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1. 发明授权

US06224907B1 Anti-asthma therapy 有权
标题翻译：抗哮喘治疗
公开(公告)号：US06224907B1
公开(公告)日：2001-05-01
申请号：US09250288
申请日：1999-02-12
申请人： Nipun Davar , Atul Devdatt Ayer , Paul Minn Hwang , Padmaja Shivanand , Brenda J. Pollock
发明人： Nipun Davar , Atul Devdatt Ayer , Paul Minn Hwang , Padmaja Shivanand , Brenda J. Pollock
IPC分类号： A61K924
CPC分类号： A61K31/41 , A61K9/0004 , A61K9/2027 , A61K9/2054 , A61K31/352 , A61K31/381 , A61K31/4045 , A61K31/47
摘要： A dosage form is disclosed for administering a leukatriene-receptor antagonist to a patient over time.
摘要翻译：公开了一种随着时间向患者施用白三烯受体拮抗剂的剂型。

2. 发明申请

US20100266682A1 POLYETHYLENE GLYCOL-COATED SODIUM CARBONATE AS A PHARMACEUTICAL EXCIPIENT AND COMPOSITIONS PRODUCED FROM THE SAME 审中-公开
标题翻译：聚乙烯包覆的碳酸钙作为药物制剂及其制备的组合物
公开(公告)号：US20100266682A1
公开(公告)日：2010-10-21
申请号：US12764489
申请日：2010-04-21
申请人： Nipun Davar , Pauly Kavalakatt , Indiran Pather , Sangita Ghosh
发明人： Nipun Davar , Pauly Kavalakatt , Indiran Pather , Sangita Ghosh
IPC分类号： A61K9/14 , A61K31/437 , A61K9/20 , A61K9/48 , A61P25/20 , A61K31/46
CPC分类号： A61K9/14 , A61K9/0031 , A61K9/0036 , A61K9/0056 , A61K9/006 , A61K31/437 , A61K31/4748 , A61K47/10
摘要： Non-effervescent pharmaceutical compositions having at least one particle of carbonate coated by a layer of polyethylene glycol that substantially covers the at least one carbonate particle are described. Compositions are also described where the compositions include a weakly basic therapeutic agent, a first pH-modifying agent having at least one particle of carbonate coated by a layer of polyethylene glycol, and a second pH-modifying agent. The weakly basic therapeutic agent could be, but is not limited to, zolpidem or scopolamine. Compositions including zolpidem and scopolamine are used to treat insomnia and depression, respectively.
摘要翻译：描述了具有基本上覆盖至少一种碳酸盐颗粒的由一层聚乙二醇涂覆的至少一种碳酸颗粒的非泡腾药物组合物。还描述了组合物，其中组合物包括弱碱性治疗剂，具有至少一种由一层聚乙二醇涂覆的碳酸颗粒的第一pH调节剂和第二pH调节剂。弱碱性治疗剂可以是但不限于唑吡旦或东莨菪碱。组合物包括唑吡旦和东莨菪碱分别用于治疗失眠和抑郁症。

3. 发明申请

US20120128778A1 COMPOSITIONS AND METHODS FOR ONCE-DAILY ADMINISTRATION OF A TRILAYER OSMOTIC TABLET 审中-公开
标题翻译：组合物和方法，用于一日三次管理木质板
公开(公告)号：US20120128778A1
公开(公告)日：2012-05-24
申请号：US13303623
申请日：2011-11-23
申请人： Nipun Davar , Sangita Ghosh
发明人： Nipun Davar , Sangita Ghosh
IPC分类号： A61K9/14 , A61K31/4535 , A61K31/5517 , A61K31/47 , A61P1/04 , A61K31/426 , A61P25/08 , A61P25/18 , A61P11/06 , A61K31/357 , A61K31/56
CPC分类号： A61K31/5517 , A61K9/0004 , A61K9/2086 , A61K9/209 , A61K31/138 , A61K31/426 , A61K31/435 , A61K31/4535 , A61K31/57 , A61K31/7048 , A61K2300/00
摘要： A trilayer osmotic tablet is described. The tablet includes a core, a semi-permeable membrane disposed generally around the core, and an orifice in the semi-permeable membrane in fluid communication with the core. The core includes first, second, and third layers. The first layer is in fluid communication with the orifice. The second layer includes a therapeutically effective dose of a drug and is located adjacent to the first layer. The third layer is located adjacent the second layer. The tablet may include a coating having therapeutically effective doses of at least one additional drug disposed in the coating that generally surrounds the semi-permeable membrane. The at least one additional drug in the coating may be the same or different from the drug in the trilayer core. Methods for treating epilepsy, psychiatric disorders, asthma, and peptic ulcer disease by administering these compositions are also described.
摘要翻译：描述了三层渗透片。片剂包括芯，通常围绕芯部设置的半透膜和半芯渗透膜中的与芯体流体连通的孔口。核心包括第一层，第二层和第三层。第一层与孔口流体连通。第二层包括治疗有效剂量的药物并且位于第一层附近。第三层位于第二层附近。片剂可以包括具有治疗有效剂量的至少一种额外药物的涂层，其设置在通常围绕半透膜的涂层中。涂层中的至少一种另外的药物可以与三层核心中的药物相同或不同。还描述了通过施用这些组合物治疗癫痫症，精神疾病，哮喘和消化性溃疡疾病的方法。

