxy, heteroaryloxy, cycloalkyloxy, heterocycloalkyloxy, arylamino, heteroarylamino, cycloalkylamino, heterocycloalkyl amino, arylthio, heteroarylthio, cycloalkylthio, heterocycloalkylthio, or cyclic olefin, any of which may be substituted or non-substituted; or substituted alkyl, substituted alkyl oxy or substituted alkyl amino wherein the substituent is an aryl, a heteroaryl, a cycloalkyl, a heterocycloalkyl or a cyclic olefin, any of which may be substituted or non-substituted. X is C or N. n and p are independently whole numbers selected from 0, 1 and 2. (CH2)n and (CH2)p may be substituted or non-substituted. Ar1 and Ar2 are independently aryl or heteroaryl groups which may be substituted or non-substituted. Certain specific compounds are excluded.The compounds can be used in a medicament or a method for the reduction or prevention of the emission of sperm, or for the reduction or prevention of transmission of viral agents transmitted in seminal fluid.
摘要翻译：具有式I的化合物.R 1，R 2，R 3和R 4独立地为H或低级烷基。 R5是芳基，杂芳基，环烷基，杂环烷基，芳氧基，杂芳氧基，环烷氧基，杂环烷氧基，芳基氨基，杂芳基氨基，环烷基氨基，杂环烷基氨基，芳硫基，杂芳硫基，环烷硫基，杂环烷硫基或环烯烃，其中任何一个可以是取代或未取代的; 或取代的烷基，取代的烷基氧基或取代的烷基氨基，其中取代基是芳基，杂芳基，环烷基，杂环烷基或环烯烃，其中任何一个可以被取代或未取代。 X是C或N.n，p独立地是选自0,1和2的整数。（CH 2）n和（CH 2）p可以是取代或未取代的。 Ar 1和Ar 2独立地为可被取代或未取代的芳基或杂芳基。排除某些具体化合物。这些化合物可以用于减少或预防精子发射的药物或方法，或用于减少或防止在精液中传播的病毒剂的传播。

2. 发明授权

US10484398B2 Threat intelligence on a data exchange layer 有权
公开(公告)号：US10484398B2
公开(公告)日：2019-11-19
申请号：US14912743
申请日：2014-09-29
申请人： McAfee, LLC , Christopher Smith , Edward T. McDonald , Don R. Hanson, II
发明人： Christopher Smith , Edward T. McDonald , Don R. Hanson, II
IPC分类号： H04L29/06
摘要： In an example, a threat intelligence controller is configured to operate on a data exchange layer (DXL). The threat intelligence controller acts as a DXL consumer of reputation data for a network object, which may be reported in various different types and from various different sources. Of the devices authorized to act as reputation data producers, each may have its own trust level. As the threat intelligence controller aggregates data from various providers, it may weight the reputation reports according to trust level. The threat intelligence engine thus builds a composite reputation for the object. When it receives a DXL message requesting a reputation for the object, it publishes the composite reputation on the DXL bus.

3. 发明申请

US20180303456A1 PORTABLE MEDICAL STATION 审中-公开
公开(公告)号：US20180303456A1
公开(公告)日：2018-10-25
申请号：US15953417
申请日：2018-04-14
申请人： Jack Tawil , David Jack Tawil , Christopher Smith , Holland Bennett
发明人： Jack Tawil , David Jack Tawil , Christopher Smith , Holland Bennett
IPC分类号： A61B8/00 , A61B7/02 , A61B5/01 , A61B5/00 , A61B5/021 , A61B5/0245 , A61B50/33 , G06F1/16
CPC分类号： A61B8/4427 , A61B5/01 , A61B5/021 , A61B5/0245 , A61B5/4803 , A61B5/7445 , A61B7/02 , A61B50/33 , A61B2050/3011 , G06F1/1626 , G06F1/1628 , G06F1/1643 , G06F1/1647 , G06F1/1684 , G06F1/1686 , G06F1/1688
摘要： At least one embodiment is a portable medical station comprising a main body, which is disposed at least partially inside of a bag. Coupled to the main body is at least one tray and a plurality of handles. There are also a plurality of screens coupled to the main body and at least one computer coupled to the main body, wherein the portable medical station is foldable inside of the bag so that the portable medical station is movable while being substantially folded inside of the bag.

