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1. 发明授权

US09133506B2 Methods and systems for analyzing biological samples 有权
标题翻译：分析生物样品的方法和系统
公开(公告)号：US09133506B2
公开(公告)日：2015-09-15
申请号：US12087543
申请日：2007-01-09
申请人： Nir Katzir , Tsafrir Kolatt , Irit Bar-Am
发明人： Nir Katzir , Tsafrir Kolatt , Irit Bar-Am
IPC分类号： G06F19/20 , C12Q1/06 , C12Q1/68 , G06K9/00
CPC分类号： C12Q1/6841 , G06K9/00134
摘要： Methods, computer readable storage media and systems which can be used for analyzing labeled biological samples, identifying chromosomal aberrations, identifying genetically abnormal cells and/or computationally scanning the samples using randomly or randomized scanning methods are provided. Specifically, the present invention can be used to analyze FISH-stained samples and automatically identify chromosomal aberrations associated with abnormal intensity ratio of stained occurrences in the sample.
摘要翻译：提供了可用于分析标记的生物样品，识别染色体畸变，识别遗传异常细胞和/或使用随机或随机扫描方法计算扫描样品的方法，计算机可读存储介质和系统。具体地，本发明可用于分析FISH染色的样品，并自动识别与样品中染色事件的异常强度比相关的染色体畸变。

2. 发明申请

US20090048785A1 Methods And Systems For Analyzing Biological Samples 有权
标题翻译：用于分析生物样品的方法和系统
公开(公告)号：US20090048785A1
公开(公告)日：2009-02-19
申请号：US12087543
申请日：2007-01-09
申请人： Nir Katzir , Tsafrir Kolatt , Irit Bar-Am
发明人： Nir Katzir , Tsafrir Kolatt , Irit Bar-Am
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： C12Q1/6841 , G06K9/00134
摘要： Methods, computer readable storage media and systems which can be used for analyzing labeled biological samples, identifying chromosomal aberrations, identifying genetically abnormal cells and/or computationally scanning the samples using randomly or randomized scanning methods are provided. Specifically, the present invention can be used to analyze FISH-stained samples and automatically identify chromosomal aberrations associated with abnormal intensity ratio of stained occurrences in the sample.
摘要翻译：提供了可用于分析标记的生物样品，识别染色体畸变，识别遗传异常细胞和/或使用随机或随机扫描方法计算扫描样品的方法，计算机可读存储介质和系统。具体地，本发明可用于分析FISH染色的样品，并自动识别与样品中染色事件的异常强度比相关的染色体畸变。

3. 发明授权

US6043039A Method of and composite for in situ fluorescent hybridization 失效
标题翻译：原位荧光杂交法及复合方法
公开(公告)号：US6043039A
公开(公告)日：2000-03-28
申请号：US122661
申请日：1998-07-27
申请人： Irit Bar-Am , Cathy Janish , Yuval Garini , Dario Cabib , Robert A. Buckwald
发明人： Irit Bar-Am , Cathy Janish , Yuval Garini , Dario Cabib , Robert A. Buckwald
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/533 , G01N33/566
CPC分类号： C12Q1/6841
摘要： A fluorescent in situ hybridization method including the steps of (a) obtaining a chromosome spread of a species; (b) preparing a hybridization composite containing a plurality of chromosomal paints each of the plurality of chromosomal paints being labeled with a different fluorophore-or-combination-of-fluorophores, such that an averaged specific activity of highly repetitive sequences in the hybridization composite substantially equals an averaged specific activity of unique sequences in the hybridization composite; (c) denaturing the hybridization composite and subjecting the hybridization composite to conditions for allowing at least a part of the highly repetitive sequences in the hybridization composite to reanneal while at least a part of the unique sequences in the hybridization composite remaining single stranded; (d) contacting under hybridization conditions the hybridization composite with the chromosome spread; (e) washing away excess of the hybridization composite; and (d) analyzing and presenting images of the now hybridized chromosome spread.
摘要翻译：一种荧光原位杂交方法，包括以下步骤：（a）获得物种的染色体扩散; （b）制备含有多个染色体涂料的杂化复合物，所述多个染色体涂料中的每一个用不同的荧光团或荧光团组合进行标记，使得所述杂交复合物中高度重复序列的平均比活性基本上等于杂交复合物中独特序列的平均比活性; （c）使杂交复合物变性并对杂交复合物进行条件以允许杂交复合物中的至少一部分高度重复序列进行再冷凝，同时杂交复合物中至少一部分独特序列保持单链; （d）在杂交条件下使杂交复合物与染色体扩散接触; （e）洗去杂交组合物的过量; 和（d）分析和呈现现在杂交的染色体扩增的图像。

4. 发明授权

US5871932A Method of and composite for fluorescent in situ hybridization 失效
标题翻译：原位荧光杂交法及复合方法
公开(公告)号：US5871932A
公开(公告)日：1999-02-16
申请号：US25131
申请日：1998-02-17
申请人： Irit Bar-Am , Yuval Garini , Dario Cabib
发明人： Irit Bar-Am , Yuval Garini , Dario Cabib
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6841
摘要： A fluorescent in situ hybridization method including the steps of (a) obtaining a chromosome spread of a species; (b) preparing a hybridization composite containing a plurality of chromosomal paints each of the plurality of chromosomal paints being labeled with a different fluorophore-or-combination-of-fluorohores, such that an averaged specific activity of highly repetitive sequences in the hybridization composite substantially equals an averaged specific activity of unique sequences in the hybridization composite; (c) denaturing the hybridization composite and subjecting the hybridization composite to conditions for allowing at least a part of the highly repetitive sequences in the hybridization composite to reanneal while at least a part of the unique sequences in the hybridization composite remaining single stranded; (d) contacting under hybridization conditions the hybridization composite with the chromosome spread; (e) washing away excess of the hybridization composite; and (d) analyzing and presenting images of the now hybridized chromosome spread.
摘要翻译：一种荧光原位杂交方法，包括以下步骤：（a）获得物种的染色体扩散; （b）制备含有多个染色体涂料的杂化复合物，所述多个染色体涂料中的每一个都用不同的荧光团或组合的荧光体标记，使得杂交复合物中高度重复序列的平均比活性基本上等于杂交复合物中独特序列的平均比活性; （c）使杂交复合物变性并对杂交复合物进行条件以允许杂交复合物中的至少一部分高度重复序列进行再冷凝，同时杂交复合物中至少一部分独特序列保持单链; （d）在杂交条件下使杂交复合物与染色体扩散接触; （e）洗去杂交组合物的过量; 和（d）分析和呈现现在杂交的染色体扩增的图像。

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