4. 发明申请

US20120283275A1 METHODS AND DOSAGE FORMS FOR REDUCING SIDE EFFECTS OF BENZISOZAZOLE DERIVATIVES 审中-公开
标题翻译：减少苯并唑唑衍生物副作用的方法和剂型
公开(公告)号：US20120283275A1
公开(公告)日：2012-11-08
申请号：US13467761
申请日：2012-05-09
申请人： Gayatri Sathyan , Suneel Gupta , Noymi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff
发明人： Gayatri Sathyan , Suneel Gupta , Noymi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff
IPC分类号： A61K31/519 , A61P25/18
CPC分类号： A61K9/0004 , A61K31/519
摘要： Disclosed are dosage forms and methods comprising benzisoxazole derivatives. More particularly, disclosed are dosage forms, methods, and new uses of benzisoxazole derivatives that substantially reduce or substantially eliminate certain side effects of the benzisoxazole derivatives when dosed to a patient.
摘要翻译：公开了包含苯并异恶唑衍生物的剂型和方法。更具体地，公开了苯甲异恶唑衍生物的剂型，方法和新用途，其显着降低或基本上消除了当给予患者时苯并异恶唑衍生物的某些副作用。

5. 发明授权

US07335193B2 Osmotically-driven fluid dispenser 失效
标题翻译：渗透驱动的流体分配器
公开(公告)号：US07335193B2
公开(公告)日：2008-02-26
申请号：US10885188
申请日：2004-07-06
申请人： Patrick S. L. Wong , Nipun Davar
发明人： Patrick S. L. Wong , Nipun Davar
IPC分类号： A61K9/22
CPC分类号： A61K9/2846 , A61K9/0004 , A61K9/2866
摘要： Improvements in a mini-osmotic pump and coating compositions are described. The dispensing pump includes an inner fluid-filled bag encased by an osmotic layer and outer, semi-permeable membrane. The inner bag is formed with an arcuate edge at the open end of the bag to inhibit formation of fissures in the outer membrane in this edge region. The coating compositions include cellulose acetate butyrate, cellulose acetate propionate, and polymethylmethacrylate polymers, optionally mixed with ethyl cellulose in acetone based solvent systems.
摘要翻译：描述了微型渗透泵和涂料组合物的改进。分配泵包括由渗透层和外部半透膜封装的内部充满液体的袋。内袋在袋的开口端处形成有弧形边缘，以防止在该边缘区域中的外膜中的裂缝的形成。涂料组合物包括乙酸丁酸纤维素，乙酸丙酸纤维素和聚甲基丙烯酸甲酯聚合物，任选地与丙酮基溶剂体系中的乙基纤维素混合。

6. 发明申请

US20070166381A1 OSMOTIC DOSAGE FORM WITH CONTROLLED RELEASE AND FAST RELEASE ASPECTS 审中-公开
标题翻译： OSMOTIC剂型与控制释放和快速释放方面
公开(公告)号：US20070166381A1
公开(公告)日：2007-07-19
申请号：US11619468
申请日：2007-01-03
申请人： Iran Reyes , Julie Lee , Brian Barclay , Iswadi Liejanto , Nipun Davar
发明人： Iran Reyes , Julie Lee , Brian Barclay , Iswadi Liejanto , Nipun Davar
IPC分类号： A61K9/24
CPC分类号： A61K9/0004 , A61K31/506
摘要： Disclosed are osmotic dosage forms and methods that provide for fast release of drugs together with controlled release of drugs. In an aspect, disclosed are osmotic dosage forms including: a semi-permeable membrane; a lubricating subcoat located within the semi-permeable membrane; an orifice in the semi-permeable membrane located at an end of the semi-permeable membrane; a drug layer located adjacent to the orifice and within the lubricating subcoat; a push layer located within the lubricating subcoat and on a side of the drug layer opposite from the orifice; wherein an area of the orifice is greater than or equal to about 1,600 mil2; and wherein the drug layer comprises from about 20 wt % to about 90 wt % microcrystalline cellulose, and less than or equal to about 10 wt % of a drug, based on the total weight of the drug layer. Also disclosed are methods of making osmotic dosage forms.
摘要翻译：公开了提供药物快速释放以及药物控制释放的渗透剂型和方法。一方面，所公开的是渗透剂型，包括：半透膜; 位于半透膜内的润滑底涂层; 位于半透膜端部的半透膜中的孔口; 邻近孔口并位于润滑底涂层内的药物层; 位于所述润滑底层内并且在所述药物层的与所述孔相对的一侧的推层; 其中所述孔口的面积大于或等于约1,600密耳2; 并且其中基于药物层的总重量，药物层包含约20重量％至约90重量％的微晶纤维素和小于或等于约10重量％的药物。还公开了制备渗透剂型的方法。