4. 发明申请

US20180065182A1 ADDITIVE PRINTING METHOD 审中-公开
公开(公告)号：US20180065182A1
公开(公告)日：2018-03-08
申请号：US15256837
申请日：2016-09-06
申请人： David Scot Money , Christopher Smith
发明人： David Scot Money , Christopher Smith
IPC分类号： B22F3/105 , B33Y10/00 , B29C67/00 , B22F5/10 , B23K31/02 , B33Y40/00 , B33Y30/00
摘要： A manufacturing method which manufactures articles which have hollow areas inside them which are subject to their own internal vacuum. A 3-D printer can be located inside a vacuum chamber and the article(s) can be 3-D printed, thereby the hollow area inside each such article is subject to its own vacuum. When removed from the vacuum chamber, the article's hollow area remains subject to its own internal vacuum.

5. 发明申请

US20170061003A1 SYSTEM, METHOD, DEVICE AND PRODUCT FOR COMPILING AGGREGATED MEDIA IN A TIME-BASED PLAYLIST 审中-公开
标题翻译：系统，方法，设备和产品，用于在基于时间的播放列表中编译聚合媒体
公开(公告)号：US20170061003A1
公开(公告)日：2017-03-02
申请号：US15213399
申请日：2016-07-19
申请人： David A. Baird , Joseph Michael Vaillancourt , Mark Kopulos , Brittany Barbara Vaillancourt , Christopher Smith , Tibor Fulop
发明人： David A. Baird , Joseph Michael Vaillancourt , Mark Kopulos , Brittany Barbara Vaillancourt , Christopher Smith , Tibor Fulop
IPC分类号： G06F17/30 , H04N21/482 , H04N21/262
CPC分类号： G06F16/639 , G06F16/61 , G06F16/686 , G06F16/958 , H04N21/26258 , H04N21/4825
摘要： A system, method and device are provided, for creating multimedia playlists. A visual module aggregates at least one image file targeted from one or more visual media fields. A music module aggregates multiple audio files targeted from one or more audio media fields. A time module registers allocated mix duration and references elapsed mix duration versus the allocated mix duration, A news module aggregates topical information targeted from one or more news fields, pertaining to at least one of the sound files, as the sound file is added to the playlist. A publishing module compiles the aggregated visual and sound files, respectively, while updating the aggregated news. Provided the elapsed mix duration is less than or equal to the allocated mix duration, a discrete playlist is displayed on a User interface console as the sound files are played, when prompted by the system or the User.
摘要翻译：提供了一种用于创建多媒体播放列表的系统，方法和设备。视觉模块聚合至少一个从一个或多个视觉媒体领域定向的图像文件。音乐模块聚合从一个或多个音频媒体领域定向的多个音频文件。时间模块将分配的混合持续时间和参考经过的混合持续时间与分配的混合持续时间进行注册。当声音文件被添加到时，新闻模块聚合与一个或多个新闻领域有针对性的主题信息，与至少一个声音文件相关联播放列表在更新聚合新闻时，发布模块分别编译聚合的视觉和声音文件。如果经过的混合持续时间小于或等于分配的混合持续时间，则当由系统或用户提示时，离散播放列表显示在声音文件播放时的用户界面控制台上。

6. 发明授权

US09425988B2 Device for communicating in multiple modes using multi-mode applications 有权
标题翻译：用于使用多模式应用程序在多种模式下进行通信的设备
公开(公告)号：US09425988B2
公开(公告)日：2016-08-23
申请号：US11763530
申请日：2007-06-15
申请人： Christopher Smith
发明人： Christopher Smith
IPC分类号： H04M1/00 , H04L12/54 , H04W88/06
CPC分类号： H04L12/5692 , H04W88/06
摘要： Multi-mode communication devices capable of wLAN and WAN wireless network communication modes and/or wired modes can be configured to communicate for backend services (e.g. Web Services, database, events) via a network gateway to operate in response to available modes. For example, for some activities (e.g. notification messages), the devices may be configured to communication in any available mode (WAN or wLAN) while for other activities (e.g. high bandwidth communications), the devices may be restricted to one mode only (e.g. wLAN). Component applications for execution by the devices can specify message delivery properties to indicate the mode(s) to may used for a particular message. Runtime mode information may be provided and maintained automatically by a communications subsystem interface for determining mode availability. A programming tool and gateway are also described.
摘要翻译：能够进行wLAN和WAN无线网络通信模式和/或有线模式的多模式通信设备可以被配置为经由网络网关进行后端服务（例如Web服务，数据库，事件）的通信，以响应于可用的模式进行操作。例如，对于一些活动（例如通知消息），设备可以被配置为以任何可用的模式（WAN或WLAN）进行通信，而对于其他活动（例如，高带宽通信），设备可以仅限于一种模式（例如， wLAN）。用于由设备执行的组件应用可以指定消息传递属性以指示可用于特定消息的模式。可以由通信子系统接口自动提供和维护运行时模式信息，以确定模式可用性。还描述了编程工具和网关。

7. 发明授权

US09305550B2 Dialogue detector and correction 有权
标题翻译：对话检测器和校正
公开(公告)号：US09305550B2
公开(公告)日：2016-04-05
申请号：US12962551
申请日：2010-12-07
申请人： J. Carl Cooper , Mirko Vojnovic , Christopher Smith
发明人： J. Carl Cooper , Mirko Vojnovic , Christopher Smith
IPC分类号： G10L19/005 , G10L15/24 , G10L25/78
CPC分类号： H04N21/233 , G10L15/02 , G10L15/24 , G10L19/005 , G10L25/57 , G10L25/78 , G10L2015/025
摘要： An apparatus and method for tracking dialogue and other sound signals in film, television or other systems with multiple channel sound is described. One or more audio channels which is expected to carry the speech of persons appearing in the program or other particular types of sounds is inspected to determine if that channel's audio includes particular sounds such as MUEVs, including phonemes corresponding to human speech patterns. If an improper number of particular sounds such as phonemes are found in the channel(s) an action such as a report, an alarm, a correction, or other action is taken. The inspection of the audio channel(s) may be made in conjunction with the appearance of corresponding images associated with the sound, such as visemes in the video signal, to improve the determination of types of sounds such as phonemes.
摘要翻译：描述了一种用于跟踪具有多声道声音的电影，电视或其他系统中的对话和其他声音信号的装置和方法。检查期望携带出现在节目中的人的语音的一个或多个音频频道或其他特定类型的声音，以确定该频道的音频是否包括诸如MUEV的特定声音，包括对应于人类语音模式的音素。如果在频道中发现诸如音素之类的不正确数量的特定声音，则采取诸如报告，报警，校正或其他动作的动作。音频通道的检查可以结合与声音相关联的图像（例如视频信号中的视力）的外观来进行，以改善诸如音素之类的声音的类型的确定。

8. 发明申请

US20140148407A1 AQUEOUS GELS 审中-公开
标题翻译：水凝胶
公开(公告)号：US20140148407A1
公开(公告)日：2014-05-29
申请号：US14124074
申请日：2012-05-09
申请人： Janet Lesley Scott , Christopher Smith , Giovanni Francesco Unali
发明人： Janet Lesley Scott , Christopher Smith , Giovanni Francesco Unali
IPC分类号： A61K8/73 , A61Q19/00 , A61Q5/00
CPC分类号： A61Q5/00 , A61K8/042 , A61K8/34 , A61K8/345 , A61K8/60 , A61K8/731 , A61K2800/33 , A61Q19/00
摘要： The invention provides an aqueous gel comprising: a) from 0.5 to 5 wt % dispersed modified cellulose biopolymer, wherein the modification consists of the cellulose having its C6 primary alcohols oxidised to carboxyl moieties (acid/COOH—) on 10 to 70% of the glucose units and substantially all the remainder of the C6 positions occupied by unmodified primary alcohols; b) a water-soluble or water-miscible organic non-solvent for the modified cellulose biopolymer; c) 0 to 10 wt % non-surfactant electrolyte, and d) water; in which the aqueous gel comprises less than 3 wt % oil phase ingredients. The aqueous gels of the invention offer excellent tactile properties, in particular superior skin feel and reduced stickiness. Furthermore, the gels have thixotropic properties, allowing their usage in pumpable or sprayable formats. They also provide sufficient structure for the suspension of a variety of particulate materials.
摘要翻译：本发明提供了一种水性凝胶，其包含：a）0.5至5重量％的分散改性纤维素生物聚合物，其中所述改性由在其氧化至羧基部分（酸/ COOH-）的C6伯醇的纤维素占10至70％葡萄糖单元和未修饰的伯醇占据的C6位置的基本上所有其余部分; b）改性纤维素生物聚合物的水溶性或水混溶性有机非溶剂; c）0-10wt％非表面活性剂电解质，和d）水; 其中水凝胶包含小于3重量％的油相成分。本发明的水性凝胶提供优异的触感性，特别是优异的皮肤感觉和降低的粘性。此外，凝胶具有触变性，允许它们以可泵送或可喷涂的形式使用。它们还为各种颗粒材料的悬浮提供足够的结构。