7. 发明申请

US20070026067A1 Liquid formulations for controlled delivery of benzisoxazole derivatives 审中-公开
标题翻译：用于控制输送苯并异恶唑衍生物的液体制剂
公开(公告)号：US20070026067A1
公开(公告)日：2007-02-01
申请号：US11495111
申请日：2006-07-28
申请人： Noymi Yam , Nipun Davar , Gayatri Sathyan , Suneel Gupta
发明人： Noymi Yam , Nipun Davar , Gayatri Sathyan , Suneel Gupta
IPC分类号： A61K9/22 , A61K31/519 , A61K31/42
CPC分类号： A61K31/519 , A61K9/0004 , A61K9/4891 , A61K31/42
摘要： Disclosed are dosage forms including a controlled release dosing structure; and a liquid formulation contained within the controlled release dosing structure; wherein the liquid formulation comprises a benzisoxazole derivative and a liquid carrier. Also disclosed are methods of making and using such dosage forms.
摘要翻译：公开了包括控释剂量结构的剂型; 和包含在控释剂量结构内的液体制剂; 其中液体制剂包含苯并异恶唑衍生物和液体载体。还公开了制备和使用这些剂型的方法。

8. 发明申请

US20090221621A1 Methods of Reducing Alcohol-Induced Dose Dumping for Opioid Sustained Release Oral Dosage Forms 审中-公开
标题翻译：降低酒精诱导剂量阿片类药物持续释放口服剂型的方法
公开(公告)号：US20090221621A1
公开(公告)日：2009-09-03
申请号：US12084396
申请日：2006-10-31
申请人： Gayatri Sathyan , Nipun Davar
发明人： Gayatri Sathyan , Nipun Davar
IPC分类号： A61K31/485 , A61P25/04
CPC分类号： A61K9/0004 , A61K9/2027 , A61K9/2054 , A61K9/2086 , A61K31/485 , A61K47/10
摘要： Disclosed are methods of sustained release administration of opioids, including but not limited to hydromorphone and oxycodone, that exhibit improved properties with respect to co-ingestion with aqueous alcohol.
摘要翻译：公开了持续释放给予阿片样物质的方法，所述阿片样物质包括但不限于氢吗啡酮和羟考酮，其在与含水醇共摄取时表现出改进的性质。

9. 发明申请

US20090202631A1 METHODS AND DOSAGE FORMS FOR CONTROLLED DELIVERY OF PALIPERIDONE AND RISPERIDONE 审中-公开
标题翻译：用于控制输送PALIPERIDONE和RISPERIDONE的方法和剂型
公开(公告)号：US20090202631A1
公开(公告)日：2009-08-13
申请号：US12428422
申请日：2009-04-22
申请人： Nyomi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff , Suneel K. Gupta , Gayatri Sathyan
发明人： Nyomi V. Yam , Iran Reyes , Nipun Davar , Atul D. Ayer , Julie Lee , Sonya Seroff , Suneel K. Gupta , Gayatri Sathyan
IPC分类号： A61K31/519 , A61K9/20
CPC分类号： A61K9/0004 , A61K9/0053 , A61K9/2086 , A61K9/209 , A61K31/506 , A61K31/519
摘要： Dosage forms and methods for providing a substantially ascending rate of release of paliperidone or risperidone are provided. The sustained release dosage forms provide therapeutically effective average steady-state plasma paliperidone or risperidone concentrations when administered once per day. This once-a-day dosing regimen results in only one peak plasma paliperidone or risperidone concentration occurrence in each 24 hour period. In addition, the peak plasma paliperidone or risperidone concentration occurs at a later time following dose administration and exhibits a lesser magnitude than the peak plasma paliperidone or risperidone concentration that occurs following administration of paliperidone or risperidone in an immediate-release dosage form.
摘要翻译：提供了用于提供帕培酮或利培酮的基本上升释放速率的剂型和方法。当每天施用一次时，持续释放剂型提供治疗有效的平均稳态血浆普利培酮或利培酮浓度。这种每天一次的给药方案导致每24小时内出现一次峰值血浆普利培酮或利培酮浓度。此外，剂量给药后的较晚时间，峰值血浆普利培酮或利培酮浓度发生在比立即释放剂型给药帕立哌酮或利培酮后出现的峰值血浆普利培酮或利培酮浓度更小的程度。

10. 发明申请

US20080249497A1 Osmotically-driven fluid dispenser 审中-公开
公开(公告)号：US20080249497A1
公开(公告)日：2008-10-09
申请号：US11974116
申请日：2007-10-10
申请人： Patrick S.L. Wong , Nipun Davar
发明人： Patrick S.L. Wong , Nipun Davar
IPC分类号： A61B19/00
CPC分类号： A61K9/2846 , A61K9/0004 , A61K9/2866
摘要： Improvements in a mini-osmotic pump and coating compositions are described. The dispensing pump includes an inner fluid-filled bag encased by an osmotic layer and outer, semi-permeable membrane. The inner bag is formed with an arcuate edge at the open end of the bag to inhibit formation of fissures in the outer membrane in this edge region. The coating compositions include cellulose acetate butyrate, cellulose acetate propionate, and polymethylmethacrylate polymers, optionally mixed with ethyl cellulose in acetone based solvent systems.

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