9. 发明授权

US08661335B2 Methods and systems for identifying content elements 有权
标题翻译：用于识别内容元素的方法和系统
公开(公告)号：US08661335B2
公开(公告)日：2014-02-25
申请号：US12885775
申请日：2010-09-20
申请人： Alexander Sherkin , Peter Gordon Beshai , Viera Bibr , Christopher Smith , Kamen Vitanov
发明人： Alexander Sherkin , Peter Gordon Beshai , Viera Bibr , Christopher Smith , Kamen Vitanov
IPC分类号： G06F17/00 , G06F15/16
CPC分类号： G06F17/30719
摘要： A method of identifying content of interest in a structured electronic document by an electronic device having a processor, an input device, and a display device, includes rendering a structured electronic document to the display device; receiving through the input device at least two separate indications of content elements within the rendered structured electronic document; and identifying with the processor a common characteristic of the indicated content elements, and identifying any further content element within the rendered structured electronic document sharing the common characteristic with the indicated content elements.
摘要翻译：一种通过具有处理器，输入设备和显示设备的电子设备识别结构化电子文档中的感兴趣内容的方法，包括：将结构化电子文档呈现给显示设备; 通过输入设备接收呈现的结构化电子文档内的内容元素的至少两个独立指示; 以及用所述处理器识别所指示的内容元素的共同特征，以及识别所呈现的结构化电子文档中与所指示的内容元素共享共同特征的任何另外的内容元素。

10. 发明授权

US08455239B2 Yeast organism producing isobutanol at a high yield 有权
标题翻译：以高产率生产异丁醇的酵母生物
公开(公告)号：US08455239B2
公开(公告)日：2013-06-04
申请号：US12820505
申请日：2010-06-22
申请人： Reid M. Renny Feldman , Uvini Gunawardena , Jun Urano , Peter Meinhold , Aristos Aristidou , Catherine Asleson Dundon , Christopher Smith
发明人： Reid M. Renny Feldman , Uvini Gunawardena , Jun Urano , Peter Meinhold , Aristos Aristidou , Catherine Asleson Dundon , Christopher Smith
IPC分类号： C12P7/04 , C12P7/16 , C12N1/15 , C12N1/16 , C12N15/00 , C12N9/88
CPC分类号： C12P7/16 , C12N9/0006 , C12N9/0008 , C12N9/1022 , C12N9/88 , C12N9/90 , C12N15/81 , C12Y101/01001 , C12Y101/01008 , C12Y101/01086 , C12Y101/05003 , C12Y202/01006 , C12Y401/01001 , C12Y401/01074 , C12Y402/01009 , Y02E50/10
摘要： The present invention provides recombinant mircoorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
摘要翻译：本发明提供包含产生异丁醇的代谢途径的重组微生物和使用所述重组微生物产生异丁醇的方法。在本发明的各个方面，重组微生物可以包含导致丙酮酸脱羧酶和/或甘油-3-磷酸脱氢酶活性降低的修饰。在本文所述的各种实施方案中，重组微生物可以是酵母进化枝，Crabtree阴性酵母微生物，Crabtree阳性酵母微生物，WGD（全基因组复制）酵母微生物，WGD前（全基因组复制）酵母微生物，和非发酵酵母微生物。

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